| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2014: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2012: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
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| Outline of Final Research Achievements |
Mutations in the TET2 gene, which encodes an enzyme converting methylcytosine to hydroxymethylcytosine in the genome, are frequently found in a wide variety of hematologic malignancies. In this research, we demonstrated frequent novel RHOA gene mutations and the relationship between the mutations of TET2 and RHOA in angioimmunoblastic T-cell lymphoma. These findings were published in Nature Genetics in 2014. Furthermore, using model mice in which TET2 is knocked down, we demonstrated development of T-cell lymphoma and epigenetic dysregulation by the defect of TET2 function.
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