Translational Research of Ghrelin in Cardiometabolic Diseases and Its Potent Regulatory Role of Autonomic Nerve Function

• Project/Area Number: 24390204
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: National Cardiovascular Center Research Institute
• Principal Investigator: KISHIMOTO Ichiro 独立行政法人国立循環器病研究センター, 病院, 医長 (80312221)
• Co-Investigator(Kenkyū-buntansha): TOKUDOME Takeshi 国立循環器病研究センター, 研究所, 室長 (00443474) ; KANGAWA Kenji 国立循環器病研究センター, 研究所, 研究所長 (00112417) ; AKAMIZU Takashi 和歌山県立医科大学, 医学部, 教授 (20231813) ; SOEKI Takeshi 徳島大学, ヘルスバイオサイエンス研究部, 講師 (60393211)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000); Fiscal Year 2014: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2013: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000); Fiscal Year 2012: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
• Keywords: グレリン / 自律神経 / 循環器・高血圧 / 糖尿病 / トランスレーショナルリサーチ / 生理活性

Outline of Final Research Achievements

One bolus subcutaneous administration of ghrelin prevents arrhythmia and reduces mortality in the acute phase of myocardial infarction (MI), while continuous administration improves LV dysfunction and attenuates early cardiac remodeling after acute MI. The mechanism of ghrelin’s action is related to down-regulation of the cardiac sympathetic nerve activity (SNA).The detrimental effect of a lack of endogenous ghrelin on malignant arrhythmia within 30 minutes after MI were also demonstrated in mice deficient for ghrelin, which have deteriorated heart function and high mortality after MI. The underlying mechanism is associated with the impaired inhibition of cardiac sympathetic activation by ghrelin.These results suggest existance of the stomach-brain-heart axis.

Research Products

• [Journal Article] The cardiovascular action of hexarelin (2014)
  • Author(s): Mao Y, Tokudome T, Kishimoto I
  • Journal Title: Journal of Geriatric Cardiology Volume: 11 Pages: 1-6
  • Peer Reviewed
• [Journal Article] Ghrelin as a treatment for cardiovascular diseases (2014)
  • Author(s): Mao Y, Tokudome T, Kishimoto I
  • Journal Title: Hypertension Volume: 64 Issue: 3 Pages: 450-454
  • DOI: 10.1161/hypertensionaha.114.03726
  • Peer Reviewed
• [Journal Article] Effect of ghrelin on autonomic activity in healthy volunteers (2014)
  • Author(s): Soeki T, Koshiba K, Niki T, Kusunose K, Yamaguchi K, Yamada H, Wakatsuki T, Shimabukuro M, Minakuchi K, Kishimoto I, Kangawa K, Sata M
  • Journal Title: Peptides Volume: 62 Pages: 1-5
  • DOI: 10.1016/j.peptides.2014.09.015
  • Peer Reviewed / Open Access
• [Journal Article] Ghrelin and the cardiovascular system (2014)
  • Author(s): Tokudome T, Kishimoto I, Miyazato M, Kangawa K
  • Journal Title: Front Horm Res Volume: 43 Pages: 125-133
  • DOI: 10.1159/000360593
  • ISBN: 9783318026733, 9783318026740
  • Peer Reviewed
• [Journal Article] One dose of oral hexarelin protects chronic cardiac function after myocardial infarction (2014)
  • Author(s): Mao Y, Tokudome T, Kishimoto I, Otani K, Miyazato M, Kangawa K
  • Journal Title: Peptides Volume: 56 Pages: 156-162
  • DOI: 10.1016/j.peptides.2014.04.004
  • Peer Reviewed / Open Access
• [Journal Article] Clinical effects of ghrelin on gastrointestinal involvement in patients with systemic sclerosis (2014)
  • Author(s): Ariyasu H, Iwakura H, Yukawa N, Murayama T, Yokode M, Tada H, Yoshimura K, Teramukai S, Ito T, Shimizu A, Yonezawa A, Kangawa K, Mimori T, Akamizu T
  • Journal Title: Endocr J Volume: 61 Pages: 735-742
  • NAID: 130004443975
  • Peer Reviewed
• [Journal Article] Des-acyl ghrelin protects microvascular endothelial cells from oxidative stress-induced apoptosis through sirtuin 1 signaling pathway (2014)
  • Author(s): Shimada T, Furuta H, Doi A, Ariyasu H, Kawashima H, Wakasaki H, Nishi M, Sasaki H, Akamizu T
  • Journal Title: Metabolism Volume: 63 Issue: 4 Pages: 469-474
  • DOI: 10.1016/j.metabol.2013.12.011
  • Peer Reviewed
• [Journal Article] 生理活性ペプチド グレリンの循環器疾患治療への応用の可能性 (2014)
  • Author(s): 宮里 幹也、徳留 健、岸本 一郎、寒川 賢治
  • Journal Title: 生命科学から創薬へのイノベーション Volume: 1 Pages: 23-29
• [Journal Article] Molecular evolution of ghrelin receptors (2014)
  • Author(s): Kaiya, H: Kangawa, K: Miyazato, M
  • Journal Title: JOURNAL OF MOLECULAR ENDOCRINOLOGY Volume: T87 Pages: 100-100
  • Peer Reviewed
• [Journal Article] Circulating Des-acyl Ghrelin Improves Cardiovascular Risk Prediction in Older Hypertensive Patients (2014)
  • Author(s): Yano Y, Nakazato M, Toshinai K, Inokuchi T, Matsuda S, Hidaka T, Hayakawa M, Kangawa K, Shimada K, Kario K
  • Journal Title: Am J Hypertens Volume: 27 Issue: 5 Pages: 723-733
  • DOI: 10.1093/ajh/hpt232
  • Peer Reviewed
• [Journal Article] Hexarelin treatment in male ghrelin knockout mice after myocardial infarction (2013)
  • Author(s): Mao Y, Tokudome T, Kishimoto I, Otani K, Hosoda H, Nagai C, Minamino N, Miyazato M, Kangawa K
  • Journal Title: Endocrinology Volume: 154 Issue: 10 Pages: 3847-3845
  • DOI: 10.1210/en.2013-1291
  • Peer Reviewed
• [Journal Article] Renal Insufficiency without Albuminuria is Associated with Peripheral Artery Atherosclerosis and Lipid Metabolism Disorders in Patients with Type 2 Diabetes (2013)
  • Author(s): Takahiro Yamashita, Hisashi Makino, Rieko Nakatani, Yoko Ohata, Yoshihiro Miyamoto and Ichiro Kishimoto
  • Journal Title: Journal of Atheroscierosis and Thrombosis Volume: 20(11) Pages: 790-797
  • NAID: 130004845417
  • Peer Reviewed
• [Journal Article] グレリンによる循環器疾患治療の可能性、Recent Advances in Cardiovascular Disease (2013)
  • Author(s): 徳留健、岸本一郎、宮里幹也、寒川賢治
  • Journal Title: 循環器病研究の進歩 Volume: XXXIV No.1 Pages: 58-68
• [Journal Article] Ghrelin prevents the development of experimental diabetic neuropathy in rodents. (2013)
  • Author(s): Tsuchimochi W, Kyoraku I, Yamaguchi H, Toshinai K, Shiomi K, Kangawa K, Nakazato M
  • Journal Title: Eur J Pharmacol Volume: 702 Issue: 1-3 Pages: 187-193
  • DOI: 10.1016/j.ejphar.2013.01.035
  • Peer Reviewed
• [Journal Article] Ghrelin discovery: a decade after (2013)
  • Author(s): Kojima, M: Kangawa, K
  • Journal Title: Endocr Dev Volume: 25 Pages: 1-4
  • DOI: 10.1159/000346036
• [Journal Article] Excessive sympathoactivation and deteriorated heart function after myocardial infarction in male ghrelin knockout mice (2013)
  • Author(s): Mao Y, Tokudome T, Otani K, Kishimoto I, Miyazato M, Kangawa K
  • Journal Title: Endocrinology Volume: 154 Issue: 5 Pages: 1854-1863
  • DOI: 10.1210/en.2012-2132
  • Peer Reviewed
• [Journal Article] Overexpression of intraislet ghrelin enhances β-cell proliferation after streptozotocin-induced β-cell injury in mice (2013)
  • Author(s): Bando M, Iwakura H, Ariyasu H, Koyama H, Hosoda K, Adachi S, Nakao K, Kangawa K, Akamizu T
  • Journal Title: Am J Physiol Endocrinol Metab Volume: 305 Issue: 1 Pages: E140-E148
  • DOI: 10.1152/ajpendo.00112.2013
  • Peer Reviewed
• [Journal Article] Ghrelin protects the heart against ischemia-induced arrhythmias by preserving connexin-43 protein (2013)
  • Author(s): Soeki T, Niki T, Uematsu E, Bando S, Matsuura T, Kusunose K, Ise T, Ueda Y, Tomita N, Yamaguchi K, Koshiba K, Yagi S, Fukuda D, Taketani Y, Iwase T, Yamada H, Wakatsuki T, Akaike M, Shimabukuro M, Kishimoto I, Kangawa K, Sata M
  • Journal Title: Heart Vessels Volume: 28 Issue: 6 Pages: 795-801
  • DOI: 10.1007/s00380-013-0333-2
  • Peer Reviewed
• [Journal Article] 新規ホルモンの探索 (2013)
  • Author(s): 宮里幹也、寒川賢治
  • Journal Title: 内分泌･糖尿病・代謝内科 Volume: 36 Pages: 15-21
• [Journal Article] 未知の生理活性ペプチドへの挑戦 グレリンを中心として (2013)
  • Author(s): 寒川賢治
  • Journal Title: 実験医学 Volume: 31 Pages: 2991-2997
• [Journal Article] グレリンの臨床応用の可能性 (2013)
  • Author(s): 寒川賢治
  • Journal Title: 臨床消化器内科 Volume: 28 Pages: 675-680
• [Journal Article] A link between FTO, ghrelin, and impaired brain food-cue responsivity (2013)
  • Author(s): Karra E, O'Daly OG, Choudhury AI, Yousseif A, Millership S, Neary MT, Scott WR, Chandarana K, Manning S, Hess ME, Iwakura H, Akamizu T, Millet Q, Gelegen C, Drew ME, Rahman S, Emmanuel JJ, Williams SC, Rüther UU, Brüning JC, Withers DJ, Zelaya FO, Batterham RL
  • Journal Title: J Clin Invest Volume: 123(8) Issue: 8 Pages: 3539-3551
  • DOI: 10.1172/jci44403
  • Peer Reviewed
• [Journal Article] The sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates lymphocyte trafficking in mice (2012)
  • Author(s): Fukuhara S, et al
  • Journal Title: J Clin Invest Volume: (In press)(未定) Issue: 4 Pages: 1416-1426
  • DOI: 10.1172/jci60746
  • Peer Reviewed
• [Journal Article] One dose of ghrelin prevents the acute and sustained increase in cardiac sympathetic tone after myocardial infarction (2012)
  • Author(s): Schwenke DO, Tokudome T, Kishimoto I, Horio T, Cragg PA, Shirai M, Kangawa K
  • Journal Title: Endocrinology Volume: 153(5) Issue: 5 Pages: 2436-2443
  • DOI: 10.1210/en.2011-2057
  • Peer Reviewed
• [Journal Article] Ghrelin Prevents Incidence of Malignant Arrhythmia after Acute Myocardial Infarction through Vagal Afferent Nerves (2012)
  • Author(s): Mao Y, Tokudome T, Otani K, Kishimoto I, Nakanishi M, Hosoda H, Miyazato M, Kangawa K
  • Journal Title: Endocrinology Volume: (in press) Issue: 7 Pages: 3426-3434
  • DOI: 10.1210/en.2012-1065
  • Peer Reviewed
• [Journal Article] Natriuretic peptide receptor guanylyl cyclase-A protects podocytes from aldosterone-induced glomerular injury (2012)
  • Author(s): Ogawa Y, Mukoyama M, Yokoi H, Kasahara M, Mori K, Kato Y, Kuwabara T, Imamaki H, Kawanishi T, Koga K, Ishii A, Tokudome T, Kishimoto I, Sugawara A, Nakao K
  • Journal Title: J Am Soc Nephrol Volume: 23:1198-1209 Issue: 7 Pages: 1198-1209
  • DOI: 10.1681/asn.2011100985
  • Peer Reviewed
• [Journal Article] Induced pluripotent stem cells generated from diabetic patients with mitochondrial DNA A3243G mutation (2012)
  • Author(s): J.Fujikura, M.Sone, K.Hosoda, K.Nakao, et al
  • Journal Title: Diabetologia Volume: (in press) Issue: 6 Pages: 1689-1698
  • DOI: 10.1007/s00125-012-2508-2
  • Peer Reviewed
• [Journal Article] 迅速検査を活用したHbAlc検査の意義と有用性 (2012)
  • Author(s): 岸本一郎
  • Journal Title: 糖尿病BOX&NET. Volume: 32 Pages: 7-7
• [Journal Article] Adrenal tumor volume in a genetically engineered mouse model of neuroblastoma determined by magnetic resonance imaging. (2012)
  • Author(s): Kawano K, Hattori Y, Iwakura H, Akamizu T, Maitani Y.
  • Journal Title: Exp Ther Med. Volume: 4 Pages: 61-64
• [Journal Article] Therapeutic potential of ghrelin in restricting-type ahorexla nervosa. (2012)
  • Author(s): Hotta M, Ohwada R, Akamizu T, Shibasaki T, Kangawa K.
  • Journal Title: Methods Enzymol Volume: 514 Pages: 381-398
  • DOI: 10.1016/b978-0-12-381272-8.00024-6
• [Journal Article] Transgenic mice overexpressing ghrelin or ghrelin analog (2012)
  • Author(s): Ariyasu H, Nakao K, et al
  • Journal Title: Methods Enzymol. Volume: 514 Pages: 371-377
  • DOI: 10.1016/b978-0-12-381272-8.00023-4
  • Peer Reviewed
• [Journal Article] Diagnostic criteria, clinical features, and incidence of thyroid storm based on nationwide surveys (2012)
  • Author(s): Akamizu T, Satoh T, Isozaki O, Suzuki A, Wakino S, Iburi T, Tsuboi K, Monden T, Kouki T, Otani H, Teramukai S, Uehara R, Nakamura Y, Nagai M, Mori M
  • Journal Title: Thyroid Volume: 22 Issue: 7 Pages: 661-679
  • DOI: 10.1089/thy.2011.0334
  • Peer Reviewed
• [Journal Article] Growth stimulating antibody, as another predisposing factor of Graves’ disease (GD): analysis using monoclonal TSH receptor antibodies derived from patients with GD (2012)
  • Author(s): Ihara Y, Kanda y Seo M, Watanabe Y, Akamizu T, TanakaY.
  • Journal Title: Endocrine Journal Volume: 59 Issue: 7 Pages: 571-577
  • DOI: 10.1507/endocrj.EJ11-0348
  • NAID: 10031064211
  • ISSN: 0918-8959, 1348-4540
• [Journal Article] The physiological significance and potential clinical applications of ghrelin. (2012)
  • Author(s): Akamizu T
  • Journal Title: Eur J Intern Med Volume: 23 Issue: 3 Pages: 197-202
  • DOI: 10.1016/j.ejim.2011.12.001
  • Peer Reviewed
• [Presentation] 授乳期肥大におけるアルドステロン系の関与 (2014)
  • Author(s): 大谷 健太郎、徳留 健、岸本 一郎、池田 智明、中尾 一和、寒川 賢治
  • Organizer: 第18回日本心血管内分泌代謝学会学術総会
  • Place of Presentation: 横浜市開港記念会館
  • Year and Date: 2014-11-21 – 2014-11-22
• [Presentation] グレリンによる循環器疾患治療の可能性 (2014)
  • Author(s): 徳留 健
  • Organizer: 第18回日本心血管内分泌代謝学会学術総会
  • Place of Presentation: 横浜市開港記念会館
  • Year and Date: 2014-11-21 – 2014-11-22
• [Presentation] 生理活性ペプチドを応用した心血管疾患の新規治療法開発に関する研究 (2014)
  • Author(s): 徳留 健
  • Organizer: 第18回日本心血管内分泌代謝学会学術総会
  • Place of Presentation: 横浜市開港記念会館
  • Year and Date: 2014-11-21 – 2014-11-22
• [Presentation] The Meet-the-Professor (MTP) session “Diagnosis and Management of Thyroid Storm” (2014)
  • Author(s): Akamizu T
  • Organizer: ICE/ENDO 2014
  • Place of Presentation: Chicago, USA
  • Year and Date: 2014-06-21 – 2014-06-24
• [Presentation] Pheochromocytoma Multisystem Crisisを来した褐色細胞腫の1例. (2013)
  • Author(s): 竹島 健,原田沙耶,浦木進丞,古川安志,太田敬之,稲葉秀文,石橋達也,高木伴幸,若崎久生,古田浩人,西 理宏,佐々木秀行,赤水尚史.
  • Organizer: 第22回臨床内分泌代謝Update.
  • Place of Presentation: 大宮ソニックシティ(埼玉県)
  • Year and Date: 2013-01-19
• [Presentation] デスアシルグレリンの新規作用の解明 (2013)
  • Author(s): 島田 健、古田浩人、土井麻子、川嶋弘道、若﨑久生、西 理宏、佐々木秀行、赤水尚史
  • Organizer: 第56回日本糖尿病学会年次学術集会
  • Place of Presentation: 熊本市民会館
• [Presentation] グレリンは参加ストレスによるβ細胞障害を防止する (2013)
  • Author(s): 西 理宏、王 穎、石橋達也、土井麻子、古田浩人、佐々木秀行、南條輝志男、赤水尚史
  • Organizer: 第56回日本糖尿病学会年次学術集会
  • Place of Presentation: 熊本市民会館
• [Presentation] Tryptophan stimulates ghrelin secretion by the ghrelin-producing cell line, MGN3-1 cells in vitro (2013)
  • Author(s): Koyama H, Iwakura H, Bando M, Hosoda H, Hosoda K, Akamizu T, Kangawa K, Nakao K
  • Organizer: ENDO 2013:The 95th Annual Meeting & Expo
  • Place of Presentation: Moscone Center, San Francisco, USA
• [Presentation] Ghrelin Protect Beta Cells From Oxidative Stress Via Both MAPK And PI3K Pathways (2013)
  • Author(s): Nishi M, Wang Y, Ishibashi T, Doi A, Furuta H, Sasaki H, Nanjo K, Akamizu T
  • Organizer: The 73rd Annual Scientific Sessions of American Diabetes Association
  • Place of Presentation: McCormick Place Convention Center, Chicago, USA
• [Presentation] Des-acyl ghrelin protects microvascular endothelial cells from oxidative stress-induced apoptosis through sirtuin 1 signalling pathway (2013)
  • Author(s): Furuta H, Shimada T, Doi A, Nishi M, Sasaki H, Akamizu T
  • Organizer: EASD 49th Annual Meeting
  • Place of Presentation: Fira de Barcelona, Barcelona, Spain
• [Presentation] シンポジウム3生理活性ペプチド、タンパク質による新しい心血管系の治療戦略「グレリンの心血管系における臨床応用」 (2013)
  • Author(s): 赤水尚史
  • Organizer: 第17回日本心血管内分泌代謝学会学術総会
  • Place of Presentation: 千里ライフサイエンスセンター
  • Invited
• [Presentation] The comparison of the effect of two Chinese herbal medicines (Bofu-tsusho-san and Dai-saiko-to) on metabolic disorders in obstructive sleep apnea patients with sustained obesity and hypertension. (2012)
  • Author(s): Kazuo Chin, Kimihiko Murase, Yoshiro Tayama, Yuka Harada, Tsuneto Akashiba, Koichiro Tastumi, Yuichi Inoue, Makoto Satoh, Shigeru Sakurai, Hiroki Sakakibara, Toshiaki Shiomi, Hiroshi Kimura, Soichiro Miyazaki, Toru Tsuda, Kazuhisa Bessho, Kazuya Yoshida, Kenji Ueshima, Takashi Akamizu, Hiroshi Kadotani, Yuma Hoshino, Toru Oga.
  • Organizer: The 17th Congress of the APSR.
  • Place of Presentation: The Hong Kong Convention and Exhibition Centre.
  • Year and Date: 2012-12-14
• [Presentation] 橋本病と木村病に外眼筋腫大と眼瞼腫脹を合併し高IgG4血症を呈した一例 (2012)
  • Author(s): 宮本和佳, 舩橋友美, 玉川えり, 竹島 健, 早川隆洋, 山岡博之, 古川安志, 稲葉秀文, 西 理宏, 佐々木秀行, 赤水尚史
  • Organizer: 第55回日本甲状腺学会学術集会
  • Place of Presentation: アクロス福岡(福岡県)
  • Year and Date: 2012-11-30
• [Presentation] 甲状腺眼症の合併が疑われた多中心性キャッスルマン病の一例 (2012)
  • Author(s): 古川安志, 松野正平, 玉川えり, 竹島 健. 宮本和佳, 稲葉秀文, 若崎久生, 古田浩人, 西 理宏, 佐々木秀行, 赤水尚史
  • Organizer: 第55回日本甲状腺学会学術集会
  • Place of Presentation: アクロス福岡(福岡県)
  • Year and Date: 2012-11-30
• [Presentation] チアマソール使用中にぶどう膜炎を来たしたHTLV-1陽性Basedow病の一例. (2012)
  • Author(s): 船橋友美, 竹島 健, 若崎久生, 西理宏, 玉川えり, 山岡博之, 宮本和佳, 古川安志, 稲葉秀文, 佐々木秀行, 赤水尚史.
  • Organizer: 第55回日本甲状腺学会学術集会
  • Place of Presentation: アクロス福岡(福岡県)
  • Year and Date: 2012-11-29
• [Presentation] バセドウ病治療経過中に褐色細胞腫クリーゼを来した1例. (2012)
  • Author(s): 竹島 健, 原田沙耶, 舩橋友美, 玉川えり, 山岡博之, 宮本和佳, 古川安志, 稲葉秀文, 若崎久生, 西 理宏, 赤水尚史.
  • Organizer: 第55回日本甲状腺学会学術集会
  • Place of Presentation: アクロス福岡(福岡県)
  • Year and Date: 2012-11-29
• [Presentation] 妊娠に伴う甲状腺中毒症に関する検討 (2012)
  • Author(s): 稲葉秀文, 竹島 健, 古川安志, 舩橋友美, 玉川えり, 山岡博之, 宮本和佳, 太田敬之, 若畸久生, 西 理宏、赤水尚史
  • Organizer: 第55回日本甲状腺学会学術集会
  • Place of Presentation: アクロス福岡(福岡県)
  • Year and Date: 2012-11-29
• [Presentation] 2型糖尿病患者における非侵襲的検査法デュアルスキャンによる内臓脂肪量の評価 (2012)
  • Author(s): 大畑洋子, 田中彩子, 中谷理恵子, 泰江慎太郎, 岩本紀之, 槇野久士, 東将浩, 岸本一郎
  • Organizer: 第33回日本肥満学会
  • Place of Presentation: ホテルグランヴィア京都(京都府)
  • Year and Date: 2012-10-11
• [Presentation] シンポジウム2バセドウ病外科治療の変遷(特別発言) (2012)
  • Author(s): 赤水尚史
  • Organizer: 第45回日本甲状腺外科学会学術集会
  • Place of Presentation: はまぎんホール(神奈川県)
  • Year and Date: 2012-10-04
• [Presentation] Ghrelin protects the heart against ischemia-induced arrhythmias by modulating autonomic nerve activity. (2012)
  • Author(s): Takeshi Soeki, Toshiyuki Niki, Sachiko Bando, Koji Yamaguchi, Yoshio Taketani, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Kenji Kangawa, Masataka Sata.
  • Organizer: European Society of Cardiology 2012
  • Place of Presentation: ICM (Munich, Germany)
  • Year and Date: 2012-08-29
• [Presentation] Novel Diagnostic Criteria and Clinico-Epidemiological Features of Thyroid Storm Based on a Japanese Nationwide Survey (2012)
  • Author(s): Takashi Akamizu, Tetsurou Satoh, Osamu Isozaki, Atsushi Suzuki, Shu Wakino, Tadao Iburi, Kumiko Tsuboi, Tsuyoshi Monden, Tsuyoshi Kouki, Naotetsu Kanamoto, Hajime Otani, Satoshi Teramukai, Masatomo Mori
  • Organizer: ENDO 2012: The 94th Annual Meeting & Expo
  • Place of Presentation: George R. Brown Convention Center (Houston, USA)
  • Year and Date: 2012-06-24
• [Presentation] 2型糖尿病患者における非侵襲的検査法デュアルスキャンによる内臓脂肪量の評価 (2012)
  • Author(s): 大畑洋子, 田中彩子, 中谷理恵子, 泰江慎太郎, 岩本紀之, 槇野久士, 東将浩, 岸本一郎
  • Organizer: 第55回日本糖尿病学会学術集会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2012-05-18
• [Presentation] Plasma ghrelin levels appeared to be elevated in patients with medium-chain acyl-CoA dehydrogenase deficiency and glutaric aciduria type II : Evidence for that acyl-CoA is the substrate for ghrelin acylation (2012)
  • Author(s): T. Akamizu, N. Sakura, Y. Shigematsu, G. Tajima, A. Ohtake, H. Hosoda, H. Iwakura, H. Ariyasu, K. Kangawa
  • Organizer: 15th International & 14th European Congress of Endocrinology (ICE/ECE 2012)
  • Place of Presentation: The Fortezza da Basso (FIOrence, ltaly)
  • Year and Date: 2012-05-05
• [Presentation] 多発性嚢胞腎の経過中にDIHSを来たし,続いて1型糖尿病と橋本病を発症した一例 (2012)
  • Author(s): 石橋達也, 稲葉秀文, 田中宏典, 古川安志, 太田敬之, 若畸久生, 古田浩人, 西 理宏, 佐々木秀行, 赤水尚史
  • Organizer: 第85回日本内分泌学会学術総会
  • Place of Presentation: 名古屋国際会議場(愛知県)
  • Year and Date: 2012-04-19
• [Presentation] シンポジウム2自己免疫機序と内分泌代謝疾患(バセドウ病の免疫学的成因解析と新規治療法開発) (2012)
  • Author(s): 稲葉秀文, 赤水尚史, Leslie J DeGroot
  • Organizer: 第85回日本内分泌学会学術総会
  • Place of Presentation: 名古屋国際会議場(愛知県)
  • Year and Date: 2012-04-19
• [Presentation] 全身性強皮症患者における消化管障害に対するグレリンの臨床効果に関するクロスオーバー試験 (2012)
  • Author(s): 有安宏之, 岩倉 浩, 村山敏典, 湯川尚一郎, 吉村健一, 横出正之, 三森経世, 中尾一和, 寒川賢治, 赤水尚史
  • Organizer: 第109回日本内科学会総会
  • Place of Presentation: みやこめっせ(京都府)
  • Year and Date: 2012-04-14
• [Presentation] 2型糖尿病患者における非侵襲的検査法デュアルスキャンによる内臓脂肪量の評価 (2012)
  • Author(s): 大畑洋子, 田中彩子, 中谷理恵子, 泰江慎太郎, 岩本紀之, 槇野久士, 東将浩, 岸本一郎
  • Organizer: 第109回日本内科学会総会
  • Place of Presentation: みやこめっせ(京都府)
  • Year and Date: 2012-04-14
• [Presentation] 全身性強皮症患者における消化管障害に対するグレリンの臨床効果に関するクロスオーバー試験 (2012)
  • Author(s): 有安宏之, 岩倉 浩, 寒川賢治, 中尾一和, 赤水尚史
  • Organizer: 第85回日本内分泌学会学術総会
  • Place of Presentation: 名古屋国際会議場(愛知県)
• [Book] 最新内分泌代謝学 「ナトリウム利尿ペプチド系」 (2013)
  • Author(s): 岸本一郎, 徳留 健
  • Publisher: (株)診断と治療社