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Investigation for pathogenesis of cutaneous severe adverse drug reaction.

Research Project

Project/Area Number 24390275
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Dermatology
Research InstitutionHokkaido University

Principal Investigator

ABE Riichiro  北海道大学, 医学(系)研究科(研究院), 准教授 (60344511)

Co-Investigator(Kenkyū-buntansha) FUJITA Yasuyuki  北海道大学, 北海道大学病院, 助教 (80374437)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2014: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
Keywords薬疹 / アレルギー / 重症薬疹 / モデルマウス / 細胞死
Outline of Final Research Achievements

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening, cutaneous adverse drug reactions that are accompanied by keratinocyte cell death. Dead keratinocytes from SJS/TEN lesions exhibited necrosis, bymorphological criteria. We identified annexin A1 as a key mediator of keratinocyte death via formyl peptide receptor 1 (FPR1). Our results demonstrate that a necroptosis pathway, likely mediated by annexin 1 acting through the FPR1 receptor, contributes to SJS/TEN.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (4 results)

All 2014 2013 2012

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 1 results) Presentation (1 results)

  • [Journal Article] An annexin A1-FPR1 interaction contributes to necroptosis of keratinocytes in severe cutaneous adverse drug reactions.2014

    • Author(s)
      Saito N, Qiao H, Yanagi T, Shinkuma S, Nishimura K, Suto A, Fujita Y, Suzuki S, Nomura T, Nakamura H, Nagao K, Obuse C, Shimizu H, Abe R.
    • Journal Title

      Science Translational Medicine

      Volume: 6 Issue: 245 Pages: 245-295

    • DOI

      10.1126/scitranslmed.3008227

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Disturbed balance in three subpopulations of CD4(+)Foxp3(+) regulatory T cells in Stevens-Johnson syndrome and toxic epidermal necrolysis patients.2013

    • Author(s)
      Yoshioka N, Suto A, Abe R, Saito N, Murata J, Hayashi-Ujiie I, Hoshina D, Fujita Y, Shimizu H.
    • Journal Title

      Clin Immunol

      Volume: 148 Issue: 1 Pages: 89-91

    • DOI

      10.1016/j.clim.2013.04.002

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stevens-Johnson syndrome/toxic epidermal necrolysis mouse model generated by using PBMCs and the skin of patients.2013

    • Author(s)
      Saito N, Yoshioka N, Abe R, Qiao H, Fujita Y, Hoshina D, Suto A, Kase S, Kitaichi N, Ozaki M, Shimizu H.
    • Journal Title

      Journal of Allergy and Clinical Immunology

      Volume: 131 Issue: 2 Pages: 434-441

    • DOI

      10.1016/j.jaci.2012.09.014

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] 薬疹を理解するための免疫学.2012

    • Author(s)
      阿部理一郎
    • Organizer
      第111回日本皮膚科学会総会
    • Place of Presentation
      京都国際会館(京都)
    • Year and Date
      2012-06-01
    • Related Report
      2012 Annual Research Report

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Published: 2012-04-24   Modified: 2019-07-29  

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