Thrombotic phenotypes of two antithrombotic factors, protein S and ADAMTS13
Project/Area Number |
24390250
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Hematology
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Research Institution | National Cardiovascular Center Research Institute |
Principal Investigator |
MIYATA TOSHIYUKI 独立行政法人国立循環器病研究センター, 研究所, 部長 (90183970)
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Co-Investigator(Kenkyū-buntansha) |
KOKAME Koichi 独立行政法人国立循環器病研究センター, 研究所, 室長 (40270730)
AKIYAMA Masashi 独立行政法人国立循環器病研究センター, 研究所, 室長 (30298179)
BANNO Fumiaki 独立行政法人国立循環器病研究センター, 研究所, 研究員 (00373514)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2014: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2012: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
|
Keywords | 静脈血栓症 / 凝固制御因子 / ADAMTS13 / 血栓性血小板減少性紫斑病 / フォンビルブランド因子 / プロテインS / 血小板凝集 / 静脈血栓塞栓症 / 抗凝固機構 / 血栓症 / 遺伝子変異 / 血小板 |
Outline of Final Research Achievements |
We generated monoclonal antibodies to the protein S K196E mutant and developed a simple and reliable method for the identification of protein S K196E carriers. The novel method allowed identifying mutation carriers even under warfarin treatment or pregnancy. We found that ADAMTS13 deficiency promoted venous thrombus formation induced by the electrolytic stimulation in mouse model. We have performed the candidate gene analysis (C3, CFH, CFB, CFI, MCP, and THBD) in 46 patients with atypical hemolytic uremic syndrome, aHUS. We identified C3 I1157T mutation in multiple aHUS families who are mainly localized in the Kansai area.
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Report
(4 results)
Research Products
(87 results)
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[Journal Article] Eculizumab in the treatment of atypical hemolytic uremic syndrome in an infant leads to cessation of peritoneal dialysis and improvement of severe hypertension.2015
Author(s)
Ohta T, Urayama K, Tada Y, Furue T, Imai S, Matsubara K, Ono H, Sakano T, Jinno K, Yoshida Y, Miyata T, Fujimura Y.
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Journal Title
Pediatr Nephrol.
Volume: 30
Issue: 4
Pages: 603-608
DOI
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Peer Reviewed / Open Access
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[Journal Article] Contribution of ADAMTS13 to the better cell engraftment efficacy in mouse model of bone marrow transplantation2014
Author(s)
Matsui H, Takeda M, Soejima K, Matsunari Y, Kasuda S, Ono S, Nishio K, Shima M, Banno F, Miyata T, Sugimoto M
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Journal Title
Haematologica
Volume: 99
Pages: 211-213
Related Report
Peer Reviewed / Open Access
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[Journal Article] Analysis of patients with atypical hemolytic uremic syndrome treated at the Mie University Hospital: Concentration of C3 p.I1157T mutation.2014
Author(s)
Matsumoto T, Fan X, Ishikawa E, Ito M, Amano K, Toyoda H, Komada Y, Ohishi K, Katayama N, Yoshida Y, Matsumoto M, Fujimura Y, Ikejiri M, Wada H, Miyata T.
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Journal Title
Int J Hematol.
Volume: 100
Issue: 5
Pages: 437-442
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Long term follow up of congenital thrombotic thrombocytopenic purpura (Upshaw-Schulman syndorome) on hemodialysis for 19 years: a case report2013
Author(s)
Mise K, Ubara Y, Matsumoto M, Sumida K, Hiramatsu R, Hasegawa E, Yamanouchi M, Hayami N, Suwabe T, Hoshino J, Sawa N, Ohashi K, Kokame K, Miyata T, Fujimura Y, Takaichi K.
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Journal Title
BMC Nephrol.
Volume: 14
Issue: 1
Pages: 156-156
DOI
Related Report
Peer Reviewed
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[Journal Article] Protein S K196E mutation, a genetic risk factor venous thromboembolism, is limited to Japanese.2013
Author(s)
Liu W, Yin T, Okuda H, Harada KH, Li Y, Xu B, Yang J, Wang H, Fan X, Koizumi A, Miyata T
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Journal Title
Thromb Res
Volume: 132
Pages: 314-315
Related Report
Peer Reviewed
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[Journal Article] ADAMTS13 safeguards the myocardium in a mouse model of acute myocardial infarction.2012
Author(s)
Masaaki Doi, Hideto Matsui, Yukiji Takeda, Yoshihiko Saito, Maiko Takeda, Yasunori Matsunari, Kenji Nishio, Midori Shima, Fumiaki Banno, Masashi Akiyama, Koichi Kokame, Toshiyuki Miyata, and Mitsuhiko Sugimoto.
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Journal Title
Thromb. Haemost.
Volume: 108
Issue: 12
Pages: 1236-1238
DOI
Related Report
Peer Reviewed
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[Presentation] “Registry of congenital TMAs in Japan”2014
Author(s)
Masanori Matsumoto, Toshiyuki Miyata, Yoshihiro Fujimura
Organizer
The 8th congress of Asia Pacific Society on Thrombosis and Haemostasis- 2014
Place of Presentation
Hanoi, Vietnam
Year and Date
2014-10-09 – 2014-10-11
Related Report
Invited
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[Presentation] 血栓形成の分子機構2012
Author(s)
宮田敏行
Organizer
日本バイオマテリアル学会シンポジウム2012
Place of Presentation
仙台市(招待講演)
Year and Date
2012-11-27
Related Report
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