Development of a novel vascular-targeting therapy through stem cell research
Project/Area Number |
24390197
|
Research Category |
Grant-in-Aid for Scientific Research (B)
|
Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Circulatory organs internal medicine
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Research Institution | Kyoto University |
Principal Investigator |
YAMASHITA Jun 京都大学, iPS細胞研究所, 教授 (50335288)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2014: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2013: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2012: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
|
Keywords | 血管新生 / 多能性幹細胞 / 内皮細胞 / 分化 / 血管内皮増殖因子 / アンジオポイエチン / 幹細胞 / 血管形成 / マイクロRNA / シグナル / キナーゼ |
Outline of Final Research Achievements |
Purpose of this study is that development of novel therapies for ischemic heart disease or cancer through manipulating vascular formation using advanced pluripotent stem cell research. We demonstrated that kappa-opioid receptor suppressed tumor angiogenesis through inhibiting expression of type II vascular endothelial growth factor receptor. In addition, we reported a novel function of angiopoietin-1 in coronary vein formation as a collaboration with Department of cardiovascular medicine, University of Tokyo.
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Report
(4 results)
Research Products
(56 results)
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[Journal Article] Dual modulation of the mitochondrial permeability transition pore and redox signaling synergistically promotes cardiomyocyte differentiation from pluripotent stem cells.2014
Author(s)
Cho SW, Park JS, Heo HJ, Park SW, Song S, Kim I, Han YM, Yamashita JK, Youm JB, Han J, Koh GY.
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Journal Title
J Am Heart Assoc
Volume: 3(2)
Issue: 2
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Myocardium-derived angiopoietin-1 is essential for coronary vein formation in the developing heart2014
Author(s)
Arita Y, Nakaoka Y, Matsunaga T, Kidoya H, Yamamizu K, Arima Y, Kataoka-Hashimoto T, Ikeoka K, Yasui T, Masaki T, Yamamoto K, Higuchi K, Park JS, Shirai M, Nishiyama K, Yamagishi H, Otsu K, Kurihara H, Minami T, Yamauchi-Takihara K, Koh GY, Mochizuki N, Takakura N, Sakata Y, Yamashita JK, Komuro I.
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Journal Title
Nat Commun
Volume: 5
Pages: 4552-4552
Related Report
Peer Reviewed / Open Access
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[Journal Article] Human iPS cell-engineered cardiac tissue sheets with cardiomyocytes and vascular cells for cardiac regeneration.2014
Author(s)
Masumoto H, Ikuno T, Takeda M, Fukushima H, Marui A, Katayama S, Shimizu T, Ikeda T, Okano T, Sakata R, Yamashita JK.
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Journal Title
Sci Rep
Volume: 4
Issue: 1
Pages: 6716-6716
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Kappa-Opioids inhibit tumor angiogenesis by suppressing VEGF signaling.2013
Author(s)
Yamamizu K, Furuta S, Hamada Y, Yamashita A, Kuzumaki N, Narita M, Doi K, Katayama S, Nagase H, Yamashita JK, Narita M.
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Journal Title
Scientific Reports
Volume: 3
Issue: 1
Pages: 3213-3213
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Effect of k-opioid receptor agonist on the growth of non-small cell lung cancer (NSCLC) cells2012
Author(s)
Kuzumaki N, Suzuki A, Narita M, Hosoya T, Nagasawa A, Imai S, Yamamizu K, Morita H, Nagase H, Okada Y, Okano HJ, Yamashita JK, Okano H, Suzuki T, Narita M
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Journal Title
Br J Cancer
Volume: 106(Epub 2012 Feb 16)
Issue: 6
Pages: 1148-1152
DOI
Related Report
Peer Reviewed
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[Journal Article] Pluripotent stem cell-engineered cell sheets re-assembled with defined cardiovascular populations ameliorate reduction in infarct heart function with cardiomyocyte-mediated neovascularization2012
Author(s)
Masumoto H, Matsuo T, Yamamizu K, Uosaki H, Narazaki G, Katayama S, Marui A, Shimizu T, Ikeda T, Okano T, Sakata R, Yamashita JK
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Journal Title
Stem Cells
Volume: 30
Issue: 6
Pages: 1196-1205
DOI
Related Report
Peer Reviewed
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