Establishment of radioimmunotherapy for advanced rectal cancer; Induction of efficient abscopal effect
Project/Area Number |
24390309
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Digestive surgery
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Research Institution | The University of Tokyo |
Principal Investigator |
KITAYAMA Joji 東京大学, 医学部附属病院, 准教授 (20251308)
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Co-Investigator(Kenkyū-buntansha) |
SUNAMI Eiji 東京大学, 医学部附属病院, 講師 (70345205)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2014: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2012: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
|
Keywords | abscopal effect / 免疫放射線療法 / apscopal / phospatydyl serine / PSPLA-1 / 直腸癌 / 放射線療法 / abscopal / 放射線 / 肺転移 |
Outline of Final Research Achievements |
The addition of lentinan, anti-tumor polysaccharide isolated from the fruit body of shiitake, on radiation to subcutaneous tumor of LuM-1 increased the number of Gr-1(+)CD11b(+) MDSC in splenocytes, although it could not induce the augment of antitumor effects of irradiated tumor as well as non-irradiated lung metastasis. Transfection of PS-PLA1 to LuM-1 can induce PS expression of irradiated cells. The effect of PS-PLA1 on radiosensitivity is under investigation. On the other hand, in patients with rectal cancer who received neoadjuvant chemoradiotherapy (CRT), the response is significantly associated with preoperative number of CD4(+) helper T lymphocytes, as well as platelet number, soluble CD40-ligand (sCD40L). Altogether, our data suggest that the tumor response of rectal cancer against RT is at least partly dependent on host immune response. Combination of immunotherapy to conventional (chemo)radiotherapy is a new approach for the improvement of the treatment of rectal cancer.
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Report
(4 results)
Research Products
(11 results)
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[Journal Article] Prognostic impact of primary tumor resection and lymph node dissection in stage IV colorectal cancer with unresectable metastasis: a propensity score analysis in a multicenter retrospective study.2014
Author(s)
Ishihara S, Hayama T, Yamada H, Nozawa K, Matsuda K, Miyata H, Yoneyama S, Tanaka T, Tanaka J, Kiyomatsu T, Kawai K, Nozawa H, Kanazawa T, Kazama S, Yamaguchi H, Sunami E, Kitayama J, Hashiguchi Y, Sugihara K, Watanabe T.
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Journal Title
Ann Surg Oncol
Volume: 21
Issue: 9
Pages: 2949-55
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Prognostic impact of tumor location in stage IV colon cancer: a propensity score analysis in a multicenter study.2014
Author(s)
Ishihara S, Nishikawa T2, Tanaka T2, Tanaka J2, Kiyomatsu T2, Kawai K2, Hata K2, Nozawa H2, Kanazawa T2, Kazama S2, Yamaguchi H2, Sunami E2, Kitayama J2, Hashiguchi Y3, Sugihara K4, Watanabe T5.
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Journal Title
Int J Surg.
Volume: 12(9)
Issue: 9
Pages: 925-30
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] 局所進行直腸癌に対する術前化学放射線療法に関する検討2014
Author(s)
須並 英二,川合 一茂,清松 知充,風間 伸介,野澤 宏彰,金沢 孝満,田中 潤一郎,田中 敏明,米山 さとみ,室野 浩司,山口 博紀,石原 聡一郎,北山 丈二,渡邉 聡明
Organizer
第114回日本外科学会定期学術集会
Place of Presentation
国立京都国際会館(京都市)
Year and Date
2014-04-03 – 2014-04-05
Related Report
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