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Multimodal neuroimaging study of disruption of neural network in dementing illnesses

Research Project

Project/Area Number 24390278
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Psychiatric science
Research InstitutionTohoku University

Principal Investigator

Mori Etsuro  東北大学, 医学(系)研究科(研究院), 教授 (30368477)

Project Period (FY) 2012-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2014: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2013: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2012: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Keywords認知症 / 神経イメージング
Outline of Final Research Achievements

Clinical and neuroimaging information of patients with dementia was databased, and symptomatic features of each cause of dementia and association between symptoms and images were analyzed. Regarding DLB, we developed a pareidolia test, validated it, and studied the pathomechanism and responsible lesions for it. The tests are open to the public via the web, and are also taken up in clinical guidelines and textbooks for dementia with Lewy bodies. MRI studies of idiopathic normal pressure hydrocephalus showed that narrowing of the high convexity predicted the most postoperative improvement, and that the white matter abnormality of the corona radiata between the lateral ventricle and the Sylvian fissures, changes in connection with the improvement of symptoms after shunt operation, suggesting it is relevant to the pathomechanism of symptoms.

Report

(6 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • 2012 Annual Research Report

Research Products

(34 results)

All 2017 2016 2015 2014 2013 2012 Other

All Journal Article (27 results) (of which Peer Reviewed: 27 results,  Open Access: 12 results,  Acknowledgement Compliant: 9 results) Presentation (4 results) (of which Int'l Joint Research: 1 results,  Invited: 2 results) Book (1 results) Remarks (2 results)

  • [Journal Article] Longitudinal study of cognitive and cerebral metabolic changes in Parkinson's disease.2017

    • Author(s)
      Baba T, Hosokai Y, Nishio Y, Kikuchi A, Hirayama K, Suzuki K, Hasegawa T, Aoki M, Takeda A, Mori E.
    • Journal Title

      J Neurol Sci

      Volume: 372 Pages: 288-293

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A change in brain white matter after shunt surgery in idiopathic normal pressure hydrocephalus: a tract-based spatial statistics study.2017

    • Author(s)
      Kanno S, Saito M, Kashinoura T, Nishio Y, Iizuka O, Kikuchi H, Takagi M, Iwasaki M, Takahashi S, Mori E.
    • Journal Title

      Fluids and Barriers of the CNS

      Volume: 14 Pages: 1-1

    • DOI

      10.1186/s12987-016-0048-8

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The Pareidolia Test: A Simple Neuropsychological Test Measuring Visual Hallucination-Like Illusions.2016

    • Author(s)
      Mamiya Y, Nishio Y, Watanabe H, Yokoi K, Uchiyama M, Baba T, Iizuka O, Kanno S, Kamimura N, Kazui H, Hashimoto M, Ikeda M, Takeshita C, Shimomura T, Mori E.
    • Journal Title

      PLoS One

      Volume: 11

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] High-Convexity Tightness Predicts the Shunt Response in Idiopathic Normal Pressure Hydrocephalus.2016

    • Author(s)
      Narita W, Nishio Y, Baba T, Iizuka O, Ishihara T, Matsuda M, Iwasaki M, Tominaga T, Mori E.
    • Journal Title

      AJNR Am J Neuroradiol

      Volume: 37 Pages: 1831-1837

    • DOI

      10.3174/ajnr.a4838

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] On the utility of MIBG SPECT/CT in evaluating cardiac sympathetic dysfunction in Lewy body diseases2016

    • Author(s)
      Odagiri H, Baba T, Nishio Y, Iizuka O, Matsuda M, Inoue K, Kikuchi A, Hasegawa T, Aoki M, Takeda A, Taki Y, Mori E
    • Journal Title

      PLoS One

      Volume: 11(4) Pages: 0152746-0152746

    • DOI

      10.1371/journal.pone.0152746

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Damage to the Left Precentral Gyrus Is Associated With Apraxia of Speech in Acute Stroke.2016

    • Author(s)
      Itabashi R, Nishio Y, Kataoka Y, Yazawa Y, Furui E, Matsuda M, Mori E.
    • Journal Title

      Stroke

      Volume: 47 Pages: 31-6

    • DOI

      10.1161/strokeaha.115.010402

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Loss of awareness of hyposmia is associated with mild cognitive impairment in Parkinson's disease.2016

    • Author(s)
      Kawasaki I., Baba T., Takeda A., Mori E.
    • Journal Title

      Parkinsonism Relat Disord.

      Volume: 22 Pages: 74-79

    • DOI

      10.1016/j.parkreldis.2015.11.015

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Clinical characteristics of idiopathic normal pressure hydrocephalus with Lewy body diseases.2015

    • Author(s)
      Odagiri H, Baba T, Nishio Y, Iizuka O, Narita W, Matsuda M, Mori E.
    • Journal Title

      J Neurol Sci

      Volume: 359 Pages: 309-11

    • DOI

      10.1016/j.jns.2015.10.044

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diagnostic Accuracy of 123I-Meta-Iodobenzylguanidine Myocardial Scintigraphy in Dementia with Lewy Bodies: A Multicenter Study.2015

    • Author(s)
      Yoshita M, Arai H, Arai H, Arai T, Asada T, Fujishiro H, Hanyu H, Iizuka O, Iseki E, Kashihara K, Kosaka K, Maruno H, Mizukami K, Mizuno Y, Mori E, Nakajima K, Nakamura H, Nakano S, Nakashima K, Nishio Y, et al.
    • Journal Title

      PLoS ONE

      Volume: 10 Pages: 0-0

    • DOI

      10.1371/journal.pone.0120540

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Long-term donepezil use for dementia with Lewy bodies: results from an open-label extension of phase III trial.2015

    • Author(s)
      Mori E, Ikeda M, Nagai R, Matsuo K, Nakagawa M, Kosaka K.
    • Journal Title

      Alzheimer's Research & Therapy.

      Volume: - Pages: 5-5

    • DOI

      10.1186/s13195-014-0081-2

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Donepezil for dementia with Lewy bodies: a randomized placebo-controlled, confirmatory phase III trial.2015

    • Author(s)
      Ikeda M, Mori E, Matsuo K, Nakagawa M, Kosaka K.
    • Journal Title

      Alzheimer's Research & Therapy.

      Volume: 7 Pages: 4-4

    • DOI

      10.1186/s13195-014-0083-0

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 1.Neural Substrates of Cognitive Subtypes in Parkinson's Disease: A 3-Year Longitudinal Study2014

    • Author(s)
      Shoji Y¸ Nishio Y, Baba T, Uchiyama M, Yokoi K, Ishioka T, Hosokai Y, Hirayama K, Fukuda H, Aoki M, Hasegawa T, Takeda A, Mori E.
    • Journal Title

      PLOS ONE

      Volume: 9(10)

    • DOI

      10.1371/journal.pone.0110547

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 1.MR imaging of subcallosal artery infarct causing amnesia after surgery for anterior communicating artery aneurysm2014

    • Author(s)
      Mugikura S, Kikuchi H, Fujii T, Murata T, Takase K, Mori E, Marinković S, Takahashi S
    • Journal Title

      AJNR Am J Neuroradiol

      Volume: 35 Pages: 2293-2301

    • DOI

      10.3174/ajnr.a4057

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The neural basis of dishonest decisions that serve to harm or help the target2014

    • Author(s)
      Abe N, Fujii T, Ito A, Ueno A, Koseki Y, Hashimoto R, Hayashi A, Mugikura S, Takahashi S, Mori E
    • Journal Title

      Brain Cogn

      Volume: 90 Pages: 41-49

    • DOI

      10.1016/j.bandc.2014.06.005

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Olfactory dysfunction and dementia in Parkinson's disease.2014

    • Author(s)
      Takeda A, Baba T, Kikuchi A, Hasegawa T, Sugeno N, Konno M, Miura E, Mori E.
    • Journal Title

      J Parkinson Dis

      Volume: 4 Pages: 181-187

    • DOI

      10.3233/jpd-130277

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dissociable neural systems for moral judgment of anti- and pro-social lying2014

    • Author(s)
      Hayashi A, Abe N, Fujii T, Ito A, Ueno A, Koseki Y, Mugikura S, Takahashi S, Mori E
    • Journal Title

      Brain Res

      Volume: 1556 Pages: 46-56

    • DOI

      10.1016/j.brainres.2014.02.011

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hallucinators find meaning in noises: Pareidolic illusions in dementia with Lewy bodies.2014

    • Author(s)
      Yokoi K, Nishio Y, Uchiyama M, Shimomura T, Iizuka O, Mori E.
    • Journal Title

      Neuropsychologia

      Volume: 56 Pages: 245-254

    • DOI

      10.1016/j.neuropsychologia.2014.01.017

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Multiple thalamo-cortical disconnections in anterior thalamic infarction: complications for thalamic mechanisms of memory and language.2014

    • Author(s)
      Nishio Y, Hashimoto M, Ishii K, Ito D, Mugikura S, Takahashi S, Mori E
    • Journal Title

      Neuropsychologia

      Volume: 53 Pages: 264-273

    • DOI

      10.1016/j.neuropsychologia.2013.11.025

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A dilated surface appearance on basiparallel anatomic scanning-magnetic resonance imaging is a useful tool for the diagnosis of spontaneous vertebral artery dissection in lateral medullary infarction.2014

    • Author(s)
      Itabashi R, Mori E, Furui E, Sato S, Yazawa Y, Kawata K, Fujiwara S.
    • Journal Title

      J Stroke Cerebrovasc Dis

      Volume: 23 Pages: 805-810

    • DOI

      10.1016/j.jstrokecerebrovasdis.2013.07.003

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Incidence of cardioembolic stroke including paradoxical brain embolism in patients with acute ischemic stroke before and after the Great East Japan Earthquake.2014

    • Author(s)
      Itabashi R, Furui E, Sato S, Yazawa Y, Kawata K, Mori E.
    • Journal Title

      Cerebrovasc Dis

      Volume: 37 Pages: 431-437

    • DOI

      10.1159/000363129

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Voxel-based morphometry of disproportionate cerebrospinal fluid space distribution for the differential diagnosis of idiopathic normal pressure hydrocephalus.2014

    • Author(s)
      Yamashita F, Sasaki M, Saito M, Mori E, Kawaguchi A, Kudo K, Natori T, Uwano I, Ito K, Saito K.
    • Journal Title

      J Neuroimaging

      Volume: 24 Pages: 359-365

    • DOI

      10.1111/jon.12049

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 認知機能変動評価尺度(Cognitive Fluctuation Inventory:CFI)の内容妥当性と評価者間信頼性の検討2014

    • Author(s)
      橋本衛, 眞鍋雄太, 森悦朗, 博野信次, 小阪憲司, 池田学
    • Journal Title

      Brain Nerve

      Volume: 66 Pages: 175-183

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Encoding- and retrieval-related brain activity underlying false recognition2013

    • Author(s)
      Abe N, Fujii T, Suzuki M, Ueno A, Shigemune Y, Mugikura S, Takahashi S. Mori E
    • Journal Title

      Neurosci Res

      Volume: 76(4) Pages: 240-250

    • DOI

      10.1016/j.neures.2013.05.006

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hypometabolism in the supplementary and anterior cingulate cortices is related to dysphagia in Parkinson's disease: a cross-sectional and 3-year longitudinal cohort study2013

    • Author(s)
      Akio Kikuchi, Toru Baba, Takafumi Hasegawa, Michiko Kobayashi, Naoto Sugeno, Masatoshi Konno, Emiko Miura, Yoshiyuki Hosokai, Toshiyuki Ishioka, Yoshiyuki Nishio, Kazumi Hirayama, Kyoko Suzuki, Masashi Aoki, ShokiTakahashi, Hiroshi Fukuda, Yasuto Itoyama, Etsuro Mori, Atsushi Takeda
    • Journal Title

      BMJ Open.

      Volume: 3

    • DOI

      10.1136/bmjopen-2012-002249

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pareidolias : complex visual illusions in dementia with Lewy bodies.2012

    • Author(s)
      Uchiyama M, Nishio y Yokoi K, Hirayama K, Imamura T, Shimomura T, Mori E.
    • Journal Title

      Brain

      Volume: 135 Pages: 2458-269

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Attentional Set-Shifting Deficit in Parkinson's Disease Is Associated with Prefrontal Dysfunction: An FDG-PET Study2012

    • Author(s)
      Yoichi Sawada, Yoshiyuki Nishio, Kyoko Suzuki, Kazumi Hirayama, Atsushi Takeda, Yoshiyuki Hosokai, Toshiyuki Ishioka, Yasuto Itoyama, Shoki Takahashi, Hiroshi Fukuda, Etsuro Mori
    • Journal Title

      PLoS One

      Volume: 7(6)

    • DOI

      10.1371/journal.pone.0038498

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cholinergic deficit and response to donepezil therapy in Parkinson's disease with dementia2012

    • Author(s)
      Hiraoka K, Okamura N, Funaki Y, Hayashi A, Tashiro M, Hisanaga K, Fujii T, Takeda A, Y anai K, Iwata R, Mori E
    • Journal Title

      European Neurology

      Volume: 68 Pages: 137-143

    • DOI

      10.1159/000338774

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] A new manual ROI improves diagnostic accuracy for cardiac2015

    • Author(s)
      H. Odagiri, T. Baba, Y. Nishio, O. Iizuka, M. Matsuda, K. Inoue, M. Iwasaki, Y. Taki, E. Mori
    • Organizer
      19TH INTERNATIONAL CONGRESS OF PARKINSON’S DISEASE AND MOVEMENT DISORDERS
    • Place of Presentation
      SAN DIEGO, CA, USA
    • Year and Date
      2015-06-14
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Cholinesterase inhibitors in Lewy body dementia2014

    • Author(s)
      Etsuro Mori
    • Organizer
      Cold Spring Harbor Conference: Lewy Body Dementia, Current Status, Future Directions
    • Place of Presentation
      Cold Spring Harbor, NY, USA
    • Year and Date
      2014-11-16 – 2014-11-19
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Developing and establishing a brand-new treatment2014

    • Author(s)
      Etsuro Mori
    • Organizer
      12th International Symposium on Thrombolusis and Thronbectomy and Acute Stroke Treatment
    • Place of Presentation
      Mannheim, Germany
    • Year and Date
      2014-10-18 – 2014-10-20
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 認知症の症候学と画像診断2012

    • Author(s)
      森悦朗
    • Organizer
      日本高次脳機能障害学会
    • Place of Presentation
      宇都宮(招待講演)
    • Year and Date
      2012-11-22
    • Related Report
      2012 Annual Research Report
  • [Book] Cognitive Impairments of Dementia with Lewy Bodies. in Kosaka K. ed. Dementia with Lewy Bodies2016

    • Author(s)
      Mori E.
    • Total Pages
      13
    • Publisher
      Springer Japan, Tokyo
    • Related Report
      2016 Annual Research Report
  • [Remarks] 東北大学大学院医学系研究科 高次機能障害学分野リソース

    • URL

      http://www.bncn.med.tohoku.ac.jp/resources/index.html

    • Related Report
      2015 Annual Research Report
  • [Remarks] 東北大学大学院医学系研究科 高次機能障害学分野

    • URL

      http://www.bncn.med.tohoku.ac.jp/

    • Related Report
      2014 Annual Research Report

URL: 

Published: 2012-04-23   Modified: 2019-07-29  

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