The molecular mechanism of major intracranial arterial stenosis

• Project/Area Number: 24390343
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: Kyoto University
• Principal Investigator: MIYAMOTO Susumu 京都大学, 医学(系)研究科(研究院), 教授 (70239440)
• Co-Investigator(Kenkyū-buntansha): TAKAGI Yasushi 京都大学, 医学研究科, 准教授 (40312227) ; TAKAHASHI Jun 国立循環器病研究センター, 部長 (90551408)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000); Fiscal Year 2014: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000); Fiscal Year 2013: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2012: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
• Keywords: 脳神経外科学 / 脳卒中 / 脳血管障害 / 頭蓋内主幹動脈 / もやもや病 / 脳梗塞 / 遺伝子

Outline of Final Research Achievements

1. iPS cell was established from fibroblast obtained from the patients with familial moyamoya disease. Abnormal smooth muscle and endothelial cells were induced from these cells.
2. The tiny tips of middle cerebral arteries were obtained during surgical procedures. They were analyzed immunohistochemically. Abnormality in media and intima was recognized. This observation indicated that moyamoya disease affeted the peripheral intracranial arteries.

Research Products

• [Journal Article] Unstable moyamoya disease: clinical features and impact on perioperative ischemic complications. (2015)
  • Author(s): Funaki T, Takahashi JC, Takagi Y, Kikuchi T, Yoshida K, Mitsuhara T, Kataoka H, Okada T, Fushimi Y, Miyamoto S.
  • Journal Title: J Neurosurg Volume: 122 Issue: 2 Pages: 400-7
  • DOI: 10.3171/2014.10.jns14231
  • Peer Reviewed / Open Access
• [Journal Article] Exacerbation of intracranial aneurysm and aortic dissection in hypertensive rat treated with the prostaglandin F-receptor antagonist AS604872. (2014)
  • Author(s): Fukuda M, Aoki T, Manabe T, Maekawa A, Shirakawa T, Kataoka H, Takagi Y, Miyamoto S, Narumiya S.
  • Journal Title: J Pharmacol Sci. Volume: 126 Pages: 230-42
  • NAID: 130004700281
  • Peer Reviewed
• [Journal Article] Cognitive function of patients with adult moyamoya disease. (2014)
  • Author(s): Araki Y, Takagi Y, Ueda K, Ubukata S, Ishida J, Funaki T, Kikuchi T, Takahashi JC, Murai T, Miyamoto S.
  • Journal Title: J Stroke Cerebrovasc Dis. Volume: 23 Issue: 7 Pages: 1789-94
  • DOI: 10.1016/j.jstrokecerebrovasdis.2014.04.032
  • NAID: 120005468377
  • Peer Reviewed
• [Journal Article] Incidence of late cerebrovascular events after direct bypass among children with moyamoya disease: a descriptive longitudinal study at a single center. (2014)
  • Author(s): Funaki T, Takahashi JC, Takagi Y, Yoshida K, Araki Y, Kikuchi T, Kataoka H, Iihara K, Sano N, Miyamoto S.
  • Journal Title: Acta Neurochir (Wien). Volume: 156 Issue: 3 Pages: 551-9
  • DOI: 10.1007/s00701-013-1975-7
  • Peer Reviewed
• [Journal Article] Impact of posterior cerebral artery involvement on long-term clinical and social outcome of pediatric moyamoya disease. (2013)
  • Author(s): Funaki T, Takahashi JC, Takagi Y, Yoshida K, Araki Y, Kikuchi T, Kataoka H, Iihara K, Miyamoto S.
  • Journal Title: J Neurosurg Pediatr. Volume: 12(6) Issue: 6 Pages: 626-32
  • DOI: 10.3171/2013.9.peds13111
  • Peer Reviewed
• [Journal Article] Rapid Progression of Unilateral Moyamoya Disease in a Patient with a Family History and an RNF213 Risk Variant (2013)
  • Author(s): Mineharu Y, Hitomi T, Kobayashi H Koizumi A. et al.
  • Journal Title: Cerebrovasc Dis Volume: 36(2) Issue: 2 Pages: 155-7
  • DOI: 10.1159/000352065
  • Peer Reviewed
• [Journal Article] The moyamoya disease susceptibility variant RNF213 R4810K (rs112735431) (2013)
  • Author(s): Hitomi T, Habu T, Kobayashi H, Okuda H, Harada KH, Osafune K, Taura D, Sone M, Asaka I, Ameku T, Watanabe A, Kasahara T, Sudo T, Shiota F, Hashikata H, Takagi Y, Morito D, Miyamoto S, Nakao K, Koizumi A
  • Journal Title: Biochem Biophys Res Commun. Volume: 439(4) Issue: 4 Pages: 419-426
  • DOI: 10.1016/j.bbrc.2013.08.067
  • Peer Reviewed
• [Journal Article] Notch signaling regulates nucleocytoplasmic Olig2 translocation in reactive astro (2013)
  • Author(s): Marumo T, et al.
  • Journal Title: Neurosci Res Volume: 75 Pages: 204-209
  • Peer Reviewed
• [Journal Article] Functional recovery of the murine brain ischemia model using human induced plurip. (2012)
  • Author(s): Gomi M, et al.
  • Journal Title: Brain Res Volume: 1459 Pages: 52-60
  • Peer Reviewed
• [Journal Article] Transplantation of telencephalic neural progenitors induced from embryonic stem c (2012)
  • Author(s): Fujimoto M, et al.
  • Journal Title: Lab Invest Volume: 92 Pages: 522-531
  • Peer Reviewed