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A role of p53-induced senescence in life style-related disease

Research Project

Project/Area Number 24390195
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionNiigata University

Principal Investigator

MINAMINO Tohru  新潟大学, 医歯学系, 教授 (90328063)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2014: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2013: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2012: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Keywords老化 / p53 / 生活習慣病 / 細胞老化
Outline of Final Research Achievements

The prevalence of obesity, diabetes and heart failure increases with aging, and there is evidence that these age-related disorders share common pathologic features such as chronic low-grade inflammation and systemic metabolic dysfunction. Cellular senescence was initially discovered by in vitro studies, but it is now widely accepted that this process also occurs in vivo with aging. The p53 signaling pathway has a central role in the regulation of cellular senescence, and our study indicates that cellular senescence has a causative role in the progression of age-related disorders, such as diabetes, vascular aging, and heart failure.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (84 results)

All 2015 2014 2013 2012 Other

All Journal Article (34 results) (of which Peer Reviewed: 34 results,  Open Access: 19 results) Presentation (36 results) (of which Invited: 24 results) Book (13 results) Remarks (1 results)

  • [Journal Article] Pathological Role of Adipose Tissue Dysfunction in Cardio-Metabolic Disorders.2015

    • Author(s)
      Shimizu I, Yoshida Y, Minamino T.
    • Journal Title

      Int Heart J

      Volume: 印刷中

    • NAID

      130005070025

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Electrocardiographic abnormalities and risk of developing cardiac events in extracardiac sarcoidosis.2015

    • Author(s)
      Nagao S, Watanabe H, Sobue Y, Kodama M, Tanaka J, Tanabe N, Suzuki E, Narita I, Watanabe E, Aizawa Y, Minamino T.
    • Journal Title

      Int J Cardiol

      Volume: 189 Pages: 1-5

    • DOI

      10.1016/j.ijcard.2015.03.175

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Liver Congestion in Heart Failure Contributes to Inappropriately Increased Serum Hepcidin despite Anemia2015

    • Author(s)
      Ohno Y, Hanawa H, Jiao S, Hayashi Y, Yoshida K, Suzuki T, Kashimura T, Obata H, Tanaka K, Watanabe T, Minamino T.
    • Journal Title

      The Tohoku Journal of Experimental Medicine

      Volume: 235 Issue: 1 Pages: 69-79

    • DOI

      10.1620/tjem.235.69

    • NAID

      130004822430

    • ISSN
      0040-8727, 1349-3329
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Complement C1q-induced activation of β-catenin signalling causes hypertensive arterial remodelling.2015

    • Author(s)
      Sumida T, Naito AT, Nomura S, Nakagawa A, Higo T, Hashimoto A, Okada K, Sakai T, Ito M, Yamaguchi T, Oka T, Akazawa H, Lee JK, Minamino T, Offermanns S, Noda T, Botto M, Kobayashi Y, Morita H, Manabe I, Nagai T, Shiojima I, Komuro I.
    • Journal Title

      Nat Commun

      Volume: 6 Issue: 1 Pages: 6241-6241

    • DOI

      10.1038/ncomms7241

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Characteristics of neoplastic cardiac tamponade and prognosis after pericardiocentesis: a single-center study of 113 consecutive cancer patients.2015

    • Author(s)
      Takayama T, Okura Y, Okada Y, Honma K, Nashimoto A, Sato N, Yokoyama A, Minamino T.
    • Journal Title

      Int J Clin Oncol

      Volume: 印刷中

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] DNA damage response and metabolic disease.2014

    • Author(s)
      Shimizu I, Yoshida Y, Suda M, Minamino T.
    • Journal Title

      Cell Metab

      Volume: 20 Issue: 6 Pages: 967-977

    • DOI

      10.1016/j.cmet.2014.10.008

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A crucial role for CDC42 in senescence-associated inflammation and atherosclerosis.2014

    • Author(s)
      Ito TK, Yokoyama M, Yoshida Y, Nojima A, Kassai H, Oishi K, Okada S, Kinoshita D, Kobayashi Y, Fruttiger M, Aiba A, Minamino T.
    • Journal Title

      PLoS One

      Volume: 9 Issue: 7 Pages: e102186-e102186

    • DOI

      10.1371/journal.pone.0102186

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Relative refractoriness of left ventricular contraction underlies human tachycardia-induced mechanical and electrical alternans.2014

    • Author(s)
      Kashimura T, Kodama M, Watanabe T, Tanaka K, Hayashi Y, Ohno Y, Obata H, Ito M, Hirono S, Hanawa H, Minamino T.
    • Journal Title

      Pacing Clin Electrophysiol

      Volume: 37 Issue: 2 Pages: 197-206

    • DOI

      10.1111/pace.12230

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hyperglycemia causes cellular senescence via a SGLT2- and p21-dependent pathway in proximal tubules in the early stage of diabetic nephropathy.2014

    • Author(s)
      Kitada K, Nakano D, Ohsaki H, Hitomi H, Minamino T, Yatabe J, Felder RA, Mori H, Masaki T, Kobori H, Nishiyama A.
    • Journal Title

      J Diabetes Complications

      Volume: 28 Issue: 5 Pages: 604-611

    • DOI

      10.1016/j.jdiacomp.2014.05.010

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Emerging issues in radiogenic cataracts and cardiovascular disease.2014

    • Author(s)
      Hamada N, Fujimichi Y, Iwasaki T, Fujii N, Furuhashi M, Kubo E, Minamino T, Nomura T, Sato H.
    • Journal Title

      J Radiat Res

      Volume: 55 Issue: 5 Pages: 831-846

    • DOI

      10.1093/jrr/rru036

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Inhibition of endothelial p53 improves metabolic abnormalities related to dietary obesity.2014

    • Author(s)
      Yokoyama M, Okada S, Nakagomi A, Moriya J, Shimizu I, Nojima A, Yoshida Y, Ichimiya H, Kamimura N, Kobayashi Y, Ohta S, Fruttiger M, Lozano G, Minamino T.
    • Journal Title

      Cell Rep

      Volume: 7 Issue: 5 Pages: 1691-1703

    • DOI

      10.1016/j.celrep.2014.04.046

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Involvement of TERT in heterochromatin maintenance.2014

    • Author(s)
      Maida Y, Yasukawa M, Okamoto N, Ohka S, Kinoshita K, Totoki Y, Ito TK, Minamino T, Nakamura H, Yamaguchi S, Shibata T, Masutomi K.
    • Journal Title

      Mol Cell Biol

      Volume: 印刷中 Issue: 9 Pages: 1576-1593

    • DOI

      10.1128/mcb.00093-14

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Inappropriate expression of hepcidin by liver congestion contributes to anemia and relative iron deficiency.2014

    • Author(s)
      Suzuki T, Hanawa H, Jiao S, Ohno Y, Hayashi Y, Yoshida K, Kashimura T, Obata H, Minamino T.
    • Journal Title

      J Card Fail

      Volume: 20 Issue: 4 Pages: 268-277

    • DOI

      10.1016/j.cardfail.2014.01.008

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Efficacy of bepridil to prevent ventricular fibrillation in severe form of early repolarization syndrome2014

    • Author(s)
      Katsuumi G, Shimizu W, Watanabe H, Noda T, Nogami A, Ohkubo K, Makiyama T, Takehara N, Kawamura Y, Hosaka Y, Sato M, Fukae S, Chinushi M, Oda H, Okabe M, Kimura A, Maemura K, Watanabe I, Kamakura S, Horie M, Aizawa Y, Makita N, Minamino T
    • Journal Title

      Int J Cardiol

      Volume: 172 Issue: 2 Pages: 519-522

    • DOI

      10.1016/j.ijcard.2014.01.036

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Augmentation of the J wave by rapid pacing in a patient with vasospastic angina.2014

    • Author(s)
      Sato A, Watanabe H, Sonoda K, Chinushi M, Tsuda T, Izumi D, Furushima H, Minamino T.
    • Journal Title

      Int J Cardiol.

      Volume: 172 Issue: 1 Pages: e111-e113

    • DOI

      10.1016/j.ijcard.2013.12.121

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Notch signaling regulates the lifespan of vascular endothelial cells via a p16-dependent pathway.2014

    • Author(s)
      Yoshida Y, Hayashi Y, Suda M, Tateno K, Okada S, Moriya J, Yokoyama M, Nojima A, Yamashita M, Kobayashi Y, Shimizu I, Minamino T.
    • Journal Title

      PLoS One

      Volume: 20 Issue: 6 Pages: e100359-e100359

    • DOI

      10.1371/journal.pone.0100359

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Arachidonate 12/15-lipoxygenase-induced inflammation and oxidative stress are involved in the development of diabetic cardiomyopathy.2014

    • Author(s)
      Suzuki H, Kayama Y, Sakamoto M, Iuchi H, Shimizu I, Yoshino T, Katoh D, Nagoshi T, Tojo K, Minamino T, Yoshimura M, Utsunomiya K.
    • Journal Title

      Diabetes

      Volume: 64 Issue: 2 Pages: 618-630

    • DOI

      10.2337/db13-1896

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Short QT syndrome in a boy diagnosed on screening for heart disease.2014

    • Author(s)
      Suzuki H, Hoshina S, Ozawa J, Sato A, Minamino T, Aizawa Y, Saitoh A.
    • Journal Title

      Pediatr Int.

      Volume: 56 Issue: 5 Pages: 774-774

    • DOI

      10.1111/ped.12308

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Inhibition of endothelial p53 improves metabolic abnormalities related to dietary abesity.2014

    • Author(s)
      Yokoyama M,Nakagomi A,Moriya J,Shimizu I,Nojima a,Yoshida Y,Ichimiya H,Kamimura N,Kobayashi Y,Ohta S,Fruttiger M,Lozano G,Minamino T.
    • Journal Title

      Cell Reports

      Volume: 印刷中

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of flecainide on exercise-induced ventricular arrhythmias and recurrences in genotype-negative patients with catecholaminergic polymorphic ventricular tachycardia.2013

    • Author(s)
      Watanabe H, van der Werf C, Horie M. et al.
    • Journal Title

      Heart Rhythm

      Volume: 10 Issue: 4 Pages: 542-547

    • DOI

      10.1016/j.hrthm.2012.12.035

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tumor suppressor p53 inhibits systemic autoimmune diseases by inducing regulatory T cells.2013

    • Author(s)
      Kawashima H, Takatori H, Suzuki K, Iwata A, Yokota M, Suto A, Minamino T, Hirose K, Nakajima H
    • Journal Title

      J Immunol.

      Volume: 19 Issue: 7 Pages: 3614-3623

    • DOI

      10.4049/jimmunol.1300509

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Notch activation mediates angiotensin II-induced vascular remodeling by promoting the proliferation and migration of vascular smooth muscle cells2013

    • Author(s)
      Ozasa Y, Akazawa H, Qin Y, Tateno K, Ito K, Kudo-Sakamoto Y, Yano M, Yabumoto C, Naito AT, Oka T, Lee JK, Minamino T, Nagai T, Kobayashi Y, Komuro I
    • Journal Title

      Hypertens Res

      Volume: 36(10) Issue: 10 Pages: 859-65

    • DOI

      10.1038/hr.2013.52

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Semaphorin-induced inflammation contributes to insulin resistance in dietary obesity.2013

    • Author(s)
      Shimizu I, Yoshida Y, Moriya J, Nojima A, Uemura A, Kobayashi Y, Minamino T.
    • Journal Title

      Cell Metab

      Volume: 18 Issue: 4 Pages: 491-504

    • DOI

      10.1016/j.cmet.2013.09.001

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Malfunction of cardiac resynchronization therapy due to subsequent fracture of the ring and tip conductors of a co-radial left ventricular bipolar lead.2013

    • Author(s)
      Sato A, Chinushi M, Izumi D, Furushima H, Minamino T.
    • Journal Title

      Intern Med

      Volume: 52 Pages: 1189-93

    • NAID

      130003365633

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] SCN5A mutation associated with ventricular fibrillation, early repolarization, and concealed myocardial abnormalities2013

    • Author(s)
      Watanabe H, Ohkubo K, Watanabe I, Matsuyama TA, Ishibashi-Ueda H, Yagihara N, Shimizu W, Horie M, Minamino T, Makita N
    • Journal Title

      Int J Cardiol.

      Volume: 165 Issue: 2 Pages: e21-e23

    • DOI

      10.1016/j.ijcard.2012.10.074

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A mutant mRNA expression in an endomyocardial biopsy sample obtained from a patient with a cardiac variant of Fabry disease caused by a novel acceptor splice site mutation in the invariant AG of intron 5 of the α-galactosidase A gene.2013

    • Author(s)
      Watanabe T, Hanawa H, Suzuki T, Jiao S, Yoshida K, Ogura M, Ohno Y, Hayashi Y, Ito M, Kashimura T, Obata H, Sato A, Ozawa T, Kodama M, Sakuraba H, Minamino T.
    • Journal Title

      Intern Med.

      Volume: 52 Pages: 777-80

    • NAID

      130003365972

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of mutations in L-type calcium channel genes in Brugada syndrome, early repolarization syndrome, and idiopathic ventricular fibrillation associated with right bundle branch block.2013

    • Author(s)
      Watanabe H, Minamino T.
    • Journal Title

      Circ J

      Volume: 77 Pages: 1689-90

    • NAID

      10031173746

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Haploinsufficiency of akt1 prolongs the lifespan of mice2013

    • Author(s)
      Nojima A, Yamashita M, Yoshida Y, Shimizu I, Ichimiya H, Kamimura N, Kobayashi Y, Ohta S, Ishii N, Minamino T
    • Journal Title

      PLoS One

      Volume: 8(7) Issue: 7 Pages: e69178-e69178

    • DOI

      10.1371/journal.pone.0069178

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death.2013

    • Author(s)
      Bezzina CR, Makita N(63人中31番目)et al
    • Journal Title

      Nat Genet.

      Volume: 45 Issue: 9 Pages: 1044-1049

    • DOI

      10.1038/ng.2712

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Brain-derived neurotrophic factor protects against cardiac dysfunction after myocardial infarction via a central nervous system-medeiated pathway2012

    • Author(s)
      Okada S, Yokoyama M, Toko H, Tateno K, Moriya J, Shimizu I, Nojima A, Ito T, Yoshida Y, Kobayashi Y, Katagiri H, Minamino T, Komuro I
    • Journal Title

      Arterioscler Thromb Vasc Biol

      Volume: 32(8) Issue: 8 Pages: 1902-9

    • DOI

      10.1161/atvbaha.112.248930

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] p53-induced adipose tissue inflammation is critically involved in the development of insulin resistance in heart failure2012

    • Author(s)
      Shimizu I, Yoshida Y, Katsuno T, Tateno K, Okada S, Moriya J, Yokoyama M, Nojima A, Ito T, Zechner R, Komuro I, Kobayashi Y, Minamino T
    • Journal Title

      Cell Metab

      Volume: 15 Issue: 1 Pages: 51-64

    • DOI

      10.1016/j.cmet.2011.12.006

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Complement C1q activates canonical Wnt signaling and promotes aging-related phenotypes2012

    • Author(s)
      Naito AT, Sumida T, Nomura S, Liu ML, Higo T, Nakagawa A, Okada K, Sakai T, Hashimoto A, Hara Y, Shimizu I, Zhu W, Toko H, Katada A, Akazawa H, Oka T, Lee JK, Minamino T, Nagai T, Walsh K, Kikuchi A, Matsumoto M, Botto M, Shiojima I, Komuro I
    • Journal Title

      Cell

      Volume: 149 Issue: 6 Pages: 1298-1313

    • DOI

      10.1016/j.cell.2012.03.047

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aldosterone Does Not Contribute to Renal p21 Expression During the Development of Angiotensin II-Induced Hypertension in Mice2012

    • Author(s)
      Nakano D, Minamino T, et al
    • Journal Title

      Am J Hypertens

      Volume: 25 Issue: 3 Pages: 354-358

    • DOI

      10.1038/ajh.2011.224

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Agonist-independent constitutive activity of angiotensin II receptor promotes cardiac remodeling in mice2012

    • Author(s)
      Yasuda N, Akazawa H, Ito K, Shimizu I, Kudo-Sakamoto Y, Yabumoto C, Yano M, Yamamoto R, Ozasa Y, Minamino T, Naito AT, Oka T, Shiojima I, Tamura K, Umemura S, Nemer M, Komuro I
    • Journal Title

      Hypertension

      Volume: 59 Issue: 3 Pages: 627-633

    • DOI

      10.1161/hypertensionaha.111.175208

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] Role of senescence-associated inflammation in lifestyle-related disease.2015

    • Author(s)
      Minamino T.
    • Organizer
      2015 Seoul Symposium on Obesity & Diabetes
    • Place of Presentation
      Seoul National University Hospital (韓国)
    • Year and Date
      2015-03-28
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Capillary rarefaction mediates whitening of brown fat and contributes to insulin resistance in obesity.2014

    • Author(s)
      Shimizu I, Walsh K, Minamino T.
    • Organizer
      The 58th Annual Scientific Meeting of The Korean Society of Cardiology.
    • Place of Presentation
      Korea(韓国)
    • Year and Date
      2014-11-28
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 加齢疾患における脂肪不全の意義2014

    • Author(s)
      清水逸平,吉田陽子,Kenneth Walsh,南野 徹
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2014-11-25
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Molecular analysis of fat accumulation from the aspect of aging signals.2014

    • Author(s)
      Minamino T.
    • Organizer
      International Symposium for the Study of Obesity.
    • Place of Presentation
      シーガイアコンベンションセンター(Miyazaki)
    • Year and Date
      2014-10-26
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] A critical role of senescence-induced inflammation in cardiovascular disease.2014

    • Author(s)
      Minamino T.
    • Organizer
      第18回日本心不全学会 日本&台湾セッション
    • Place of Presentation
      大阪国際会議場(大阪)
    • Year and Date
      2014-10-11
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 老化の観点から生活習慣病を考える2014

    • Author(s)
      Minamino T.
    • Organizer
      第135回日本内科学会信越地方会特別講演
    • Place of Presentation
      キッセイ文化ホール(松本)
    • Year and Date
      2014-10-04
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 細胞老化シグナルによる炎症制御と疾患2014

    • Author(s)
      Minamino T.
    • Organizer
      第35回日本炎症・再生医学会シンポジウム
    • Place of Presentation
      万国津梁館(沖縄)
    • Year and Date
      2014-07-01 – 2014-07-04
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 老化再生からみた循環器疾患治療2014

    • Author(s)
      Minamino T.
    • Organizer
      第32回日本臨床化学会甲信越支部総会シンポジウム
    • Place of Presentation
      鵜の浜ニューホテル(上越)
    • Year and Date
      2014-06-29
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 細胞老化シグナルによる炎症制御と疾患2014

    • Author(s)
      Minamino T.
    • Organizer
      第18回日本適応学会シンポジウム
    • Place of Presentation
      一橋大学一橋講堂(東京)
    • Year and Date
      2014-06-21 – 2014-06-22
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 健康寿命は延伸可能か?2014

    • Author(s)
      Minamino T.
    • Organizer
      第14回日本抗加齢医学会シンポジウム
    • Place of Presentation
      大阪国際会議場(大阪)
    • Year and Date
      2014-06-06 – 2014-06-08
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] The efficacy of combination therapy in patients with pulmonary hypertension.2014

    • Author(s)
      Minamino T.
    • Organizer
      3th International Pulmonary Hypertension Forum
    • Place of Presentation
      リスボン(Portugal)
    • Year and Date
      2014-04-04 – 2014-04-06
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 臓器連関とインスリン感受性2013

    • Author(s)
      Minamino T.
    • Organizer
      第86回日本内分泌学会総会シンポジウム
    • Place of Presentation
      仙台(仙台国際センター)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Lifespan regulatory system as a potential therapeutic target for cardiovascular disease.2013

    • Author(s)
      Minamino T.
    • Organizer
      International Association of Gerontology and Geriatrics
    • Place of Presentation
      Seoul(韓国)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 血管老化とNO2013

    • Author(s)
      Minamino T.
    • Organizer
      第13回日本抗加齢医学会ランチョンセミナー
    • Place of Presentation
      横浜(パシフィコ横浜)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Circadian clock and cardiovascular aging.2013

    • Author(s)
      Minamino T.
    • Organizer
      IEEE EMBC
    • Place of Presentation
      Osaka(大阪国際会議場)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 心-脂肪連関による心不全発症のメカニズム2013

    • Author(s)
      Minamino T.
    • Organizer
      第17回日本心臓リハビリテーション学会シンポジウム
    • Place of Presentation
      仙台(仙台国際センター)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Role of cellular aging signals in cardiovascular and metabolic disease.2013

    • Author(s)
      Minamino T.
    • Organizer
      BCVS
    • Place of Presentation
      Las Vegas(アメリカ)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 老化シグナルネットワークによる循環代謝制御2013

    • Author(s)
      Minamino T.
    • Organizer
      第86回日本生化学会大会シンポジウム
    • Place of Presentation
      横浜(パシフィコ横浜)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 血管老化シグナルネットワークによる循環代謝制御2013

    • Author(s)
      Minamino T.
    • Organizer
      第21回日本血管生物医学会シンポジウム
    • Place of Presentation
      大阪(千里阪急ホテル)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Cellular aging signal network and lifestyle-related disease2013

    • Author(s)
      Minamino T
    • Organizer
      日本循環器学会
    • Place of Presentation
      パシフィコ横浜(横浜市)(招待講演)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 老化、 細胞死と循環代謝性疾患2012

    • Author(s)
      Minamino T
    • Organizer
      日本Cell Death学会
    • Place of Presentation
      名古屋大学(名古屋市)(招待講演)
    • Year and Date
      2012-07-28
    • Related Report
      2012 Annual Research Report
  • [Presentation] Aging and cardiovascular disease2012

    • Author(s)
      Minamino T
    • Organizer
      American Heart Association
    • Place of Presentation
      USA, Los Angeles Convention Ctr(招待講演)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 臓器間ネットワークによる循環代謝制御2012

    • Author(s)
      Minamino T
    • Organizer
      日本内分泌学会
    • Place of Presentation
      名古屋国際会議場(名古屋市)(招待講演)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Aktlによる寿命調節機構2012

    • Author(s)
      Minamino T
    • Organizer
      日本抗加齢医学会
    • Place of Presentation
      パシフィコ横浜(招待講演)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 脂肪老化制御と生活習慣病2012

    • Author(s)
      Minamino T
    • Organizer
      日本抗加齢医学会
    • Place of Presentation
      パシフィコ横浜(横浜市)(招待講演)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Regulation of Cardiovascular Metabolism by the Aging Signal Network.2012

    • Author(s)
      Minamino T
    • Organizer
      日本高血圧学会
    • Place of Presentation
      ウェスティンナゴヤキャッスル・名古屋能楽堂(名古屋市)(招待講演)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 老化シグナルネットワークによる循環代謝制御2012

    • Author(s)
      Minamino T
    • Organizer
      日本肥満学会
    • Place of Presentation
      ホテルグランヴィア京都(京都市)(招待講演)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 臓器間老化シグナル制御と生活習慣痾2012

    • Author(s)
      Minamino T
    • Organizer
      日本心血管内分泌代謝学会
    • Place of Presentation
      東京大学(東京都)(招待講演)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 高血圧と血管老化のメカニズム2012

    • Author(s)
      Minamino T
    • Organizer
      日本血管生物医学会
    • Place of Presentation
      あわぎんホール(徳島市)(招待講演)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 老化シグナルネットワークによる循環代謝制御2012

    • Author(s)
      Minamino T
    • Organizer
      日本分子生物学会
    • Place of Presentation
      福岡国際会議場(福岡市)(招待講演)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Role of senescence-associated inflammation in lifestyle-related disease.

    • Author(s)
      Minamino T.
    • Organizer
      ISHR
    • Place of Presentation
      San Diego(アメリカ)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Role of cellular aging signals in lifestyle-related disease.

    • Author(s)
      Minamino T.
    • Organizer
      Harbin Medical University
    • Place of Presentation
      Harbin(中国)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 次世代の血管新生治療の開発

    • Author(s)
      Minamino T.
    • Organizer
      第22回日本形成外科学会基礎学術集会
    • Place of Presentation
      新潟(朱鷺メッセ)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 老化からみた心血管治療としてのスタチンの有用性

    • Author(s)
      Minamino T.
    • Organizer
      第17回日本心不全学会学術集会
    • Place of Presentation
      大宮(大宮ソニックシティー)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 心血管系の老化のメカニズム

    • Author(s)
      Minamino T.
    • Organizer
      日本老年医学会 支部・地方会 第24回九州地方支部
    • Place of Presentation
      北九州(産業医科大学)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Cardiac-adipose vicious cycle is critically involved in the development of heart failure

    • Author(s)
      Minamino T
    • Organizer
      日本循環器学会
    • Place of Presentation
      パシフィコ横浜(横浜市)(招待講演)
    • Related Report
      2012 Annual Research Report
  • [Book] 抗凝固薬・高血小板薬2015

    • Author(s)
      和泉大輔、南野 徹
    • Publisher
      医薬ジャーナル社
    • Related Report
      2014 Annual Research Report
  • [Book] 虚血肢の再生治療2015

    • Author(s)
      南野 徹、須田将吉
    • Publisher
      メディカルトリビューン社
    • Related Report
      2014 Annual Research Report
  • [Book] 重症心不全の患者さんが来ました2015

    • Author(s)
      尾崎和幸、南野 徹
    • Publisher
      中外医学社
    • Related Report
      2014 Annual Research Report
  • [Book] 心不全 浮腫~塩・水過剰、新たな展開とは?2014

    • Author(s)
      小幡 裕明,南野 徹
    • Publisher
      医薬ジャーナル社
    • Related Report
      2014 Annual Research Report
  • [Book] 特集;遺伝性不整脈の診断とマネージメント -三大陸不整脈学会Expert Consensus Statementを踏まえて-2014

    • Author(s)
      渡部 裕,南野 徹
    • Publisher
      メディカルレビュー社
    • Related Report
      2014 Annual Research Report
  • [Book] インスリン抵抗性と心不全2013

    • Author(s)
      清水逸平,南野 徹
    • Publisher
      中外医学社
    • Related Report
      2013 Annual Research Report
  • [Book] 体内時計の分子機構と老化 時間薬理学による最新の治療戦略2013

    • Author(s)
      南野 徹
    • Publisher
      医薬ジャーナル社
    • Related Report
      2013 Annual Research Report
  • [Book] 慢性炎症と生活習慣病2013

    • Author(s)
      岡田将、南野 徹
    • Publisher
      南山堂
    • Related Report
      2013 Annual Research Report
  • [Book] 再生医療事業の課題解決のための手引書2013

    • Author(s)
      小澤拓也、南野 徹
    • Publisher
      株式会社技術情報協会
    • Related Report
      2013 Annual Research Report
  • [Book] 心不全や肥満における脂肪老化シグナルの意義2013

    • Author(s)
      清水逸平、南野 徹
    • Publisher
      診断と治療社
    • Related Report
      2013 Annual Research Report
  • [Book] 高齢者用食品の開発と展望2012

    • Author(s)
      南野徹
    • Total Pages
      302
    • Publisher
      シーエムシー出版
    • Related Report
      2012 Annual Research Report
  • [Book] 循環器医から寄せられる「糖尿病と血管合併症」に関する100の質問2012

    • Author(s)
      南野徹
    • Total Pages
      231
    • Publisher
      メディカルレビュー社
    • Related Report
      2012 Annual Research Report
  • [Book] 循環器疾患の最新医療2012

    • Author(s)
      舘野馨、 南野徹
    • Total Pages
      506
    • Publisher
      先端医療技術研究所
    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www.med.niigata-u.ac.jp/car/

    • Related Report
      2012 Annual Research Report

URL: 

Published: 2012-04-24   Modified: 2019-07-29  

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