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The analysis of regulatory mechanisms of degradation/aggregation of abnormally accumulated protein in fontotemporal dementia brain.

Research Project

Project/Area Number 24390283
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Psychiatric science
Research InstitutionOsaka University

Principal Investigator

TAKEDA Masatoshi  大阪大学, 医学(系)研究科(研究院), 教授 (00179649)

Co-Investigator(Kenkyū-buntansha) TANAKA Toshihisa  大阪大学, 医学(系)・研究科(研究院), 准教授 (10294068)
KUDO Takashi  大阪大学, 保健センター, 教授 (10273632)
MORIHARA Takashi  大阪大学, 医学(系)・研究科(研究院), 助教 (90403196)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2014: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2013: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
Keywordsタウ蛋白 / XIAP / アポトーシス / XIAP
Outline of Final Research Achievements

The effects of phosphorylation on interaction of tau with ubiquitin conjyugating enzyme XIAP (X-linked Inhibitor to apoptosis protein) were analayzed. Wild typed tau and Met-deleted tau were prepared and pull-down assay was caried out using XIAP after phophorylation of both tau and both tau proteins were incubated with ubiquitination enzyme sources togather with XIAP, and the effects of phosphorylation on ubiquitinaation were evaluated. No signifivcant difference was observed between non-phosphorylated samples and phosphorylated ones. Then binding partner to phosphorylated TDP-43 was invesytigated employing phosphorylated and non-phosphorylated peptides coresponding to Ser409/Ser410 of TDP-43. Then specigfic binding proteins were purified.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (10 results)

All 2015 2014 2013 2012

All Journal Article (6 results) (of which Peer Reviewed: 1 results) Presentation (4 results) (of which Invited: 1 results)

  • [Journal Article] アルツハイマー病の新規薬物の開発と臨床応用の可能性2015

    • Author(s)
      田中稔久、武田雅俊
    • Journal Title

      精神科治療学

      Volume: 30 Pages: 63-70

    • Related Report
      2014 Annual Research Report
  • [Journal Article] γ-secretase modulators and presenilin 1 mutants act differently on presenilin/γ-secretase function to cleave Aβ42 and Aβ43.2013

    • Author(s)
      Okochi M, Tagami S, Yanagida K, Takami M, Kodama TS, Mori K, Nakayama T, Ihara Y, Takeda M.
    • Journal Title

      Cell Rep.

      Volume: 3 Issue: 1 Pages: 42-51

    • DOI

      10.1016/j.celrep.2012.11.028

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Alzheimer disease and tau protein.2012

    • Author(s)
      Tanaka T, Maruyama D, TakedaM
    • Journal Title

      Rinsho Shinkeigaku

      Volume: 52 Pages: 1171-1173

    • NAID

      130004505095

    • Related Report
      2012 Annual Research Report
  • [Journal Article] アミロイド沈着、神経原線維変化と認知機能低下2012

    • Author(s)
      田中稔久、武田雅俊
    • Journal Title

      老年精神医学雑誌

      Volume: 23 Pages: 434-440

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 認知症の薬理学的理解と臨床への活用 臨床精神薬理2012

    • Author(s)
      田中稔久、武田雅俊
    • Journal Title

      臨床精神薬理

      Volume: 15 Pages: 1285-1296

    • Related Report
      2012 Annual Research Report
  • [Journal Article] アルツハイマー病の薬物療法の展開2012

    • Author(s)
      田中稔久、武田雅俊
    • Journal Title

      臨床精神医学

      Volume: 41 Pages: 1681-1691

    • Related Report
      2012 Annual Research Report
  • [Presentation] 認知症におけるタウの分子病理2014

    • Author(s)
      田中稔久
    • Organizer
      第20回近畿老年期認知症研究会
    • Place of Presentation
      リーガロイヤルNCB(大阪)
    • Year and Date
      2014-07-05
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] N-terminal modification of tau regulates its degradation.2013

    • Author(s)
      Tanaka T, Maruyama D, Sato M, Terada M, Takeda M.
    • Organizer
      Alzheimer's Association International Conference (AAIC2013), Boston, U.S.A., July 13-18(17), 2013.
    • Place of Presentation
      Boston, USA.
    • Related Report
      2013 Annual Research Report
  • [Presentation] Phosphorylation of tau at Ser214 regulates degradation process of tau.2012

    • Author(s)
      Tanaka T, Maruyama D, Takeda M
    • Organizer
      Alzheimer's Association International Conference (AAIC2012)
    • Place of Presentation
      Vancouver (Canada)
    • Year and Date
      2012-07-17
    • Related Report
      2012 Annual Research Report
  • [Presentation] アルツハイマー病とタウ蛋白 シンポジウム「アルツハイマー病の新展開-分子病態から治療戦略へ New Development for Alzheimer's Diseas←From Molecular Pathogenesis to Therapeutic Strategy」2012

    • Author(s)
      田中稔久
    • Organizer
      第53回日本神経学会学術大会
    • Place of Presentation
      東京国際フォーラム(東京)(招待講演)
    • Year and Date
      2012-05-24
    • Related Report
      2012 Annual Research Report

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Published: 2012-04-24   Modified: 2019-07-29  

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