Study on the pathophysiological roles of seipin, a generalized lipodystrophy causative gene product

• Project/Area Number: 24390237
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Endocrinology
• Research Institution: Jichi Medical University (2014-2015); Kyoto University (2012-2013)
• Principal Investigator: Ebihara Ken 自治医科大学, 医学部, 准教授 (70362514)
• Co-Investigator(Kenkyū-buntansha): ABE MEGUMI 京都大学, 生命科学研究科, 助教 (20568688) ; KUSAKABE TORU 京都大学, 医学研究科, 准教授 (60452356)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000); Fiscal Year 2014: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2013: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000); Fiscal Year 2012: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
• Keywords: セイピン / 脂肪萎縮症 / ラットモデル / 精神発達遅滞 / 精子低形成 / レプチン / ラット / 疾患特異的iPS細胞

Outline of Final Research Achievements

Mutations of BSCL2 cause the most severe form of congenital generalized lipodystrophy (CGL). BSCL2mRNAis highly expressed in the brain and testis in addition to the adipose tissue in human, suggesting physiological roles of seipin in non-adipose tissues. Since we found BSCL2 mRNA expression pattern among organs in rat is similar tohumanwhile it is not highly expressed in mouse brain,we generated a Bscl2/seipin knockout (SKO) rat. SKO rats showed total lack of white adipose tissues, while physiologically functional brown adipose tissuewas preserved. Besides the lipodystrophic phenotypes, SKO rats showed impairment of spatial working memory with brainweight reduction and infertility with azoospermia.We confirmed reduction of brain volume and number of sperm in human patients with BSCL2 mutation. This is the first report demonstrating that seipin is necessary for normal brain development and spermatogenesis in addition to white adipose tissue development.

Research Products

• [Journal Article] Impaired adipogenic capacity in induced pluripotent stem cells from lipodystrophic patients with BSCL2 mutations (2016)
  • Author(s): 1.E. Mori, J. Fujikura, M. Noguchi, K. Nakao, M. Matsubara, M. Sone, D. Taura, T. Kusakabe, K. Ebihara, T. Tanaka, K. Hosoda, K. Takahashi, I. Asaka, N. Inagaki, K. Nakao
  • Journal Title: Metabolism. Volume: 65 Pages: 543-546
  • DOI: 10.1016/j.metabol.2015.12.015
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Hyperleptinemia suppresses aggravation of arthritis of collagen-antibody-induced arthritis in mice. (2015)
  • Author(s): Okano T, Koike T, Tada M, Sugioka Y, Mamoto K, Inui K, Okihana H, Ebihara K, Nakao K, Nakamura H.
  • Journal Title: J Orthop Sci Volume: 20(6) Pages: 1106-1113
  • DOI: 10.1007/s00776-015-0768-7
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] ・Seipin is necessary for normal brain development and spermatogenesis in addition to adipogenesis. (2015)
  • Author(s): Ebihara C, Ebihara K, Aizawa-Abe M, Mashimo T, Tomita T, Zhao M, Gumbilai VM, Kusakabe T, Yamamoto Y, Aotani D, Yamamoto-Kataoka S, Sakai T, Hosoda K, Serikawa T, Nakao K
  • Journal Title: Human Molecular Genetics Volume: 24 Pages: 4238-4249
  • DOI: 10.1093/hmg/ddv156
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Leptin improves fatty liver independently of insulin sensitization and appetite suppression in hepatocyte-specific Pten-deficient mice with insulin hypersensitivity. (2015)
  • Author(s): Yamamoto-Kataoka S, Ebihara K, Aizawa-Abe M, Nishio M, Kusakabe T, Yamamoto Y, Aotani D, Sakai T, Zhao M, Ebihara C, Gumbilai VM, Hosoda K, Suzuki A, Nakao K
  • Journal Title: HORMONE AND METABOLIC RESEARCH Volume: 47 Pages: 168-175
  • DOI: 10.1055/s-0034-1395531
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Leptin restores the insulinotropic effect of exenatide in a mouse model of type 2 diabetes with increased adiposity induced by streptozotocin and high-fat diet (2014)
  • Author(s): T. Sakai, T. Kusakabe, K. Ebihara, D. Aotani, S. Yamamoto-Kataoka, Z. Mingming, VM. Gumbilai, C. Ebihara, M. Aizawa-Abe, Y. Yamamoto, M. Noguchi, J. Fujikura, K. Hosoda, N. Inagaki, K. Nakao
  • Journal Title: Am J Physiol Endocrinol Metab Volume: 307 Pages: 712-719
  • DOI: 10.1152/ajpendo.00272.2014
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Generation of leptin-deficient Lepmkyo/Lepmkyo rats and identification of leptin-responsive genes in the liver. (2013)
  • Author(s): M. Aizawa-Abe, K. Ebihara, C. Ebihara, T. Mashimo, A. Takizawa, T. Tomita, T. Kusakabe, Y. Yamamoto, D. Aotani, S. Yamamoto-Kataoka, T. Sakai, K. Hosoda, T. Serikawa, K. Nakao
  • Journal Title: Physiol Genomics Volume: 45(17) Pages: 786-793
  • DOI: 10.1152/physiolgenomics.00040.2013
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] In vitro characterization and engraftment of adipocytes derived from human induced pluripotent stem cells and embryonic stem cells. (2013)
  • Author(s): M. Noguchi, K. Hosoda, E. Mori, M. Nakane, K. Nakao, D. Taura, Y. Yamamoto, T. Kusakabe, M. Sone, H. Sakurai, J. Fujikura, K. Ebihara, K. Nakao
  • Journal Title: Stem Cells Dev Volume: 22(21) Pages: 2895-2905
  • DOI: 10.1089/scd.2013.0113
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Early Changes of Abdominal Adiposity Detected with Weekly Dual Bioelectrical Impedance Analysis During Calorie Restriction. (2013)
  • Author(s): M. Ida, M. Hirata, S. Odori, E. Mori, E. Kondo, J. Fujikura, T. Kusakabe, K. Ebihara, K. Hosoda, K. Nakao.
  • Journal Title: Obesity Volume: 21(9)
  • DOI: 10.1002/oby.20300
  • Peer Reviewed
• [Journal Article] Intracerebroventricular administration of C-type natriuretic peptide suppresses food intake via activation of the melanocortin system in mice. (2013)
  • Author(s): N. Yamada-Goto, G. Katsuura, K. Ebihara, M. Inuzuka, Y. Ochi, Y. Yamashita, T. Kusakabe, A. Yasoda, N. Asahara-Satoh, H. Ariyasu, K. Hosoda, K. Nakao.
  • Journal Title: Diabetes Volume: 62(5) Pages: 1500-1504
  • DOI: 10.2337/db12-0718
  • NAID: 120005244943
  • Peer Reviewed
• [Journal Article] GPR119 expression in normal human tissues and islet cell tumors: evidence for its islet-gastrointestinal distribution, expression in pancreatic beta and alpha cells, and involvement in islet function (2013)
  • Author(s): Odori S, Nakao K, et al
  • Journal Title: Metabolism. Volume: 62 Pages: 70-78
  • DOI: 10.1016/j.metabol.2012.06.010
  • NAID: 120005242664
  • Peer Reviewed
• [Journal Article] Intracerebroventricular administration of C-type natriuretic peptide suppresses food intake via activation of the melanocortin system in mice. (2012)
  • Author(s): N. Yamada-Goto, G. Katsuura, K. Ebihara, M. Inuzuka, Y. Ochi, Y. Yamashita, T. Kusakabe, A. Yasoda, N. Asahara- Satoh, H. Ariyasu, K. Hosoda. K. Nakao
  • Journal Title: J Neuroendocrinol Volume: (掲載決定)
  • NAID: 120005244943
  • Peer Reviewed
• [Journal Article] Leptin activates hepatic 5’ AMP-Activated Protein Kinase through sympathetic nervous system and α1 adrenergic receptor: A potential mechanism for improvement of fatt Li Yver in lipodystrophy by leptin (2012)
  • Author(s): Miyamoto L, Nakao K, et al
  • Journal Title: J Biol Chem Volume: 287 Pages: 40441-40447
  • DOI: 10.1074/jbc.m112.384545
  • Peer Reviewed
• [Journal Article] Premature Atherosclerosis in a Japanese Diabetic Patient with Atypical Familial Partial Lipodystrophy and Hypertriglyceridemia (2012)
  • Author(s): M. Iwanishi, K. Ebihara, T. Kusakabe, S. Harada, J. Ito-Kobayashi, A. Tsuji, K. Hosoda, K. Nakao
  • Journal Title: Intern. Med. Volume: 51巻 Issue: 18 Pages: 2573-2579
  • DOI: 10.2169/internalmedicine.51.7461
  • NAID: 130002062378
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed
• [Journal Article] Functional Magnetic Resonance Imaging Analysis of Food-Related Brain Activity in Patients with Lipodystrophy Undergoing Leptin Replacement Therapy (2012)
  • Author(s): Aotani D, Nakao K, et al
  • Journal Title: J Clin Endocrinol Metab Volume: 97 Pages: 3663-3671
  • DOI: 10.1210/jc.2012-1872
  • Peer Reviewed
• [Journal Article] Impairment of fear-conditioning responses and changes of brain neurotrophic factors in diet-induced obese mice (2012)
  • Author(s): N.Yamada-Goto, K.Ebihara, K.Hosoda, K.Nakao, et al
  • Journal Title: Journal of Neuroendocrinology Volume: (in press) Pages: 1120-1125
  • DOI: 10.1111/j.1365-2826.2012.02327.x
  • Peer Reviewed
• [Journal Article] Amylin improves the effect of leptin on insulin sensitivity in leptin-resistant diet-induced obese mice (2012)
  • Author(s): T.Kusakabe, K.Ebihara, K.Nakao, et al
  • Journal Title: Am J Physiol Endocrinol Metab. Volume: 302
  • DOI: 10.1152/ajpendo.00198.2011
  • Peer Reviewed
• [Presentation] Seipin is necessary for normal brain development and spermatogenesis in addition to adipogenesis (2015)
  • Author(s): Ebihara C, Ebihara K, Aizawa-Abe M, Yamamoto Y, Yamamoto-Kataoka S, Zhao M, Gumbilai V, Hosoda K, Serikawa T, Nakao K
  • Organizer: Obesity Week 2015 / TOS Annual Meeting & ASMBS Annual Meeting
  • Place of Presentation: 米国、ロサンゼルス
  • Year and Date: 2015-11-07
  • Int'l Joint Research
• [Presentation] Seipin is necessary for normal brain development and spermatogenesis in addition to adipogenesis (2015)
  • Author(s): Ebihara C, Ebihara K, Aizawa-Abe M, Yamamoto Y, Yamamoto-Kataoka S, Zhao M, Gumbilai V, Hosoda K, Serikawa T, Nakao K
  • Organizer: Keystone Symposia: Diabetes
  • Place of Presentation: 日本、京都
  • Year and Date: 2015-10-27
  • Int'l Joint Research
• [Presentation] Seipin is necessary for normal brain development and spermatogenesis in addition to adipogenesis (2015)
  • Author(s): Ebihara C, Ebihara K, Aizawa-Abe M, Mashimo T, Tomita T, Zhao M, Gumbilai V, Kusakabe T, Yamamoto Y, Aotani D, Yamamoto-Kataoka S, Sakai T, Hosoda K, Serikawa T, Nakao K
  • Organizer: 22nd European Congress on Obesity
  • Place of Presentation: チェコ共和国、プラハ
  • Year and Date: 2015-05-07
  • Int'l Joint Research
• [Presentation] セイピン欠損（SKO）ラットを用いた先天性全身性脂肪萎縮症原因遺伝子セイピンの生理的意義の解明 (2015)
  • Author(s): 海老原千尋、海老原 健、阿部 恵、真下知士、細田公則、芹川忠夫、中尾一和
  • Organizer: 第88回日本内分泌学会学術総会
  • Place of Presentation: 東京、ホテルニューオータニ
  • Year and Date: 2015-04-27
• [Presentation] Pathophysiological role of Bscl2/Seipin haploinsufficiency in adiposity and metabolism (2015)
  • Author(s): Chihiro Ebihara, Ken Ebihara, Megumi Aizawa-Abe, Mingming Zhao, Valentino Gumbilai, Yuji Yamamoto, Kiminori Hosoda, Kazuwa Nakao
  • Organizer: The Endocrine Sosiety’s 97th Annual Meeting
  • Place of Presentation: 米国、サンディエゴ
  • Year and Date: 2015-03-07
• [Presentation] セイピン欠損（SKO）ラットを用いた先天性全身性脂肪萎縮症原因遺伝子セイピンの生理的意義の解明 (2015)
  • Author(s): 海老原千尋、海老原 健、阿部 恵、真下知士、細田公則、芹川忠夫、中尾一和
  • Organizer: 第29回日本糖尿病・肥満動物学会
  • Place of Presentation: 京都市、京都大学医学部創立百周年記念施設「芝蘭会館」
  • Year and Date: 2015-02-13
• [Presentation] Translational Research of Leptin for Lipodystrophy in Japan (2014)
  • Author(s): Ken Ebihara, Megumi Aizawa-Abe, Kiminori Hosoda, Toru Kusakabe, Daisuke Aotani, Kazuwa Nakao
  • Organizer: Lipodystrophy in 2014: Leptin and Beyond
  • Place of Presentation: 米国、アナーバー
  • Year and Date: 2014-10-18
  • Invited
• [Presentation] 疾患モデルラットを用いた脂肪細胞関連遺伝子の病態生理的意義の解明 (2014)
  • Author(s): 海老原 健、阿部 恵、細田公則、中尾一和
  • Organizer: 第37回日本高血圧学会総会
  • Place of Presentation: 横浜市、パシフィコ横浜
  • Year and Date: 2014-10-18
  • Invited
• [Presentation] The human lipodystrophy gene product, seipin plays physiological roles in the brain development and spermatogenesis in addition to the adipogenesis Translational Research of Leptin for Lipodystrophy in Japan (2014)
  • Author(s): Chihiro Ebihara, Ken Ebihara, Megumi Aizawa-Abe, Tomoji Mashimo, Tsutomu Tomita, Mingming Zhao, Valentino Gumbilai, Yuji Yamamoto, Sachiko Yamamoto-Kataoka, Kiminori Hosoda, Tadao Serikawa, Kazuwa Nakao
  • Organizer: Lipodystrophy in 2014: Leptin and Beyond
  • Place of Presentation: 米国、アナーバー
  • Year and Date: 2014-10-17 – 2014-10-18
• [Presentation] 脂肪細胞由来ホルモン、レプチンのトランスレーショナルリサーチ (2014)
  • Author(s): 海老原 健、阿部 恵、細田公則、中尾一和
  • Organizer: 第32回内分泌代謝学サマーセミナー
  • Place of Presentation: 山梨県、河口湖富士レークホテル
  • Year and Date: 2014-07-10
  • Invited
• [Presentation] Improvement effect of thiazolidine on fatty liver and type 2 diabetes requires adipose tissue: An evidence from the comparison between mice and rats (2014)
  • Author(s): Chihiro Ebihara, Ken Ebihara, Megumi Aizawa-Abe, Yuji Yamamoto, Sachiko Yamamoto-Kataoka, Mingming Zhao, Valentino Gumbilai, Kiminori Hosoda, Kazuwa Nakao
  • Organizer: The Endocrine Sosiety’s 96th Annual Meeting
  • Place of Presentation: 米国、シカゴ
  • Year and Date: 2014-06-22
• [Presentation] 脂肪細胞由来ホルモン、レプチンのトランスレーショナルリサーチ (2013)
  • Author(s): 海老原健
  • Organizer: 第86回日本内分泌学会学術総会
  • Place of Presentation: 仙台市、仙台国際センター
• [Presentation] 新規モデルラットを用いたチアゾリジン誘導体（TZD）の脂肪肝改善メカニズムの解明 (2013)
  • Author(s): 海老原千尋、海老原健、阿部 恵、日下部徹、青谷大介、片岡祥子、酒井 建、趙 明明、Valentino Gumbilai、細田公則、中尾一和
  • Organizer: 第86回日本内分泌学会学術総会
  • Place of Presentation: 仙台市、仙台国際センター
• [Presentation] レプチンによる脂肪肝改善メカニズムの解明-肝特異的Pten欠損マウスを用いた検討- (2013)
  • Author(s): 片岡祥子、海老原健、阿部 恵、日下部徹、山本祐二、青谷大介、酒井 建、海老原千尋、細田公則、中尾一和
  • Organizer: 第86回日本内分泌学会学術総会
  • Place of Presentation: 仙台市、仙台国際センター
• [Presentation] 肥満2型糖尿病治療におけるレプチン/GLP-1受容体作動薬共投与の有用性 (2013)
  • Author(s): 酒井 建、日下部徹、海老原健、青谷大介、片岡祥子、海老原千尋、阿部 恵、山本祐二、藤倉純二、細田公則、中尾一和
  • Organizer: 第86回日本内分泌学会学術総会
  • Place of Presentation: 仙台市、仙台国際センター
• [Presentation] 脂肪萎縮症におけるレプチンの黒色表皮腫改善効果 (2013)
  • Author(s): 日下部徹、海老原健、髭 秀樹、阿部 恵、青谷大介、片岡祥子、酒井 建、海老原千尋、藤倉純二、細田公則、中尾一和
  • Organizer: 第56回日本糖尿病学会年次学術集会
  • Place of Presentation: 熊本市、ホテル日航熊本他
• [Presentation] 先天性全身性脂肪萎縮症６歳児症例におけるレプチン補充療法の有用性 (2013)
  • Author(s): 海老原千尋、海老原健、阿部 恵、日下部徹、青谷大介、片岡祥子、酒井 建、趙 明明、Gumbilai Valentino、細田公則、中尾一和
  • Organizer: 第56回日本糖尿病学会年次学術集会
  • Place of Presentation: 熊本市、ホテル日航熊本他
• [Presentation] 部分性脂肪萎縮症に対するレプチン補充療法の有用性 (2013)
  • Author(s): 青谷大介、海老原健、日下部徹、阿部 恵、片岡祥子、酒井 建、海老原千尋、藤倉純二、細田公則、中尾一和
  • Organizer: 第56回日本糖尿病学会年次学術集会
  • Place of Presentation: 熊本市、ホテル日航熊本他
• [Presentation] The human lipodystrophy gene product, seipin plays physiological roles beyond the adipose tissue (2013)
  • Author(s): Ken Ebihara, Megumi Aizawa-Abe, Tshutomu Tomita, Toru Kusakabe, Yuji Yamamoto, Daisuke Aotani, Sachiko Yamamoto-Kataoka, Takeru Sakai, Valentino Milton Gumbilai, Mingming Zhao, Kiminori Hosoda and Kazuwa Nakao.
  • Organizer: The Endocrine Society’s 95th Annual Meeting & Expo
  • Place of Presentation: アメリカ、サンフランシスコ
• [Presentation] レプチンによる膵臓内脂肪蓄積の減少とインクレチン作用の増強 (2013)
  • Author(s): 酒井 建、日下部徹、海老原健、青谷大介、片岡祥子、趙 明明、Milton Valentino、海老原千尋、阿部 恵、藤倉純二、山本祐二、細田公則、中尾一和
  • Organizer: 第34回日本肥満学会
  • Place of Presentation: 東京都、東京国際フォーラム
• [Presentation] レプチン欠損Lepmkyo/Lepmkyoラットを用いた肝臓におけるレプチン感受性遺伝子の同定 (2013)
  • Author(s): 阿部 恵、海老原健、海老原千尋、日下部徹、青谷大介、酒井 建、片岡祥子、趙 明明、バレンチノ ガンブリアイ、山本祐二、細田公則、中尾一和
  • Organizer: 第34回日本肥満学会
  • Place of Presentation: 東京都、東京国際フォーラム
• [Presentation] ニューロメジンＵのインスリン抵抗性における意義 (2013)
  • Author(s): 青谷大介、海老原健、日下部徹、阿部 恵、片岡祥子、酒井 建、海老原千尋、藤倉純二、細田公則、中尾一和
  • Organizer: 第34回日本肥満学会
  • Place of Presentation: 東京都、東京国際フォーラム
• [Presentation] Impact of successful leptin replacement therapy in Japan on adult and child, systemic and partial lipodystrophy. (2013)
  • Author(s): Kazuwa Nakao, Kiminori Hosoda, Ken Ebihara, Toru Kusakabe, Megumi Aizawa-Abe, Daisuke Aotani.
  • Organizer: The 2013 Obesity Week
  • Place of Presentation: アメリカ、アトランタ
• [Presentation] The role of neuromedin U in glucose homeostasis. (2013)
  • Author(s): Daisuke Aotani, Ken Ebihara, Toru Kusakabe, Megumi Aizawa-Abe, Sachiko Kataoka, Takeru Sakai, Chihiro Ebihara, Kiminori Hosoda, Kazuwa Nakao.
  • Organizer: The 2013 Obesity Week
  • Place of Presentation: アメリカ、アトランタ
• [Presentation] 肥満症治療におけるレプチンの可能性 (2012)
  • Author(s): 海老原健、阿部 恵、日下部徹、青谷大介、細田公則、中尾一和
  • Organizer: 第33回 日本肥満学会
  • Place of Presentation: 京都市、ホテルグランヴィア京都
  • Year and Date: 2012-10-12
• [Presentation] レプチン/GLP-1受容体作動薬共投与による肥満2型糖尿病治療の有用性 (2012)
  • Author(s): 酒井 建、日下部徹、海老原健、青谷大介、片岡祥子、海老原千尋、阿部 恵、藤倉純二、山本祐二、細田公則、中尾一和
  • Organizer: 第33回 日本肥満学会
  • Place of Presentation: 京都市、ホテルグランヴィア京都
  • Year and Date: 2012-10-12
• [Presentation] 脂肪萎縮症原因遺伝子scipinの生体における意義に関する検討 (2012)
  • Author(s): 海老原千尋、阿部 恵、海老原健、Valentino Milton Gumbilai、日下部徹、青谷大介、酒井 建、趙 明明、山本祐二、細田公則、中尾一和
  • Organizer: 第33回 日本肥満学会
  • Place of Presentation: 京都市、ホテルグランヴィア京都
  • Year and Date: 2012-10-12
• [Presentation] Benefical Effects of Combination Therapy With Lept in and Exenatide in a Mouse Model of Type2 Diabetes With Increased Adiposity (2012)
  • Author(s): Takeru Sakai, Toru Kusakabe, Ken Ebihara, Daisuke Aotani, Sachiko Kataoka, Chihiro Ebihara, Yuj i Yamamoto, Megumi Abe, Junji Fujikura, Kiminori Hosoda, Kazuwa Nakao
  • Organizer: 2nd scientific sessions American Diabetes Associatic
  • Place of Presentation: Philadelphia(University)
  • Year and Date: 2012-06-10
• [Presentation] レプチン/GLP-1受容体作動薬共投与による肥満2型糖尿病治療の有用性 (2012)
  • Author(s): 酒井 建、日下部徹、海老原健、青谷大介、片岡祥子、海老原千尋、山本祐二、阿部 恵、藤倉純二、細田公則、中尾一和
  • Organizer: 第55回 日本糖尿病学会年次学術集会
  • Place of Presentation: 横浜市、パシフィコ横浜
  • Year and Date: 2012-05-17
• [Presentation] Development of Leptin Deficient Rats-Evidence of Superiority Over Lepob/Lepob Mice as a Model For Human Obesity. (2012)
  • Author(s): M. Aizawa-Abe, K. Ebihara, C. Ebihara, T. Kusakabe, T. Serikawa, D. Aotani, V.M.J. Gumbili, T. Mashimo, K. Nakao
  • Organizer: 19th European Congress on Obesity
  • Place of Presentation: Lyon(Frarnce)
  • Year and Date: 2012-05-10
• [Presentation] Leptin Modulates brain activity associated with feeding behavior in patients with Lipodystrophy. (2012)
  • Author(s): D. Aotani, K. Ebihara, N. Sawamoto, T. Kusakabe, M. Aizawa-Abe, S. Kataoka, T. Sakai, C. Ebihara, J. Fujikura, K. Hosoda, H. Fukuyama & K. Nakao.
  • Organizer: 19th European Congress on Obesity
  • Place of Presentation: Lyon(Frarnce)
  • Year and Date: 2012-05-10
• [Presentation] Development of leptin deficient Lepmkyo/ Lepmkyo rat-evidence for its superiority over Lepob/ Lepob mouse as a model for human obesity. (2012)
  • Author(s): M. Aizawa-Abe, K. Ebihara, C. Ebihara, T. Kusakabe, D. Aotani, V. Gumbili, T. Mashirao, T. Serikawa & K. Nakao
  • Organizer: 15th International & 14th European Congress of Endocrinology
  • Place of Presentation: Florence(Italy)
  • Year and Date: 2012-05-05
• [Presentation] Leptin Modulates brain activity associated with feeding behavior in patients with Lipodystrophy. (2012)
  • Author(s): D. Aotani, K. Ebihara, N. Sawamoto, T. Kusakabe, M. Aizawa-Abe, S. Kataoka, T. Sakai, C. Ebihara, J. Fujikura, K. Hosoda, H. Fukuyama & K. Nakao.
  • Organizer: 15th International & 14th European Congress of Endocrinology
  • Place of Presentation: Florence(Italy)
  • Year and Date: 2012-05-05
• [Presentation] レプチン、アミリン共投与による糖脂質代謝改善に関する検討 (2012)
  • Author(s): 日下部徹、海老原健、酒井 建、青谷大介、片岡祥子、海老原千尋、趙 明明、Milton Valentino、阿部 恵、藤倉純二、細田公則、中尾一和
  • Organizer: 第85回 日本内分泌学会学術総会
  • Place of Presentation: 名古屋市、名古屋国際会議場
  • Year and Date: 2012-04-19
• [Presentation] 遺伝子改変ラットを用いたチアゾリジンの脂肪肝に対する効果の種族差の検討 (2012)
  • Author(s): 阿部 恵、海老原健、海老原千尋、口下部徹、青谷大介、片岡祥子、酒井 建、趙 明明、Valentino MJ Gumbilai , 細田公則、芹川忠夫、中尾一和
  • Organizer: 第85回 日本内分泌学会学術総会
  • Place of Presentation: 名古屋市、名古屋国際会議場
  • Year and Date: 2012-04-19
• [Presentation] 肥満2型糖尿病に対するレプチン、アミリン共投与の有用性に関する検討 (2012)
  • Author(s): 日下部徹、海老原健、酒井 建、青谷大介、片岡祥子、海老原千尋、阿部 恵、,藤倉純二、細田公則、中尾一和
  • Organizer: 第109回 日本内科学会総会
  • Place of Presentation: 京都市、みやこめっせ
  • Year and Date: 2012-04-14
• [Presentation] レプチンを用いた非アルコール性脂肪肝治療の可能性に関する検討 (2012)
  • Author(s): 片岡祥子、海老原健、阿部 恵、日下部徹、青谷大介、酒井 建、藤倉純二、細田公則、中尾一和
  • Organizer: 第109回 日本内科学会総会
  • Place of Presentation: 京都市、みやこめっせ
  • Year and Date: 2012-04-14
• [Presentation] fMR Iを用いた、脂肪萎縮症の食欲異常およびレプチン治療による効果の検討 (2012)
  • Author(s): 青谷大介、海老原健、澤本伸克、日下部徹、阿部 恵、片岡祥子、酒井 建、細田公則、福山秀直、中尾一和
  • Organizer: 第109回 日本内科学会総会
  • Place of Presentation: 京都市、みやこめっせ
  • Year and Date: 2012-04-14
• [Book] Innovative Medicine: Basic Research and Development (2015)
  • Author(s): Ebihara K, Nakao K
  • Publisher: Springer Open