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Does acute pain progress to chronic pain: mechanisms of persistent postoperative pain

Research Project

Project/Area Number 24390365
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Anesthesiology/Resuscitation studies
Research InstitutionShinshu University

Principal Investigator

KAWAMATA Mikito  信州大学, 学術研究院医学系, 教授 (90315523)

Co-Investigator(Kenkyū-buntansha) TANAKA Satoshi  信州大学, 学術研究院医学系, 准教授 (60293510)
SUGIYAMA Yuki  信州大学, 学術研究院医学系, 助教 (10468100)
ISHIDA Takashi  信州大学, 医学部附属病院, 助教(診療) (60531952)
SUGIYAMA Daisuke  信州大学, 医学部, 助教(特定雇用) (40467189)
KAWAMATA Tomoyuki  信州大学, 医学部, 准教授 (80336388)
Project Period (FY) 2012-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2014: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2013: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
Fiscal Year 2012: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
Keywords術後痛 / 遷延性術後痛 / 動物モデル / 筋肉 / 慢性炎症 / マイクログリア / 筋挫傷 / 脊髄後角 / 麻酔科学 / 周術期管理学 / 周術期疼痛学 / 急性術後痛 / 慢性痛化 / 皮膚切開 / 筋傷害 / 脊髄 / 急性痛 / 慢性痛
Outline of Final Research Achievements

We hypothesized that muscle injury with persistent inflammation would induce persistent postoperative pain (PPOP). We prepared two types of muscle injury, plantar muscle incision and plantar muscle cryoinjury caused by liquid nitrogen of the rat hind paw. Plantar muscle cryoinjury induced greater mechanical hyperalgesia from day 5 to 8 and spontaneous pain from day 3 to 7 compared with plantar muscle incision. In plantar muscle cryoinjury, the number of inflammatory cells in injured muscle and spinal Iba-1 expression were significantly higher compared with those in plantar muscle incision. Taken together, plantar muscle cryoinjury is a more appropriate model of PPSP compared with plantar muscle incision. This model effectively reflected the characteristics of PPSP. In addition, the results of this study suggest that spinal microglial activation is involved in the pathogenic mechanism of PPOP.

Report

(5 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (42 results)

All 2016 2015 2014 2013 2012

All Journal Article (18 results) (of which Peer Reviewed: 18 results,  Open Access: 5 results,  Acknowledgement Compliant: 4 results) Presentation (14 results) (of which Int'l Joint Research: 1 results,  Invited: 6 results) Book (9 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Spinal nociceptive transmission by mechanical stimulation of bone marrow.2016

    • Author(s)
      Ishida T, Tanaka S, Sekiguchi T, Sugiyama D, Kawamata M.
    • Journal Title

      Mol Pain.

      Volume: 12 Pages: 1-15

    • DOI

      10.1177/1744806916628773

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Severe Re-expansion Pulmonary Edema Induced by One-Lung Ventilation.2015

    • Author(s)
      Sugiyama Y, Shimizu F, Shimizu S, Urasawa M, Tanaka S, Kawamata M.
    • Journal Title

      Respir Care

      Volume: 60 Issue: 8 Pages: e134-e140

    • DOI

      10.4187/respcare.03759

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Transversus abdominis plane block with 0.25 % levobupivacaine: a prospective, randomized, double‐blinded clinical study2015

    • Author(s)
      Ishida T, Sakamoto A, Tanaka H, Ide S, Ishida K, Tanaka S, Mori T, Kawamata M
    • Journal Title

      J Anesth

      Volume: 29 Issue: 4 Pages: 557-61

    • DOI

      10.1007/s00540-015-1993-0

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] In vivo support for the new concept of pulmonary blood flow-mediated CO2 gas excretion in the lungs2015

    • Author(s)
      Kawai Y, Ajima K, Kaidoh M, Sakaguchi M, Tanaka S, Kawamata M, Kimura H, and Ohhashi T
    • Journal Title

      Am J Physiol Lung Mol

      Volume: in press Issue: 12 Pages: 263-8

    • DOI

      10.1152/ajplung.00205.2014

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 遷延性術後痛のメカニズム2015

    • Author(s)
      田中 聡, 吉山 勇樹, 川真田 樹人
    • Journal Title

      神経内科

      Volume: 83 Pages: 125-130

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Evaluation of physical activity of anesthesiologists in the operating room during daily working using a triaxial accelerometer. Arch Environ Occup Health2015

    • Author(s)
      Tanaka H, Kawamata T, Nose H, Genno H, Kawamata M
    • Journal Title

      Arch Environ Occup Health

      Volume: 70 Pages: 77-80

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Calcitonin Gene-related Peptide Is Involved in Inflammatory Pain but Not in Postoperative Pain2014

    • Author(s)
      Ishida, K, Kawamata T, Tanaka S, Shindo T, Kawamata M
    • Journal Title

      Anesthesiology

      Volume: 121 Issue: 5 Pages: 1068-1079

    • DOI

      10.1097/aln.0000000000000364

    • NAID

      40020663802

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Anesthetic Management Using Remifentanil Target-Controlled Infusion for an Infant with Trisomy 13 (Patau's Syndrome) Undergoing Glaucoma Surgery -A Case Report-2014

    • Author(s)
      Sugiyama D, Tanaka S, Imai E, Tanaka T, Ide S, Kawamata M
    • Journal Title

      Anesthesia and Resuscitation

      Volume: 50 Pages: 85-87

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Successful intubation using Mcgrath®MAC in a patient with Treacher Collins Syndrome.2014

    • Author(s)
      Tsujimoto T, Tanaka S, Yoshiyama Y, Sugiyama Y, Kawamata M
    • Journal Title

      Middle East J Anesthesiol

      Volume: 22 Pages: 523-525

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pulmonary alveolar hemorrhage from a pulmonary artery false aneurysm after Swan-Ganz catheterization in a thoracic aortic aneurysm patient -A case report-.2014

    • Author(s)
      Sugiyama D, Ikeno S, Tsuchihashi T, Yokota S, Ina H, Kono T, Yamashita K, Kawamata M
    • Journal Title

      Korian J Anesthesiol

      Volume: 67 Pages: 346-349

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 帝王切開術麻酔の現況に関する全国アンケート調査の結果報告2013

    • Author(s)
      田中秀典, 川股知之, 日向俊輔, 上山博史, 角倉弘之, 川真田樹人
    • Journal Title

      日本臨床麻酔学会誌

      Volume: 33 Pages: 411-420

    • NAID

      10031171381

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 遷延性術後痛とは?2013

    • Author(s)
      川真田樹人
    • Journal Title

      Practice of Pain Management

      Volume: 4(2) Pages: 421-425

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] エアウェイスコープ®挿管時に咽頭裂傷を来した挿管困難の1症例2013

    • Author(s)
      関口剛美、杉山由紀、川股知之、川真田樹人
    • Journal Title

      麻酔

      Volume: 62 Pages: 1410-1412

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 神経根性疼痛モデルにおける脊髄膠様質細胞の興奮性シナプス伝達2013

    • Author(s)
      寺島 嘉紀, 川真田 樹人, 竹林 庸雄, 田中 智, 谷本 勝正, 山下 敏彦
    • Journal Title

      Journal of Musculoskeletal Pain Research

      Volume: 5 Pages: 61-65

    • NAID

      40019746828

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 側彎症妊婦の帝王切開における脊髄くも膜下硬膜外併用麻酔の経験(原著論文/症例報告)2013

    • Author(s)
      清澤 研吉, 川股 知之, 山本 克己, 川真田 樹人
    • Journal Title

      麻酔

      Volume: 62 Pages: 859-862

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Misplacement of a guidewire into the vertebral vein through the internal juglar vein.2012

    • Author(s)
      Ide S, Kawamata T, Imai N, Ando A, Kawamata M.
    • Journal Title

      J Caridothorac Vasc Anesth

      Volume: 26 Issue: 2 Pages: 17-18

    • DOI

      10.1053/j.jvca.2011.11.004

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vivo patch-clamp recording from locus coeruleus neurons in the rat brainstem2012

    • Author(s)
      Sugiyama D, Hur SW, Pickering AE, Kase D, Kim SJ, Kawamata M, Imoto K, Furue H
    • Journal Title

      Journal of Physiology

      Volume: (in press) Issue: 10 Pages: 2225-2231

    • DOI

      10.1113/jphysiol.2011.226407

    • NAID

      120007108244

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Successful tracheal intubation with the McGrath MAC video laryngoscope after failure with the Pentax-AWS in the patient with cervical spine immobilization.2012

    • Author(s)
      Hyuga S, Sekiguchi T, Ishida T, Yamamoto K, Sugiyama Y, Kawamata M.
    • Journal Title

      Can J Anaesth

      Volume: 59 Issue: 12 Pages: 1154-1155

    • DOI

      10.1007/s12630-012-9790-9

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) Channels are involved in Neuropathic Pain in Rats2015

    • Author(s)
      Ishida K, Tanaka S, Zhang H, Kawamata M
    • Organizer
      Annual Meeting of American Society of Anesthesiologists
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2015-10-24
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 術後痛のメカニズムと術後鎮痛の新たな治療戦略.2015

    • Author(s)
      川真田 樹人
    • Organizer
      第35回 鎮痛薬・オピオイドペプチドシンポジウム
    • Place of Presentation
      和歌山県立情報交流センタービッグユー(和歌山県田辺市新庄町)
    • Year and Date
      2015-10-16
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 遷延性術後痛と創部の炎症(シンポジウム)2015

    • Author(s)
      吉山勇樹
    • Organizer
      第49回日本ペインクリニック学会
    • Place of Presentation
      大阪、グランスタン大阪
    • Year and Date
      2015-07-23 – 2015-07-25
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 遷延性術後痛への対応 遷延性術後痛と創部の炎症(基礎研究)2015

    • Author(s)
      吉山 勇樹, 杉山 由紀, 田中 聡, 川真田 樹人
    • Organizer
      日本ペインクリニック学会第49回大会
    • Place of Presentation
      グランフロント大阪(大阪府大阪市北区)
    • Year and Date
      2015-07-23
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 遷延性術後痛:機序から診療まで2015

    • Author(s)
      川真田 樹人
    • Organizer
      日本ペインクリニック学会第49回大会
    • Place of Presentation
      グランフロント大阪(大阪府大阪市北区)
    • Year and Date
      2015-07-23
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 先天性無痛症患者の遺伝子学的解析によるSCN9Aの新規ミスセンス変異の発見.2015

    • Author(s)
      杉山 由紀, 清沢 研吉, 吉山 勇樹, 石田 高志, 田中 聡, 川真田 樹人
    • Organizer
      日本麻酔科学会第62回学術集会
    • Place of Presentation
      ポートピアホテル(兵庫県神戸市 中央区)
    • Year and Date
      2015-05-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] 合理的な術後鎮痛2014

    • Author(s)
      川真田樹人
    • Organizer
      日本麻酔科学会関東甲信越・東京支部第54回合同学術集会
    • Place of Presentation
      東京、京王プラザホテル
    • Year and Date
      2014-08-30
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 術後痛: 急性痛から慢性痛へ2014

    • Author(s)
      川真田 樹人
    • Organizer
      第36回日本疼痛学会
    • Place of Presentation
      大阪、KKRホテル大阪
    • Year and Date
      2014-06-20 – 2014-06-21
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] McGRATH MAC Video Laryngoscope Facilitate Easier Nasogastric Tube Insertion in Intubated Patients2013

    • Author(s)
      Yoshiyama Y, Kawamata T, Tsujimoto T, Urasawa M, Kawamata M
    • Organizer
      Annual Meeting of American Society of Anesthesiologists
    • Place of Presentation
      San Francisco
    • Related Report
      2013 Annual Research Report
  • [Presentation] Lumbar Epidural Anesthesia Does Not Affect the Suppressive Effect of Landiolol on Endotracheal Intubation-Induced Tachycardia2013

    • Author(s)
      Urasawa M, Kawamata T, Shimizu F, Ando N, Kitoh T, Ina H, Kawamata M
    • Organizer
      Annual Meeting of American Society of Anesthesiologists
    • Place of Presentation
      San Francisco
    • Related Report
      2013 Annual Research Report
  • [Presentation] Activation of Trransient Receptor Potential M8 by Cooling and Application of Menthol Can Reduce Propofol Injection-Induced Pain2013

    • Author(s)
      Watanabe N, Ishida T, Kawamata M
    • Organizer
      Annual Meeting of American Society of Anesthesiologists
    • Place of Presentation
      San Francisco
    • Related Report
      2013 Annual Research Report
  • [Presentation] The Effect of the TRPV1 Antagonist JTS-653 in a Rat Model of Postoperative Pain2013

    • Author(s)
      Ishida T, Sakata M, Hamada Y, Matsuo A, Kawamata M
    • Organizer
      Annual Meeting of American Society of Anesthesiologists
    • Place of Presentation
      San Francisco
    • Related Report
      2013 Annual Research Report
  • [Presentation] McGrath MAC Facilitates Transesophageal Echocardiography Probe Insertion2013

    • Author(s)
      akahashi C, Ishida T, Kawamata M
    • Organizer
      Annual Meeting of American Society of Anesthesiologists
    • Place of Presentation
      San Francisco
    • Related Report
      2013 Annual Research Report
  • [Presentation] Characteristics of spinal dorsal horn neurons responding to mechanical stimulation of bone marrow2012

    • Author(s)
      Ishida T, Tanaka S, Kawamata T, Kawamata M
    • Organizer
      Annual Meeting of American Society of Aneshthes iologists
    • Place of Presentation
      Chicago(招待講演)
    • Year and Date
      2012-10-14
    • Related Report
      2012 Annual Research Report
  • [Book] 術後痛 1)開胸術後痛痛みのScience&Practice8 臨床に役立つ神経障害性痛の理解2015

    • Author(s)
      田中 聡, 川真田 樹人
    • Total Pages
      285
    • Publisher
      文光堂
    • Related Report
      2015 Annual Research Report
  • [Book] 神経筋疾患. ペインコントロール.今日の治療指針2015

    • Author(s)
      川真田 樹人
    • Total Pages
      1197
    • Publisher
      医学書院
    • Related Report
      2015 Annual Research Report
  • [Book] 痛みの生理学. 麻酔科学レビュー20152015

    • Author(s)
      川真田 樹人
    • Total Pages
      297
    • Publisher
      総合医学社
    • Related Report
      2015 Annual Research Report
  • [Book] 新戦略に基づく麻酔・周術期医学 麻酔科医のための周術期の疼痛管理2014

    • Author(s)
      田中 聡, 川真田 樹人
    • Total Pages
      8
    • Publisher
      中山書店
    • Related Report
      2014 Annual Research Report
  • [Book] 痛みのScience&Practice 手術後鎮痛のすべて:手術痛と手術後痛2013

    • Author(s)
      川真田樹人
    • Total Pages
      8
    • Publisher
      文光堂
    • Related Report
      2013 Annual Research Report
  • [Book] 痛みのScience&Practice 手術後鎮痛のすべて:ヒト研究からみた手術後痛のメカニズム2013

    • Author(s)
      田中聡, 川真田樹人
    • Total Pages
      5
    • Publisher
      文光堂
    • Related Report
      2013 Annual Research Report
  • [Book] 痛みのScience&Practice 手術後鎮痛のすべて:PCAによる手術後鎮痛2013

    • Author(s)
      川真田樹人
    • Total Pages
      5
    • Publisher
      文光堂
    • Related Report
      2013 Annual Research Report
  • [Book] 病態・疾患別 がん性痛の治療2013

    • Author(s)
      井出進、川真田樹人
    • Total Pages
      6
    • Publisher
      文光堂
    • Related Report
      2013 Annual Research Report
  • [Book] レボブピバカイン2012

    • Author(s)
      布施谷仁志、田中聡、川真田樹人
    • Publisher
      真興交易医書
    • Related Report
      2012 Annual Research Report
  • [Patent(Industrial Property Rights)] 穿刺針および穿刺針キット2013

    • Inventor(s)
      井出進、川真田樹人
    • Industrial Property Rights Holder
      信州大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2013-042679
    • Filing Date
      2013-05-03
    • Related Report
      2013 Annual Research Report

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Published: 2012-04-24   Modified: 2019-07-29  

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