Neurodevelopmental pathophysiology and biomarkers for early detection in prodromal stage of schizophrenia
Project/Area Number |
24390281
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Psychiatric science
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Research Institution | University of Toyama |
Principal Investigator |
SUZUKI Michio 富山大学, 医学薬学研究部(医学), 教授 (40236013)
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Co-Investigator(Kenkyū-buntansha) |
TAKAHASHI Tsutomu 富山大学, 大学院医学薬学研究部(医学), 准教授 (60345577)
HIGUCHI Yuko 富山大学, 附属病院, 講師 (60401840)
TAKAYANAGI Yoichiro 富山大学, 附属病院, 講師 (40574942)
MIZUNO Masafumi 東邦大学, 医学部, 教授 (80245589)
MATSUMOTO Kazunori 東北大学, 医学系研究科, 准教授 (40301056)
SUMIYOSHI Tomiki 富山大学, 大学院医学薬学研究部(医学), 准教授 (80286062)
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Co-Investigator(Renkei-kenkyūsha) |
NAKAMURA Kazue 富山大学, 附属病院, 助教 (00447658)
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Project Period (FY) |
2012-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥12,220,000 (Direct Cost: ¥9,400,000、Indirect Cost: ¥2,820,000)
|
Keywords | 統合失調症 / 前駆期 / 神経発達 / 磁気共鳴画像(MRI) / ミスマッチ陰性電位 / 進行性脳病態 / 早期診断 / 判別分析 / 初回エピソード / ミスマッチ陰性電位(MMN) / 磁気共鳴画像(MRI) / ミスマッチ陰性電位(MMN) |
Outline of Final Research Achievements |
Multimodal investigations of brain structure and function in subjects at risk for developing schizophrenia and patients with schizophrenia have revealed that a number of neurobiological changes, including shallowing of the cortical sulci, alterations in cortical thickness and local cortical gyrification, and amplitude reduction of mismatch negativity, do occur prior to the onset of psychosis. Among these, some are static and suggestive of the neurodevelopmental deviation, and others are progressive and may underlie the onset of psychosis. These changes could be applicable to biomarkers in prodromal state of schizophrenia for prediction of future development of psychosis.
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Report
(5 results)
Research Products
(68 results)
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[Journal Article] The Disrupted-in-Schizophrenia-1 Ser704Cys polymorphism and brain neurodevelopmental markers in schizophrenia and healthy subjects.2015
Author(s)
Takahashi T, Nakamura M, Nakamura Y, Aleksic B, Kido M, Sasabayashi D, Takayanagi Y, Furuichi A, Nishikawa Y, Noguchi K, Ozaki N, Suzuki M
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Journal Title
Prog Neuropsychopharmacol Biol Psychiatry
Volume: 56
Pages: 11-17
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Identification of Rare, Single-Nucleotide Mutations in NDE1 and Their Contributions to Schizophrenia Susceptibility.2015
Author(s)
Kimura H, Tsuboi D, Wang C, Kushima I, Koide T, Ikeda M, Iwayama Y, Toyota T, Yamamoto N, Kunimoto S, Nakamura Y, Yoshimi A, Banno M, Xing J, Takasaki Y, Yoshida M, Aleksic B, Uno Y, Okada T, Iidaka T, Inada T, Suzuki M, Ujike H, Kunugi H, Kato T, Yoshikawa T, Iwata N, Kaibuchi K
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Journal Title
Schizophrenia Bulltein
Volume: 41
Issue: 3
Pages: 744-753
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Differential impacts of duration of untreated psychosis (DUP) on cognitive function in first-episode schizophrenia according to mode of onset2015
Author(s)
Shinya Ito, Takahiro Nemoto, Naohisa Tsujino, Noriyuki Ohmuro, Kazunori Matsumoto, Hiroo Matsuoka, Kodai Tanaka, Shimako Nishiyama, Michio Suzuki, Hirohisa Kinoshita, Hiroki Ozawa, Hirokazu Fujita, Shinji Shimodera, Toshifumi Kishimoto, Kunichika Matsumoto, Tomonori Hasegawa, Masafumi Mizuno
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Journal Title
European Psychiatry
Volume: 30
Issue: 8
Pages: 995-1001
DOI
Related Report
Peer Reviewed
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[Journal Article] The polymorphism of YWHAE, a gene encoding 14-3-3epsilon, and brain morphology in schizophrenia: a voxel-based morphometric study.2014
Author(s)
Kido M, Nakamura Y, Nemoto K, Takahashi T, Aleksic B, Furuichi A, Nakamura Y, Ikeda M, Noguchi K, Kaibuchi K, Iwata N, Ozaki N, Suzuki M
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Journal Title
PLoS One
Volume: 9
Issue: 8
Pages: e103571-e103571
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] The polymorphism of YWHAE, a gene encoding 14-3-3epsilon, and orbitofrontal sulcogyral pattern in patients with schizophrenia and healthy subjects.2014
Author(s)
Takahashi T, Nakamura Y, Nakamura Y, Aleksic B, Takayanagi Y, Furuichi A, Kido M, Nakamura M, Sasabayashi D, Ikeda M, Noguchi K, Kaibuchi K, Iwata N, Ozaki N, Suzuki M
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Journal Title
Prog Neuropsychopharmacol Biol Psychiatry
Volume: 51
Pages: 166-171
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Common variants at 1p36 are associated with superior frontal gyrus volume.2014
Author(s)
Hashimoto R, Ikeda M, Yamashita F, Ohi K, Yamamori H, Yasuda Y, Fujimoto M, Fukunaga M, Nemoto K, Takahashi T, Tochigi M, Onitsuka T, Yamasue H, Matsuo K, Iidaka T, Iwata N, Suzuki M, Takeda M, Kasai K, Ozaki N
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Journal Title
Translational Psychiatry
Volume: 4
Issue: 10
Pages: e472-e472
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Increased pituitary volume in subjects at risk for psychosis and patients with first-episode schizophrenia.2013
Author(s)
Takahashi T, Nakamura K, Nishiyama S, Furuichi A, Ikeda E, Kido M, Nakamura Y, Kawasaki Y, Noguchi K, Seto H, Suzuki M
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Journal Title
Psychiatry and Clinical Neurosciences
Volume: 67
Issue: 7
Pages: 540-548
DOI
Related Report
Peer Reviewed
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[Journal Article] Volume reductions in frontopolar and left perisylvian cortices in methamphetamine induced psychosis2013
Author(s)
Aoki Y, Orikabe L, Takayanagi Y, Yahata N, Mozue Y, Sudo Y, Ishii T, Itokawa M, Suzuki M, Kurachi M, Okazaki Y, Kasai K, Yamasue H
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Journal Title
Schizophrenia Research
Volume: 147
Issue: 2-3
Pages: 355-361
DOI
Related Report
Peer Reviewed
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[Journal Article] Reduced anterior cingulate gray matter volume and thickness in subjects with deficit schizophrenia.2013
Author(s)
Takayanagi M, Wentz J, Takayanagi Y, Schretlen DJ, Ceyhan E, Wang L, Suzuki M, Sawa A, Barta PE, Ratnanather JT, Cascella NG
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Journal Title
Schizophrenia Research
Volume: 150
Issue: 2-3
Pages: 484-490
DOI
Related Report
Peer Reviewed
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[Journal Article] Analysis of the VAV3 as candidate gene for schizophrenia : evidences from voxel based morphometry and mutation screening.2012
Author(s)
Aleksic B, Kushima I, Hashimoto R, Ohi K, Ikeda M, Yoshimi A, Nakamura Y, Ito Y, Okochi T, Fukuo Y, Yasuda Y, Fukumoto M, Yamamori H, Ujike H, Suzuki M, Inada T, Takeda M, Kaibuchi K, Iwata N, Ozaki N
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Journal Title
Schizophrenia Bulletin
Volume: 39
Issue: 3
Pages: 39-39
DOI
Related Report
Peer Reviewed
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[Presentation] At-risk mental stateにおける眼窩前頭皮質の脳溝脳回パターンと脳溝数.2015
Author(s)
中村美保子, 高橋努, 片桐直之, 佐久間篤, 笹林大樹, 高柳陽一郎, 古市厚志, 木戸幹雄, 西川祐美子, 松本和紀, 水野雅文, 鈴木道雄
Organizer
第19回日本精神保健・予防学会学術集会
Place of Presentation
仙台
Year and Date
2015-12-12
Related Report
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[Presentation] 統合失調症の皮質下体積のメタアナリシス.2015
Author(s)
岡田直大, 福永雅喜, 山下典生, 越山太輔, 山森英長, 大井一高, 安田由華, 藤本美智子, 渡邉嘉之, 八幡憲明, 根本清貴, 磯部昌憲, 磯村周一, 夏堀龍暢, 成田 尚, 橋本直樹, 宮田 淳, 小池進介, 高橋 努, 山末英典, 松尾幸治, 鬼塚俊明, 飯高哲也, 吉村玲児, 渡邉義文, 鈴木道雄, 武田雅俊, 尾崎紀夫, 笠井清登, 橋本亮太
Organizer
第37回日本生物学的精神医学会
Place of Presentation
東京
Year and Date
2015-09-24
Related Report
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[Presentation] Labeled Cortical Distance Mappingを用いた、精神病発症高リスク群における前部帯状回と中前頭回の形態研究.2015
Author(s)
高柳 陽一郎, Kulason S, 笹林 大樹, 中村 美保子, 高橋 努, 古市 厚志, 木戸 幹雄, 西川 祐美子, 片桐 直之, 佐久間 篤, 松本 和紀, 水野 雅文, Ratnanather T, 鈴木 道雄
Organizer
第37回日本生物学的精神医学会
Place of Presentation
東京
Year and Date
2015-09-24
Related Report
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[Presentation] Cortical thickness changes in individuals at risk of psychosis.2015
Author(s)
Sasabayashi D, Takayanagi Y, Nakamura M, Takahashi T, Furuichi A, Kido M, Nishikawa Y, Katagiri N, Sakuma A, Koike S, Yamasue H, Matsumoto K, Mizuno M, Kasai K, Suzuki M
Organizer
29th European College of Neuropsychopharmacology (ECNP) Congress
Place of Presentation
Amsterdam
Year and Date
2015-08-29
Related Report
Int'l Joint Research
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[Presentation] Altered depth of the olfactory sulcus in ultra high-risk individuals.2014
Author(s)
Takahashi T, Wood SJ, Yung AR, Nelson B, Lin A, Yucel M, Phillips LJ, Suzuki M, Brewer WJ, McGorry PD, Velakoulis D, Pantelis C
Organizer
9th International Conference on Early Psychosis
Place of Presentation
Tokyo
Year and Date
2014-11-17 – 2014-11-19
Related Report
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[Presentation] Cortical thickness changes in subjects at risk for developing psychosis.2014
Author(s)
Takayanagi Y, Sasabayashi D, Nakamura M, Takahashi T, Furuichi A, Kido M, Nishikawa Y, Katagiri N, Sakuma A, Matsumoto K, Mizuno M, Suzuki M
Organizer
9th International Conference on Early Psychosis
Place of Presentation
Tokyo
Year and Date
2014-11-17 – 2014-11-19
Related Report
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[Presentation] The polymorphism of YWHAE, a gene encoding 14-3-3epsilon, and brain morphology in schizophrenia: a voxel-based morphometric study.2014
Author(s)
Kido M, Nakamura Y, Nemoto K, Takahashi T, Aleksic B, Furuichi A, Nakamura Y, Ikeda M, Noguchi K, Kaibuchi K, Iwata N, Ozaki N, Suzuki M
Organizer
22nd World Congress of Psychiatric Genetics
Place of Presentation
Copenhagen
Year and Date
2014-10-12 – 2014-10-16
Related Report
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[Presentation] Novel rare disruptive variants in Rho GTPase Activating Protein 10 (ARHGAP10) in schizophrenia and autism spectrum disorder.2014
Author(s)
Wang C, Tsuboi D, Kushima I, Kunimoto S, Yoshimi A, Nakamura Y, Koide T, Kimura H, Takasaki Y, Xing J, Uno Y, Okada T, Iidaka T, Aleksic B, Mori D, Suzuki M, Ujike H, Ikeda M, Iwata N, Kaibuchi K, Ozaki N
Organizer
22nd World Comgress of Psychiatric Genetics
Place of Presentation
Copenhagen
Year and Date
2014-10-12 – 2014-10-16
Related Report
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[Presentation] DISC1 polymorphism and orbitofrontal sulcogyral pattern in schizophrenia and healthy subjects.2014
Author(s)
Nakamura M, Takahashi T, Nakamura Y, Aleksic B, Kido M, Sasabayashi D, Takayanagi Y, Furuichi A, Nishikawa Y, Noguchi K, Ozaki N, Suzuki M
Organizer
第36回日本生物学的精神医学会・第57回日本神経化学会大会合同年会
Place of Presentation
奈良
Year and Date
2014-09-29 – 2014-10-01
Related Report
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[Presentation] At-risk mental stateにおける大脳皮質厚の変化.2014
Author(s)
笹林大樹, 高柳陽一郎, 中村美保子, 高橋 努, 古市厚志, 木戸幹雄, 西川祐美子, 片桐直之, 佐久間篤, 松本和紀, 水野雅文, 鈴木道雄
Organizer
第36回日本生物学的精神医学会・第57回日本神経化学会大会合同年会
Place of Presentation
奈良
Year and Date
2014-09-29 – 2014-10-01
Related Report
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[Presentation] DISC1 Ser704Cys polymorphism and midline brain structures in schizophrenia and healthy subjects.2014
Author(s)
Takahashi T, Nakamura M, Nakamura Y, Aleksic B, Kido M, Sasabayashi D, Takayanagi Y, Furuichi A, Nishikawa Y, Noguchi K, Ozaki N, Suzuki M
Organizer
第36回日本生物学的精神医学会・第57回日本神経化学会大会合同年会
Place of Presentation
奈良
Year and Date
2014-09-29 – 2014-10-01
Related Report
-
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[Presentation] The polymorphism of YWHAE, a gene encoding 14-3-3epsilon, and orbitofrontal sulcogyral pattern in schizophrenia and healthy subjects.2014
Author(s)
Takahashi T, Nakamura Y, Nakamura Y, Aleksic B, Takayanagi Y, Furuichi A, Kido M, Noguchi K, Kaibuchi K, Ozaki N, Suzuki M
Organizer
4th Schizophrenia International Research Society Conference
Place of Presentation
Florence
Year and Date
2014-04-05 – 2014-04-09
Related Report
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[Presentation] Developing a computer aided diagnosis tool of schizophrenia using voxel-based morphometry.2013
Author(s)
Nemoto K, Yamashita F, Ohnishi T, Yamasue H, Takahashi T, Fukunaga M, Ohi K, Hashimoto R, Suzuki M, Kasai K, Asada T
Organizer
11th World Congress of Biological Psychiatry
Place of Presentation
Kyoto
Related Report
-
[Presentation] 統合失調症患者における自己参照過程の神経基盤の変化- fMRI による検討.2013
Author(s)
古市厚志, 高橋 努, 川崎康弘, 中村主計, 谷野亮一郎, 池田英二, 木戸幹雄, 中村祐美子, 倉知正佳, 野口 京, 鈴木道雄
Organizer
第8回日本統合失調症学会
Place of Presentation
浦河
Related Report
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[Presentation] KALRN, EPHB1遺伝子のリシーケンス・関連解析と統合失調症の脆弱性への寄与.2013
Author(s)
久島 周, アレクシッチ・ブランコ, 中村由嘉子, 池田匡志, 伊藤佳人, 椎野智子, 大河内智, 福生泰久, 氏家 寛, 鈴木道雄, 稲田俊也, 橋本亮太, 武田雅俊, 貝淵弘三, 岩田仲生, 尾崎紀夫
Organizer
第8回日本統合失調症学会
Place of Presentation
浦河
Related Report
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[Presentation] At-risk mental stateにおける嗅溝の形態変化.2013
Author(s)
高橋 努, 中村祐美子, 中村主計, 西山志満子, 高柳陽一郎, ,池田英二, 古市厚志, 木戸幹雄, 中村美保子, 笹林大樹, 野口 京, 鈴木道雄
Organizer
第17回日本精神保健予防学会
Place of Presentation
東京
Related Report
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