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Molecular clarification of trans-differentiation to brown adipocytes through the action of soluble receptor LR11

Research Project

Project/Area Number 24390231
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Metabolomics
Research InstitutionToho University (2013-2014)
Chiba University (2012)

Principal Investigator

BUJO Hideaki  東邦大学, 医学部, 教授 (80291300)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥14,820,000 (Direct Cost: ¥11,400,000、Indirect Cost: ¥3,420,000)
Fiscal Year 2014: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
KeywordsLR11 / 脂肪細胞 / 褐色 / エネルギー産生 / トランスディファレンシエーション / 糖尿病 / 可溶性 / 白血病 / アルツハイマー病 / 褐色細胞 / 分化 / 肥満
Outline of Final Research Achievements

The aim of study is to clarify the physiological significance of and molecular mechanism underlying the trans-differentiation of brown from white adipocytes in LR11-deficent mice, together with the analyses of LR11-overexpressing hematological cells and LR11-decreasing neuronal tissues. Our findings demonstrate that the soluble form of LR11 (sLR11) suppresses thermogenesis in adipose tissue in a cell autonomous manner. Mice lacking LR11 were protected from diet-induced obesity due to increased browning of white adipose tissue and hyper-metabolism. In addition, the shedding of LR11 is regulated by proteinase with other molecules, and the soluble form and the left intracellular form may function as independent molecules for the regulation of cell phenotype. Thus, the regulation of slR11 production is expected as a novel target for developing strategies to treat obesity and diabetes.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (6 results)

All 2014 2013 2012

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results)

  • [Journal Article] Circulating soluble LR11, a novel marker of smooth muscle cell proliferation, is enhanced after coronary stenting in response to vascular injury.2014

    • Author(s)
      Ogita M, Miyauchi K, Jiang M, Kasai T, Tsuboi S, Naito R, Konishi H, Dohi T, Yokoyama T, Okazaki S, Shimada K, Bujo H, Daida H.
    • Journal Title

      Atherosclerosis

      Volume: 237 Pages: 374-378

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] G-CSF induces the release of the soluble form of LR11, a regulator of myeloid cell mobilization in bone marrow2014

    • Author(s)
      Shimizu N, Nakaseko C, Jiang M, Nishii K, Yokote K, Iseki T, Higashi M, Tamaru J, Schneider WJ, Bujo H
    • Journal Title

      Ann Hematol

      Volume: (印刷中) Issue: 7 Pages: 1111-1122

    • DOI

      10.1007/s00277-014-2033-0

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The soluble form of LR11 is a regulator of hypoxia-induced, uPAR-mediated adhesion of immature hematological cells2013

    • Author(s)
      Keigo Nishii, Chiaki Nakaseko, Meizi Jiang, Naomi Shimizu, Masahiro Takeuchi, Wolfgang Johann Schneider, and Hideaki Bujo
    • Journal Title

      The Journal of Biological Chemistry

      Volume: 288(17) Issue: 17 Pages: 11877-11886

    • DOI

      10.1074/jbc.m112.442491

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] LR11 : a novel biomarker identified in follicular lymphoma2013

    • Author(s)
      Kawaguchi T, Ohwada C, Takeuchi M, Shimizu N, Sakaida E, Takeda Y, Sakai S, Tsukamoto S, Yamazaki A, Sugita Y, Jiang M, Higashi M, Yokote K, Tamura J, Bujo H, Nakaseko C
    • Journal Title

      Br J Haematol

      Volume: 163(2) Issue: 2 Pages: 277-280

    • DOI

      10.1111/bjh.12467

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Platelet-rich plasma inhibits the apoptosis of highly adipogenic homogeneous preadipocytes in an in vitro culture system.2012

    • Author(s)
      Fukaya Y, Kuroda M, Aoyagi Y, Asada S, Kubota Y, Okamoto Y, Nakayama T, Sai to Y, Satoh Y, Bujo H
    • Journal Title

      Exp Mol Med

      Volume: 44 Issue: 5 Pages: 330-339

    • DOI

      10.3858/emm.2012.44.5.037

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Circulating Soluble LRU in Patients with Diabetic Retinopathy.2012

    • Author(s)
      Takahashi M, Bujo H, Shiba T, Jiang M, Maeno T, Shirai K
    • Journal Title

      Am J Ophthalmol

      Volume: 154 Issue: 1 Pages: 187-192

    • DOI

      10.1016/j.ajo.2012.01.035

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed

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Published: 2012-04-24   Modified: 2019-07-29  

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