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Towards preclinical diagnosis of Alzheimer's disease based on the default network activity

Research Project

Project/Area Number 24390292
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Radiation science
Research InstitutionKyoto University

Principal Investigator

FUKUYAMA Hidenao  京都大学, 医学(系)研究科(研究院), 教授 (90181297)

Co-Investigator(Kenkyū-buntansha) URAYAMA Shin-ichi  京都大学, 大学院医学研究科, 助教 (10270729)
ASO Toshihiko  京都大学, 大学院医学研究科, 助教 (50397543)
MATSUHASHI Masao  京都大学, 学内共同利用施設等, 准教授 (40456885)
OISHI Naoya  京都大学, 大学院医学研究科, 助教 (40526878)
SUZUKI Takashi  京都大学, 大学院医学研究科, 助教 (10572224)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2014: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥10,790,000 (Direct Cost: ¥8,300,000、Indirect Cost: ¥2,490,000)
Keywords機能的MRI / デフォルトモードネットワーク / アルツハイマー病 / 認知症 / 脳血流 / レーザースペックル血流計 / レーザスペックル血流計 / MEG / 非侵襲的脳機能計測 / レーザースペックル法
Outline of Final Research Achievements

Default mode network (DMN) is a large-scale brain network with intriguing properties, but observation of the DMN has been heavily relied on blood flow-based methods such as functional MRI. Our project aimed at establishing measurement of "true" neural activity by using diffusion-weighted functional MRI. Human and animal MRI studies were conducted on DMN connectivity as well as DfMRI signal origin. At the same time, we have newly developed a high-performance measurement system that enables simultaneous measurements of cerebral blood flow changes using laser speckle blood flow imaging and hemodynamic responses using optical intrinsic signal imaging. With the system, we found dynamic changes in cerebral blood flow and hemoglobin with high spatial and temporal resolution during whisker stimulation in a rat brain. These results indicate that our system is useful to elucidate a precise mechanism of neurovascular coupling.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (39 results)

All 2015 2014 2013 2012 Other

All Journal Article (20 results) (of which Peer Reviewed: 18 results,  Acknowledgement Compliant: 4 results,  Open Access: 8 results) Presentation (17 results) (of which Invited: 1 results) Book (1 results) Remarks (1 results)

  • [Journal Article] The Uncinate Fasciculus as a Predictor of Conversion from aMCI to Alzheimer Disease2015

    • Author(s)
      Hiyoshi-Taniguchi K, Oishi N, Namiki C, Miyata J, Murai T, Cichocki A, Fukuyama H
    • Journal Title

      J Neuroimaging

      Volume: in press Issue: 5 Pages: 748-753

    • DOI

      10.1111/jon.12196

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional relevance of the precuneus in verbal politeness.2015

    • Author(s)
      Ashizuka A, Mima T, Sawamoto N, Aso T, Oishi N, Sugihara G, Kawada R, Takahashi H, Murai T, Fukuyama H.
    • Journal Title

      Neurosci Res.

      Volume: 91 Pages: 48-56

    • DOI

      10.1016/j.neures.2014.10.009

    • NAID

      120005593691

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Freezing of gait and white matter changes: a tract-based spatial statistics study2015

    • Author(s)
      Iseki K, Fukuyama H, Oishi N, Tomimoto H, Otsuka Y, Nankaku M, Benninger D, Hallett M, Hanakawa T
    • Journal Title

      J Clin Mov Disord

      Volume: in press Issue: 1 Pages: 1-9

    • DOI

      10.1186/s40734-014-0011-2

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hypothalamic-Amygdalar-Brainstem Volume Reduction in a Patient with Narcolepsy Secondary to Diffuse Axonal Injury2015

    • Author(s)
      Walid Y, Sugihara G, Oishi N, Kubota M, Ubukata S, Murai T, Ueda K
    • Journal Title

      J Clin Sleep Med

      Volume: in press

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional Heterogeneity in Default Mode Network Edges2015

    • Author(s)
      Aso T, Fukuyama H
    • Journal Title

      Brain Connectivity

      Volume: in press

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Parkinson's disease patients showed delayed awareness of motor intention.2015

    • Author(s)
      Tabu H, Aso T, Matsuhashi M, Ueki Y, Takahashi R, Fukuyama H, Shibasaki H, Mima T
    • Journal Title

      Neurosci Res.

      Volume: in press Pages: 0-0

    • DOI

      10.1016/j.neures.2015.01.012

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Task-specific brain reorganization in motor recovery induced by a hybrid-rehabilitation combining training with brain stimulation after stroke.2015

    • Author(s)
      Koganemaru S, Sawamoto N, Aso T, Sagara A, Ikkaku T, Shimada K, Kanematsu M, Takahashi R, Domen K, Fukuyama H, Mima T.
    • Journal Title

      Neurosci Res.

      Volume: 92 Pages: 29-38

    • DOI

      10.1016/j.neures.2014.10.004

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Simultaneous Measurement of Local Brain Temperature and Cerebral Blood Flow Change in Rats for Quantitative Functional Brain Imaging2014

    • Author(s)
      Suzuki T, Oishi N, Fukuyama H
    • Journal Title

      Proceedings of the 2014 IEEE International Conference on Complex Medical Engineering

      Volume: 1 Pages: 214-219

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Nicotinic acetylcholine receptor density in cognitively intact subjects at an early stage of Parkinson's disease2014

    • Author(s)
      Isaias I, Spiegel J, Brumberg J, Cosgrove KP, Marotta G, Oishi N, Higuchi T, Kusters S, Schiller M, Dillmann U, Van Dyck C, Buck A, Herrmann K, Schloegl S, Volkmann J, Lassmann M, Fassbender K, Lorenz R, Samnick S
    • Journal Title

      Front. Aging Neurosci.

      Volume: 6 Pages: 160-160

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Voxel-based clustered imaging by multiparameter diffusion tensor images for glioma grading2014

    • Author(s)
      Inano Rika, Oishi Naoya, Kunieda Takeharu, Arakawa Yoshiki, Yamao Yukihiro, Shibata Sumiya, Kikuchi Takayuki, Fukuyama Hidenao, Miyamoto Susumu
    • Journal Title

      NeuroImage: Clinical

      Volume: 5 Pages: 396-407

    • DOI

      10.1016/j.nicl.2014.08.001

    • NAID

      120005477685

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Silent Information Regulator 2 Homolog 1 Counters Cerebral Hypoperfusion Injury by Deacetylating Endothelial Nitric Oxide Synthase2014

    • Author(s)
      Hattori Y, Okamoto Y, Maki T, Yamamoto Y, Oishi N, Yamahara K, Nagatsuka K, Takahashi R, Kalaria RN, Fukuyama H, Kinoshita M, Ihara M
    • Journal Title

      Stroke

      Volume: 45 Issue: 11 Pages: 3403-3411

    • DOI

      10.1161/strokeaha.114.006265

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] アルツハイマー型認知症の評価-C-11 PiB PETなどによるアミロイドイメージング2014

    • Author(s)
      大石直也、福山秀直
    • Journal Title

      INNERVISION

      Volume: 29 Pages: 100-102

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Water diffusion reveals networks that modulate multiregional morphological plasticity after repetitive brain stimulation2014

    • Author(s)
      Abe, M., H. Fukuyama and T. Mima
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume: 111 Issue: 12 Pages: 4608-4613

    • DOI

      10.1073/pnas.1320223111

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Motor recovery and microstructural change in rubro-spinal tract in subcortical stroke2014

    • Author(s)
      Takenobu Y, Hayashi T, Moriwaki H, Nagatsuka, K, Naritomi H, Fukuyama H
    • Journal Title

      Neuroimage: Clinical

      Volume: 4 Pages: 201-208

    • DOI

      10.1016/j.nicl.2013.12.003

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Intraoperative dorsal language network mapping by using single-pulse electrical stimulation.2014

    • Author(s)
      Yamao Y, Matsumoto R, Kunieda T, Arakawa Y, Kobayashi K, Usami K, Shibata S, Kikuchi T, Sawamoto N, Mikuni N, Ikeda A, Fukuyama H, Miyamoto S.
    • Journal Title

      Hum Brain Mapp

      Volume: 印刷中 Issue: 9 Pages: 74-85

    • DOI

      10.1002/hbm.22479

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] アルツハイマー病の画像診断 機能的MRIと拡散強調MRI2014

    • Author(s)
      麻生俊彦、福山秀直
    • Journal Title

      Pharma Medica

      Volume: 32(1) Pages: 23-27

    • Related Report
      2013 Annual Research Report
  • [Journal Article] A comparison of three brain atlases for MCI prediction.2013

    • Author(s)
      Ota K, Oishi N, Ito K, Fukuyama H.
    • Journal Title

      J Neurosci Methods.

      Volume: 221 Pages: 139-150

    • DOI

      10.1016/j.jneumeth.2013.10.003

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of diffusion-weighted fMRI and BOLD fMRI responses in a verbal working memory task.2013

    • Author(s)
      Aso, T., Urayama, S., Fukuyama, H., & Le Bihan, D.
    • Journal Title

      Neuroimage

      Volume: 67 Pages: 25-32

    • DOI

      10.1016/j.neuroimage.2012.11.005

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Challenge to Diffuse Optical Tomography using the Radiative Transport Equation2012

    • Author(s)
      Oishi N, Fukuyama H
    • Journal Title

      Proceedings of the 2012 IEEE International Conference oD Complex Medical Engineering

      Volume: 1 Pages: 261-266

    • DOI

      10.1109/iccme.2012.6275595

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Overlapping but distinct default network functions revealed by independent component analysis2012

    • Author(s)
      Aso T, Fukuyama H
    • Journal Title

      Proceedings of the 2012 IEEE International Conference oD Complex Medical Engineering

      Volume: 1 Pages: 370-375

    • DOI

      10.1109/iccme.2012.6275598

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] FMRIによるNIRS信号源の検証2014

    • Author(s)
      麻生俊彦
    • Organizer
      臨床神経生理学会
    • Place of Presentation
      福岡
    • Year and Date
      2014-11-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] MRIを用いた術前後の運動機能と脳機能ネットワークの解明2014

    • Author(s)
      山尾 幸広,澤本 伸克,國枝 武治,菊池 隆幸,松本 理器,池田 昭夫,高橋 良輔,福 山 秀直,宮本 享
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-11 – 2014-09-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] パーキンソン病および関連疾患におけるNeuroimaging2014

    • Author(s)
      福山秀直
    • Organizer
      Osaka DaT Imaging Conference
    • Place of Presentation
      大阪
    • Year and Date
      2014-08-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] A functional MRI study on thought suppression.2014

    • Author(s)
      Kiyonaka T, Aso, T
    • Organizer
      The 18th Association for the Scientific Study of Consciousness
    • Place of Presentation
      オーストラリア
    • Year and Date
      2014-07-16 – 2014-07-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] Brain imaging techniques in CNS disorders -Toward in vivo observation of neuron-glia interaction dynamics2014

    • Author(s)
      Aso T, Fukuyama H
    • Organizer
      DFG-JSPSシンポジウム
    • Place of Presentation
      ドイツ
    • Year and Date
      2014-06-29 – 2014-06-30
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Simultaneous Measurement of Local brain temperature and Cerebral Blood Flow Change in Rats for Quantitative Functional Brain Imaging.2014

    • Author(s)
      Suzuki T., Oishi N., Fukuyama H.
    • Organizer
      International Conference on Complex Medical Engineering 2014 Taipei
    • Place of Presentation
      台湾
    • Year and Date
      2014-06-25 – 2014-06-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Structural MRI for early diagnosis of dementia2014

    • Author(s)
      Oishi N.
    • Organizer
      International Conference on Complex Medical Engineering 2014 Taipei
    • Place of Presentation
      台湾
    • Year and Date
      2014-06-25 – 2014-06-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Reliable MEG Spike Foci Estimation by Temporal Spread Imaging with Random Trigger Test.2014

    • Author(s)
      Matsuhashi M., Mima T., Fukuyama H., Matsumoto R., Kobayashi K.
    • Organizer
      International Conference on Complex Medical Engineering 2014 Taipei
    • Place of Presentation
      台湾
    • Year and Date
      2014-06-25 – 2014-06-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 脳機能解析におけるビッグデータ解析2014

    • Author(s)
      松橋眞生
    • Organizer
      第55回日本神経学会学術大会
    • Place of Presentation
      福岡
    • Year and Date
      2014-05-21 – 2014-05-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] Sequential abnormal events in high temperature superconducting MRI magnet2014

    • Author(s)
      Urayama S., Terao Y., Ozaki O., Kitaguchi H., Kawashima S., Hase T., Sato K., Fukuyama H.
    • Organizer
      22nd International Society for Magnetic Resonance in Medicine Milan
    • Place of Presentation
      イタリア
    • Year and Date
      2014-05-15
    • Related Report
      2014 Annual Research Report
  • [Presentation] High Temperature Superconducting (HTS) Magnet for MRI2014

    • Author(s)
      Urayama S.
    • Organizer
      4th International Conference on Superconductivity and Magnetizm Antalya
    • Place of Presentation
      トルコ
    • Year and Date
      2014-04-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] 機能的MRIによる皮質ネットワークの実在性の検証2014

    • Author(s)
      麻生俊彦、浦山慎一、福山秀直
    • Organizer
      第16回日本ヒト脳機能マッピング学会
    • Place of Presentation
      仙台市
    • Related Report
      2013 Annual Research Report
  • [Presentation] Simultaneous Measurement of Local Brain Temperature and Cerebral Blood Flow Change in Rats for Quantitative Functional Brain Imaging2014

    • Author(s)
      Takashi Suzuki, Naoya Oishi, Hidenao Fukuyama
    • Organizer
      International Conference on Complex Medical Engineering
    • Place of Presentation
      Taipei, Taiwan
    • Related Report
      2013 Annual Research Report
  • [Presentation] Comparison of Spin-echo and Gradient-echo BOLD Signals in The Default Network2013

    • Author(s)
      Toshihiko Aso, Shin-ichi Urayama, Hidenao Fukuyama
    • Organizer
      The 19th Annual Meeting of the Organization for Human Brain Mapping
    • Place of Presentation
      Seattle, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Predicting Alzheimer’s disease using a voxel-based approach: A comparison of three different atlases2013

    • Author(s)
      Kenichi Ota, Naoya Oishi, Kengo Ito, Hidenao Fukuyama
    • Organizer
      The 19th Annual Meeting of the Organization for Human Brain Mapping
    • Place of Presentation
      Seattle, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] MCIにおける脳糖代謝分布パターンの多様性とADへの移行予測に関する検討2013

    • Author(s)
      大石直也、伊藤健吾、福山秀直
    • Organizer
      第54回日本神経学会総会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] 赤外温度イメージングを用いたラット局所脳神経活動の評価2012

    • Author(s)
      鈴木 崇士
    • Organizer
      第24回日本脳循環代謝学会総会
    • Place of Presentation
      リーガロイヤルホテル広島(広島県)
    • Year and Date
      2012-11-08
    • Related Report
      2012 Annual Research Report
  • [Book] 認知症と画像診断(総論).脳とこころのプライマリケア2知能の衰え2013

    • Author(s)
      大石直也、福山秀直
    • Publisher
      シナジー
    • Related Report
      2013 Annual Research Report
  • [Remarks] 研究業績

    • URL

      http://hbrc.kuhp.kyoto-u.ac.jp/AnnualBulletin.html

    • Related Report
      2014 Annual Research Report

URL: 

Published: 2012-04-24   Modified: 2019-07-29  

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