Development of glycoprotein-biomrkers for biliary tract cancers and establishment of novel diagnostic system using the combination of these biomarkers
| Project/Area Number |
24390323
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAKAYAMA Masamiti 東京女子医科大学, 医学部, 講師 (00338980)
ARIIZUMI Syunichi 東京女子医科大学, 医学部, 講師 (40277158)
UTSUNOMIYA Hirohuto 和歌山県立医科大学, 中央機器施設, 准教授 (60264876)
SHODA Junichi 筑波大学, 医学医療系, 教授 (90241827)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2014: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2012: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
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| Keywords | 胆道癌 / 糖鎖構造解析 / レクチン / 糖蛋白質 / バイオマーカー / 肝内胆管癌 / 糖鎖医学 / 胆道癌モデル |
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| Outline of Final Research Achievements |
We have found a biliary tract cancer-specific glycoprotein biomarker, that is named WFA-positive sialyl-MUC1 (WFA-MUC1), and established a high sensitive assay system. In this study, we measured the levels of WFA-MUC1 in the serum from biliary tract cancers and intrahepatic cholangiocarcinoima under the project of multicenter-based clinical trial, and discuss the clinical significance of this biomarker. The serum concentraions of WFA-MUC1 were significantly higher in the cases of biliary tract cancers and intrahepatic cholangiocarcinoma than in those of benign biliary tract diseases and controls. The serum levels were not different in terms of the tumor stage and histology. The ROC analysis revealed that the capability of WFA-MUC1 to distinguish biliary tract cancers from benign diseases was superior to those of CA19-9 and CEA. Determination of WFA-MUC1 in the serum may be useful for the clinical practice of biliary tract cancers and intrahepatic cholangiocarcinoima.
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Report
(4 results)
Research Products
(121 results)
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[Journal Article] 特集 膵癌に対する術前治療をめぐって Borderline resectable膵癌に対する化学放射線療法を用いた治療戦略2014
Author(s)
羽鳥隆, 鈴木修司, 大島奈々, 鈴木隆二, 君島映, 出雲渉, 古川徹, 田原純子, 高山敬子, 清水京子, 白鳥敬子, 三橋紀夫, 山本雅一*
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Journal Title
胆と膵
Volume: 35
Pages: 43-47
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] 特集 膵癌に対する術前治療をめぐって2014
Author(s)
羽鳥隆, 鈴木修司, 大島奈々, 鈴木隆二, 君島映, 出雲渉, 古川徹, 田原純子, 高山敬子, 清水京子, 白鳥敬子, 三橋紀夫, 山本雅一*
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Journal Title
胆と膵
Volume: 35
Pages: 43-47
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] 特集 消化器外科におけるチーム医療 食道癌治療におけるチーム医療の現状と展望2014
Author(s)
成宮孝祐, 太田正穂, 工藤健司, 佐藤拓也, 白井雄史, 金子由香, 伊藤俊一, 堀部達也, 工藤弦, 菊地剛, 山中昭広, 井手博子, 小谷透, 山本雅一
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Journal Title
消化器外科
Volume: 37
Pages: 335-341
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] 糖原病Ia型に合併した多発幹細胞腺腫の1例2014
Author(s)
植村修一郎, 有泉俊一, 高橋豊, 大森亜紀子, 小寺由人, 片桐聡, 橋本悦子, 中野雅行, 山本雅一
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Journal Title
日本消化器病学会雑誌
Volume: 111
Pages: 787-796
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Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Clinicopathological characterization of so-called "cholangiocarcinoma with intraductal papillary growth" with respect to "intraductal papillary neoplasm of bile duct (IPNB)".2014
Author(s)
Nakanuma Y, Sato Y, Ojima H, Kanai Y, Aishima S, Yamamoto M, Ariizumi S, Furukawa T, Hayashi H, Unno M, Ohta T
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Journal Title
International Journal of Clinical and Experimental Pathology
Volume: 7
Pages: 3112-3122
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Acceleration training for management of non-alcoholic fatty liver disease: a pilot study.2014
Author(s)
Oh S, Shida T, Onozuka T, Maruyama T, Eguchi K, Isobe T, Okamoto Y, Someya N, Tanaka K, Tozawa A, Arai E, Shoda J.
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Journal Title
Ther Clin Risk Manag
Volume: 10
Pages: 925-936
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Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Peroxidoxin I plays a ptotective role against UVA irradiation through reduction of oxidative stress.2014
Author(s)
Ito T, Kimura S, Seto K, Warabi E, Kawauchi Y, Shoda J, Tabuchi K, Yamagata K, Hasegawa S, Bukawa H, Ishii T, Yanagawa T.
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Journal Title
J Dermatol Sci
Volume: 74
Pages: 9-17
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Expression of N-acetylglucosaminyltransferase V in the subserosal layer correlates with postsurgical survival of pathological tumor stage 2 carcinoma of the gallbladder.2014
Author(s)
Onuki, K., Sugiyama, H., Ishige, K., Kawamoto, T., Ota, T., Ariizumi, S., Yamato, M., Kadota, S., Takeuchi, K., Ishikawa, A., Onodera, M., Onizawa, K., Yamamoto, M., Miyoshi, E., Shoda, J.
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Journal Title
J Gastroenterol
Volume: 49
Pages: 702-714
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Expression of N-acetylglucosaminyltransferase V in the subserosal layer correlates with postsurgical survival of pathological tumor stage 2 carcinoma of the gallbladder.2013
Author(s)
Onuki K, Sugiyama H, Ishige K, Kawamoto T, Ota T, Ariizumi S, Yamato M, Kadota S, Takeuchi K, Ishikawa A, Onodera M, Onizawa K, Yamamoto M, Miyoshi E, Shoda J
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Journal Title
J Gastroenterol
Volume: 49
Pages: 702-714
Related Report
Peer Reviewed
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[Journal Article] Deletion of Nrf2 leads to rapid progression of steatohepatitis in mice fed atherogenic plus high-fat diet2013
Author(s)
Okada K, Warabi E, Sugimoto H, Horie M, Gotoh N, Tokushige K, Hashimoto E, Utsunomiya H, Takahashi H, Ishii T, Yamamoto M, Shoda J
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Journal Title
J Gastroenterol
Volume: 48
Pages: 620-632
NAID
Related Report
Peer Reviewed
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[Journal Article] Glycoproteomics-based cancer marker discovery adopting dual enrichment with Wisteria floribunda agglutinin for high specific glyco-diagnosis of cholangiocarcinoma.2013
Author(s)
Matsuda A, Kuno A, Matsuzaki H, Kawamoto T, Shinkai T, Nakanuma Y, Yamamoto M, Ohkohchi N, Ikehara Y, Shoda J, Hirabayashi J, Narimatsu H
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Journal Title
J Proteomics
Volume: 85
Pages: 1-11
DOI
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Peer Reviewed
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[Journal Article] Novel virtual hepatectomy is useful is for evaluation of the portal territory for anatomical sectionectomy,segmentsctomy,and hemihepatectomy2013
Author(s)
Ariizumi S, Takahashi Y, Kotera Y, Omori A, Yoneda G, Mu H, Katagiri S, Egawa H, Yamamoto M
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Journal Title
JHBPS
Volume: 20
Pages: 396-402
Related Report
Peer Reviewed
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[Journal Article] Disease recurrence plays a minor role as a cause for retransplantation after living-donor liver transplantation for primary biliary cirrhosis:A multicenter studt in Japan2013
Author(s)
Egawa H, Nakanura Y, Maehara Y, Uemoto S, Eguchi S, Sato Y, Shirabe K, Takatsuki M, Mori A, Yamamoto M, Tsubouchi H
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Journal Title
Hepatology Res
Volume: 43
Pages: 502-507
Related Report
Peer Reviewed
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[Presentation] 肝切除周術期管理の工夫2014
Author(s)
山本雅一
Organizer
第2回広島周術期フォーラム
Place of Presentation
ANAクラウンプラザホテル広島（広島県広島市）
Year and Date
2014-07-02
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[Presentation] （シンポジウム1 早期肝細胞癌の基礎・診断・治療・予後）Glypican3陽性の早期肝細胞癌は二次発癌が高率である2014
Author(s)
有泉俊一, ChenI-pei, 片桐聡, 小寺由人, 高橋豊, 大森亜紀子, 山下信吾, 尾形哲, 江川裕人, 中野雅行, 山本雅一
Organizer
第50回日本肝癌研究会
Place of Presentation
国立京都国際会館（京都府京都市）
Year and Date
2014-06-05
Related Report
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[Presentation] （パネルディスカッション6 混合型肝癌の病理と診断）細胆管細胞癌の切除成績は混合型肝癌とは異なる2014
Author(s)
有泉俊一, 片桐聡, 小寺由人, 高橋豊, 大森亜紀子, 山下信吾, 尾形哲, 江川裕人, 中野雅行, 斎藤明子, 山本雅一
Organizer
第50回日本肝癌研究会
Place of Presentation
国立京都国際会館（京都府京都市）
Year and Date
2014-06-05
Related Report
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[Presentation] Master-class liver operations2014
Author(s)
Yamamoto Masakazu, Katagiri Satoshi, Chinburen Jigjidsuren
Organizer
Master class on "The trestment of HCC"
Place of Presentation
Shimkent, Kazakhstan
Year and Date
2014-05-01
Related Report
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[Presentation] 多血性早期肝細胞癌の1例2014
Author(s)
有泉俊一, 高橋豊, 大森亜紀子, 小寺由人, 尾形哲, 山下信吾, 片桐聡, 山本雅一, 中野雅行
Organizer
第49回肝癌症例検討会
Place of Presentation
秋葉原コンベンションホール（東京都千代田区）
Year and Date
2014-04-19
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