Comprehensive analysis of exercise-induced metabolic alteration through the investigation of the function of novels isoforms of PGC1a
| Project/Area Number |
24390234
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Kobe University |
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Principal Investigator |
WATARU Ogawa 神戸大学, 医学(系)研究科(研究院), 教授 (40294219)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2014: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2012: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
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| Keywords | 糖尿病 / エネルギー代謝 / 肥満 / インスリン抵抗性 / メタボリックシンドローム / エネルギー消費 / 運動 / 代謝制御 / 遺伝子発現 |
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| Outline of Final Research Achievements |
We have characterized the physiological function of novel isoforms of PGC1α mainly by the investigation of metabolic phenotypes of mice that specifically lack the genes for these isoforms. These novel isoforms, PGC1αb and PGC1αc, are greatly induced in skeletal muscle in response to exercise and increased energy expenditure through stimulating fatty acid metabolism and mitochondrial proton leakage. These isoforms also play an important role for the maintenance of exercise capacity. Novel isoforms that transcribed from the same exon as PGC1αb and PGC1αc were transcribed were identified, and termed PGC1α2, 3, and 4. PGC1α2, 3, and 4 however do not possess such metabolic function in skeletal muscle.
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Report
(4 results)
Research Products
(16 results)
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[Journal Article] A minimally invasive system for glucose area under the curve measurement using interstitial fluid extraction technology : evaluation of the accuracy and usefulness with oral glucose tolerance tests in subjects with and without diabetes.2012
Author(s)
Sakaguchi K, Hirota Y, Hashimoto N, Ogawa W, Sato T, Okada S, Hagino K, Asakura Y, Kikkawa Y, Kojima J, Maekawa Y, Nakajima H.
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Journal Title
Diabetes Technol Ther.
Volume: 14
Pages: 485-491
DOI
Related Report
Peer Reviewed
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