Development of therapeutic strategy targeting common pathway of cartilage degeneration
Project/Area Number |
24390350
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Orthopaedic surgery
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Research Institution | University of Toyama |
Principal Investigator |
KIMURA Tomoatsu 富山大学, 大学院医学薬学研究部(医学), 教授 (80167379)
|
Co-Investigator(Kenkyū-buntansha) |
KAWAGUCHI Yoshiharu 富山大学, 大学院医学薬学研究部(医学), 准教授 (00262527)
SEKI Shoji 富山大学, 大学院医学薬学研究部(医学), 助教 (00432112)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Fiscal Year 2014: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
|
Keywords | 関節 / 軟骨 / 椎間板 / 変形性関節症 / 転写阻害 |
Outline of Final Research Achievements |
Intervertebral disc disease (IVD) and osteoarthritis (OA) are the most common musculoskeletal diseases and numerous molecular mechanisms have been associated with these conditions. We identified c-fos/AP-1 as a molecule that shares pathological pathways in both of IVD and OA. Using newly developed specific inhibitor for the c-fos/AP-1, we demonstrated that the inhibitor mainly reduced expression of matrix-degrading enzymes, such as mmp-13 and adamts5 in disc cells, disc tissue, as well as in chondrocytes. Medication of the c-fos/AP-1 inhibitor to IVD and OA model animals demonstrated remarkable inhibitory effect on the progression of these conditions. Thus, therapeutic strategies targeting c-fos/AP-1 could become an important direction to treat both of IVD and OA.
|
Report
(4 results)
Research Products
(12 results)
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[Journal Article] Cartilage intermediate layer protein promotes lumbar disc degeneration.2014
Author(s)
Seki S, Tsumaki N, Motomura H, Nogami M, Kawaguchi Y, Hori, T Suzuki K, Yahara Y, Higashimoto M, Oya T, Ikegawa S, Kimura T.
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Journal Title
Biochem Biophys Res Commun
Volume: 446
Issue: 4
Pages: 876-881
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Lumbar disc degeneration is linked to a carbohydrate sulfotransferase 3 variant.2013
Author(s)
You-Qiang Song, Tatsuki Karasugi, Kenneth M.C. Cheung, Kazuhiro Chiba, Daniel W.H. Ho, Atsushi Miyake, Patrick Y.P. Kao, Kit Ling Sze, Anita Yee, Atsushi Takahashi, Yoshiharu Kawaguchi, Yasuo Mikami, Morio Matsumoto, Daisuke Togawa, Masahiro Kanayama, Dongquan Shi, Jin Dai, Qing Jiang, Tomoatsu Kimura, et al.
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Journal Title
J Clin Invest.
Volume: 123
Pages: 4909-4917
Related Report
Peer Reviewed
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