Development of an autonomous and flexible artificial heart control method to intervene in control of the cardiovascular system
Project/Area Number |
24390308
|
Research Category |
Grant-in-Aid for Scientific Research (B)
|
Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
General surgery
|
Research Institution | National Cardiovascular Center Research Institute |
Principal Investigator |
OHNUMA Kentaro 独立行政法人国立循環器病研究センター, 研究所, 特任研究員 (50527992)
|
Co-Investigator(Kenkyū-buntansha) |
TATSUMI Eisuke 独立行政法人国立循環器病研究センター, 研究所, 部長 (00216996)
SUMIKURA Hirohito 独立行政法人国立循環器病研究センター, 研究所, 特任研究員 (20433998)
|
Co-Investigator(Renkei-kenkyūsha) |
TAKEWA Yoshiaki 独立行政法人国立循環器病研究センター, 研究所, 室長 (20332405)
TSUKIYA Tomonori 独立行政法人国立循環器病研究センター, 研究所, 室長 (00311449)
MIZUNO Toshihide 独立行政法人国立循環器病研究センター, 研究所, 室長 (40426515)
HOMMA Akihiko 東京電機大学, 理工学部, 教授 (20287428)
KISHIMOTO Yuichiro 独立行政法人国立循環器病研究センター, 研究所, 流動研究員
KISHIMOTO Satoru 独立行政法人国立循環器病研究センター, 研究所, 流動研究員 (60714532)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Fiscal Year 2014: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2013: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2012: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
|
Keywords | 人工心臓 / 駆動制御 / 生体計測 / 確率過程 / 相互引き込み |
Outline of Final Research Achievements |
In this study, we developed an autonomous and flexible artificial heart control method to intervene in control of the cardiovascular system. First, the flow rate control algorithm was constructed on the basis of a stochastically searching algorithm. The validity of the constructed control algorithm was examined in a mock circuit simulated a left heart bypass support. As a result, in response to a low-flow state with the different causes, the flow rate of the VAD reached a target value with self-adaptive behavior without designing the detailed control rule based on the experience or the model of the cardiovascular system. Next, we analyzed RR interval of ECG obtained from an animal model with pulsatile LVAD. It was confirmed that the heart rate was attracted to the beating rate of the VAD in this analysis. The algorithm to intervene in control of the cardiovascular system was constructed on the basis of this result and it was integrated with the autonomous flow rate control algorithm.
|
Report
(4 results)
Research Products
(40 results)
-
[Journal Article] Development of a flow rate monitoring method for the wearable ventricular assist device driver2014
Author(s)
Ohnuma K, Homma A, Sumikura H, Tsukiya T, Takewa Y, Mizuno T, Mukaibayashi H, Kojima K, Katano K, Taenaka Y, Tatsumi E
-
Journal Title
J Artif Organs
Volume: Published online
Issue: 2
Pages: 106-113
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
-
-
[Journal Article] Fundamental Examination of an Application of Wearable Pneumatic Drive Unit for Pneumatic Total Artificial Heart System2014
Author(s)
住倉博仁, 本間章彦, 大沼健太郎, 妙中義之, 武輪能明, 梅木昭秀, 水野敏秀, 築谷朋典, 片桐伸将, 藤井 豊、角田幸秀、向林 宏、片野一夫、福井康裕、巽 英介
-
Journal Title
IEEJ Transactions on Electronics, Information and Systems
Volume: 134
Issue: 6
Pages: 839-847
DOI
NAID
ISSN
0385-4221, 1348-8155
Related Report
Peer Reviewed
-
-
-
[Presentation] 腎動脈補助用カテーテル式補助循環装置の開発と評価2015
Author(s)
住倉博仁, 大沼健太郎, 花田 繁, 築谷朋典, 水野敏秀, 本間章彦, 向林 宏, 小嶋孝一, 武輪能明, 巽 英介
Organizer
人工心臓と補助循環懇話会学術集会 (43)
Place of Presentation
熱海市
Year and Date
2015-02-20 – 2015-02-21
Related Report
-
[Presentation] 動圧浮上式超小型遠心ポンプを用いた体外設置型左心補助システムの慢性動物実験評価2015
Author(s)
岸本 諭, 武輪能明, 築谷朋典, 水野敏秀, 住倉博仁, 藤井 豊, 大沼健太郎, 東郷好美, 伊達数馬, 片桐伸将, 角田, 幸秀, 巽 英介
Organizer
人工心臓と補助循環懇話会学術集会 (43)
Place of Presentation
熱海市
Year and Date
2015-02-20 – 2015-02-21
Related Report
-
[Presentation] 体外設置式補助人工心臓用モニタリングシステムの開発2014
Author(s)
大沼健太郎, 住倉博仁, 本間章彦, 築谷朋典, 武輪能明, 水野敏秀, 妙中義之, 片野一夫, 小嶋孝一, 向林 宏, 巽 英介
Organizer
日本人工臓器学会大会 (52)
Place of Presentation
札幌市
Year and Date
2014-10-17 – 2014-10-19
Related Report
-
[Presentation] 体外設置式補助人工心臓用小型ポータブル駆動装置の開発2014
Author(s)
大沼健太郎, 住倉博仁, 本間章彦, 築谷朋典, 武輪能明, 水野敏秀, 向林 宏, 片野一夫, 小嶋孝一, 妙中義之, 巽 英介
Organizer
日本人工臓器学会大会 (52)
Place of Presentation
札幌市
Year and Date
2014-10-17 – 2014-10-19
Related Report
-
[Presentation] Development of a compact drive unit with high controllability for a pneumatic total artificial heart system2014
Author(s)
Ohnuma K, Sumikura H, Homma A, Tsukiya T, Takewa Y, Mizuno T, Katano K, Kojima K, Mukaibayashi H, Taenaka Y, Tatsumi E.
Organizer
ESAO
Place of Presentation
Rome
Year and Date
2014-09-17
Related Report
-
-
-
[Presentation] Development or a compact pneumatic drive unit with a DC servo motor for a ventricular assist device2014
Author(s)
Sumikura H, Ohnuma K, Homma A, Taenaka Y, Takewa Y, Tsukiya T, Mizuno T, Mukaibayashi H, Katano K, Kojima K, Fukui Y, Tatsumi E.
Organizer
ASAIO
Place of Presentation
Washington D.C.
Year and Date
2014-06-18 – 2014-06-21
Related Report
-
-
-
-
-
-
-
-
-
-
[Presentation] In vitro and in vivo evaluation of a compact wearable pneumatic drive unit for a ventricular assist device2013
Author(s)
Sumikura H, Homma A, Ohnuma K, Taenaka Y, Takewa Y, Mizuno T, Tsukiya T, Katagiri N, Kakuta Y, Mukaibayashi H, Katano K, Kojima K, Fukui Y, Tatsumi E
Organizer
American Society for Artificial Internal Organs (59)
Place of Presentation
Chicago
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-