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Investigation of development of new treatment for refractory depression by modification of glutamate neuropterans mission

Research Project

Project/Area Number 24390280
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Psychiatric science
Research InstitutionTokyo Medical and Dental University

Principal Investigator

Nishikawa Toru  東京医科歯科大学, 医歯(薬)学総合研究科, 教授 (00198441)

Co-Investigator(Renkei-kenkyūsha) KURUMAJI Akeo  東京医科歯科大学, 大学院医歯学総合研究科, 教授 (00251504)
YANAMOTO Naoki  東京医科歯科大学, 医学部附属病院, 講師 (70312296)
JITOKU Daisuke  東京医科歯科大学, 大学院医歯学総合研究科, 助教 (10613854)
UEZATO Akihito  東京医科歯科大学, 大学院医歯学総合研究科, 助教 (90547449)
Takeuchi Takashi  東京医科歯科大学, 医学部附属病院, 講師 (70345289)
KYONO Hoshu  東京医科歯科大学, 医学部附属病院, 助教 (70615658)
Project Period (FY) 2012-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2014: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2012: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Keywordsグルタミン酸伝達 / NMDA受容体 / D-セリン / 難治性抑うつ状態 / NMDA受容体グリシン調節部位 / 内側前頭葉皮質 / キラルアミノ酸分析 / In vivo ダイアリシス / アミノ酸分析 / In vivoダイアリシス / ドーパミン代謝 / 行動変化
Outline of Final Research Achievements

On the basis of NMDA receptor blocking action of ketamine that has been reported to show fast-ameliorating effects on refractory depression, the molecular and cellular mechanisms underlying signaling of a NMDA receptor co-agonist, D-serine, have been investigated to obtain a clue for a novel antidepressant. It is indicated that D-serine synthesizing enzyme, serine racemase, Dsm-1 protein which modifies the tissue and extracellular contents of D-serine and zinc ion may modify the extracellular concentrations of D-serine and/or glutamate that acts on the NMDA receptor. Therefore, the three or related molecules could be candidate targets for development of a novel antidepressant that possesses an inhibitory influence on the NMDA receptor. An open-labeled clinical trial of ifenprodil, a NMDA receptor subunit antagonist (GRIN2B), has been initiated.

Report

(5 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (157 results)

All 2016 2015 2014 2013 2012 Other

All Int'l Joint Research (1 results) Journal Article (47 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 34 results,  Open Access: 4 results,  Acknowledgement Compliant: 3 results) Presentation (106 results) (of which Int'l Joint Research: 2 results,  Invited: 23 results) Book (2 results) Remarks (1 results)

  • [Int'l Joint Research] Harvard Medical School(米国)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Slow sleep spindle and procedural memory consolidation in patients with major depressive disorder2016

    • Author(s)
      Nishida M, Nakashima Y, Nishikawa T
    • Journal Title

      Nature and Science of Sleep

      Volume: 8 Pages: 63-72

    • DOI

      10.2147/nss.s100337

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of cerebral blood flow in oral somatic delusion in patients with and without a history of depression: a comparative case series.2015

    • Author(s)
      Watanabe M, Umezaki Y, Miura A, Shinohara Y, Yoshikawa T, Sakuma T, Shitano C, Katagiri A, Takenoshita M, Toriihara A, Uezato A, Nishikawa T, Motomura H, Toyofuku A.
    • Journal Title

      BMC Psychiatry.

      Volume: 15 Issue: 1 Pages: 15-42

    • DOI

      10.1186/s12888-015-0422-0

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Neuronal serine racemase regulates extracellular D-serine levels in the adult mouse hippocampus2015

    • Author(s)
      Ishiwata S, Umino A, Balu D, Coyle JT, Nishikawa T
    • Journal Title

      J Neural Transm

      Volume: 122 Issue: 8 Pages: 1099-1103

    • DOI

      10.1007/s00702-015-1388-2

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Reduced cortical expression of a newly identified splicing variant of the DLG1 gene in patients with early-onset schizophrenia.2015

    • Author(s)
      Uezato A, Yamamoto N, Iwayama Y, Hiraoka S, Hiraaki E, Umino A, Haramo E, Umino M, Yoshikawa T, Nishikawa T
    • Journal Title

      Translational Psychiatry

      Volume: 5 Issue: 10 Pages: e654-e654

    • DOI

      10.1038/tp.2015.154

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Decrease in the Volume of Gray Matter as a Risk Factor for Postoperative Delirium Revealed by an Atlas-based Method.2015

    • Author(s)
      Shioiri, A.; Kurumaji, A.;Takeuchi, T.;Nemoto, K.;Arai, H.;Nishikawa, T.
    • Journal Title

      Am J Geriatr Psychiatry

      Volume: - Issue: 7 Pages: 528-536

    • DOI

      10.1016/j.jagp.2015.09.002

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Altered sleep spindle in delayed encephalopathy after acute carbon monoxide poisoning2015

    • Author(s)
      Yoshiike T, Nishida M, Yagishita K, Nariai T, Ishii K, Nishikawa T
    • Journal Title

      Journal of Clinical Sleep Medicine

      Volume: 印刷中

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reduced cortical expression of a newly identified splicing variant of the DLG1 gene in patients with early-onset schizophrenia.2015

    • Author(s)
      Uezato A, Yamamoto N, Iwayama Y, Hiraoka S, Hiraaki E, Umino A, Haramo E, Umino M, Yoshikawa T, Nishikawa T.
    • Journal Title

      Transl Psychiatry

      Volume: 5 Issue: 1 Pages: 130-130

    • DOI

      10.1186/s12888-016-0835-4

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 統合失調症のグルタミン酸仮説と診断の可能性.【特集】精神科治療学創刊30 周年記念特集①―精神科医療技術の将来―2015

    • Author(s)
      上里彰仁, 山本直樹, 西川 徹
    • Journal Title

      精神科治療学

      Volume: 30 Pages: 11-17

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 「女性に多い精神疾患の診断と治療」【女性ヘルスケア集中講義!-次世代の女性医学の可能性を求めて-】 こんなときどうする? 他科との境界領域の患者さんがやってきた2015

    • Author(s)
      甫母瑞枝, 西川徹
    • Journal Title

      産婦人科の実際

      Volume: 64 Pages: 1456-1465

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 炭酸リチウムの投与回数の変更によって夜間せん妄が惹起された高齢者双極性感情障害の1 例2015

    • Author(s)
      田村赳紘, 光定博生, 治徳大介, 阿部又一郎, 車地曉生, 西川徹.
    • Journal Title

      臨床精神医学

      Volume: 44 Pages: 1217-1223

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association study of H2AFZ with schizophrenia in a Japanese case-control sample.2015

    • Author(s)
      Jitoku D, Yamamoto N, Iwayama Y, Toyota T, Miyagi M, Enokida T, Tasaka T, Umino M, Umino A, Uezato A, Iwata Y, Suzuki K, Kikuchi M, Hashimoto T, Kanahara N, Kurumaji A, Yoshikawa T, Nishikawa T.
    • Journal Title

      J Neural Transm

      Volume: 印刷中

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association study of H2AFZ with schizophrenia in a Japanese case-control sample.2014

    • Author(s)
      Jitoku D, Yamamoto N, Iwayama Y, Toyota T, Miyagi M, Enokida T, Tasaka Y, Umino M, Umino A, Uezato A, Iwata Y, Suzuki K, Kikuchi M, Hashimoto T, Kanahara N, Kurumaji A, Yoshikawa T, Nishikawa T.
    • Journal Title

      Journal of Neural Transmission

      Volume: 11 Issue: 6 Pages: 1-9

    • DOI

      10.1007/s00702-014-1332-x

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Identification of a developmentally-regulated and psychostimulant-inducible novel rat gene mrt3 in the neocortex.2014

    • Author(s)
      Yamamoto N, Muraoka S, Kajii Y, Umino A, Nishikawa T. Identification of a developmentally-regulated and psychostimulant-inducible novel rat gene mrt3 in the neocortex
    • Journal Title

      Eur Neuropsychopharmacol.

      Volume: 24 Issue: 10 Pages: 1687-1697

    • DOI

      10.1016/j.euroneuro.2014.07.010

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Comparison of Pharmacotherapy of Inpatients with Major Depressive Disorders between Single Episode and Recurrent One.2014

    • Author(s)
      Kurumaji A, Narushima K, Takeda M, Jitoku D, Kyono H, Hobo M, Mitsusada H, Nishida M, Atsuta H, Tamai S, Takagi S, Fujita M, Kawamata K, Okuzumi S, Hino K, Tsutsui K, Nishikawa T
    • Journal Title

      Clinical Neuropsychophramacology and Therapeutics

      Volume: 3 Pages: 5-10

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of Developmentally Regulated PCP-Responsive Non-Coding RNA, prt6, in the Rat Thalamus.2014

    • Author(s)
      Takebayashi H, Yamamoto N, Umino A, Nishikawa T
    • Journal Title

      PLoS One

      Volume: 9 Issue: 6 Pages: e97955-e97955

    • DOI

      10.1371/journal.pone.0097955

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Topographical distribution of fast and slow sleep spindles in medicated depressive patients.2014

    • Author(s)
      Nishida M, Nakashima Y, Nishikawa T
    • Journal Title

      J Clin Neurophysiol

      Volume: 31 Issue: 5 Pages: 402-408

    • DOI

      10.1097/wnp.0000000000000068

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical course of the bipolar II disorder in a Japanese sample.2014

    • Author(s)
      Kurumaji A, Narushima K, Ooshima K, Yukizane T, Takeda M, Nishikawa T
    • Journal Title

      J Affective Disorders

      Volume: 168 Pages: 363-366

    • DOI

      10.1016/j.jad.2014.07.023

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oral Dysesthesia Rating Scale: a tool for assessing psychosomatic symptoms in oral regions2014

    • Author(s)
      17.Uezato A, Toyofuku A, Umezaki Y, Watanabe M, Toriihara A, Tomita M, Yamamoto Na, Kurumaji A, Nishikawa T
    • Journal Title

      BMC Psychiatry

      Volume: 14 Issue: 1 Pages: 1696-1696

    • DOI

      10.1186/s12888-014-0359-8

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Predictive factors for comorbid psychiatric disorders and their impact on vision-related quality of life in patients with high myopia2014

    • Author(s)
      Yokoi T, Moriyama M, Hayashi K, Shimada N, Tomita M, Yamamoto N, Nishikawa T, Ohno-Matsui K
    • Journal Title

      Int Ophthalmol

      Volume: 34 Issue: 2 Pages: 171-183

    • DOI

      10.1007/s10792-013-9805-8

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] グルタミン酸伝達を支える脳のビタミンB 関連D-セリン代謝 ―生理と病態―2014

    • Author(s)
      西川 徹
    • Journal Title

      ビタミン

      Volume: 88 Pages: 508-514

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 哺乳類脳内における細胞外液中D-セリンの調節メカニズムと統合失調症2014

    • Author(s)
      石渡 小百合、西川 徹
    • Journal Title

      Journal of the Society of Japanese Women Scientists

      Volume: 14 Pages: 10-15

    • NAID

      130003397220

    • Related Report
      2014 Annual Research Report
  • [Journal Article] グルタミン酸仮説における治療抵抗性と今後の展望2014

    • Author(s)
      上里彰仁、山本直樹、西川 徹
    • Journal Title

      臨床精神薬理

      Volume: 17 Pages: 1625-1630

    • Related Report
      2014 Annual Research Report
  • [Journal Article] D-セリンと統合失調症2014

    • Author(s)
      西川 徹
    • Journal Title

      アミノ酸研究

      Volume: 8 Pages: 218-228

    • NAID

      130005395506

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ketamine : Rapid acting antidepressant actions- basic and clinical puzzles2014

    • Author(s)
      西川 徹
    • Journal Title

      日本生物学的精神医学会誌

      Volume: 25 Pages: 131-134

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 統合失調症のグルタミン酸仮説と診断の可能性2014

    • Author(s)
      上里彰仁、山本直樹、西川 徹
    • Journal Title

      精神科治療学

      Volume: 30 Pages: 11-17

    • Related Report
      2014 Annual Research Report
  • [Journal Article] パーキンソン病治療経過中に発症した幻覚妄想状態に対してdonepezilが著効した1症例2014

    • Author(s)
      治徳大介、佐藤友紀、西川徹、車地暁生
    • Journal Title

      精神科

      Volume: 25 Pages: 363-368

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 精神疾患のゲノム解析2014

    • Author(s)
      治徳大介、西川徹、吉川武男
    • Journal Title

      Medical Science Digest

      Volume: 40 Pages: 232-235

    • Related Report
      2014 Annual Research Report
  • [Journal Article] D-セリンと統合失調症2013

    • Author(s)
      石渡 小百合、西川 徹
    • Journal Title

      日本生物学的精神医学会誌

      Volume: Vol. 24, No. 3 Pages: 135-144

    • NAID

      130005395506

    • Related Report
      2013 Annual Research Report
  • [Journal Article] 精神疾患とグルタミン酸神経伝達:臨床的観点から2013

    • Author(s)
      石渡 小百合、西川 徹
    • Journal Title

      脳21

      Volume: Vol. 16, No. 3 Pages: 64-69

    • Related Report
      2013 Annual Research Report
  • [Journal Article] NMDAレセプターと統合失調症2013

    • Author(s)
      西川 徹, 石渡小百合
    • Journal Title

      日本神経精神薬理学雑誌

      Volume: 33 Pages: 217-224

    • Related Report
      2013 Annual Research Report
  • [Journal Article] 統合失調症の分子病態2013

    • Author(s)
      上里彰仁, 西川徹
    • Journal Title

      日本臨牀

      Volume: Vol.71, No. 4 Pages: 591-598

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Increasing effects of S-methyl-L-cysteine on the extracellular D-serine concentrations in the rat medial frontal cortex.2013

    • Author(s)
      Ishiwata S, Ogata S, Umino A, Shiraku H, Ohashi y Kaji Y, Nishikawa T.
    • Journal Title

      Amino Acids.

      Volume: 44 (5) Issue: 5 Pages: 1391-5

    • DOI

      10.1007/s00726-013-1464-6

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Modulation of extracellular d-serine content by calcium permeable AMPA receptors in rat medial prefrontal cortex as revealed by in vivo microdialysis.2013

    • Author(s)
      Ishiwata S, Umino A, Umino M, Yorita K, Fukui K, Nishikawa T.
    • Journal Title

      Int J Neuropsychopharmacol

      Volume: VOL. 16, NO. 6 Issue: 6 Pages: 1395-406

    • DOI

      10.1017/s1461145712001484

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Brain perfusion asymmetry in patients with oral somatic delusions2013

    • Author(s)
      Umezaki Y, Katagiri A, Watanabe M, Takenoshita M, Sakuma T, Sako E, Sato Y, Toriihara A, Uezato A, Shibuya H, Nishikawa T, Motomura H, Toyofuku A
    • Journal Title

      Eur Arch Psychiatry Clin Neurosci

      Volume: VOL. 263, NO. 4 Issue: 4 Pages: 315-23

    • DOI

      10.1007/s00406-013-0390-7

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Experiential auditory hallucinations due to chronic epileptic discharges after radiotherapy for oligoastrocytoma.2013

    • Author(s)
      Sasaki T, Kodaka F, Taniguchi G, Nishikawa T, Watanabe M
    • Journal Title

      Epileptic Disorder

      Volume: 15(2) Issue: 2 Pages: 188-192

    • DOI

      10.1684/epd.2013.0574

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Brain perfusion asymmetries in patients with oral somatic delusions.2013

    • Author(s)
      Umezaki Y, Katagiri A, Watanabe M, Takenoshita M, Sakuma T, Sako E, Sato Y, Toriihara A, Uezato A, Shibuya H, Nishikawa T, Motomura H, Toyofuku A.
    • Journal Title

      European Archives of Psychiatry and Clinical Neuroscience.

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Improvement of asymmetrical temporal blood flow in refractory oral somatic delusion after successful electroconvulsive therapy.2012

    • Author(s)
      Uezato A, Yamamoto N, Kurumaji A, Toriihara A, Umezaki Y, Toyofuku A, Nishikawa T.
    • Journal Title

      J ECT.

      Volume: 28 Pages: 50-51

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Further evidence for a male-selective genetic association of synapse-associated protein 97 (SAP97) gene with schizophrenia2012

    • Author(s)
      Uezato A, Kimura-Sato J, Yamamoto N, Iijima Y, Kunugi H, Nishikawa T
    • Journal Title

      Behavioral and Brain Functions

      Volume: 8 Issue: 1 Pages: 2-2

    • DOI

      10.1186/1744-9081-8-2

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Quantification of Dopamine Transporter in Human Brain Using Positron Emission Tomography with 18F-FE-PE2I.2012

    • Author(s)
      Sasaki T, Ito H, Kimura H, Arakawa R, Takano H, Seki C, Kodaka F, Fujie S, Takahata K, Nogami T, Suzuki M, Fujiwara H, Takahashi H, Nakao R, Fukumura T, Varrone A, Halldin C, Nishikawa T, Suhara T.
    • Journal Title

      J Nuc Med.

      Volume: 53 Issue: 7 Pages: 1065-1073

    • DOI

      10.2967/jnumed.111.101626

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sorting nexin 27 interacts with multidrug resistance-associated protein 4(MRP4) and mediates internalization of MRP42012

    • Author(s)
      Hayashi H, Naoi S, Nakagawa T, Nishikawa T, Fukuda H, Imajoh-OhmiS, Kondo A, Kubo K, Yabuki T, HattoriA, Hirouchi M, Sugiyama Y
    • Journal Title

      The Journal of Biological Chemistry

      Volume: 287 Issue: 18 Pages: 15054-65

    • DOI

      10.1074/jbc.m111.337931

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Modulation of extracellular d-serine content by calcium permeable AMPA receptors in rat medial prefrontal cortex as revealed by in vivo microdialysis.2012

    • Author(s)
      Ishiwata S, Umino A, Umino M, Yorita K, Fukui K, Nishikawa T.
    • Journal Title

      Int J Neuropsychopharmacol.

      Pages: 1-12

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An anxiogenic drug, fg 7142, induced an increase in mrna of btg2 and adamtsl in the hippocampus of adult mice.2012

    • Author(s)
      Kurumaji A, Nishikawa T.
    • Journal Title

      Behav Brain Funct.

      Volume: 8 Issue: 1 Pages: 43-43

    • DOI

      10.1186/1744-9081-8-43

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Donepezil-induced sleep spindle in a patient with dementia with Lewy bodies.2012

    • Author(s)
      Ozaki A, Nishida M, Koyama K, Ishikawa K, Nishikawa T.
    • Journal Title

      Psychogeriatrics.

      Volume: 2 Pages: 255-8

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] パーキンソン病の幻覚・妄想状態にaripiprazoleが著効した一症例2012

    • Author(s)
      武田充弘, 川俣光太郎, 石橋哲, 西川徹, 車地暁生
    • Journal Title

      精神科

      Volume: 20 Pages: 343-349

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 統合失調症のDA仮説2012

    • Author(s)
      山本直樹, 西川徹
    • Journal Title

      Progress in Medicine

      Volume: 32

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 東日本大震災後一ヵ月半経過時における石巻市こころのケアチームに参加して2012

    • Author(s)
      治徳大介, 金子慈史, 西川徹
    • Journal Title

      外来精神医療

      Volume: 12 (1) Pages: 17-20

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 1.統合失調症の分子病態, II.統合失調症の基礎

    • Author(s)
      上里彰仁, 西川徹
    • Journal Title

      特集「統合失調症-病態解明と治療最前線-」

      Volume: (印刷中)

    • Related Report
      2012 Annual Research Report
  • [Presentation] Calcium-Permeable AMPA Receptor and Asc-1 Transporter Regulate the Cortical Extracellular D-Serine Concentration:Potential Targets for Development of Novel Pharmacotherapy for NMDA Receptor Dysfunction in Schizophrenia2015

    • Author(s)
      Nishikawa T
    • Organizer
      ACNP 54th Annual Meeting
    • Place of Presentation
      Florida
    • Year and Date
      2015-12-09
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 哺乳動物の脳における細胞外 D-セリン濃度調節の分子細胞メカニズム:統合失調症の病態における障害の可能性2015

    • Author(s)
      西川徹
    • Organizer
      第38回日本分子生物学会年会第88回日本生化学会大会合同年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-12-03
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 薬剤性非心原性肺水腫を発症後に KL-6 高値が持続した高齢うつ病の一例2015

    • Author(s)
      田村赳紘 , 光定博生 , 阿部又一郎 , 治徳大介 , 車地曉生 , 西川徹
    • Organizer
      第 28 回日本総合病院精神医学会総会
    • Place of Presentation
      徳島
    • Year and Date
      2015-11-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] 統合失調症発症のメカニズム2015

    • Author(s)
      西川徹
    • Organizer
      第 25 回日本臨床精神神経薬理学会
    • Place of Presentation
      東京
    • Year and Date
      2015-10-29
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] グルタミン酸受容体機能制御による統合失調症の新規治療法の検討2015

    • Author(s)
      西川徹
    • Organizer
      第 17 回感情・行動・認知(ABC) 研究会
    • Place of Presentation
      大阪
    • Year and Date
      2015-10-24
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 喪失の重荷と診断基準化の臨床的意義―双極性うつ病患者の入院事例からの一考察2015

    • Author(s)
      阿部又一郎 , 道垣内美保 , 斎藤美由紀 , 光定博生 , 車地曉生 , 西川徹
    • Organizer
      第 22 回日本多文化間精神医学会
    • Place of Presentation
      東京
    • Year and Date
      2015-10-04
    • Related Report
      2015 Annual Research Report
  • [Presentation] 統合失調症の primary cilia 病態の解析2015

    • Author(s)
      塩飽裕紀、西川徹
    • Organizer
      第 45 回日本神経精神薬理学会第 37 回日本生物学的精神医学会 合同年会
    • Place of Presentation
      東京
    • Year and Date
      2015-09-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] Phencyclidine に発達依存的応答を示す遺伝子 PRT7 と統合失調症との関連解析2015

    • Author(s)
      山本直樹 , 本間斐 , 治徳大介 , 海野麻未 , 岩山佳美 , 吉川武男 , 西川徹
    • Organizer
      第 45 回日本神経精神薬理学会第 37 回日本生物学的精神医学会合同年会
    • Place of Presentation
      東京
    • Year and Date
      2015-09-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] 亜鉛の内側前頭皮質細胞外液中 D-セリンおよび D-セリン関連アミノ酸への影響2015

    • Author(s)
      石渡小百合、西川徹、海野麻未
    • Organizer
      第 45 回日本神経精神薬理学会第 37 回日本生物学的精神医学会 合同年会
    • Place of Presentation
      東京
    • Year and Date
      2015-09-25
    • Related Report
      2015 Annual Research Report
  • [Presentation] ラット大脳新皮質におけるトポイソメラーゼ遺伝子群の発達による変化と薬理学的統合失調症動物モデルが成立する発達段階の関係2015

    • Author(s)
      海野真一 , 海野麻未 , 西川徹
    • Organizer
      第 45 回日本神経精神薬理学会第 37 回日本生物学的精神医学会 合同年会 2015.09.25
    • Place of Presentation
      東京
    • Year and Date
      2015-09-25
    • Related Report
      2015 Annual Research Report
  • [Presentation] 亜鉛の内側前頭皮質細胞外液中 D-セリンおよび D-セリン関連アミノ酸への影響2015

    • Author(s)
      石渡小百合 , 海野麻未 , 西川徹
    • Organizer
      第 45 回日本神経精神薬理学会· 第 37 回日本生物学的精神医学会合同年会
    • Place of Presentation
      東京
    • Year and Date
      2015-09-25
    • Related Report
      2015 Annual Research Report
  • [Presentation] 術後せん妄危険因子としての脳体積減少に関する Atlas-based 法を用いた研究2015

    • Author(s)
      車地曉生 , 塩入明子 , 竹内崇 , 荒井裕国 , 西川徹 , 根本清貴
    • Organizer
      第 45 回日本神経精神薬理学会第 37 回日本生物学的精神医学会
    • Place of Presentation
      東京
    • Year and Date
      2015-09-25
    • Related Report
      2015 Annual Research Report
  • [Presentation] 統合失調症の分子科学的理解を目指して2015

    • Author(s)
      西川徹
    • Organizer
      第 45 回日本神経精神薬理学会第 37 回日本生物学的精神医学会 合同年会
    • Place of Presentation
      東京
    • Year and Date
      2015-09-24
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 統合失調症に対する D-cycloserine 二重盲検試験の概要と症例報告2015

    • Author(s)
      上里彰仁、西川徹
    • Organizer
      第 11 回 D-アミノ酸学会学術講演会 2015.08.25 新潟
    • Place of Presentation
      新潟
    • Year and Date
      2015-08-25
    • Related Report
      2015 Annual Research Report
  • [Presentation] Psychotomimetic-responsive non-coding RNAs and schizophrenia. Symposium: MicroRNA and epigenetic changing in CNS2015

    • Author(s)
      Nishikawa T
    • Organizer
      第 38 回日本神経科学大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-07-30
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 東京医科歯科大学における双極性障害集団心理教育プログラムの現状2015

    • Author(s)
      治徳大介 , 染谷あやの , 松岡裕美 , 板坂典郎 , 日野恒平 , 光定博生 , 阿部又一郎 , 竹内崇 , 山本直樹 , 車地暁生 , 西川徹
    • Organizer
      第 12 回日本うつ病学会· 第15 回日本認知療法学会合同総会
    • Place of Presentation
      東京
    • Year and Date
      2015-07-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] レビー小体型認知症のジセステジアに対してタンドスピロンが著効した一症例2015

    • Author(s)
      半田剛久 , 治徳大介 , 光定博生 , 阿部又一郎 , 竹内崇 , 山本直樹 , 車地暁生 , 西川徹
    • Organizer
      第 111 回日本精神神経学会学術総会
    • Place of Presentation
      大阪
    • Year and Date
      2015-06-06
    • Related Report
      2015 Annual Research Report
  • [Presentation] Assessing patients with psychosomatic oral dysesthesia (oral cenesthopathy) by Oral DRS2015

    • Author(s)
      Uezato A, Toyofuku A, Yamamoto N, Kurumaji A, Nishikawa T
    • Organizer
      WPA Rregional Congress Osaka Japan 2015
    • Place of Presentation
      Osaka
    • Year and Date
      2015-06-05
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 悪性緊張病を合併した特発性肺動脈性肺高血圧へ安全に ECT が施行できた一例2015

    • Author(s)
      甫母瑞枝, 上里彰仁, 光定博生, 治徳大介, 日野恒平, 竹内崇, 山本直樹, 車地暁生, 阿部又一郎, 西川徹
    • Organizer
      第 111 回日本精神神経学会学術総会
    • Place of Presentation
      大阪
    • Year and Date
      2015-06-04
    • Related Report
      2015 Annual Research Report
  • [Presentation] 東京医科歯科大学医学部附属病院における精神科リエゾンチームの現状2015

    • Author(s)
      武藤仁志、野崎優衣、佐々木芽里、竹内崇、松岡裕美、土肥美沙、西川徹
    • Organizer
      第 111 回日本精神神経学会学術総会
    • Place of Presentation
      大阪
    • Year and Date
      2015-06-04
    • Related Report
      2015 Annual Research Report
  • [Presentation] 東京医科歯科大学における躁・うつ再発予防外来の現状2015

    • Author(s)
      治徳大介 , 染谷あやの , 松岡裕美 , 板坂典郎 , 日野恒平 , 光定博生 , 阿部又一郎 , 竹内崇 , 山本直樹 , 車地暁生 , 西川徹
    • Organizer
      第 111 回日本精神神経学会学術総会
    • Place of Presentation
      大阪
    • Year and Date
      2015-06-04
    • Related Report
      2015 Annual Research Report
  • [Presentation] 拡散テンソル画像解析による統合失調症の上小脳脚白質線維異常と症状との関係2015

    • Author(s)
      板坂典郎、車地暁生、上里彰仁、治徳大介、甫母瑞枝、光定博生、竹内崇、 山本直樹、西川徹
    • Organizer
      第10回統合失調症学会
    • Place of Presentation
      麹町、東京
    • Year and Date
      2015-03-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] 薬理ゲノムからみた統合失調症病態ー包括的理解を目指してー2015

    • Author(s)
      西川徹
    • Organizer
      第10回統合失調症学会
    • Place of Presentation
      麹町、東京
    • Year and Date
      2015-03-27
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 統合失調症の分子病態を探るー神経発達の視点からー2015

    • Author(s)
      西川徹
    • Organizer
      第11回統合失調症研究会
    • Place of Presentation
      品川、東京
    • Year and Date
      2015-02-14
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 統合失調症のシナプス―グリア系障害の治療法開発を目指して2015

    • Author(s)
      西川徹、福井清、田中光一、有馬邦正、大森哲郎、岡崎光俊
    • Organizer
      第6回公開シンポジウム 脳とこころの病気の克服をめざして~脳科学からのアプローチ~
    • Place of Presentation
      大手町、東京
    • Year and Date
      2015-01-29
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Dysregulation of the NMDA type glutamate receptor and schizophrenia.2014

    • Author(s)
      Nishikawa T
    • Organizer
      Medical Research Institute 40th Anniversary 13th Surugadai International Symposium
    • Place of Presentation
      お茶の水、東京
    • Year and Date
      2014-11-28
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 脳科学から見た統合失調症研究の最先端2014

    • Author(s)
      西川徹、福井清、田中光一、有馬邦正、大森哲郎、岡崎光俊
    • Organizer
      第24回地域精神保健講座
    • Place of Presentation
      錦糸町、東京
    • Year and Date
      2014-11-14
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 双極Ⅱ型障害入院患者の臨床経過に関する研究2014

    • Author(s)
      車地暁生、成島健二、大島一成、行実知昭、武田充弘、西川徹
    • Organizer
      第34回日本精神科診断学会
    • Place of Presentation
      松山、愛媛県
    • Year and Date
      2014-11-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] 女性と精神疾患2014

    • Author(s)
      西川徹
    • Organizer
      第29回日本女性医学学会学術集会
    • Place of Presentation
      麹町、東京
    • Year and Date
      2014-11-01
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Neural mechanisms underlying psychiatric symptoms of dementia with Lewy bodies and Parkinson’s disease: Implications for rational pharmacotherapy.2014

    • Author(s)
      Nishikawa T
    • Organizer
      14th International College of Geriatric Psychoneuropharmacology (ICGP) & 19th Japan Congress of Neuropsychiatry, Joint Congress
    • Place of Presentation
      筑波、茨城県
    • Year and Date
      2014-10-03
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 統合失調症関連遺伝子とクロマチン制御2014

    • Author(s)
      山本直樹、西川徹
    • Organizer
      第36回日本生物学的精神医学会・第57回日本神経化学会大会 合同年会
    • Place of Presentation
      奈良市、奈良県
    • Year and Date
      2014-10-01
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 前脳部CaMKⅡ発現ニューロン特異的dsm-1欠損マウスの脳内アミノ酸濃度2014

    • Author(s)
      石渡小百合、海野麻未、西川徹
    • Organizer
      第36回日本生物学的精神医学会・第57回日本神経化学会大会 合同年会
    • Place of Presentation
      奈良市、奈良県
    • Year and Date
      2014-10-01
    • Related Report
      2014 Annual Research Report
  • [Presentation] ラット脳における統合失調症様症状発現薬投与後遺伝子発現パターンの発達による変化とその分子機序2014

    • Author(s)
      海野真一、山本直樹、荒木誠、竹林裕直、海野麻未、上里彰仁、車地暁生、西川徹
    • Organizer
      第36回日本生物学的精神医学会・第57回日本神経化学会大会 合同年会
    • Place of Presentation
      奈良市、奈良県
    • Year and Date
      2014-10-01
    • Related Report
      2014 Annual Research Report
  • [Presentation] Splicing制御因子SRSF1遺伝子と統合失調症の関連解析2014

    • Author(s)
      野中美佐、山本直樹、治徳大介、岩山佳美、吉川武男、西川徹
    • Organizer
      第36回日本生物学的精神医学会・第57回日本神経化学会大会 合同年会
    • Place of Presentation
      奈良市、奈良県
    • Year and Date
      2014-10-01
    • Related Report
      2014 Annual Research Report
  • [Presentation] H2AFZ遺伝子と統合失調症との遺伝子関連研究2014

    • Author(s)
      治徳大介、山本直樹、岩山佳美、上里彰仁、吉川武男、車地暁生、西川徹
    • Organizer
      第36回日本生物学的精神医学会・第57回日本神経化学会大会 合同年会
    • Place of Presentation
      奈良市、奈良県
    • Year and Date
      2014-09-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] HSPA1B遺伝子と統合失調症の関連解析2014

    • Author(s)
      白石知也、山本直樹、治徳大介、岩山佳美、吉川武男、西川徹
    • Organizer
      第36回日本生物学的精神医学会・第57回日本神経化学会大会 合同年会
    • Place of Presentation
      奈良市、奈良県
    • Year and Date
      2014-09-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] 統合失調症における拡散異方性度と平均拡散能を指標とした拡散テンソル画像解析2014

    • Author(s)
      板坂典郎、車地暁生、上里彰仁、治徳大介、甫母瑞枝、光定博生、竹内 崇、山本 直樹、西川 徹
    • Organizer
      第36回日本生物学的精神医学会・第57回日本神経化学会大会 合同年会
    • Place of Presentation
      奈良市、奈良県
    • Year and Date
      2014-09-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] パーキンソン病治療経過中に発症した幻覚妄想状態に対してdonepezilが著効した一症例2014

    • Author(s)
      治徳大介、佐藤友紀、山本直樹、車地暁生、西川徹
    • Organizer
      第36回日本生物学的精神医学会・第57回日本神経化学会大会 合同年会
    • Place of Presentation
      奈良市、奈良県
    • Year and Date
      2014-09-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] 統合失調症様症状発現薬に発達依存的に発言応答を示す細胞間基質遺伝子と統合失調症との関連解析2014

    • Author(s)
      小野恵子、山本直樹、治徳大介、岩山佳美、吉川武男、西川徹
    • Organizer
      第36回日本生物学的精神医学会・第57回日本神経化学会大会 合同年会
    • Place of Presentation
      奈良市、奈良県
    • Year and Date
      2014-09-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] 統合失調症様症状発現薬に発達依存的応答を示す遺伝子WDR3およびALG1と統合失調症との関連解析2014

    • Author(s)
      小林桃子、山本 直樹、治徳 大介、岩山 佳美、吉川 武男、西川 徹
    • Organizer
      第36回日本生物学的精神医学会・第57回日本神経化学会大会 合同年会
    • Place of Presentation
      奈良市、奈良県
    • Year and Date
      2014-09-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] Possible implication of disturbed brain D-serine signaling in the pathophysiology of schizophrenia.2014

    • Author(s)
      Nishikawa T.
    • Organizer
      The 2nd International Conference of D-Amino Acid Research
    • Place of Presentation
      Utsunomiya, Tochigi
    • Year and Date
      2014-09-04
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Glutamatergic and gabaergic regulation of the extracellular D-serine concentrations in the medial frontal cortex.2014

    • Author(s)
      Ishiwata S, Umino A, Iwama H, Nishikawa T
    • Organizer
      The 2nd International Conference of D-Amino Acid Research
    • Place of Presentation
      Utsunomiya, Tochigi
    • Year and Date
      2014-09-04
    • Related Report
      2014 Annual Research Report
  • [Presentation] Neuronal regulation of tissue and extracellular D-serine concentrations in the rat brain.2014

    • Author(s)
      Umino A, Iwama H, Ishiwata S, Itasaka M, Nishikawa T
    • Organizer
      The 2nd International Conference of D-Amino Acid Research
    • Place of Presentation
      Utsunomiya, Tochigi
    • Year and Date
      2014-09-03
    • Related Report
      2014 Annual Research Report
  • [Presentation] Genetic association and postmortem analyses of papst1, a D-serine modulator in schizophrenia and bipolar disorder2014

    • Author(s)
      Uezato A, Shimazu D, Jitoku D, Iwayama Y, Toyota T, Yamada K, Yoshikawa T, Yamamoto N, Nishikawa T
    • Organizer
      The 2nd International Conference of D-Amino Acid Research
    • Place of Presentation
      Utsunomiya, Tochigi
    • Year and Date
      2014-09-03
    • Related Report
      2014 Annual Research Report
  • [Presentation] 都市部における自殺関連行動患者の実態2014

    • Author(s)
      竹内崇、京野穂集、武田充弘、治徳大介、上里彰仁、甫母瑞枝、光定博生、日野恒平、寺澤佑哉、冨岡悠、山本直樹、車地暁生、西川徹
    • Organizer
      第110回日本精神神経学会学術総会
    • Place of Presentation
      横浜市、神奈川県
    • Year and Date
      2014-06-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Postnatal development of patterns of basal and schizophrenomimetic phencyclidine-induced gene expression in the rat neocortex2014

    • Author(s)
      Umino M, Umino A, Yamamoto N, Nishikawa T
    • Organizer
      29th CINP world congress of neuropsychopharmacology
    • Place of Presentation
      Vancouver, Canada
    • Year and Date
      2014-06-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] Identification of developmentally regulated NMDA receptor antagonist phencyclidine-responsive transcripts in the rat brain.2014

    • Author(s)
      Yamamoto N, Takebayashi H, Umino A, Nishikawa T
    • Organizer
      29th CINP world congress of neuropsychopharmacology
    • Place of Presentation
      Vancouver, Canada
    • Year and Date
      2014-06-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] Changes in extracellular contents of D-serine and D-serine-NMDA receptor-associated amino acids by selective suppression of serine racemase expression in forebrain glutamatergic neurons.2014

    • Author(s)
      Ishiwata S, Umino A, Balu D, Coyle J.T, Nishikawa T
    • Organizer
      29th CINP world congress of neuropsychopharmacology
    • Place of Presentation
      Vancouver, Canada
    • Year and Date
      2014-06-23 – 2014-06-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] Neuron-glia regulation of D-serine signaling : Implication in schizophrenia.2014

    • Author(s)
      Nishikawa T.
    • Organizer
      Symposium “Neuron-glia interaction in schizophrenia: Focus on D-serine” 29th CINP world congress of neuropsychopharmacology
    • Place of Presentation
      Vancouver, Canada
    • Year and Date
      2014-06-23
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Association study of H2AFZ with schizophrenia in a Japanese case-control sample.2014

    • Author(s)
      Jitoku D, Yamamoto N, Iwayama Y, Umino M, Umino A, Uezato A, Kurumaji A, Yoshikawa T, Nishikawa T
    • Organizer
      29th CINP world congress of neuropsychopharmacology
    • Place of Presentation
      Vancouver, Canada
    • Year and Date
      2014-06-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] D-セリンと統合失調症2014

    • Author(s)
      西川徹
    • Organizer
      日本アミノ酸学会 第4回産官学連携シンポジウム -豊かな生活を支えるアミノ酸の科学―
    • Place of Presentation
      東京大学、東京
    • Year and Date
      2014-06-16
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 分子から見た統合失調症のメカニズム2014

    • Author(s)
      西川徹
    • Organizer
      山口大学医学部・特別専門講義 第6回神経科学特別講演会
    • Place of Presentation
      山口大学、宇部市、山口県
    • Year and Date
      2014-04-08
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] グルタミン酸伝達を支える脳のVB関連D-セリン代謝ー生理と病態ー2014

    • Author(s)
      西川 徹
    • Organizer
      ビタミン B 研究委員会 平成25年度シンポジウム 『ビタミンB群が担う脳内アミノ酸代謝と疾患をターゲットにした次世代学術研究ービタミン研究が切り拓く疾患生命科学のフロンティア』
    • Place of Presentation
      大阪
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 脳のD-セリンシグナリングと統合失調症2014

    • Author(s)
      西川 徹
    • Organizer
      第87回 日本薬理学会年会 『D-アミノ酸の多様な生体機能』
    • Place of Presentation
      仙台
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 統合失調症の分子メカニズムを探る2013

    • Author(s)
      西川徹
    • Organizer
      つくばブレインサイエンスセミナー200回記念講演会
    • Place of Presentation
      茨城(招待講演)
    • Year and Date
      2013-02-09
    • Related Report
      2012 Annual Research Report
  • [Presentation] 統合失調症のシナプスーグリア系病態の研究2013

    • Author(s)
      西川徹
    • Organizer
      第4回公開シンポジウム 脳とこころの病気の克服をめざして~脳科学からのアプローチ~
    • Place of Presentation
      東京(招待講演)
    • Year and Date
      2013-01-31
    • Related Report
      2012 Annual Research Report
  • [Presentation] こころの病と脳のはたらき2013

    • Author(s)
      西川徹
    • Organizer
      平成24年度メンタルヘルス講演会
    • Place of Presentation
      茨城(招待講演)
    • Year and Date
      2013-01-25
    • Related Report
      2012 Annual Research Report
  • [Presentation] Clozapine投与後に脳波徐波化と認知機能障害を呈した統合失調症の一例2013

    • Author(s)
      福島康浩、治徳大介、古田光、池井大輔、玉井眞一郎、寺澤佑哉、光定博生、上里彰仁、京野穂集、甫母瑞枝、武田充弘、竹内崇、山本直樹、車地暁生、西川徹
    • Organizer
      第109回日本精神神経学会学術総会
    • Place of Presentation
      福岡
    • Related Report
      2013 Annual Research Report
  • [Presentation] ECTにより幻覚妄想状態の悪化を呈したパーキンソン症候群のl例2013

    • Author(s)
      京野穂集、三瀬耕平、武田充弘、車地暁生、西川徹
    • Organizer
      第109回日本精神神経学会学術総会
    • Place of Presentation
      福岡
    • Related Report
      2013 Annual Research Report
  • [Presentation] 東京医科歯科大学医学部附属病院精神科外来の初診うつ病性障害患者の実態2013

    • Author(s)
      竹内崇、武田充弘、治徳大介、京野穂集、上里彰仁、光定博生、甫母瑞枝、玉井眞一郎、池井大輔、寺澤佑哉、川俣光太郎、山本直樹、車地暁生、西川徹
    • Organizer
      第109回日本精神神経学会学術総会
    • Place of Presentation
      福岡
    • Related Report
      2013 Annual Research Report
  • [Presentation] Oral PRSを用いた口腔異常感の評価2013

    • Author(s)
      上里彰仁、豊福明、梅崎陽二朗、鳥井原彰、神戸陽、甫母瑞枝、玉井眞一郎、山本直樹、車地暁生、西川徹
    • Organizer
      第109回日本精神神経学会学術総会
    • Place of Presentation
      福岡
    • Related Report
      2013 Annual Research Report
  • [Presentation] ラット内側前頭葉皮質における多様な細胞外D-セリン調節2013

    • Author(s)
      石渡小百合、海野麻未、小方茂弘、海野真一、西川徹
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 前脳グルタミン酸神経およびastrocyte 発現SR特異的欠損マウスの海馬領域における細胞外および組織中D-セリン量の変化2013

    • Author(s)
      石渡小百合, 海野麻未, Darrick T. Balu, Joseph T. Coyle, 西川 徹
    • Organizer
      第9回D-アミノ酸研究会
    • Place of Presentation
      大阪
    • Related Report
      2013 Annual Research Report
  • [Presentation] 統合失調症の分子病態2013

    • Author(s)
      西川 徹
    • Organizer
      奈良先端科学技術大学院大学 特別講義
    • Place of Presentation
      奈良
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] A change in transcriptional regulation in the hippocampus of mice sensitized with methamphetamine.2013

    • Author(s)
      A. Kurumaji, M. Itasaka, S. Ishiwata, T. Nishikawa
    • Organizer
      Neuro 2013
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] Psychostimulant methamphetamine-induced genes: expression, characterization and genetic association with schizophrenia.2013

    • Author(s)
      N. Yamamoto, M. Umino, S. Muraoka, A. Umino, D. Jitoku, Y. Iwayama, T. Yoshikawa, T. Nishikawa
    • Organizer
      Neuro 2013
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] Genetic association study of PAPST1 ( 3'-Phsophoadenosine 5'-Phosphosulfate Transporter 1 ) with schizophrenia.2013

    • Author(s)
      D. Jitoku, N. Yamamoto, Y. Iwayama, T. Yoshikawa, A. Uezato, A. Kurumaji, T. Nishikawa
    • Organizer
      Neuro 2013
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] Postnatal development of gene expression patterns in rat brain following acute treatment with a schizophrenomimetic methamphetamine.2013

    • Author(s)
      M. Umino, A. Umino, N. Yamamoto, T. Nishikawa
    • Organizer
      11th World Congress of Biological Psychiatry
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] Association study of methamphetamine-and phencyclidine-responsive gene mprt1 in schizophrenia.2013

    • Author(s)
      M. Kobayashi, N. Yamamoto, D. Jitoku, Y. Iwayama, T. Yoshikawa, T. Nishikawa
    • Organizer
      11th World Congress of Biological Psychiatry
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] D-serine signaling in schizophrenia: Implications for novel therapy development.2013

    • Author(s)
      T. Nishikawa
    • Organizer
      11th World Congress of Biological Psychiatry
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Identification of developmentally-regulated phencyclidine-inducible gene and its genetic association with schizophrenia.2013

    • Author(s)
      A. Uezato, J. Kimura-Sato, S. Hiraoka, N. Yamamoto, Y. Kajii, Y. Kuroda, A. Umino, Y. Iijima, H. Kunugi, T. Nishikawa
    • Organizer
      11th World Congress of Biological Psychiatry
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] In vivo evidence for involvement of AMPA receptors and neural amino acid transporters in the modulation of the extracellular D-serine contents in the rat medial prefrontal cortex.2013

    • Author(s)
      S. Ishiwata, A. Umino, S. Ogata, M. Umino, T. Nishikawa
    • Organizer
      11th World Congress of Biological Psychiatry
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] Antipsycotic drugs fail to influence prefrontal activation during verbal fluency test in schizophrenia as measured by a multi-channel near-infrared spectroscopy.2013

    • Author(s)
      M. Itasaka, A. Kurumaji, A. Uezato, M. Hobo, D. Jitoku, N. Yamamoto, H. Mitsusada, M. Takeda, T. Takeuchi, T. Nishikawa
    • Organizer
      11th World Congress of Biological Psychiatry
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] Dusp1 shows differential regulation in the hippocampus of mice sensitized with methamphetamine.2013

    • Author(s)
      A. Kurumaji, M. Itasaka, S. Ishiwata, T. Nishikawa
    • Organizer
      11th World Congress of Biological Psychiatry
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] Evidence for involvement of neuronal cells in the regulation of the tissue and extracellular D-serine contents in rat medial prefrontal cortex.2013

    • Author(s)
      A. Umino, H. Iwama, M. Itasaka, M. Umino, S. Ishiwata, T. Nishikawa
    • Organizer
      11th World Congress of Biological Psychiatry
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] 脳科学から見た統合失調症研究の最先端2012

    • Author(s)
      西川徹
    • Organizer
      第22回地域精神保健講座
    • Place of Presentation
      東京(招待講演)
    • Year and Date
      2012-11-30
    • Related Report
      2012 Annual Research Report
  • [Presentation] 東京医科歯科大学医学部精神科に歯学部より紹介された口腔異常感症症例についての検討2012

    • Author(s)
      甫母瑞枝, 上里彰仁, 山本直樹, 車地暁生, 竹内崇, 武田充弘, 治徳大介, 京野穂集, 光定博生, 玉井眞一郎, 池井大輔, 寺澤佑哉, 川俣光太郎, 西川徹.
    • Organizer
      第108回総合病院精神学会
    • Place of Presentation
      東京
    • Year and Date
      2012-11-30
    • Related Report
      2012 Annual Research Report
  • [Presentation] 口腔異常感評価尺度Oral PRSの開発と信頼性評価2012

    • Author(s)
      上里彰仁, 豊福明, 梅崎陽二朗, 鳥井原明, 山本直樹, 車地暁生, 西川徹
    • Organizer
      第32回日本精神科診断学会
    • Place of Presentation
      沖縄(招待講演)
    • Year and Date
      2012-11-23
    • Related Report
      2012 Annual Research Report
  • [Presentation] Clozapine投与後に脳波徐波化と認知機能障害を呈した1例2012

    • Author(s)
      福島康浩, 治徳大介, 川俣光太郎, 池井大輔, 玉井眞一郎, 寺澤佑哉, 光定博生, 上里彰仁, 京野穂集, 甫母瑞枝, 武田充弘, 竹内崇, 山本直樹, 車地暁生, 西川徹
    • Organizer
      東京精神医学会 第96回学術集会
    • Place of Presentation
      東京
    • Year and Date
      2012-11-17
    • Related Report
      2012 Annual Research Report
  • [Presentation] NMDAレセプターと統合失調症2012

    • Author(s)
      西川徹
    • Organizer
      第22回日本臨床精神神経薬理学会-第42回日本神経精神薬理学会合同年会
    • Place of Presentation
      宇都宮(招待講演)
    • Year and Date
      2012-10-20
    • Related Report
      2012 Annual Research Report
  • [Presentation] 東京医科歯科大学医学部付属病院精神科外来における初診の気分障害患者の治療の実態2012

    • Author(s)
      竹内崇, 武田充弘, 治徳大介, 上里彰仁, 京野穂集, 甫母瑞枝, 高木俊輔, 光定博生, 玉井 眞一郎, 池井 大輔, 川俣光太郎, 川元茉莉乃, 三瀬耕平, 福島康浩, 山本 直樹, 車地暁生, 西川徹
    • Organizer
      第22回日本臨床精神神経薬理学会・第42回日本神経精神薬理学会合同年会
    • Place of Presentation
      宇都宮
    • Year and Date
      2012-10-18
    • Related Report
      2012 Annual Research Report
  • [Presentation] 統合失調症様症状惹起薬に対する発達依存的遺伝子応答と統合失調症の発症機構2012

    • Author(s)
      西川徹
    • Organizer
      第34回日本生物学的精神医学会
    • Place of Presentation
      神戸(招待講演)
    • Year and Date
      2012-09-28
    • Related Report
      2012 Annual Research Report
  • [Presentation] D-セリンと統合失調症2012

    • Author(s)
      西川徹
    • Organizer
      第34回日本生物学的精神医学会
    • Place of Presentation
      神戸(招待講演)
    • Year and Date
      2012-09-28
    • Related Report
      2012 Annual Research Report
  • [Presentation] 統合失調症における運動誘発錯視の知覚変容2012

    • Author(s)
      板坂典郎, 車地暁生, 上里彰仁, 甫母瑞枝, 池井大輔, 高木俊輔, 玉井眞一郎, 川俣光太郎, 京野穂集, 武田充弘, 成島健二, 治徳大輔, 竹内崇, 西川徹
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋
    • Year and Date
      2012-09-21
    • Related Report
      2012 Annual Research Report
  • [Presentation] 統合失調症の新しい治療と予防をめざして2012

    • Author(s)
      西川徹
    • Organizer
      脳科学研究戦略推進プログラム 公開シンポジウムin-KYOTO
    • Place of Presentation
      京都(招待講演)
    • Year and Date
      2012-09-08
    • Related Report
      2012 Annual Research Report
  • [Presentation] Molecular basis of schizophrenia, Lecture"Research on Neurological Diseases & Mental Ilness".2012

    • Author(s)
      Nishikawa T.
    • Organizer
      ISP2012 (International Summer Program 2012)Tokyo Medical & Dental University.
    • Place of Presentation
      Tokyo(招待講演)
    • Year and Date
      2012-08-28
    • Related Report
      2012 Annual Research Report
  • [Presentation] 統合失調症の病態解明はどこまで進んだか-新しい治療法への展望2012

    • Author(s)
      西川徹
    • Organizer
      第2回 多摩精神医学研究会
    • Place of Presentation
      東京(招待講演)
    • Year and Date
      2012-06-27
    • Related Report
      2012 Annual Research Report
  • [Presentation] D-Serine, glia-synapse interaction and schizophrenia.2012

    • Author(s)
      Nishikawa T.
    • Organizer
      Symposium"Novel NMDA amino acids for the pathophysiology and treatment of mental disorders"XXVIII CINP CONGRESS 2012 WORLD CONGRESS.
    • Place of Presentation
      Stockholm(招待講演)
    • Year and Date
      2012-06-06
    • Related Report
      2012 Annual Research Report
  • [Presentation] Modulation of the extracellular D-serine contents by the α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate type glutamate receptor in the rat medial frontal cortex as revealed by in vivo microdialysis.2012

    • Author(s)
      Ishiwata S, Umino A, Umino M, Nishikawa T.
    • Organizer
      XXVIII CINP CONGRESS 2012 WORLD CONGRESS
    • Place of Presentation
      Stockholm
    • Year and Date
      2012-06-06
    • Related Report
      2012 Annual Research Report
  • [Presentation] Postnatal developmental changes in the gene expression patterns induced by systemic administration of methamphetamine in the rat neocortex.2012

    • Author(s)
      Umino M, Yamamoto N, Umino A, Kurumaji A , Nishikawa T.
    • Organizer
      XXVIII CINP CONGRESS 2012 WORLD CONGRESS
    • Place of Presentation
      Stockholm
    • Year and Date
      2012-06-06
    • Related Report
      2012 Annual Research Report
  • [Presentation] Association study of phencyclidine-responsive synapse-associated protein 97(SAP97) gene in schizophrenia.2012

    • Author(s)
      Yamamoto N, Uezato A, Sato-Kimura, J Haramo E, Jitoku D, Umino M, Umino A, Kurumaji A, Iijima Y Kunugi H, Nishikawa T
    • Organizer
      XXVIII CINP CONGRESS 2012 WORLD CONGRESS
    • Place of Presentation
      Stockholm(招待講演)
    • Year and Date
      2012-06-05
    • Related Report
      2012 Annual Research Report
  • [Presentation] GABAergic regulation of extracellular D-serine concentrations in the rat medial frontal cortex of the rat as revealed by in vivo microdialysis.2012

    • Author(s)
      Umino A, Iwama H, Nishikawa T
    • Organizer
      XXVIII CINP CONGRESS 2012 WORLD CONGRESS
    • Place of Presentation
      Stockholm(招待講演)
    • Year and Date
      2012-06-05
    • Related Report
      2012 Annual Research Report
  • [Presentation] GABAergic regulation of extracellular D-serine concentrations in the rat medial frontal cortex of the rat as revealed by in vivo microdialysis.2012

    • Author(s)
      Umino A, Iwama H, Nishikawa T.
    • Organizer
      XXVIII CINP CONGRESS 2012 WORLD CONGRESS
    • Place of Presentation
      Stockholm
    • Year and Date
      2012-06-05
    • Related Report
      2012 Annual Research Report
  • [Presentation] Association study of phencyclidine-responsive synapse-associated protein 97 (SAP97) gene in schizophrenia.2012

    • Author(s)
      Yamamoto N, Uezato A, Sato-Kimura J, Haramo E, Jitoku D, Umino M, Umino A, Kurumaji A, Iijima Y, Kunugi H, Nishikawa T.
    • Organizer
      XXVIII CINP CONGRESS 2012 WORLD CONGRESS
    • Place of Presentation
      Stockholm
    • Year and Date
      2012-06-05
    • Related Report
      2012 Annual Research Report
  • [Presentation] D-Serine, glia-synapse interaction and schizophrenia.2012

    • Author(s)
      Nishikawa T
    • Organizer
      XXVIII CINP CONGRESS 2012 WORLD CONGRESS
    • Place of Presentation
      Stockholm
    • Year and Date
      2012-06-05
    • Related Report
      2012 Annual Research Report
  • [Presentation] Pharmacological characterization and exploration of novel transcripts of a developmentally regulated and phencyclidine-inducible gene, SAP97, in mammalian brains.2012

    • Author(s)
      Haramo E, Yamamoto N, Uezato A, Hiraoka S, Hiraaki E, Umino M, Umino A, Kurumaji A, Nishikawa, T.
    • Organizer
      XXVIII CINP CONGRESS 2012 WORLD CONGRESS
    • Place of Presentation
      Stockholm
    • Year and Date
      2012-06-05
    • Related Report
      2012 Annual Research Report
  • [Presentation] コンサルテーション・リエゾン精神医療におけるmirtazapineの使用経験.2012

    • Author(s)
      竹内崇, 京野穂集, 高木俊輔, 甫母瑞枝, 池井大輔, 玉井眞一郎, 川俣光太郎, 武田充弘, 治徳大介, 光定博生, 上里彰仁, 成島健二, 山本直樹, 車地暁生, 西川 徹.
    • Organizer
      第108回日本精神神経学会総会
    • Place of Presentation
      札幌
    • Year and Date
      2012-05-25
    • Related Report
      2012 Annual Research Report
  • [Presentation] 東京医科歯科大学精神科に3年半に歯学部より紹介された症例に関する検討.2012

    • Author(s)
      甫母瑞枝, 豊福明, 上里彰仁, 車地暁生, 山本直樹, 竹内崇, 武田充宏, 治徳大介, 京野穂集, 高木俊輔, 玉井眞一郎, 池井大介, 成島健二, 西川徹.
    • Organizer
      第108回日本精神神経学会総会
    • Place of Presentation
      札幌
    • Year and Date
      2012-05-25
    • Related Report
      2012 Annual Research Report
  • [Presentation] 密室死対策の重要性 症例をふまえた提言.2012

    • Author(s)
      京野穂集, 竹内崇, 武田充弘, 池井大輔, 玉井眞一郎, 高木俊輔, 治徳大介, 甫母瑞江, 上里彰仁, 山本直樹, 車地暁生, 西川徹
    • Organizer
      第108回 日本精神神経学会学術総会
    • Place of Presentation
      札幌
    • Year and Date
      2012-05-24
    • Related Report
      2012 Annual Research Report
  • [Presentation] 高齢うつ病患者に対する電気けいれん療法後の維持療法を目的としたリチウムの併用投与に関する臨床研究2012

    • Author(s)
      車地曉生, 成島健二, 京野穂集, 奥住祥子, 西多昌規, 高木俊輔, 上里彰仁, 山本直樹, 竹内崇, 西川徹
    • Organizer
      第31回リチウム研究会
    • Place of Presentation
      東京
    • Year and Date
      2012-04-14
    • Related Report
      2012 Annual Research Report
  • [Presentation] 間歇型一酸化炭素中毒の臨床経過と睡眠脳波の変化について検討した1症例2012

    • Author(s)
      吉池卓也, 西多昌規, 谷顕, 細田益宏, 熱田英範, 柳下和慶, 西川徹
    • Organizer
      第108回日本精神神経学会学術総会
    • Place of Presentation
      札幌(招待講演)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Mechanism of thymidine incorporation into astrocytic acid insoluble fraction via SLC28 and SLC29 on oxidative stress DNA injury.2012

    • Author(s)
      Tanaka K. I, Kitanaka N, Kitanaka J, Yokoyama S, Miyake T, Park M, Hanatani J, Ohi H, Kishi Y, Sato T, Nishikawa T, Takemura M, Baba A, Nishiyama N.
    • Organizer
      The ll^<th> Biennial Meeting of the Asian-Pacific Society for Neurochemistry/55^<th> Annual Meeting of the Japanese Society for Neurochemistry
    • Place of Presentation
      Kobe
    • Related Report
      2012 Annual Research Report
  • [Presentation] Isolation of ontogenic development-dependent phencyclidine-responsive non-coding transcript prt6 in the rat brain.2012

    • Author(s)
      Yamamoto N, Takebayashi H, Umino M, Umino A, Kurumaji A, Nishikawa, T.
    • Organizer
      The 11^<th> Biennial Meeting of the Asian-Pacific Society for Neurochemistry/55th Annual Meeting of the Japanese Society for Neurochemistry
    • Place of Presentation
      Kobe
    • Related Report
      2012 Annual Research Report
  • [Presentation] Association Study of Nogo-Related Genes with Schizophrenia in a Japanese Case control Sample.2012

    • Author(s)
      Jitoku D, Hattori E, Iwayama Y, Yamada K, Toyota T, Maekawa M, Nishikawa T, Yoshikawa T.
    • Organizer
      20th World Congress of Psychiatric Genetics 2012
    • Place of Presentation
      Hamburg
    • Related Report
      2012 Annual Research Report
  • [Presentation] 間歇型一酸化炭素中毒の臨床経過と睡眠脳波の変化について検討した1症例2012

    • Author(s)
      吉池卓也, 酉多昌規, 谷顕, 細田益宏, 熱田英範, 柳下和慶, 西川徹
    • Organizer
      第108回日本精神神経学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Annual Research Report
  • [Presentation] 中性アミノ酸トランスポーターAsc-1阻害薬S-methyl-L-cysteineのラット内側前頭葉皮質における細胞外D-セリン濃度に与える影響.2012

    • Author(s)
      石渡小百合, 小方茂弘, 海野麻未, 西川徹.
    • Organizer
      第8回D-アミノ酸研究会学術講演会
    • Place of Presentation
      滋賀
    • Related Report
      2012 Annual Research Report
  • [Book] 不安 「第2章 脳 神経系」 「緊急度・重症度からみた症状別看護過程 第2版」 井上智子・稲瀬直彦 編集2014

    • Author(s)
      西多昌規、西川 徹
    • Total Pages
      1097
    • Publisher
      医学書院
    • Related Report
      2014 Annual Research Report
  • [Book] 抑うつ(うつ病)病期・病態・重症度からみた疾患別看護過程+病態関連図 第2版2012

    • Author(s)
      竹内崇, 西川徹
    • Publisher
      医学書院
    • Related Report
      2012 Annual Research Report
  • [Remarks] 東京医科歯科大学大学院医歯学総合研究科精神行動医科学分野・精神科

    • URL

      http://www.tmd.ac.jp/med/psyc/index.html

    • Related Report
      2015 Annual Research Report

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Published: 2012-04-24   Modified: 2022-01-27  

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