Exploring rare variants associated with pediatric asthma for personalized medicine by exome analysis
Project/Area Number |
24390251
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
膠原病・アレルギー・感染症内科学
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Research Institution | University of Tsukuba |
Principal Investigator |
Noguchi Emiko 筑波大学, 医学医療系, 教授 (40344882)
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Co-Investigator(Kenkyū-buntansha) |
Okamura Koji 国立成育医療研究センター, システム発生再生医学研究部, 室長 (80456194)
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Project Period (FY) |
2012-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2014: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
|
Keywords | エクソーム / アレルギー / 気管支喘息 |
Outline of Final Research Achievements |
The aim of this study is to investigate rare variants associated with asthma by exome analysis using next generation sequencer. We performed exome analyses on 67 patients who were diagnosed with asthma. Control genotype/allele frequencies were obtained from Human Genetic Variation Database. In the genomic regions which were identified to be associated with asthma by genome-wide association studies, we found two missense variants (one in IL1RL1 and the other in GSDMB) to be possibly associated with asthma (P < 0.05). We also found several candidate rare variants to be associated with asthma.
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Report
(5 results)
Research Products
(24 results)
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[Journal Article] Variants near the HLA complex group 22 gene (HCG22) confer increased susceptibility to late-onset asthma in Japanese populations.2016
Author(s)
Yatagai Y, Hirota T, Sakamoto T, Yamada H, Masuko H, Kaneko Y, Iijima H, Naito T, Noguchi E, Tamari M, Kubo M, Takahashi A, Konno S, Makita H, Nishimura M, Hijikata M, Keicho N, Homma S, Taguchi Y, Azuma A, Kudoh S, Hizawa N.
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Journal Title
J Allergy Clin Immunol
Volume: 印刷中
Issue: 1
Pages: 281-283
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Role of Lung Function Genes in the Development of Asthma2015
Author(s)
Yamada H, Masuko H, Yatagai Y, Sakamoto T, Kaneko Y, Iijima H, Naito T, Noguchi E, Konno S, Nishimura M, Hirota T, Tamari M, Hizawa N
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Journal Title
PLoS One
Volume: -
Issue: 1
Pages: e0145832-e0145832
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Genomewide association study identifies HAS2 as a novel susceptibility gene for adult asthma in a Japanese population2014
Author(s)
Yatagai Y, Sakamoto T, Yamada H, Masuko H, Kaneko Y, Iijima H, Naito T, Noguchi E, Hirota T, Tamari M, Konno S, Nishimura M, Hizawa N
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Journal Title
Clin Exp Allergy
Volume: 44
Issue: 11
Pages: 1327-1334
DOI
Related Report
Peer Reviewed
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[Journal Article] Genetic polymorphisms in the IL22 gene are associated with psoriasis vulgaris in a Japanese population.2013
Author(s)
Saeki H, Hirota T, Nakagawa H, Tsunemi Y, Kato T, Shibata S, Sato S, Doi S, Miyatake A, Ebe K, Noguchi E, Ebihara T, Amagaii M, Esaki H, Takeuchi S, Furue M, Nakamura Y, Tamari M.
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Journal Title
J Dermatol Sci.
Volume: 71
Issue: 2
Pages: 148-150
DOI
Related Report
Peer Reviewed
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[Journal Article] A Distinct Sensitization Pattern Associated with Asthma and the Thymic Stromal Lymphopoietin (TSLP) Genotype2013
Author(s)
Iijima H, Kaneko Y; Yamada H, Yatagai Y, Masuko H, Sakamoto T, Naito T, Hirota T, Tamari M, Konno S, Nishimura M, Noeuchi E, Hizawa N
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Journal Title
Allergol Int
Volume: 62
Pages: 123-130
Related Report
Peer Reviewed
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[Journal Article] Generation of induced pluripotent stem cells from human nasal epithelial cells using a Sendai virus vector2012
Author(s)
Ono M, Hamada Y, Horiuchi Y, Matsuo-Takasaki M, Imoto Y, Satomi K, Arinami T, Hasegawa M, Fujioka T, Nakamura Y, Noguchi E
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Journal Title
PLoS One
Volume: 7
Issue: 8
Pages: e42855-e42855
DOI
Related Report
Peer Reviewed
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[Journal Article] Association of adiponectin polymorphism with cord blood adiponectin concentrations and intrauterine growth2012
Author(s)
Saito M, Kamoda T, Nishimura K, Miyazono Y, Kanai Y, Kato Y, Iwabuchi A, Fukushima H, Hamada H, Arinami T, Sumazaki R, Noeuchi E
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Journal Title
J Hum Genet
Volume: 57
Pages: 109-114
Related Report
Peer Reviewed
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