Towards preclinical diagnosis of Alzheimer's disease based on the default network activity
| Project/Area Number |
24390292
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Kyoto University |
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Principal Investigator |
FUKUYAMA Hidenao 京都大学, 医学(系)研究科(研究院), 教授 (90181297)
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| Co-Investigator(Kenkyū-buntansha) |
URAYAMA Shin-ichi 京都大学, 大学院医学研究科, 助教 (10270729)
ASO Toshihiko 京都大学, 大学院医学研究科, 助教 (50397543)
MATSUHASHI Masao 京都大学, 学内共同利用施設等, 准教授 (40456885)
OISHI Naoya 京都大学, 大学院医学研究科, 助教 (40526878)
SUZUKI Takashi 京都大学, 大学院医学研究科, 助教 (10572224)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2014: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥10,790,000 (Direct Cost: ¥8,300,000、Indirect Cost: ¥2,490,000)
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| Keywords | 機能的MRI / デフォルトモードネットワーク / アルツハイマー病 / 認知症 / 脳血流 / レーザースペックル血流計 / レーザスペックル血流計 / MEG / 非侵襲的脳機能計測 / レーザースペックル法 |
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| Outline of Final Research Achievements |
Default mode network (DMN) is a large-scale brain network with intriguing properties, but observation of the DMN has been heavily relied on blood flow-based methods such as functional MRI. Our project aimed at establishing measurement of "true" neural activity by using diffusion-weighted functional MRI. Human and animal MRI studies were conducted on DMN connectivity as well as DfMRI signal origin. At the same time, we have newly developed a high-performance measurement system that enables simultaneous measurements of cerebral blood flow changes using laser speckle blood flow imaging and hemodynamic responses using optical intrinsic signal imaging. With the system, we found dynamic changes in cerebral blood flow and hemoglobin with high spatial and temporal resolution during whisker stimulation in a rat brain. These results indicate that our system is useful to elucidate a precise mechanism of neurovascular coupling.
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Report
(4 results)
Research Products
(39 results)
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[Journal Article] Task-specific brain reorganization in motor recovery induced by a hybrid-rehabilitation combining training with brain stimulation after stroke.2015
Author(s)
Koganemaru S, Sawamoto N, Aso T, Sagara A, Ikkaku T, Shimada K, Kanematsu M, Takahashi R, Domen K, Fukuyama H, Mima T.
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Journal Title
Neuroscience Research
Volume: 92
Pages: 29-38
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Nicotinic acetylcholine receptor density in cognitively intact subjects at an early stage of Parkinson's disease2014
Author(s)
Isaias I, Spiegel J, Brumberg J, Cosgrove KP, Marotta G, Oishi N, Higuchi T, Kusters S, Schiller M, Dillmann U, Van Dyck C, Buck A, Herrmann K, Schloegl S, Volkmann J, Lassmann M, Fassbender K, Lorenz R, Samnick S
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Journal Title
Front. Aging Neurosci.
Volume: 6
Pages: 160-160
Related Report
Peer Reviewed / Open Access
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[Journal Article] Silent Information Regulator 2 Homolog 1 Counters Cerebral Hypoperfusion Injury by Deacetylating Endothelial Nitric Oxide Synthase2014
Author(s)
Hattori Y, Okamoto Y, Maki T, Yamamoto Y, Oishi N, Yamahara K, Nagatsuka K, Takahashi R, Kalaria RN, Fukuyama H, Kinoshita M, Ihara M
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Journal Title
Stroke
Volume: 45
Pages: 3403-3411
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Intraoperative dorsal language network mapping by using single-pulse electrical stimulation2014
Author(s)
Yamao Y, Matsumoto R, Kunieda T, Arakawa Y, Kobayashi K, Usami K, Shibata S, Kikuchi T, Sawamoto N, Mikuni N, IkedaA, Fukuyama H, Miyamoto S
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Journal Title
Human Brain Map
Volume: (in press)(E-pub)
Pages: 4345-4361
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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