The development of novel tools for the diagnosis, prevention, and treatment of cardiovascular diseases based on Cyclophilin A

• Project/Area Number: 24390193
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Tohoku University
• Principal Investigator: SATOH Kimio 東北大学, 高度教養教育・学生支援機構, 准教授 (80436120)
• Co-Investigator(Kenkyū-buntansha): 高橋 潤 東北大学, 大学病院, 講師 (00375081) ; 福本 義弘 久留米大学, 医学部, 教授 (70363372)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000); Fiscal Year 2014: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000); Fiscal Year 2013: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000); Fiscal Year 2012: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
• Keywords: 心血管疾患 / 動脈硬化 / 肺高血圧症 / バイオマーカー / 臨床応用研究 / トランスレーショナルリサーチ / 酸化ストレス / 基礎研究の臨床応用 / サイクロフィリンA / 血管平滑筋細胞 / 肺高血圧症の予後予測 / 冠動脈疾患の早期診断 / 発症前診断法 / 大動脈瘤

Outline of Final Research Achievements

Based on this research funding, we demonstrated that plasma CyPA levels are increased in patients with coronary artery disease (CAD). Plasma CyPA levels were significantly higher in patients with coronary stenosis compared to those without it. A positive correlation was noted between plasma CyPA levels and significant coronary stenosis. The average number of stenotic coronary arteries and the need for coronary intervention were significantly increased in the quartiles of higher CyPA levels. Furthermore, plasma levels of CyPA significantly reduced after medical treatment of risk factors. Importantly, plasma CyPA levels predicted all-cause death, rehospitalization and coronary revascularization in CAD patients and that combination with other biomarkers (hsCRP, BNP) further enhanced the prognostic impacts of CyPA in those patients. During the 3 years funding period, we had 42 presentations in international conferences and published 36 original papers.

Research Products

• [Journal Article] Basigin promotes cardiac fibrosis and failure in response to chronic pressure-overload in mice. (2016)
  • Author(s): Suzuki K, Satoh K, Ikeda S, Sunamura S, Otsuki T, Satoh T, Kikuchi N, Omura J, Kurosawa R, Nogi M, Numano K, Sugimura K, Aoki T, Tatebe S, Miyata S, Mukherjee R, Spinale FG, Kadomatsu K, Shimokawa H.
  • Journal Title: Arterioscler Thromb Vasc Biol. Volume: 36 Issue: 4 Pages: 636-646
  • DOI: 10.1161/atvbaha.115.306686
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] SmgGDS as a crucial mediator of the inhibitory effects of statins on cardiac hypertrophy and fibrosis -Novel mechanism of the pleiotropic effects of statins- (2016)
  • Author(s): Kudo S, Satoh K, Nogi M, Suzuki K, Sunamura S, Omura J, Kikuchi N, Kurosawa R, Satoh T, Minami T, Ikeda S, Miyata S, Shimokawa H.
  • Journal Title: Hypertension Volume: 67 Issue: 5 Pages: 878-889
  • DOI: 10.1161/hypertensionaha.115.07089
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Thrombin-activatable fibrinolysis inhibitor in chronic thromboembolic pulmonary hypertension. (2016)
  • Author(s): Yaoita N, Satoh K, Satoh T, Sugimura K, Tatebe S, Yamamoto S, Aoki T, Miura M, Miyata S, Kawamura T, Horiuchi H, Fukumoto Y, Shimokawa H.
  • Journal Title: Arterioscler Thromb Vasc Biol. Volume: 36 Issue: 6 Pages: 1293-1301
  • DOI: 10.1161/atvbaha.115.306845
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Statins up-regulate SmgGDS through β1-integrin/Akt1 pathway in endothelial cells. (2016)
  • Author(s): Minami T, Satoh K, Nogi M, Kudo S, Miyata S, Tanaka S, Shimokawa H. Statins up-regulate SmgGDS through β1-integrin/Akt1 pathway in endothelial cells.
  • Journal Title: Cardiovasc Res. Volume: 109 Issue: 1 Pages: 151-161
  • DOI: 10.1093/cvr/cvv253
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] RhoA/Rho-kinase in the cardiovascular system. (2016)
  • Author(s): Shimokawa H, Sunamura S, Satoh K.
  • Journal Title: Circ Res. Volume: 118 Issue: 2 Pages: 352-366
  • DOI: 10.1161/circresaha.115.306532
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Multiple Beneficial Effects of Balloon Pulmonary Angioplasty in Patients With Chronic Thromboembolic Pulmonary Hypertension (2016)
  • Author(s): Tatebe S, Sugimura K, Aoki T, Miura M, Nochioka K, Miyamichi-Yamamoto S, Yaoita N, Suzuki H, Sato H, Satoh K, Fukumoto Y, Shimokawa H.
  • Journal Title: Circulation Journal Volume: 80 Issue: 4 Pages: 980-988
  • DOI: 10.1253/circj.CJ-15-1212
  • NAID: 130005139581
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Balloon pulmonary angioplasty improves biventricular functions and pulmonary flow in patients with chronic thromboembolic pulmonary hypertension. (2016)
  • Author(s): Sato H, Ota H, Sugimura K, Aoki T, Tatebe S, Miura M, Yamamoto S, Yaoita N, Suzuki H, Satoh K, Takase K, Shimokawa H.
  • Journal Title: Circ J. Volume: 80
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] PDE1C negatively regulates growth factor receptor degradation and promotes vascular smooth muscle cell proliferation. (2015)
  • Author(s): Satoh K, Kikuchi N, Kurosawa R, Shimokawa H.
  • Journal Title: Circ Res. Volume: 116 Issue: 7 Pages: 1098-1100
  • DOI: 10.1161/circresaha.115.306139
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Cyclophilin A in Cardiovascular Homeostasis and Diseases (2015)
  • Author(s): Satoh K
  • Journal Title: The Tohoku Journal of Experimental Medicine Volume: 235 Issue: 1 Pages: 1-15
  • DOI: 10.1620/tjem.235.1
  • NAID: 130004822422
  • ISSN: 0040-8727, 1349-3329
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Rho-kinase inhibition during early cardiac development causes arrhythmogenic right ventricular cardiomyopathy in mice. (2015)
  • Author(s): Ellawindy A, Satoh K, Sunamura S, Kikuchi N, Suzuki K, Minami T, Ikeda S, Tanaka S, Shimizu T, Enkhjargal B, Miyata S, Taguchi Y, Handoh T, Kobayashi K, Kobayashi K, Nakayama K, Miura M, Shimokawa H.
  • Journal Title: Arterioscler Thromb Vasc Biol. Volume: 35 Issue: 10 Pages: 2172-2184
  • DOI: 10.1161/atvbaha.115.305872
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] 2015 ATVB plenary lecture: translational research on Rho-kinase in cardiovascular medicine. (2015)
  • Author(s): Shimokawa H, Satoh K.
  • Journal Title: Arterioscler Thromb Vasc Biol. Volume: 35 Issue: 8 Pages: 1756-1769
  • DOI: 10.1161/atvbaha.115.305353
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Light and dark of reactive oxygen species for vascular function. (2015)
  • Author(s): Shimokawa H, Satoh K.
  • Journal Title: J Cardiovasc Pharmacol. Volume: 65 Issue: 5 Pages: 412-418
  • DOI: 10.1097/fjc.0000000000000159
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Cyclophilin A: Novel biomarker for oxidative stress and cardiovascular diseases. General Methods in Biomarker Research and Their Applications, (2015)
  • Author(s): Satoh K, Shimokawa H.
  • Journal Title: Springer Reference, London Volume: In: Preedy VR, Patel VB (eds) Pages: 405-438
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Basigin mediates pulmonary hypertension by promoting inflammation and vascular smooth muscle cell proliferation. (2014)
  • Author(s): Satoh K, Satoh T, Kikuchi N, Omura J, Kurosawa R, Suzuki K, Sugimura K, Aoki T, Nochioka K, Tatebe S, Yamamoto S, Miura M, Shimizu T, Ikeda S, Yaoita N, Fukumoto Y, Minami T, Miyata S, Nakamura K, Ito H, Kadomatsu K, Shimokawa H.
  • Journal Title: Circ Res. Volume: 115 Issue: 8 Pages: 738-750
  • DOI: 10.1161/circresaha.115.304563
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Vascular function. (2014)
  • Author(s): Shimokawa H, Satoh K.
  • Journal Title: Arterioscler Thromb Vasc Biol. Volume: 34 Issue: 11 Pages: 2359-2362
  • DOI: 10.1161/atvbaha.114.304119
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] High-sensitivity C-reactive protein: still need for next-generation biomarkers for remote future cardiovascular events. (2014)
  • Author(s): Satoh K, Shimokawa H.
  • Journal Title: Eur Heart J. Volume: 35 Issue: 27 Pages: 1776-1778
  • DOI: 10.1093/eurheartj/ehu115
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Dual roles of vascular-derived reactive oxygen species-With a special reference to hydrogen peroxide and cyclophilin A (2014)
  • Author(s): Kimio Satoh, Shigeo Godo, Hiroki Saito, Budbazar Enkhjargal, Hiroaki Shimokawa
  • Journal Title: Journal of molecular and cellular cardiology Volume: (In press) Pages: 50-56
  • DOI: 10.1016/j.yjmcc.2013.12.022
  • Peer Reviewed / Open Access
• [Journal Article] Globotriaosylceramide induces endothelial dysfunction in Fabry disease. (2014)
  • Author(s): Satoh K.
  • Journal Title: Arterioscler Thromb Vasc Biol. Volume: 34 Issue: 1 Pages: 2-4
  • DOI: 10.1161/atvbaha.113.302744
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Crucial role of rho-kinase in pressure overload-induced right ventricular hypertrophy and dysfunction in mice. (2014)
  • Author(s): Ikeda, S., Satoh, K., Kikuchi, N., Miyata, S., Suzuki, K., Omura, J., Shimizu, T., Kobayashi, K., Kobayashi, K., Fukumoto, Y., Sakata, Y., and Shimokawa, H.
  • Journal Title: Arterioscler. Thromb. Vasc Biol. Volume: 34 Issue: 6 Pages: 1260-1271
  • DOI: 10.1161/atvbaha.114.303320
  • Peer Reviewed / Open Access
• [Journal Article] Combination therapy with fasudil and sildenafil ameliorates monocrotaline-induced pulmonary hypertension and survival in rats. (2014)
  • Author(s): Elias-Al-Mamun M, Satoh K, Tanaka S, Shimizu T, Nergui S, Miyata S, Fukumoto Y, Shimokawa H.
  • Journal Title: Circ J. Volume: 78 Pages: 967-976
  • NAID: 130003391036
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Endothelial AMPK regulates blood pressure and coronary flow responses through hyperpolarization mechanism in mice. (2014)
  • Author(s): Enkhjargal B, Godo S, Sawada A, Nergui S, Saito H, Noda K, Satoh K, Shimokawa H.
  • Journal Title: Arterioscler Thromb Vasc Biol. Volume: 34 Issue: 7 Pages: 1505-1513
  • DOI: 10.1161/atvbaha.114.303735
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Platelets are highly activated in patients of chronic thromboembolic pulmonary hypertension (CTEPH). (2014)
  • Author(s): Yaoita N, Shirakawa R, Fukumoto Y, Sugimura K, Miyata S, Miura Y, Nochioka K, Miura M, Tatebe S, Aoki T, Miyamichi-Yamamoto S, Satoh K, Kimura T, Shimokawa H, Horiuchi H.
  • Journal Title: Arterioscler Thromb Vasc Biol. Volume: 34 Issue: 11 Pages: 2486-2494
  • DOI: 10.1161/atvbaha.114.304404
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Enhanced [18F]fluorodeoxyglucose accumulation in the right ventricular free wall predicts long-term prognosis of patients with pulmonary hypertension: a preliminary observational study. (2014)
  • Author(s): Tatebe S, Fukumoto Y, Oikawa-Wakayama M, Sugimura K, Satoh K, Miura Y, Aoki T, Nochioka K, Miura M, Yamamoto S, Tashiro M, Kagaya Y, Shimokawa H.
  • Journal Title: Eur Heart J Cardiovasc Imaging. Volume: 15 Issue: 6 Pages: 666-672
  • DOI: 10.1093/ehjci/jet276
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] OCT imaging for the management of pulmonary hypertension. (2014)
  • Author(s): Dai Z, Fukumoto Y, Tatebe S, Sugimura K, Miura Y, Nochioka K, Aoki T, Miyamichi-Yamamoto S, Yaoita N, Satoh K, Shimokawa H.
  • Journal Title: JACC-Cardiovasc Imaging. Volume: 7 Issue: 8 Pages: 843-845
  • DOI: 10.1016/j.jcmg.2014.01.020
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Visualization of Complete Regression of Pulmonary Arterial Remodeling on Optical Coherence Tomography in a Patient With Pulmonary Arterial Hypertension. (2014)
  • Author(s): Dai Z, Sugimura K, Fukumoto Y, Tatebe S, Miura Y, Nochioka K, Aoki T, Miyamichi-Yamamoto S, Yaoita N, Satoh K, Shimokawa H.
  • Journal Title: Circ J. Volume: 78 Pages: 2771-2773
  • NAID: 130004700253
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Extracorporeal low-energy shock wave therapy exerts anti-inflammatory effects in acute myocardial infarction in rats in vivo. (2014)
  • Author(s): Abe Y, Ito K, Hao K, Shindo T, Ogata T, Kagaya Y, Kurosawa R, Nishimiya K, Satoh K, Miyata S, Kawakami K, Shimokawa H.
  • Journal Title: Circ J. Volume: 78 Pages: 2915-2925
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Dipeptidyl Peptidase-4 Inhibitors (2013)
  • Author(s): 佐藤公雄 (Kimio Satoh)
  • Journal Title: Circulation Journal Volume: 77 Issue: 5 Pages: 1156-1157
  • DOI: 10.1253/circj.CJ-13-0064
  • NAID: 10031151374
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed
• [Journal Article] Linoleic Acid (2013)
  • Author(s): Satoh K
  • Journal Title: Circulation Journal Volume: 77 Issue: 11 Pages: 2702-2703
  • DOI: 10.1253/circj.CJ-13-1155
  • NAID: 10031196820
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed
• [Journal Article] Plasma Cyclophilin A Is a Novel Biomarker for Coronary Artery Disease (2013)
  • Author(s): Satoh K, Fukumoto Y, Sugimura K, Miura Y, Aoki T, Nochioka K, Tatebe S, Miyamichi-Yamamoto S, Shimizu T, Osaki S,Takagi Y, Tsuburaya R, Ito Y, Matsumoto Y, Nakayama M, Takeda M, Takahashi J, Ito K, Yasuda S, Shimokawa H
  • Journal Title: Circulation Journal Volume: 77 Issue: 2 Pages: 447-455
  • DOI: 10.1253/circj.CJ-12-0805
  • NAID: 10031138924
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed
• [Journal Article] Crucial Role of ROCK2 in vascular smooth muscle cells for hypoxia-induced pulmonary hypertension in mice. (2013)
  • Author(s): Shimizu T, Fukumoto Y, Tanaka S, Satoh K, Ikeda S, Shimokawa H.
  • Journal Title: Arterioscler Thromb Vasc Biol. Volume: 33 Issue: 12 Pages: 2780-2791
  • DOI: 10.1161/atvbaha.113.301357
  • Peer Reviewed
• [Journal Article] Three-dimensional-optical coherence tomography imaging of chronic thromboembolic pulmonary hypertension. (2013)
  • Author(s): Koichiro Sugimura
  • Journal Title: European Heart Journal. Volume: Jul;34(28) Issue: 28 Pages: 2121-2121
  • DOI: 10.1093/eurheartj/eht203
  • Peer Reviewed
• [Journal Article] Optical Coherence Tomography Is Superior to Intravascular Ultrasound for Diagnosis of Distal-Type Chronic Thromboembolic Pulmonary Hypertension (2013)
  • Author(s): Tatebe S
  • Journal Title: Circulation Journal Volume: 77 Issue: 4 Pages: 1081-1083
  • DOI: 10.1253/circj.CJ-12-1493
  • NAID: 130003361592
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed
• [Journal Article] Combination therapy with atorvastatin and amlodipine suppresses angiotensin II-induced aortic aneurysm formation. (2013)
  • Author(s): Takahashi K, Matsumoto Y, Do E Z, Kanazawa M, Satoh K, Shimizu T, Sato A, Fukumoto Y, Shimokawa H.
  • Journal Title: PLoS One. Volume: 8 Issue: 8 Pages: e72558-e72558
  • DOI: 10.1371/journal.pone.0072558
  • Peer Reviewed
• [Journal Article] Rho-Kinase Activation in Patients With Heart Failure (2013)
  • Author(s): Do E Z, Fukumoto Y, Sugimura K, Miura Y, Tatebe S, Yamamoto S, Aoki T, Nochioka K, Nergui S, Yaoita N, Satoh K, Kondo M, Nakano M, Wakayama Y, Fukuda K, Nihei T, Kikuchi Y, Takahashi J, Shimokawa H.
  • Journal Title: Circulation Journal Volume: 77 Issue: 10 Pages: 2542-2550
  • DOI: 10.1253/circj.CJ-13-0397
  • NAID: 10031191794
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed
• [Journal Article] Current Perspectives on Protective Roles of Erythropoietin in Cardiovascular System: Erythropoietin Receptor as a Novel Therapeutic Target (2012)
  • Author(s): Kagaya Y, Asaumi Y, Wang W, Takeda M, Nakano M, Satoh K, Fukumoto Y, Shimokawa H.
  • Journal Title: The Tohoku Journal of Experimental Medicine Volume: 227 Issue: 2 Pages: 83-91
  • DOI: 10.1620/tjem.227.83
  • NAID: 10030779568
  • ISSN: 0040-8727, 1349-3329
  • Peer Reviewed
• [Journal Article] Clinical Significance of Reactive Post-Capillary Pulmonary Hypertension in Patients With Left Heart Disease (2012)
  • Author(s): Tatebe S
  • Journal Title: Circulation Journal Volume: 76 Issue: 5 Pages: 1235-1244
  • DOI: 10.1253/circj.CJ-11-1288
  • NAID: 10030132858
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed
• [Journal Article] Percutaneous Transluminal Pulmonary Angioplasty Markedly Improves Pulmonary Hemodynamics and Long-Term Prognosis in Patients With Chronic Thromboembolic Pulmonary Hypertension (2012)
  • Author(s): Sugimura K
  • Journal Title: Circulation Journal Volume: 76 Issue: 2 Pages: 485-488
  • DOI: 10.1253/circj.CJ-11-1217
  • NAID: 10030036102
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed
• [Presentation] Cyclophilin A and Its Receptor Basigin Promote Vascular Smooth Muscle Proliferation and Pulmonary Hypertension ―Possible Novel Therapeutic Target Pathway― (2016)
  • Author(s): Satoh K.
  • Organizer: 第80回日本循環器学会学術集会プレナリーセッション(PL08:Progress and Future in Pulmonary Hypertension Clinic)
  • Place of Presentation: 仙台国際センター（宮城県仙台市）
  • Year and Date: 2016-03-18
  • Int'l Joint Research / Invited
• [Presentation] Crucial roles of nitric oxide synthases in β-adrenoceptor-mediated bladder relaxation in mice. (2016)
  • Author(s): Satake Y, Kaiho Y, Satoh K, Yamashita S, Tsutsui M, Shimokawa H, Arai Y.
  • Organizer: 31st Annual European association of urology (EAU) Congress
  • Place of Presentation: Munich, Germany
  • Year and Date: 2016-03-11
  • Int'l Joint Research
• [Presentation] Selenoprotein P promotes vascular smooth muscle cell proliferation and pulmonary hypertension -A possible novel therapeutic target-（Travel Award受賞） (2015)
  • Author(s): Kikuchi N, Satoh K, Omura J, Satoh T, Kurosawa R, Nogi M, Otsuki T , NumanoK, Kozu K, Suzuki K, Sunamura S, Tatebe S, Aoki T, Sugimura K, Shimokawa H.
  • Organizer: American Heart Association (AHA) Scientific Sessions
  • Place of Presentation: Orlando, USA
  • Year and Date: 2015-11-08
  • Int'l Joint Research
• [Presentation] Effects of PTPA on respiratory functions in patients with CTEPH. (2015)
  • Author(s): Aoki T, Sugimura K, Tatebe S, Miura M, Yamamoto S, Yaoita N, Suzuki H, Sato H, Satoh K, Shimokawa H.
  • Organizer: American Heart Association (AHA) Scientific Sessions
  • Place of Presentation: Orlando, USA
  • Year and Date: 2015-11-08
  • Int'l Joint Research
• [Presentation] Thrombin-activated fibrinolysis inhibitor in chronic thromboembolic pulmonary hypertension. (2015)
  • Author(s): Yaoita N, Satoh K, Satoh T, Sugimura K, Tatebe S, Yamamoto S, Aoki T, Miura M, Shimokawa H.
  • Organizer: American Heart Association (AHA) Scientific Sessions
  • Place of Presentation: Orlando, USA
  • Year and Date: 2015-11-08
  • Int'l Joint Research
• [Presentation] Basigin promotes cardiac fibrosis and failure in response to chronic pressure-overload in mice. （Travel Award受賞） (2015)
  • Author(s): Suzuki K, Satoh K, Sunamura S, Omura J, Kikuchi N, Satoh T, Kurosawa R, Kudo S, Ikeda S, Otuki T, Shimokawa H.
  • Organizer: American Heart Association (AHA) Scientific Sessions
  • Place of Presentation: Orlando, USA
  • Year and Date: 2015-11-08
  • Int'l Joint Research
• [Presentation] Endothelial AMPK exerts protective effects against hypoxia-induced pulmonary hypertension in mice in vivo. (2015)
  • Author(s): Omura J, Satoh K, Kikuchi N, Satoh T, Kurosawa R, Nogi M, Otsuki T, Kozu K, Numano K, Suzuki K, Sunamura S, Tatebe S, Aoki T, Sugimura K, Shimokawa H.
  • Organizer: American Heart Association (AHA) Scientific Sessions
  • Place of Presentation: Orlando, USA
  • Year and Date: 2015-11-08
  • Int'l Joint Research
• [Presentation] Crucial role of thrombin activatable fibrinolysis inhibitor in the pathogenesis of chronic thromboembolic pulmonary hypertension. (2015)
  • Author(s): Satoh T, Satoh K, Yaoita N, Kikuchi K, Omura J, Kurosawa R, Nogi M, Otsuki T, Kozu K, Numano K, Suzuki K, Sunamura S, Tatebe S, Aoki T, Sugimura K, Shimokawa H.
  • Organizer: American Heart Association (AHA) Scientific Sessions
  • Place of Presentation: Orlando, USA
  • Year and Date: 2015-11-08
  • Int'l Joint Research
• [Presentation] Plasma cyclophilin A as a useful biomarker for evaluation of the effects of percutaneous transluminal pulmonary angioplasty in patients with chronic thromboembolic pulmonary hypertension. (2015)
  • Author(s): Kozu K, Satoh K, Sugimura K, Aoki T, Tatebe S, Miura M, Yamamoto S, Yaoita N, Suzuki H, Otsuki T, Sato H, Miyata S, Shimokawa H.
  • Organizer: American Heart Association (AHA) Scientific Sessions
  • Place of Presentation: Orlando, USA
  • Year and Date: 2015-11-08
  • Int'l Joint Research
• [Presentation] サイクロフィリンAによる肺高血圧症促進機構とその臨床応用 (2015)
  • Author(s): 佐藤 公雄.
  • Organizer: 第4回日本肺循環学会・第3回日本肺高血圧学会 合同学術集会シンポジウム
  • Place of Presentation: ステーションコンファレンス東京（東京都千代田区）
  • Year and Date: 2015-10-03
  • Int'l Joint Research / Invited
• [Presentation] Role of cyclophilin A in cardiovascular system (2015)
  • Author(s): 佐藤 公雄.
  • Organizer: 第40回日本微小循環学会主催 サテライトシンポジウム
  • Place of Presentation: 京都国際会館（京都府京都市）
  • Year and Date: 2015-09-24
  • Int'l Joint Research / Invited
• [Presentation] Selenoprotein P Promotes Vascular Smooth Muscle Cell Proliferation and Pulmonary Hypertension-A Possible Novel Therapeutic Target- (2015)
  • Author(s): Kikuchi N, Satoh K, Omura J, Satoh T, Kurosawa R, Nogi M, Tatebe S, Aoki T, Sugimura K, Shimokawa H.
  • Organizer: European Society Congress (ESC) 2015
  • Place of Presentation: London, UK
  • Year and Date: 2015-08-29
  • Int'l Joint Research
• [Presentation] Cardiac pacemaker stimulates the brain as well as the heart in humans –A PET functional study- (2015)
  • Author(s): Suzuki H, Satoh K, Tatebe S, Matsumoto M, Kondo M, Nakano M, Fukuda K, Hiraoka K, Tashiro M, Shimokawa H.
  • Organizer: European Society Congress (ESC) 2015
  • Place of Presentation: London, UK
  • Year and Date: 2015-08-29
  • Int'l Joint Research
• [Presentation] Novel strategy for catheter interventional treatment of chronic thromboembolic pulmonary hypertension guided by optical coherence tomography imaging. (2015)
  • Author(s): Sugimura K, Aoki T, Miura M, Yaoita N, Satoh H, Satoh K, Shimokawa H.
  • Organizer: European Society Congress (ESC) 2015
  • Place of Presentation: London, UK
  • Year and Date: 2015-08-29
  • Int'l Joint Research
• [Presentation] SmgGDS as a Crucial Mediator of the Inhibitory Effects of Statins on Cardiac Hypertrophy and Fibrosis -Novel Mechanism of the Pleiotropic Effects of Statins- (2015)
  • Author(s): Kudo S, Satoh K, Nogi M, Suzuki K, Sunamura S, Omura J, Kikuchi N, Tanaka S, Minami T, Ikeda S, Shimokawa H.
  • Organizer: Scientific Session 2015 of the Arteriosclerosis, Thrombosis and Vascular Biology Council
  • Place of Presentation: San Francisco, USA
  • Year and Date: 2015-05-08
  • Int'l Joint Research
• [Presentation] Plasma Levels of Cyclophilin A Correlate with Circulating Inflammatory Cytokines in Patients with Pulmonary Hypertension. (2015)
  • Author(s): Otsuki T, Satoh K, Kikuchi N, Omura J, Kudo S, Sugimura K, Aoki T, Tatebe S, Shimokawa H.
  • Organizer: Scientific Session 2015 of the Arteriosclerosis, Thrombosis and Vascular Biology Council
  • Place of Presentation: San Francisco, USA
  • Year and Date: 2015-05-08
  • Int'l Joint Research
• [Presentation] Plasma Cyclophilin A as a Useful Biomarker for Effective Percutaneous Transluminal Pulmonary Angioplasty in Chronic Thromboembolic Pulmonary Hypertension. (2015)
  • Author(s): Satoh K, Sugimura K, Aoki T, Tatebe S, Shimizu T, Ikeda S, Yaoita N, Kudo S, Suzuki K, Omura J, Kikuchi N, Satoh T, Kurosawa R, Sunamura S, Otsuki T, Shimokawa H.
  • Organizer: Scientific Session 2015 of the Arteriosclerosis, Thrombosis and Vascular Biology Council
  • Place of Presentation: San Francisco, USA
  • Year and Date: 2015-05-08
  • Int'l Joint Research
• [Presentation] サイクロフィリンＡ受容体Basiginによる肺高血圧症促進機構 (2015)
  • Author(s): 佐藤公雄、鈴木康太、大村淳一、菊地信裕、佐藤大樹、黒澤 亮、矢尾板信裕、杉村宏一郎、福本義弘、中村一文、伊藤 浩、下川宏明
  • Organizer: 第44回日本心脈管作動物質学会学術集会
  • Place of Presentation: 高松市
  • Year and Date: 2015-02-06 – 2015-02-07
• [Presentation] Cyclophilin a and basigin promotes pulmonary hypertension by inducing inflammation and vascular smooth muscle cell proliferation. (2014)
  • Author(s): Satoh K, Suzuki K, Omura J, Kikuchi N, Miyata S, Minami T, Sugimura K, Aoki T, Nochioka K, Tatebe S, Miura M, Yamamoto S, Shimizu T, Ikeda S, Yaoita N, Fukumoto Y, Nakamura K, Ito H, Kadomatsu K, Shimokawa H.
  • Organizer: American Heart Association (AHA) Scientific Sessions
  • Place of Presentation: Chicago, USA
  • Year and Date: 2014-11-15 – 2014-11-19
• [Presentation] Crucial role of Rho-kinase in pressure overload-induced right ventricular hypertrophy and dusfunction in mice. (2014)
  • Author(s): Ikeda S, Satoh K, Kikuchi N, Miyata S, Suzuki K, Omura J, Shimizu T, Fukumoto Y, Sakata Y, Shimokawa H.
  • Organizer: 第18回日本心不全学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2014-10-10 – 2014-10-12
• [Presentation] ミニシンポジウム３：Basiginは血管平滑筋細胞増殖を促進し肺高血圧症を悪化させる. (2014)
  • Author(s): 佐藤公雄、鈴木康太、大村淳一、菊地順祐、矢尾板信裕、杉村宏一郎、福本義弘、中村一文、伊藤 浩、下川宏明
  • Organizer: 第2回日本肺高血圧学会・第3回日本肺循環学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2014-10-03 – 2014-10-04
• [Presentation] Basigin promotes vascular smooth muscle proliferation and pulmonary hypertension. (2014)
  • Author(s): 佐藤公雄、鈴木康太、大村淳一、菊地順裕、杉村宏一郎、中村一文、伊藤 浩、門松健治、下川宏明
  • Organizer: 第14回日本NO学会学術集会
  • Place of Presentation: 佐賀市
  • Year and Date: 2014-05-16 – 2014-05-17
• [Presentation] Basigin promotes vascular smooth muscle proliferation and pulmonary hypertension. (2014)
  • Author(s): Satoh K, Suzuki K, Omura J, Kikuchi N, Miyata S, Minami T, Sugimura K, Aoki T, Nochioka K , Tatebe T, Miura M, Yamamoto S, Shimizu T, Yaoita N, Fukumoto Y, Nakamura K, Ito H, Kadomatsu K, Shimokawa H.
  • Organizer: Scientific Session 2014 of the Arteriosclerosis, Thrombosis and Vascular Biology Council
  • Place of Presentation: Tronto, Canada
  • Year and Date: 2014-05-01 – 2014-05-04
• [Presentation] Basigin promotes vascular smooth muscle proliferation and pulmonary hypertension (2014 PVD Mid-Career Investigator Award) (2014)
  • Author(s): Satoh K.
  • Organizer: Arteriosclerosis, Thrombosis, and Vascular Biology 年次集会 （受賞講演）
  • Place of Presentation: カナダ･トロント
  • Invited
• [Presentation] エリスロポエチンの血管内皮保護作用と心血管恒常性維持機構 (2014)
  • Author(s): 佐藤 公雄
  • Organizer: 第59回日本透析医学会学術集会・総会･シンポジウム（招待講演）
  • Place of Presentation: 神戸
  • Invited
• [Presentation] Basigin promotes inflammation and pulmonary hypertension through synergistic cooperation with extracellular cyclophilin A. (2014)
  • Author(s): Satoh K.
  • Organizer: 第18回国際血管生物学会 The 18th International Vascular Biology Meeting （受賞講演）
  • Place of Presentation: 京都
  • Invited
• [Presentation] 選択的Rhoキナーゼ阻害薬のドラッグ･リポジショニングによる心血管病治療戦略 (2014)
  • Author(s): 佐藤 公雄
  • Organizer: 新規効能治療薬の創製～ドラッグ･リポジショニングを用いて～ （招待講演）
  • Place of Presentation: 大阪･千里
  • Invited
• [Presentation] 「動脈硬化の最新知見」サイクロフィリンAによる動脈硬化の発症機構と新規バイオマーカーとしての可能性 (2014)
  • Author(s): 佐藤 公雄
  • Organizer: 第43回日本心脈管作動物質学会 （シンポジウム）
  • Place of Presentation: 神戸
  • Invited
• [Presentation] サイクロフィリンAによる心血管病促進機構とバイオマーカーとしての可能性 (2014)
  • Author(s): 佐藤 公雄
  • Organizer: 第13回日本Nitric Oxide学会学術集会 （シンポジウム講演)
  • Place of Presentation: 那覇
  • Invited
• [Presentation] Cyclophilin A is a novel biomarker for oxidative stress and atherosclerotic diseases. (2013)
  • Author(s): Satoh K.
  • Organizer: 第1回 サイクロフィリンＡ発見30周年記念集会 （招待講演)
  • Place of Presentation: ドイツ・ハレ
  • Invited
• [Presentation] 大動脈瘤におけるDanger Signalと炎症 (2013)
  • Author(s): 佐藤 公雄
  • Organizer: 第21回日本血管生物医学会学術集会 （シンポジウム講演)
  • Place of Presentation: 大阪
  • Invited
• [Presentation] Plasma Cyclophilin A is a novel biomarker for oxidative stress and coronary artery disease. (2013)
  • Author(s): 佐藤公雄(Kimio Satoh)
  • Organizer: 日本循環器学会総会(シンポジウム)
  • Place of Presentation: 横浜(招待講演)
• [Presentation] Spontaneous Development of Arrhythmogenic Right Ventricular Cardiomyopathy in Mice Overexpressing Dominant-Negative Rho-kinase in the Cardiovascular System (2013)
  • Author(s): Alia Ellawindy
  • Organizer: 日本循環器学会総会(International Young Investigator's Award)
  • Place of Presentation: 横浜
• [Presentation] Plasma Cyclophilin A Level Is a Novel Biomarker of Vasospastic Angina (2013)
  • Author(s): 佐藤公雄(Kimio Satoh)
  • Organizer: 日本循環器学会総会
  • Place of Presentation: 横浜
• [Presentation] Plasma Cyclophilin A as a Novel Biomarker for Pulmonary Hypertension in Humans (2013)
  • Author(s): 佐藤公雄(Kimio Satoh)
  • Organizer: 日本循環器学会総会
  • Place of Presentation: 横浜
• [Presentation] Plasma Cyclophilin A as a Novel Biomarker for Pulmonary Hypertension in Humans (2012)
  • Author(s): 佐藤公雄(Kimio Satoh)
  • Organizer: 米国心臓病学会議(AHA 2012)
  • Place of Presentation: オーランド(米国)
• [Presentation] Plasma Cyclophilin A as a Novel Biomarker for Pulmonary Hypertension in Humans (2012)
  • Author(s): 佐藤公雄(Kimio Satoh)
  • Organizer: 欧州心臓学会議(ESC 2012)
  • Place of Presentation: ミュンヘン(ドイツ)
• [Book] 循環器専門医 「喫煙と循環器疾患up to date: 喫煙による酸化ストレスと動脈硬化性疾患」 (2016)
  • Author(s): 佐藤 公雄.
  • Total Pages: 5
  • Publisher: 南江堂
• [Book] 「循環器内科」特集/循環器疾患と分子遺伝学 肺高血圧症の分子基盤（改定第2版） (2015)
  • Author(s): 佐藤 公雄、下川 宏明.
  • Total Pages: 7
  • Publisher: 科学評論社
• [Book] 「循環器内科」特集/循環器疾患と分子遺伝学 肺高血圧症の分子基盤 (2015)
  • Author(s): 佐藤 公雄、下川 宏明.
  • Total Pages: 8
  • Publisher: 科学評論社
• [Book] 『酸化ストレスの医学 改訂第２版』 心疾患と酸化ストレス (2014)
  • Author(s): 佐藤 公雄、下川 宏明.
  • Total Pages: 7
  • Publisher: 診断と治療社
• [Book] 『循環器内科』第74巻第6号 特集／肺高血圧症―内科的治療の展開 Rhoキナーゼ阻害剤 (fasudil) (2013)
  • Author(s): 佐藤 公雄、下川 宏明.
  • Total Pages: 150
  • Publisher: 科学評論社
• [Book] 生体の科学・増大特集「細胞表面受容体」 エリスロポエチン受容体の心血管保護機構VoL.64 No.5 (2013)
  • Author(s): 佐藤 公雄、下川 宏明.
  • Total Pages: 520
  • Publisher: 医学書院
• [Book] 『Mebio』ターニングポイントを迎えた肺高血圧症の治療戦略 Rho-kinase阻害薬 (2013)
  • Author(s): 佐藤 公雄、下川 宏明.
  • Total Pages: 120
  • Publisher: MEDICAL VIEW
• [Book] 増刊号 『酸化ストレスと血管内皮機能障害』 (2013)
  • Author(s): 佐藤 公雄、下川 宏明.
  • Total Pages: 320
  • Publisher: 医学のあゆみ
• [Book] 『血管新生の医学』エリスロポエチンの血管内皮保護作用と血管恒常性維持機構 (2013)
  • Author(s): 佐藤 公雄、下川 宏明.
  • Total Pages: 250
  • Publisher: BIO Clinica
• [Book] 血管新生の医学IIIリズポニチンの血管内皮保護作用と血管恒常性維持機構 (2013)
  • Author(s): 佐藤公雄
  • Total Pages: 98
  • Publisher: BIO Clinica
• [Remarks] 東北大学循環器内科ホームページ
  • URL: http://www.cardio.med.tohoku.ac.jp/
• [Remarks] 東北大学循環器内科
  • URL: http://www.cardio.med.tohoku.ac.jp/
• [Remarks] 東北大学循環器内科ホームページ
  • URL: http://www.cardio.med.tohoku.ac.jp/class/staff/index02.html#sato
• [Remarks] 東北大学循環器内科
  • URL: http://www.cardio.med.tohoku.ac.jp/
• [Patent(Industrial Property Rights)] 肺高血圧症の検査方法 (2015)
  • Inventor(s): 下川宏明、佐藤公雄、菊地順裕
  • Industrial Property Rights Holder: 下川宏明、佐藤公雄、菊地順裕
  • Industrial Property Rights Type: 特許
  • Filing Date: 2015-04-01
  • Overseas
• [Patent(Industrial Property Rights)] サイクロフィリンＡによる心血管疾患の検査方法 (2014)
  • Inventor(s): 下川宏明、佐藤公雄 (国立大学法人東北大学)
  • Industrial Property Rights Holder: 下川宏明、佐藤公雄 (国立大学法人東北大学)
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2012-239615
  • Filing Date: 2014-10-30
  • Acquisition Date: 2015-02-10
• [Patent(Industrial Property Rights)] サイクロフィリンＡによる心血管疾患の検査方法 (2013)
  • Inventor(s): 下川宏明、佐藤公雄 (国立大学法人東北大学)
  • Industrial Property Rights Holder: 下川宏明、佐藤公雄 (国立大学法人東北大学)
  • Industrial Property Rights Type: 特許
  • Filing Date: 2013-10-29
  • Acquisition Date: 2015-02-10
  • Overseas
• [Patent(Industrial Property Rights)] サイクロフィリンＡによる心血管疾患の検査方法 (2013)
  • Inventor(s): 下川宏明、佐藤公雄 (国立大学法人東北大学)
  • Industrial Property Rights Holder: 下川宏明、佐藤公雄 (国立大学法人東北大学)
  • Industrial Property Rights Type: 特許
  • Filing Date: 2013-10-29
  • Overseas
• [Patent(Industrial Property Rights)] サイクロフィリンAによる心血管疾病の検査方法 (2012)
  • Inventor(s): 下川宏明,佐藤公雄（国立大学法人東北大学）
  • Industrial Property Rights Holder: 下川宏明,佐藤公雄（国立大学法人東北大学）
  • Industrial Property Number: 2012-239615
  • Filing Date: 2012-10-13