Study on the usefulness of p2PSA as a predictor of clinical progression in prostate cancer patients undergoing active surveillance
Project/Area Number |
24390369
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Urology
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Research Institution | Kagawa University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
SUGIMOTO Mikio 香川大学, 医学部附属病院, 准教授 (10243768)
TYOU Ka 香川大学, 医学部, 助教 (30524061)
HIRAMA Hiromi 香川大学, 医学部附属病院, 助教 (50552725)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2014: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2013: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥10,790,000 (Direct Cost: ¥8,300,000、Indirect Cost: ¥2,490,000)
|
Keywords | 低リスク前立腺癌 / PSA監視療法 / p2PSA / psPSA |
Outline of Final Research Achievements |
In the Japanese multicenter study cohort (the 1st cohort of this project), predictive value of serum p2PSA-related indices and other clinicopathological features at the time of starting active surveillance (AS) for the pathological reclassification at 1 year re-biopsy were investigated. By multivariate logistic regression analysis, baseline %p2PSA and ‘Phi (the Prostate Health Index)’ were the only independent predictive factors for pathological upgrade at 1 year after AS commencement. In the PRIAS-JAPAN study cohort (the 2nd cohort of this project), longitudinally stored frozen sera are under collection from patients who are newly enrolled at 25 institutions where the Institutional Review Board approved the accompanying study. The 1st analysis on the predictive value of %p2PSA and Phi for pathological reclassification is scheduled to be carried out after collection of sera from 200 patients (projected time: the end of 2015).
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Report
(4 results)
Research Products
(14 results)
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[Journal Article] Should inclusion criteria for active surveillance for low-risk prostate cancer be more stringent? From an interim analysis of PRIAS-JAPAN.2014
Author(s)
Sugimoto M, Hirama H, Yamaguchi A, Koga H, Hashine K, Ninomiya I, Shinohara N, Maruyama S, Egawa S, Sasaki H, Kakehi Y; The PRIAS-JAPAN study group.
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Journal Title
World J Urol.
Volume: Epub ahead of print
Issue: 7
Pages: 2014-2014
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] 低リスク前立腺癌に対するPSA監視療法における1年目再生検の意義.2014
Author(s)
古賀 寛史, 山口 秋人, 杉元 幹史, 平間 裕美, 二宮 郁, 橋根 勝義, 丸山 覚, 篠原 信雄, 三木 淳, 佐々木 裕, 穎川 晋, 三塚 浩二, 荒井 陽一, 筧 善行, PRIAS-JAPAN 研究グループ
Organizer
第52回日本癌治療学会
Place of Presentation
横浜市
Year and Date
2014-08-30
Related Report
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[Presentation] PRIAS-JAPAN研究における中間報告.2014
Author(s)
杉元 幹史, 平間 裕美, 筧 善行, 前田 佳子, 松田 公志, 木下 秀文, 北村 康男, 斎藤 俊弘, 内藤 誠二, 横溝 晃, 市川 智彦, 坂本 信一, 鈴木 和浩, 伊藤 一人, PRIAS-JAPAN 研究グループ
Organizer
第52回日本癌治療学会
Place of Presentation
横浜市
Year and Date
2014-08-28
Related Report
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[Presentation] PSA監視療法を施行する患者はQOLが良好か?-PRIAS-JAPAN study cohortより-.2014
Author(s)
平間 裕美, 杉元 幹史, 筧 善行, 赤倉功一郎, 千葉 量人, 鈴木 啓悦, 神谷 直人, 小川 修, 神波 大巳, 寺地 敏郎, 野本 剛史, 賀本 敏行, 月野 浩昌, PRIAS-JAPAN研究グループ
Organizer
第52回日本癌治療学会
Place of Presentation
横浜市
Year and Date
2014-08-28
Related Report
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