Identification of Symbiosis pattern decision factors and its reeducation program
Project/Area Number |
24390190
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Gastroenterology
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Research Institution | Keio University |
Principal Investigator |
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2014: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
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Keywords | プロバイオティクス / 腸内細菌 / 炎症性腸疾患 / ディスバイオーシス / 下部消化管 / マクロファージ / IL-10 / 制御性T細胞 / 先制医療 / 発酵学 |
Outline of Final Research Achievements |
In the first project, a probiotic strain, Clostridium butyricum (CB), induced FOXP3+ regulatory T cells (iTreg) in the colon of normal mice. Although CB suppressed the development of acute DSS colitis, CB did not induce iTreg, but did IL-10-producing macrophages. The preventive effect of CB was not observed in DSS-administered macrophage-specific IL-10 KO mice. In addition, CB-monoassociated mice did not develop DSS colitis (Cell Host & Microbe 2013). In the second project, surprisingly, mice treated with vancomycin and biotin-deficient diet suffered from broad alopecia on the back with dysbiosis composed of a specific lactobacillus strain that reached to 60% dominancy. Also, these mice produced a large amount of a specific amines that seemed to be the key metabolites to induce alopecia.
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] Early intervention with adalimumab may contribute to favorable clinical efficacy in patients with Crohn's disease.2014
Author(s)
Miyoshi J, Hisamatsu T,Matsuoka K,Naganuma M,Maruyama Y,Yoneno K,Mori K,Kiyohara H,Nanki K,Okamoto S,Yajima T,Iwao Y,Ogata H,Hibi T,Kan
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Journal Title
Digestion
Volume: 90(2)
Issue: 2
Pages: 130-136
DOI
Related Report
Peer Reviewed
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[Journal Article] Cross-talk between RORgammat+ innate lymphoid cells and intestinal macrophages induces mucosal IL-22 production in Crohn's disease.2014
Author(s)
1.Mizuno S, Mikami Y, Kamada N, Handa T, Hayashi A, Sato T, Matsuoka K, Matano M, Ohta Y, Sugita A, Koganei K, Sahara R, Takazoe M, Hisamatsu T, Kanai T.
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Journal Title
Inflamm Bowel Dis
Volume: 20(8)
Issue: 8
Pages: 1426-1434
DOI
Related Report
Peer Reviewed
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[Journal Article] Free cholesterol accumulation in hepatic stellate cells: Mechanism of liver fibrosis aggravation in nonalcoholic steatohepatitis in mice2014
Author(s)
Tomita, K. Teratani, T. Suzuki, T. Shimizu, M. Sato, H. Narimatsu, K. Okada, Y. Kurihara, C. Irie, R. Yokoyama, H. Shimamura, K. Usui, S. Ebinuma, H. Saito, H. Watanabe, C. Komoto, S. Kawaguchi, A. Nagao, S. Sugiyama, K. Hokari, R. Kanai, T. Miura, S. Hibi, T.
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Journal Title
Hepatology
Volume: 59
Issue: 1
Pages: 154-169
DOI
Related Report
Peer Reviewed
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[Journal Article] Macrophages and dendritic cells emerge in the liver during intestinal inflammation and predjspose the liver to inflammation.2014
Author(s)
Mikami Y, Mizuno S, Nakamoto N, Hayashi A, Sujino T, Sato T, Kamada N, Matsuoka K, Hisamatsu T, Ebinuma H, Hibi T, Yoshimura A, Kanai T.
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Journal Title
PLoS One
Volume: 9
Issue: 1
Pages: 1-1
DOI
Related Report
Peer Reviewed
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[Journal Article] Mucosal CXCR4_+ IgG plasma cells contribute to the pathogenesis of humanulcerative colitis through FcyR-mediated CD14_+ macrophage activation.2013
Author(s)
Uo M, Hisamatsu, T, Miyoshi J, Kaito D, Yoneno K, Kitazume MT, Mori M, Sugita A, Koganei K, Matsuoka K. Kanai T. Hibi T.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] T-helper 17 and interleukin-17-producing lymphoid tissue inducer-like T cells make different contributions to colitis in mice.2012
Author(s)
Ono Y, Kanai T, Sujino T, Nemoto y Kanai Y, Mikami Y, Hayashi A, Matsumoto A, Takaishi H, 09ata H, Matsuoka K, Hisamatsu T, Watanabe M, Hibi T.
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Journal Title
Gastroenterology
Volume: 148(Epub 2012 Jul 28.)
Pages: 1288-1297
Related Report
Peer Reviewed
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[Presentation] Inflammatory macrophages response to stimulation by Curdlan (beta-1,3-glucan) and may contributes to the pathogenesis of inflammatory bowel disease.2014
Author(s)
Mori M, Hisamatsu T, Suzuki H, Tokutake M, Shimamura K, Mizuno S, Nakamoto N, Ebinuma H, Matsuoka K, Kanai T.
Organizer
第43回日本免疫学会学術集会
Place of Presentation
国立京都国際会場(京都市左京区)
Year and Date
2014-12-10 – 2014-12-12
Related Report
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