| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2016: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2015: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2014: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2013: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
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| Outline of Final Research Achievements |
We investigated mechanisms involved in the regulation of sympathetic activation in heart failure The findings are as follows. Alteration of innate immunity and immune cells proportion contribute to sympathetic activation. Activation of astrocytes and microglia play a role in activation of the sympathetic nervous system. Renal denervation attenuated enhanced sympathetic drive via inhibition of hypothalamic activity. Cardiac sympathetic afferent reflex plays an important role in the progression of cardiac hypertrophy during the phase of pressure overload. As an initial step of heart failure, epithelial Na channel activation in the hypothalamus contributes to blood pressure elevation resulted from acquired salt sensitivity. These findings support a novel framework including neural, humoral, cytokines and other cell factors.
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