Development of prophylaxis and therapy system for metabolic stmdorome by regulation of AIM function
| Project/Area Number |
24390196
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | The University of Tokyo |
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Principal Investigator |
ARAI Satoko 東京大学, 医学(系)研究科(研究院), 准教授 (60422276)
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| Co-Investigator(Renkei-kenkyūsha) |
MIYAZAKI Toru 東京大学, 大学院医学系研究科, 教授 (30396270)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥15,730,000 (Direct Cost: ¥12,100,000、Indirect Cost: ¥3,630,000)
Fiscal Year 2014: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
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| Keywords | AIM / 生活習慣病 / HCC / メタボリックシンドローム / 慢性炎症 |
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| Outline of Final Research Achievements |
Since AIM (apoptosis inhibitor of macrophage), a secreted protein produced from macrophages, has been shown to be involved in metabolic syndromes such as obesity, insulin resistance and atherosclerosis, regulation of both function and amount of AIM in body can be effective to prevent or control the AIM-related diseases. In this study, we investigated mechanism and materials for regulation of function and level of AIM. In addition, we presented that AIM is involved in the obesity-derived diseases such like auto-reactive antibody production and steatosis-derived hepatocellular carcinoma. Furthermore, we performed a large-scale analysis for blood AIM concentration in human including healthy individuals and patients with liver diseases, and demonstrated that AIM can be applied for the diagnosis of HCC in humans.
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Report
(4 results)
Research Products
(29 results)
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[Journal Article] Circulating AIM Prevents Hepatocellular Carcinoma through Complement Activation2014
Author(s)
Maehara N, Arai S, Mori M, Iwamura Y, Kurokawa J, Kai T, Kusunoki S, Taniguchi K, Ikeda K, Ohara O, Yamamura K, Miyazaki T
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Journal Title
Cell Reports
Volume: 9
Issue: 1
Pages: 61-74
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Circulating AIM as an Indicator of Liver Damage and Hepatocellular Carcinoma in Humans2014
Author(s)
Yamazaki T, Mori M, Arai S, Tateishi R, Abe M, Ban M, Nishijima A, Maeda M, Asano T, Kai T, Izumino K, Takahashi J, Aoyama K, Harada S, Takebayashi T, Gunji T, Ohnishi S, Seto S, Yoshida Y, Hiasa Y, Koike K, Yamamura K, Inoue K, Miyazaki T
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Journal Title
PLOS ONE
Volume: 9
Issue: 10
Pages: e109123-e109123
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] MafB promotes atherosclerosis by inhibiting foam-cell apoptosis2014
Author(s)
Hamada M, Nakamura M, Tran MT, Moriguchi T, Hong C, Ohsumi T, Dinh TT, Kusakabe M, Hattori M, Katsumata T, Arai S, Nakashima K, Kudo T, Kuroda E, Wu CH, Kao PH, Sakai M, Shimano H, Miyazaki T, Tontonz P, Takahashi S
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Journal Title
Nat Commun
Volume: 5
Issue: 1
Pages: 3147-3147
DOI
Related Report
Peer Reviewed / Open Access
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