Comprehensive analysis of the effect of antipsychotics on DNA methylation in brain
Project/Area Number |
24390279
|
Research Category |
Grant-in-Aid for Scientific Research (B)
|
Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Psychiatric science
|
Research Institution | The University of Tokyo |
Principal Investigator |
IWAMOTO Kazuya 東京大学, 医学部附属病院, 特任准教授 (40342753)
|
Co-Investigator(Renkei-kenkyūsha) |
BUNDO Miki 東京大学, 医学部附属病院, 特任助教 (00597221)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2014: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2013: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2012: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
|
Keywords | エピジェネティクス / 抗精神病薬 / DNAメチル化 / ゲノム / エピゲノム |
Outline of Final Research Achievements |
Epigenetic status such as DNA methylation and histone protein modification is believed to be involved in the pathophyshiology of neuropsychiatric disorders. However, impact of various treatment drugs on epigenetic status remain unclear. In this project, I systematically examined the effect of antipsychotics on DNA methylation using neuroblastoma cell line.
|
Report
(4 results)
Research Products
(26 results)