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Development of the drugs targeting lung tumor endothelial cells and the companion diagnosis

Research Project

Project/Area Number 24390324
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Thoracic surgery
Research InstitutionHokkaido University

Principal Investigator

Hida Yasuhiro  北海道大学, 大学病院, 准教授 (30399919)

Co-Investigator(Kenkyū-buntansha) KAGA KICHIZO  北海道大学, 北海道大学病院, 講師 (80224335)
MATSUI YOSHIRO  北海道大学, 大学院医学研究科, 教授 (90219379)
加藤 達哉  北海道大学, 大学病院, 医員 (20624232)
樋田 京子  北海道大学, 歯学研究科(研究院), 特任准教授 (40399952)
Project Period (FY) 2012-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2014: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2013: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2012: ¥13,260,000 (Direct Cost: ¥10,200,000、Indirect Cost: ¥3,060,000)
Keywords肺癌 / 血管新生 / 腫瘍血管内皮細胞 / 内皮細胞 / コンパニオン診断 / ビグリカン / 血管内皮細胞
Outline of Final Research Achievements

Tumor endothelial cells (TEC) from mouse xenografted tumor, especially that from highly metastatic tumor expresses high level of biglycan. Knock down of biglycan by siRNA suppressed tumor cell invasion thorough endothelial cell sheet. Co-implantation of low metastatic tumor cells with TEC developed lung metastases. This metastatic ability was abandoned by suppression of biglycan expression in TEC. Immunohistochemistry of human clinical tumors revealed specific expression of biglycan in TEC. ELISA of serum showed high biglycan level in cancer patients, especially those with metastasis.

Report

(5 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (15 results)

All 2016 2015 2014 2013 Other

All Journal Article (8 results) (of which Peer Reviewed: 8 results,  Open Access: 4 results,  Acknowledgement Compliant: 1 results) Presentation (5 results) Remarks (2 results)

  • [Journal Article] Tumor angiogenesis-characteristics of tumor endothelial cells.2016

    • Author(s)
      Hida K, Maishi N, Torii C, Hida Y.
    • Journal Title

      Int J Clin Oncol

      Volume: 21 Issue: 2 Pages: 206-212

    • DOI

      10.1007/s10147-016-0957-1

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Heterogeneity of tumor endothelial cells and drug delivery2016

    • Author(s)
      Hida K, Maishi N, Sakurai Y, Hida Y, Harashima H
    • Journal Title

      Adv Drug Deliv Rev

      Volume: 99 Pages: 140-147

    • DOI

      10.1016/j.addr.2015.11.008

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CXCL 12-CXCR7 axis is important for tumor endothelial cell angiogenic property2015

    • Author(s)
      Yamada K., Maishi N., Akiyama K., Alam Mohammad Towfik, Ohga N., Kawamoto T., Shindoh M. Takahashi N., Kamiyama T., Hida Y., Taketomi A. and Hida K.
    • Journal Title

      Int J Cancer

      Volume: 137(12) Issue: 12 Pages: 2825-2836

    • DOI

      10.1002/ijc.29655

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Identification and expression of troponin T, a new marker on the surface of cultured tumor endothelial cells by aptamer ligand2014

    • Author(s)
      Ara MN., Hyodo M., Ohga N., Akiyama K., Hida K., Hida Y., Shinohara N., Harashima H
    • Journal Title

      Cancer Med

      Volume: 3 Issue: 4 Pages: 825-834

    • DOI

      10.1002/cam4.260

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Suprabasin as a novel tumor endothelial cell marker2014

    • Author(s)
      Alam Mohammad Towfik, Nagao-Kitamoto H., Ohga N., Akiyama K., Maishi N., Kawamoto T., Shinohara N., Taketomi A., Shindoh M., Hida Y. and Hida K.
    • Journal Title

      Cancer Sci

      Volume: 105 Pages: 1533-1540

    • NAID

      120005539218

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification of Novel Targets for Antiangiogenic Therapy by Comparing the Gene Expressions of Tumor and Normal Endothelial Cells2014

    • Author(s)
      Otsubo T., et al., Hida Y., Ohga N., Sato H., Kai T., Matsuki Y., Takasu H., Akiyama K., Maishi N., Kawamoto T., Shinohara N., Nonomura K., Hida K.
    • Journal Title

      Cancer Sci.

      Volume: (印刷中) Issue: 5 Pages: 560-567

    • DOI

      10.1111/cas.12394

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Heterogeneity of tumor endothelial cells2013

    • Author(s)
      Hida K., Ohga N., Akiyama K., Maishi N., Hida Y.
    • Journal Title

      Cancer Sci

      Volume: 104 Pages: 1391-1395

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Application of POLARIC fluorophores in an in vivo tumor model2013

    • Author(s)
      Maishi N., Kawamoto T., Ohga N.,Yamad K., Akiyama K., Yamamoto K. , Osawa T., Hida Y. and *Hida K.
    • Journal Title

      Oncol Rep

      Volume: 30 Pages: 1695-1700

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] Tumor endothelial cells promote metastasis2014

    • Author(s)
      Maishi N., Ohba Y., Ohga N., Akiyama K., Hamada J., Yamamoto Y., Kawamoto T., Shindoh M., Hida Y., Hida K
    • Organizer
      The 18th International Vascular Biology Meeting
    • Place of Presentation
      みやこめっせ(京都市)
    • Year and Date
      2014-04-14 – 2014-04-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] SBSN is a novel Tumor Endothelial Cell marker2014

    • Author(s)
      Alam Mohammad Towfik, Nagao H., Ohga N., Akiyama K., Maishi N., Kawamoto T., Shinohara N., Taketomi A., Shindoh M., Hida Y., Hida K.
    • Organizer
      The 18th International Vascular Biology Meeting
    • Place of Presentation
      みやこめっせ(京都市)
    • Year and Date
      2014-04-14 – 2014-04-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] CXCL12/CXCR7 axis is important for tumor endothelial cell angiogenic property2014

    • Author(s)
      Yamada K., Maishi N. Ohga N., Akiyama K., Kawamoto T., Alam Mohammad Towfik, Shindoh M. Takahashi N., Kamiyama T., Hida Y., Taketomi A., Hida K.
    • Organizer
      The 18th International Vascular Biology Meeting
    • Place of Presentation
      みやこめっせ(京都市)
    • Year and Date
      2014-04-14 – 2014-04-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] 血管内皮細胞によるがん転移促進2013

    • Author(s)
      間石奈湖,大場雄介,大賀則孝,秋山廣輔,山本和幸,浜田淳一,川本泰輔,Alam Mohammad Towfik, 大村 瞳,進藤正信,樋田泰浩,樋田京子
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
  • [Presentation] がん転移における腫瘍血管内皮細胞の役割2013

    • Author(s)
      間石奈湖,大場雄介,大賀則孝,秋山廣輔,山本和幸,浜田淳一,川本泰輔,Alam Mohammad Towfik,樋田泰浩,樋田京子
    • Organizer
      第21回日本血管生物医学会学術集会
    • Place of Presentation
      千里阪急ホテル(大阪市)
    • Related Report
      2013 Annual Research Report
  • [Remarks] 北海道大学 血管生物学教室

    • URL

      http://www.den.hokudai.ac.jp/vascular-biology/

    • Related Report
      2013 Annual Research Report
  • [Remarks] 北海道大学 血管生物学教室

    • URL

      http://www.den.hokudai.ac.jp/vascular-biology/index.html

    • Related Report
      2012 Annual Research Report

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Published: 2012-04-24   Modified: 2019-07-29  

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