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macro-cosmos in interaction between cancer and host microenvironments.

Research Project

Project/Area Number 24390315
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Digestive surgery
Research InstitutionOsaka University

Principal Investigator

YAMAMOTO Hirofumi  大阪大学, 医学(系)研究科(研究院), 准教授 (30322184)

Co-Investigator(Kenkyū-buntansha) MORI Masaki  大阪大学, 大学院医学系研究科, 教授 (70190999)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2014: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2013: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2012: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
Keywordshypoxia / microRNA / micrometastasis / C4.4A / invasion / disease recurrence / 微小転移 / 低酸素 / 核酸医薬 / ナノデリバリーシステム / 骨髄DTC / 腫瘍血管分化 / ナノデリバリー / 大腸癌のmicroRNA / 癌・間質転換 / 骨髄のmicroRNA
Outline of Final Research Achievements

Cancer progression should be understood with respect to cancer features as well as the biological response of the patient’ body. To concur cancers we need to understand tumor behaviors from early cancers to advanced ones. In this project we successfully clarified clinical significance of very early tumor cells, role of a key molecule involved in EMT, role of a hypoxic condition surrounding tumor cells in tumor progression, and we developed a novel nucleic acid medicine against therapy-resistant cancers.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (28 results)

All 2015 2014 2013 2012

All Journal Article (14 results) (of which Peer Reviewed: 13 results) Presentation (11 results) Patent(Industrial Property Rights) (3 results) (of which Overseas: 1 results)

  • [Journal Article] A glucose carbonate apatite complex exhibits in vitro and in vivo anti- tumour effects.2015

    • Author(s)
      Yamamoto H, Wu X, Nakanishi H, Yamamoto Y, Uemura M, Hata T, Nishimura J, Takemasa I, Mizushima T, Sasaki J, Imazato S, Matsuura N, Doki Y, Mori M.
    • Journal Title

      Sci Rep.

      Volume: 5 Pages: 7742-7742

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Innovative Delivery of siRNA to Solid Tumors by Super Carbonate Apatite.2015

    • Author(s)
      Wu X, Yamamoto H, Nakanishi H, Yamamoto Y, Inoue A, Tei M, Hirose H, Uemura M, Nishimura J, Hata T, Takemasa I, Mizushima T, Hossain S, Akaike T, Matsuura N, Doki Y, Mori M.
    • Journal Title

      PLoS One

      Volume: 10(3)

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Concurrent Targeting of KRAS and AKT by MiR-4689 Is a Novel Treatment Against Mutant KRAS Colorectal Cancer.2015

    • Author(s)
      Hiraki M, Nishimura J, Takahashi H, Wu X, Takahashi Y, Miyo M, Nishida N, Uemura M, Hata T, Takemasa I, Mizushima T, Soh JW, Doki Y, Mori M, Yamamoto H.
    • Journal Title

      Mol Ther Nucleic Acids

      Volume: 4

    • NAID

      130005161476

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Cancer Reprogramming Method Using MicroRNAs as a Novel Therapeutic Approach against Colon Cancer : Research for Reprogramming of Cancer Cells by MicroRNAs.2014

    • Author(s)
      Miyazaki S, Yamamoto H, Miyoshi N, Wu X, Ogawa H, Uemura M, Nishimura J, Hata T, Takemasa I, Mizushima T, Konno M, Doki Y, Mori M, Ishii H.
    • Journal Title

      A Cancer Reprogramming Method Using MicroRNAs as a Novel Therapeutic Approach against Colon Cancer : Research for Reprogramming of Cancer Cells by MicroRNAs.

      Volume: Nov 11. [Epub ahead of print]

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MicroRNA-29b is a Novel Prognostic Marker in Colorectal Cancer.2014

    • Author(s)
      Inoue A, Yamamoto H, Uemura M, Nishimura J, Hata T, Takemasa I, Ikenaga M, Ikeda M, Murata K, Mizushima T, Doki Y, Mori M.
    • Journal Title

      Ann Surg Oncol.

      Volume: Dec 4. [Epub ahead of print]

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] SCGB2A1 is a novel prognostic marker for colorectal cancer associated with chemoresistance and radioresistance.2014

    • Author(s)
      Munakata K, Uemura M, Takemasa I, Ozaki M, Konno M, Nishimura J, Hata T, Mizushima T, Haraguchi N, Noura S, Ikenaga M, Okamura S, Fukunaga M, Murata K, Yamamoto H, Doki Y, Mori M.
    • Journal Title

      Int J Oncol

      Volume: 44(5) Pages: 1521-1528

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Decreased miR340 expression in bone marrow is associated with liver metastasis of colorectal cancer.2014

    • Author(s)
      Takeyama H et al.
    • Journal Title

      Mol Cancer Ther.

      Volume: inpress

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of angiopoietin 2 attenuates lumen formation of tumor associated vessels in vivo.2013

    • Author(s)
      Suzuki R et al.
    • Journal Title

      Int J Oncol

      Volume: 43 Issue: 5 Pages: 1447-55

    • DOI

      10.3892/ijo.2013.2076

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Concurrent expression of C4.4A and Tenascin-C in yumor cells relates to poor prognosis of esophageal squamous cell carcinoma2013

    • Author(s)
      Ohtsuka M et al.
    • Journal Title

      Int J Oncol

      Volume: 43 Issue: 2 Pages: 439-46

    • DOI

      10.3892/ijo.2013.1956

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fabrication and intracellular delivery of Doxorubicin/Carbonate Apatite Nanocomposites : Effiect on growth retardation of established Colon Tumor.2013

    • Author(s)
      Hossain S, Yamamoto H, Chowdhury EH, Wu x, Akaike T, et.al
    • Journal Title

      PLoS One

      Volume: 8 Issue: 4 Pages: e60428-e60428

    • DOI

      10.1371/journal.pone.0060428

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] C4.4A expression is associated with a poor prognosis of esophageal squamous cell carcinoma2013

    • Author(s)
      Ohtuska Met al.
    • Journal Title

      Int J Oncol

      Volume: 20 Issue: 8 Pages: 2699-705

    • DOI

      10.1245/s10434-013-2900-2

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] C4. 4A Expression Is Associated wilh a Poor Prognosis of Esophageal SqualouS Cell Carcinoma.2013

    • Author(s)
      Ohtsuka M
    • Journal Title

      Ann Surg Oncol.

      Volume: (in press)

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Distinct expression of C4. 4A in colorectal cancer detected by different antibodies.2013

    • Author(s)
      Yamamoto H
    • Journal Title

      Int J Oncol.

      Volume: 42 Pages: 197-201

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] C4.4A is associated with tumor budding and epithlial-mesenchymal transition of colorectal cancer.2012

    • Author(s)
      Oshiro R
    • Journal Title

      Cancer Sci.

      Volume: 103 Pages: 1155-64

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] シンポジウム 3 「大腸癌治療におけるバイオマーカー」microRNAによる大腸癌の診断と治療への取組み2014

    • Author(s)
      山本浩文、森正樹
    • Organizer
      第69回日本大腸肛門病学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] Super carbonate apatite as simplified systemic nanoparticle carrier.2014

    • Author(s)
      Hirofumi Yamamoto, Xin Wu, Susumu Miyazaki, Mamoru Uemura, Taishi Hata, Junichi Nishimura, Ichiro Takemasa, Tsunekazu Mizushima, Yuichiro Doki, Masaki Mori
    • Organizer
      AACR annual meeting
    • Place of Presentation
      San Diego
    • Year and Date
      2014-05-03
    • Related Report
      2014 Annual Research Report
  • [Presentation] リンパ節中の微小転移量はStage II 大腸癌の再発率を規定する2013

    • Author(s)
      山本浩文 他
    • Organizer
      第68回日本消化器外科学会 シンポジウム1
    • Place of Presentation
      宮崎
    • Related Report
      2013 Annual Research Report
  • [Presentation] 食道癌におけるC4.4A発現と予後についての検討2013

    • Author(s)
      大塚正久 他
    • Organizer
      第1143回日本外科学会
    • Place of Presentation
      福岡
    • Related Report
      2013 Annual Research Report
  • [Presentation] 大腸癌におけるC4.4A発現とEMTとの関連性について2013

    • Author(s)
      大塚正久 他
    • Organizer
      第68回日本消化器外科学会
    • Place of Presentation
      宮崎
    • Related Report
      2013 Annual Research Report
  • [Presentation] 10ナノスケール超微細粒子の全身投与はマウス固形腫瘍への核酸デリバリー効果を示した2013

    • Author(s)
      呉 しん 他
    • Organizer
      第51回日本癌治療学会
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] 食道癌におけるC4. 4A発現の意義2012

    • Author(s)
      大塚正久、山本浩文、森正樹
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌 ロイトン札幌(招待講演)
    • Year and Date
      2012-09-21
    • Related Report
      2012 Annual Research Report
  • [Presentation] 転移遺伝子C4. 4Aの細胞外基質構成因子への影響2012

    • Author(s)
      大塚正久、山本浩文、森正樹
    • Organizer
      第22回日本サイトメトリー学会 学術集会
    • Place of Presentation
      千里ライフサイエンスセンター(招待講演)
    • Year and Date
      2012-06-30
    • Related Report
      2012 Annual Research Report
  • [Presentation] 大腸癌における先進部C4. 4A発現とEMTとの関連2012

    • Author(s)
      大塚正久、山本浩文、森正樹
    • Organizer
      第16回日本がん分子標的治療学会
    • Place of Presentation
      小倉 西日本総合展示場(招待講演)
    • Year and Date
      2012-06-28
    • Related Report
      2012 Annual Research Report
  • [Presentation] 転移遺伝子C4. 4Aの細胞外基質構成因子への影響2012

    • Author(s)
      大塚正久、山本浩文、森正樹
    • Organizer
      第112回日本外科学会定期学術集会
    • Place of Presentation
      千葉 幕張メッセ(招待講演)
    • Year and Date
      2012-04-14
    • Related Report
      2012 Annual Research Report
  • [Presentation] C4. 4A IS a candidate prognostic marker of esophageal cancer by association with Tenascin-C2012

    • Author(s)
      M Ohtsuka, H Yamamoto, M Mori
    • Organizer
      Nlnth AACR-Japanese Cancer Association joint conference
    • Place of Presentation
      Hawaii. Maui, Hyatt Regency laui(招待講演)
    • Year and Date
      2012-02-23
    • Related Report
      2012 Annual Research Report
  • [Patent(Industrial Property Rights)] 抗腫瘍効果を有する新規microRNA2014

    • Inventor(s)
      山本浩文 他
    • Industrial Property Rights Holder
      山本浩文 他
    • Industrial Property Rights Type
      特許
    • Filing Date
      2014-03-04
    • Related Report
      2013 Annual Research Report
  • [Patent(Industrial Property Rights)] Pharmaceutical composition for targeting cancer using carbonate apatite nanoparticle2013

    • Inventor(s)
      Yamamoto H et al.
    • Industrial Property Rights Holder
      Yamamoto H et al.
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-08-27
    • Related Report
      2013 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] miR-340を用いた大腸癌の治療剤2013

    • Inventor(s)
      山本浩文 他
    • Industrial Property Rights Holder
      山本浩文 他
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-11-05
    • Related Report
      2013 Annual Research Report

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Published: 2012-04-24   Modified: 2019-07-29  

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