| Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2015: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2014: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2013: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
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| Outline of Final Research Achievements |
Dementia is now known to be the greatest risk factor for poor prognosis of Parkinson disease (PD). Thus an early diagnosis and therapeutic intervention for cognitive impairments may enable to improve the long-term prognosis of PD. In this project, we investigated the distribution and propagation process of synuclein aggregation in PD brain by using the [11C]BF-227 PET. Nine of 19 PD cases showed high uptake in limbic system such as orbitofrontal area, amygdale, and cingulate cortex. The areas of high uptake were increasing by time-dependent manner. Other cases showed little of BF-227 signals. From these results, we speculate that there may be two patterns of synuclein deposition in PD, that is, limbic type with high BF-227 signals and brainstem type without apparent BF-227 uptake, although further study by using new probes more specific for synuclein aggregation are needed to confirm the present results.
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