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Development of new radiosensitizer based on the molecular mechanism of the recognition and repair of DNA double-strand break

Research Project

Project/Area Number 24390290
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Radiation science
Research InstitutionTokyo Institute of Technology

Principal Investigator

Matsumoto Yoshihisa  東京工業大学, 原子炉工学研究所, 准教授 (20302672)

Project Period (FY) 2012-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2014: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2013: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2012: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Keywords放射線 / 癌治療 / DNA二重鎖切断 / DNA修復 / DNA依存性プロテインキナーゼ / XRCC4 / DNA ligase IV / タンパク質リン酸化 / 癌 / 増感剤 / 放射線治療 / 放射線増感剤 / DNA二重鎖切断修復 / DNA損傷応答 / 蛋白質リン酸化 / DNA-PK
Outline of Final Research Achievements

This study aimed to clarify the regulatory mechanisms of protein-protein interaction mediated through DNA damage-induced phosphorylation of XRCC4 by DNA-PK and to explore their potential in application to the development of new radiosensitizer. The main achievements of this study include finding the importance of XRCC4 extremely C-terminal (XECT) region, which is highly conserved among vertebrates, the mechanisms of the nuclear localization and chromatin binding of XRCC4/LIG4 complex and the detection of XRCC4 S320 phosphorylation by DNA-PK in living cells. Based on these results, we tested possible radiosensitizing effects of XRCC4 phosphorylation-mimicking synthetic peptide, but the expected effects were not obtained, requiring further studies to optimize peptide sequence and the protocol of introduction into cells.

Report

(5 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (62 results)

All 2016 2015 2014 2013 2012 Other

All Int'l Joint Research (2 results) Journal Article (10 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 9 results,  Open Access: 3 results,  Acknowledgement Compliant: 6 results) Presentation (47 results) (of which Int'l Joint Research: 8 results,  Invited: 3 results) Remarks (2 results) Patent(Industrial Property Rights) (1 results)

  • [Int'l Joint Research] テキサス大学M.D.アンダーソン癌研究センター(米国)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] R.R. Government College/Indian Council of Medical Research(インド)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] In cellulo phosphorylation of XRCC4 Ser320 by DNA-PK induced by DNA damage2016

    • Author(s)
      Sharma MK, Imamichi S, Fukuchi M, Samartha RM, Tomita M, Matsumoto Y.
    • Journal Title

      Journal of Radiation Research

      Volume: 57 Issue: 2 Pages: 115-120

    • DOI

      10.1093/jrr/rrv086

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] LIG4 mediates Wnt signaling-induced radioresistance2016

    • Author(s)
      Jun S, Jung Y-S, Suh HN, Wang W, Kim MJ, Oh YS, Lien E, Shen X, Matsumoto Y, McCrea P, Li L, Chen J, *Park J-I.
    • Journal Title

      Nature Communications

      Volume: 7 Issue: 1 Pages: 10994-10994

    • DOI

      10.1038/ncomms10994

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Utilization of Cytogenetic Biomarkers as Tool for Assessment of Radiation Injury and Evaluation of Radiomodulatory Effects of Various Medicinal Plants2015

    • Author(s)
      Samartha RM, Samartha M, Matsumoto Y
    • Journal Title

      Drug Design, Development and Therapy

      Volume: 9 Pages: 5355-5372

    • DOI

      10.2147/dddt.s91299

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Asparagine 326 in the extremely C-terminal region of XRCC4 is essential for the cell survival after irradiation2015

    • Author(s)
      Wanotayan R, Fukuchi M, Imamichi S, Sharma MK, Matsumoto Y
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 457 Issue: 4 Pages: 526-531

    • DOI

      10.1016/j.bbrc.2015.01.015

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Lysine 271 but not lysine 210 of XRCC4 is required for the nuclear localization of XRCC4 and DNA ligase IV2015

    • Author(s)
      Fukuchi M, Wanotayan R, Liu S, Imamichi S, Sharma MK, Matsumoto Y
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: - Issue: 4 Pages: 687-694

    • DOI

      10.1016/j.bbrc.2015.04.093

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Ionizing radiation-induced XRCC4 phosphorylation is mediated through ATM in addition to DNA-PK2014

    • Author(s)
      Imamichi S, Sharma MK, Kamdar RP, Fukuchi M, Matsumoto Y
    • Journal Title

      Proceedings of the Japan Academy, Series B

      Volume: 90 Issue: 9 Pages: 365-372

    • DOI

      10.2183/pjab.90.365

    • NAID

      130004704867

    • ISSN
      0386-2208, 1349-2896
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Function of XRCC4 C-terminal Region in DNA Double-Strand Break Repair2014

    • Author(s)
      Wanotayan R, Sharma MK, Matsumoto Y
    • Journal Title

      Transactions of the American Nuclear Society

      Volume: 111 Pages: 1145-1148

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 二つのDNA二重鎖切断修復機構の賢い選択2014

    • Author(s)
      松本義久
    • Journal Title

      医学物理

      Volume: 34 Pages: 1-8

    • NAID

      130005002772

    • Related Report
      2014 Annual Research Report
    • Acknowledgement Compliant
  • [Journal Article] C-terminal region of DNA ligase IV drives XRCC4/DNA ligase IV complex to chromatin2013

    • Author(s)
      Liu S, Liu X, Kamdar RP, Wanotayan R, Sharma MK, Adachi N, Matsumoto Y
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 439 Issue: 2 Pages: 173-178

    • DOI

      10.1016/j.bbrc.2013.08.068

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Radiosensitization strategy through modification of DNA double-strand break repair2013

    • Author(s)
      Matsumoto Y, Imamichi S, Fukuchi M, Liu S, Wanotayan R, Kuniyoshi S, Yoshida K, Mae Y, Sharma MK
    • Journal Title

      InTech "DNA Repair-New Research Directions"

      Volume: - Pages: 639-663

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] DNA二重鎖切断修復タンパク質XRCC4の点変異体の系統的作製と機能解析2016

    • Author(s)
      福地 命, Rujira Wanotayan, Mukesh Kumar Sharma, 今道 祥二, 松本 義久
    • Organizer
      第18回癌治療増感研究シンポジウム
    • Place of Presentation
      奈良県文化会館(奈良)
    • Year and Date
      2016-02-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] DNA依存性プロテインキナーゼ(DNA-PK)の機能と放射線感受性の予測・制御2015

    • Author(s)
      松本 義久
    • Organizer
      BMB2015(第38回日本分子生物学会年会、第88回日本生化学会大会 合同大会)
    • Place of Presentation
      神戸国際会議場他(神戸)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] 低線量率γ線連続照射下における非相同末端結合の重要性2015

    • Author(s)
      冨田 雅典, 小林 純也, 大塚 健介, 松本 義久, 内海 博司
    • Organizer
      BMB2015(第38回日本分子生物学会年会、第88回日本生化学会大会 合同大会)
    • Place of Presentation
      神戸国際会議場他(神戸)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] DNA修復蛋白質XRCC4のカスパーゼ依存性切断によるスプライシング調節を介したアポトーシスの促進2015

    • Author(s)
      砂谷 優実, Radhika Pankaj Kamdar, Mukesh Kumar Sharma, 松井 理, 逆井 良, 橋本 光正, 松本 義久, 岩淵 邦芳
    • Organizer
      BMB2015(第38回日本分子生物学会年会、第88回日本生化学会大会 合同大会)
    • Place of Presentation
      神戸国際会議場他(神戸)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] Recognition and Repair of DNA Double-strand Breaks – Molecular Mechanisms and Implication in Medicine2015

    • Author(s)
      Yoshihisa Matsumoto
    • Organizer
      International Workshop on Ionizing and Non-ionizing Radiation Influence on Structure and Biophysical Properties of Living Cells
    • Place of Presentation
      Tsughkadzor, Armenia (Hotel Russia)
    • Year and Date
      2015-09-25
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Regulation of XRCC4/DNA Ligase IV Complex in DNA Double-strand Break Repair2015

    • Author(s)
      Yoshihisa Matsumoto, Mikoto Fukuchi, Sicheng Liu, Shoji Imamichi, Mukesh K Sharma
    • Organizer
      15th International Congress of Radiation Research
    • Place of Presentation
      京都国際会館(京都)
    • Year and Date
      2015-05-25
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] XRCC4 Phosphorylation By DNA-PK Essential for DNA Double-strand Break Repair2015

    • Author(s)
      Mukesh K Sharma, Shoji Imamichi, Mikoto Fukuchi, Radhika P Kamdar, Scheng Liu, Rujira Wanotayan, Yoshihisa Matsumoto
    • Organizer
      15th International Congress of Radiation Research
    • Place of Presentation
      京都国際会館(京都)
    • Year and Date
      2015-05-25
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Essential Role of Extremely C-terminal Region of XRCC4 Protein in DNA Double-strand Break Repair2015

    • Author(s)
      Rujira Wanotayan, Mikoto Fukuchi, Mukesh Kumar Sharma, Yoshihisa Matsumoto
    • Organizer
      15th International Congress of Radiation Research
    • Place of Presentation
      京都国際会館(京都)
    • Year and Date
      2015-05-25
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Differential Expression of Non-homologous End Joining Proteins in the Brain of Young and Adult2015

    • Author(s)
      Aoi Okawa, Shizuko Kakinuma, Tatsuhiko Imaoka, Yoshiya Shimada, Yoshihisa Matsumoto
    • Organizer
      15th International Congress of Radiation Research
    • Place of Presentation
      京都国際会館(京都)
    • Year and Date
      2015-05-25
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Scanning Mutation Analysis of Conserved Lysine Residues in XRCC42015

    • Author(s)
      Mikoto Fukuchi, Mukesh Kumar Sharma, Rujira Wanotayan, Reiko Watanabe, Shoji Imamichi, Sicheng Liu, Shin-ichiro Kanno, Teruya Nakamura, Akira Yasui, Yoshihisa Matsumoto
    • Organizer
      15th International Congress of Radiation Research
    • Place of Presentation
      京都国際会館(京都)
    • Year and Date
      2015-05-25
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Phosphorylation-mediated Regulation of Apoptosis By NHEJ-protein XRCC42015

    • Author(s)
      Yumi Sunatani, Mukesh Kumar Sharma, Radhika Pankaj Kamdar, Tadashi Matsui, Ryo Sakasai, Mitsumasa Hashimoto, Yoshihisa Matsumoto, Kuniyoshi Iwabuchi
    • Organizer
      15th International Congress of Radiation Research
    • Place of Presentation
      京都国際会館(京都)
    • Year and Date
      2015-05-25
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] XRCC4 Overexpression Predicts Poor Prognosis of Patients with Esophageal Squamous Cell Carcinoma Treated with Radiation Therapy2015

    • Author(s)
      Kohichi Sakata, Masakazu Hori, Masanori Someya, Kensei Nakata, Tadashi Hasegawa, Yoshihisa Matsumoto
    • Organizer
      15th International Congress of Radiation Research
    • Place of Presentation
      京都国際会館(京都)
    • Year and Date
      2015-05-25
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Asparagine 326 in the extremely C-terminal region of XRCC4 is essential for the cell survival after irradiation2015

    • Author(s)
      Rujira Wanotayan, Mikoto Fukuchi, Shoji Imamichi, Mukesh Kumar Sharma, Yoshihisa Matsumoto
    • Organizer
      The 30th RBC-NIRS Intenational Symposium
    • Place of Presentation
      Coop Inn Kyoto (Kyoto, Japan)
    • Year and Date
      2015-02-20 – 2015-02-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] XRCC4 phosphorylation as indicator of DNA-dependent protein kinase functionality in living cells2015

    • Author(s)
      Ravindra Mahadeo Samartha, Mukesh Kumar Sharma, Shoji Imamichi, Mikoto Fukuchi, Yoshihisa Matsumoto
    • Organizer
      第17回癌治療増感研究シンポジウム
    • Place of Presentation
      奈良県文化会館(奈良)
    • Year and Date
      2015-02-06 – 2015-02-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] DNA二重鎖切断の認識・修復の分子機構からがん診断・治療へ2014

    • Author(s)
      松本義久
    • Organizer
      第33回法政大学イオンビーム工学研究所シンポジウム
    • Place of Presentation
      法政大学(東京・小金井)
    • Year and Date
      2014-12-10
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] How do cell find and repair DNA double-strand breaks? – Molecular biology, cancer therapy and radioprotection2014

    • Author(s)
      Matsumoto Y
    • Organizer
      7th Thailand-Japan International Academic Conference 2014
    • Place of Presentation
      東京大学
    • Year and Date
      2014-11-22
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Function of XRCC4 C-terminal Region in DNA Double-Strand Break Repair2014

    • Author(s)
      Wanotayan R, Sharma MK, Matsumoto Y
    • Organizer
      American Nuclear Society Winter 2014
    • Place of Presentation
      Anaheim CA, USA
    • Year and Date
      2014-11-10 – 2014-11-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] DNA二重鎖切断修復におけるDNA-PKのリン酸化の意義:XRCC4リン酸化部位の同定と解析2014

    • Author(s)
      松本 義久
    • Organizer
      日本放射線影響学会第57回大会
    • Place of Presentation
      かごしま県民交流センター(鹿児島)
    • Year and Date
      2014-10-01 – 2014-10-03
    • Related Report
      2014 Annual Research Report
  • [Presentation] XRCC4リジン―アルギニン置換体の解析2014

    • Author(s)
      福地 命, クマール シャルマ ムケシュ, ワノタヤーン ルジラー, 松本 義久
    • Organizer
      日本放射線影響学会第57回大会
    • Place of Presentation
      かごしま県民交流センター(鹿児島)
    • Year and Date
      2014-10-01 – 2014-10-03
    • Related Report
      2014 Annual Research Report
  • [Presentation] Functional studies of XRCC4 C-terminal mutants2014

    • Author(s)
      Rujira Wanotayan, Mikoto Fukuchi, Mukesh Kumar Sharma, Yoshihisa Matsumoto
    • Organizer
      日本放射線影響学会第57回大会
    • Place of Presentation
      かごしま県民交流センター(鹿児島)
    • Year and Date
      2014-10-01 – 2014-10-03
    • Related Report
      2014 Annual Research Report
  • [Presentation] Targeting DNA Ligase IV C-terminus for Radiosensitization2014

    • Author(s)
      Sicheng Liu, Rujira Wanotayan, Mukesh Kumar Sharma, Yoshihisa Matsumoto
    • Organizer
      日本放射線影響学会第57回大会
    • Place of Presentation
      かごしま県民交流センター(鹿児島)
    • Year and Date
      2014-10-01 – 2014-10-03
    • Related Report
      2014 Annual Research Report
  • [Presentation] DNA損傷によって誘発されるXRCC4のリン酸化とDNA-PKcs、ATMの相補的役割2014

    • Author(s)
      松本 義久
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] DNA二重鎖切断修復におけるXRCC4のリン酸化による制御2014

    • Author(s)
      松本 義久, Sharma Mukesh Kumar, 今道 祥二
    • Organizer
      日本放射線腫瘍学会生物部会第52回生物部会学術大会
    • Place of Presentation
      メルパルク京都(京都)
    • Year and Date
      2014-07-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] XRCC4リジン-アルギニン置換体の作製と解析2014

    • Author(s)
      福地 命, Sharma Mukesh Kumar, Wanotayan Rujira, 松本 義久
    • Organizer
      日本放射線腫瘍学会生物部会第52回生物部会学術大会
    • Place of Presentation
      メルパルク京都(京都)
    • Year and Date
      2014-07-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] Involvement of DNA-PK Phosphorylation Sites in XRCC4 in the Functional Regulation of Non-Homologous End Joining Repair Pathway2014

    • Author(s)
      Sharma MK, Imamichi S, Fukuchi M, Kamdar RP, Liu S, Wanotayan R, Matsumoto Y
    • Organizer
      第20回癌治療増感研究会
    • Place of Presentation
      高知県民文化ホール(高知)
    • Year and Date
      2014-06-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] Functional Study of C-Terminal Region of XRCC4 Protein in DNA Double-Strand Break Repair through Non-Homologous End Joining Pathway2014

    • Author(s)
      Wanotayan R, Fukuchi M, Kumar MK, Matsumoto Y
    • Organizer
      第20回癌治療増感研究会
    • Place of Presentation
      高知県民文化ホール(高知)
    • Year and Date
      2014-06-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] Radiosensitization of Human Cells by DNA Ligase IV C-Terminus Ectopic Expression2014

    • Author(s)
      Liu S, Liu X, Wanotayan R, Sharma MK, Yokoya A, Matsumoto Y
    • Organizer
      第20回癌治療増感研究会
    • Place of Presentation
      高知県民文化ホール(高知)
    • Year and Date
      2014-06-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] XRCC4: The Genuine Target of DNA-PK in Non Homologous End Joining2013

    • Author(s)
      Mukesh Kumar Sharma, Radhika Pankaj Kamdar, Shoji Imamichi, Mikoto Fukuchi, Sicheng Liu, Wanotayan Rujira, Yoshihisa Matsumoto
    • Organizer
      3rd Asian Congress of Radiation Research
    • Place of Presentation
      Beijing (Beijing International Convention Center)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Identification of phosphorylation sites in XRCC4 mediating its functional regulation by DNA-PK2013

    • Author(s)
      Mukesh Kumar Sharma, Yoshihisa Matsumoto
    • Organizer
      3rd Asian Congress of Radiation Research
    • Place of Presentation
      Beijing (Beijing International Convention Center)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Mechanisms of the Recognition and Repair of DNA Double-Strand Breaks And Possible Application in Cancer Therapy2013

    • Author(s)
      Yoshihisa Matsumoto
    • Organizer
      The Fourth International Symposium on Innovative Nuclear Energy Systems
    • Place of Presentation
      Tokyo (Tokyo Institute of Technology)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Role of DNA-PKs and ATM in the phosphorylation-mediated regulation of XRCC42013

    • Author(s)
      Shoji Imamichi, Mukesh Kumar Sharma, Yoshihisa Matsumoto
    • Organizer
      29th RBC-NIRS International Symposium
    • Place of Presentation
      Kyoto (Coop Inn Kyoto)
    • Related Report
      2013 Annual Research Report
  • [Presentation] C-terminal region of DNA ligase IV drives XRCC4/DNA ligase IV complex to chromatin2013

    • Author(s)
      Sicheng Liu, Xyunyue Liu, Radhika Pankaj Kamdar, Rujira Wanotayan, Mukesh Kumar Sharma, Noritaka Adachi, Yoshihisa Matsumoto
    • Organizer
      29th RBC-NIRS International Symposium
    • Place of Presentation
      Kyoto (Coop Inn Kyoto)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Visualization of the role of NHEJ inhibition in response to ionizing radiation in HeLa Fucci cells2013

    • Author(s)
      Rujira Wanotayan, Sicheng Liu, Yoshihisa Matsumoto, Akinari Yokoya
    • Organizer
      29th RBC-NIRS International Symposium
    • Place of Presentation
      Kyoto (Coop Inn Kyoto)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Creation and analyses of systematic series of XRCC4 mutants2013

    • Author(s)
      Wanotayan, R., Fukuchi, M., Sharma, M.K., Matsumoto, Y.
    • Organizer
      第19回癌治療増感研究会
    • Place of Presentation
      東京医科歯科大学(東京)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Identification of phosphorylation sites in XRCC4 mediating its functional regulation by DNA-PK2013

    • Author(s)
      Mukesh Kumar Sharma, Radhika Pankaj Kamdar, Shoji Imamichi, Mikoto Fukuchi, Sicheng Liu, Wanotayan Rujira, Yoshihisa Matsumoto
    • Organizer
      第19回癌治療増感研究会
    • Place of Presentation
      東京医科歯科大学(東京)
    • Related Report
      2013 Annual Research Report
  • [Presentation] DNA-PKによる内在性XRCC4リン酸化の検出2013

    • Author(s)
      Mukesh Kumar Sharma, 今道祥二, 松本義久
    • Organizer
      第51 回日本放射線腫瘍学会生物部会学術大会
    • Place of Presentation
      東北大学艮陵会館(仙台)
    • Related Report
      2013 Annual Research Report
  • [Presentation] DNA二重鎖切断修復におけるXRCC4のリン酸化制御へのDNA-PK及ひATM阻害剤の影響2013

    • Author(s)
      今道祥二, 松本義久, シャルマ ムケシュクマール
    • Organizer
      日本放射線影響学会第56回大会
    • Place of Presentation
      クラウンパレス青森(青森)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Role of XRCC4 C-terminal Part in DNA Double-Strand Break Repair Revealed by Systematically Generated Mutants2013

    • Author(s)
      Rujira WANOTAYAN, Mikoto FUKUCHI, Mukesh Kumar SHARMA, Yoshihisa MATSUMOTO
    • Organizer
      日本放射線影響学会第56回大会
    • Place of Presentation
      クラウンパレス青森(青森)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Identification of the phosphorylation sites of XRCC4 by DNA-PK essential for DNA double-strand break repair2013

    • Author(s)
      Mukesh Kumar SHARMA, Shoji IMAMICHI, Radhika Pankaj KAMDAR, Mikoto FUKUCHI, Sicheng LIU, Rujira WANOTAYAN, Yoshihisa MATSUMOTO
    • Organizer
      日本放射線影響学会第56回大会
    • Place of Presentation
      クラウンパレス青森(青森)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Visualization of cell cycle arrest by X-irradiation and NHEJ inhibitors on Hela-Fucci cells2013

    • Author(s)
      Sicheng Liu, Rujira Wanotayan, Yoshihisa Matsumoto, Akinari Yokoya
    • Organizer
      日本放射線影響学会第56回大会
    • Place of Presentation
      クラウンパレス青森(青森)
    • Related Report
      2013 Annual Research Report
  • [Presentation] カスパーセによるXRCC4切断とXRCC4によるCADの核内移行促進機構の解明2013

    • Author(s)
      砂谷優実, カムダル ラディカ パンカジ, シャルマ ムケシュ クマール, 松井 理, 逆井 良, 橋本光正, 松本義久, 岩淵邦芳
    • Organizer
      日本放射線影響学会第56回大会
    • Place of Presentation
      クラウンパレス青森(青森)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Importance of DNA-PK phosphorylation in NHEJ repair and cancer radiotherapy.2013

    • Author(s)
      Sharma, M.K., Matsumoto, Y
    • Organizer
      第15回癌治療増感研究シンポジウム
    • Place of Presentation
      猿沢荘(奈良)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Functional analyses of systematic series of XRCC4 mutants in DNA double-strand break repair.2013

    • Author(s)
      Wanotayan, R., Sharma, M.K., Matsumoto, Y
    • Organizer
      第15回癌治療増感研究シンポジウム
    • Place of Presentation
      猿沢荘(奈良)
    • Related Report
      2012 Annual Research Report
  • [Presentation] In vitroおよび細胞内におけるDNA-PKによるXRCC4のリン酸化の解析(Analysis of XRCC4 phosphorylation in vitro and in cellulo bv DNA-PK)2012

    • Author(s)
      Mukesh Kumar, SHARMA, Rujira WANOTAYAN, 福地 命, 今道祥二, 松本義久
    • Organizer
      日本放射線影響学会第55回大会
    • Place of Presentation
      東北大学(仙台)
    • Related Report
      2012 Annual Research Report
  • [Presentation] アポトーシスで生じたXRCC4N末断片による非DNA損傷性アポトーシスの制御機構2012

    • Author(s)
      橋本優実, Radhika Pankaj KAMDAR, Mukesh Kumar SHARMA, 松井理, 橋本光正,松本義久,岩淵邦芳
    • Organizer
      日本放射線影響学会第55回大会
    • Place of Presentation
      東北大学(仙台)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Regulation of nonhomologous end joining repair mechanism of DNA double-strand break by kinase activity of DNA-PK.2012

    • Author(s)
      Sharma, M.K., Matsumoto, Y
    • Organizer
      28th RBC-NIRS International Symposium
    • Place of Presentation
      コープイン京都(京都)
    • Related Report
      2012 Annual Research Report
  • [Presentation] XRCC4によるASAP複合体精製制御を介したアポトーシス誘導の機構(Mechanism of a poptosis induction via regulation of ASAP complex by XRCC4)2012

    • Author(s)
      砂谷優実, Radhika Pankaj KAMDAR, Mukesh Kumar SHARMA, 松井理, 橋本光正,松本義久,岩淵邦芳
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場他(福岡)
    • Related Report
      2012 Annual Research Report
  • [Remarks] 東京工業大学 科学技術創成研究院 先導原子力研究所 松本研究室

    • URL

      http://www.nr.titech.ac.jp/~yoshim/

    • Related Report
      2015 Annual Research Report
  • [Remarks] 松本研究室ホームページ

    • URL

      http://www.nr.titech.ac.jp/~yoshim/

    • Related Report
      2014 Annual Research Report
  • [Patent(Industrial Property Rights)] DNA依存性プロテインキナーゼ活性の測定方法、被検細胞の放射線感受性の判定方法、被検細胞の癌罹患性の判定方法、DNA依存性プロテインキナーゼの阻害剤又は活性化剤のスクリーニング方法、及びキット2014

    • Inventor(s)
      松本義久、ムケッシュクマールシャルマ、今道祥二、福地命、冨田雅典
    • Industrial Property Rights Holder
      東京工業大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2014-134624
    • Filing Date
      2014-06-30
    • Related Report
      2014 Annual Research Report

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Published: 2012-04-24   Modified: 2019-07-29  

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