Elucidation of mineralocorticoid receptor/ glucocorticoid receptor paradox and its application to kidney disease therapy
| Project/Area Number |
24390214
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Juntendo University (2013-2014)
The University of Tokyo (2012) |
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Principal Investigator |
NAGASE Miki 順天堂大学, 医学(系)研究科(研究院), 准教授 (60302733)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
Fiscal Year 2012: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
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| Keywords | 鉱質コルチコイド受容体 / 糖質コルチコイド受容体 / Rac1 / 足細胞 / 蛋白尿 / メタボリックシンドローム / マクロファージ / 心筋細胞 / ポドサイト障害 / ポドサイト / 遠位尿細管細胞 / ChIP-seq / メサンギウム細胞 / 肥満糖尿病 / 糸球体足細胞 / ノックアウトマウス / RhoGDIα / 慢性炎症 / アルブミン尿 |
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| Outline of Final Research Achievements |
In the present study, we examined the mechanisms of Rac1-MR signaling in target organ injury in rodents. Podocyte-specific Rac1 activation mice as well as Rac1 KO mice spontaneously developed podocyte injury, albuminuria, and glomerulosclerosis. Rac1 activity was correlated with MR activity and organ protective response of MR antagonist. Myeloid-specific and cardiomyocyte-specific Rac1/MR KO mice were protected against renal and cardiac injury. Activation of Rac1/MR was demonstrated in obese diabetic KKAy mice, TAC-induced cardiac injury, AngII/salt-induced renal injury, and senescence-associated skin injury models.
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Report
(4 results)
Research Products
(38 results)
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[Journal Article] A novel link between Slc22a18 and fat accumulation revealed by a mutation in the spontaneously hypertensive rat.2013
Author(s)
Yamamoto, T., Izumi-Yamamoto, K., Iizuka, Y., Shirota, M., Nagase, M., Fujita, T., and Gotoda, T.
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Journal Title
Biochem Biophys Res Commun
Volume: 440
Issue: 4
Pages: 521-526
DOI
Related Report
Peer Reviewed
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