The role of stem cells in the pathogenesis of endometriosis and adenomyosis

• Project/Area Number: 24390381
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: Keio University
• Principal Investigator: MARUYAMA TETSUO 慶應義塾大学, 医学部, 講師 (10209702)
• Co-Investigator(Kenkyū-buntansha): UCHIDA Hiroshi 慶應義塾大学, 医学部, 講師 (90286534) ; MASUDA Hirotaka 慶應義塾大学, 医学部, 助教 (80317198)
• Research Collaborator: ONO Masanori 慶應義塾大学, 医学部, 共同研究員 (70348712) ; BULUN Serdar Department of Obstetrics and Gynecology, Chair ; SCIARRA John J. , Professor in Obstetrics and Gynecology
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000); Fiscal Year 2014: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2013: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2012: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
• Keywords: 幹細胞 / 子宮内膜症 / 子宮腺筋症 / 子宮筋腫 / Wnt / β-Catenin

Outline of Final Research Achievements

In this study we aimed to elucidate the role of stem cells in the pathogenesis of endometriosis and adenomyosis. Firstly, we attempted to develop a novel mouse model of peritoneal endometriosis using magnetic materials and succeeded in locating endometriotic-like lesion(s) arbitrarily at the ventral peritoneum in immunodeficient mice. Secondly, we have developed a novel cell labeling and tracking method to investigate the behavior of the labeled human endometrial stem cells during human endometrial tissue reconstitution and possibly in the process of establishment of endometriotic-like lesion in mice. Thirdly, we clarified a paracrine role of the WNT/beta-Catenin in the stem cell-driven pathogenesis of uterine leiomyoma which is thought to share some common features with adenomyosis.

Research Products

• [Journal Article] OAT4-mediated transport of olmesartan at basal plasma membrane of human placental barrier. (2015)
  • Author(s): Noguchi S, Nishimura T, Fujibayashi A, Maruyama T, Tomi M, Nakashima E
  • Journal Title: J Pharm Sci. Volume: -
  • Peer Reviewed
• [Journal Article] Serum estradiol level during withdrawal bleeding as a predictive factor for intermittent ovarian function in women with primary ovarian insufficiency (2015)
  • Author(s): Miyazaki K, Miki F, Uchida S, Masuda H, Uchida H, Maruyama T
  • Journal Title: Endocrine Journal Volume: 62 Issue: 1 Pages: 93-99
  • DOI: 10.1507/endocrj.EJ14-0189
  • NAID: 130004694069
  • ISSN: 0918-8959, 1348-4540
  • Peer Reviewed / Open Access
• [Journal Article] Does surgery improve live birth rates in patients with recurrent miscarriage caused by uterine anomalies? (2015)
  • Author(s): Sugiura-Ogasawara M, Lin B-L, Aoki K, Maruyama T, Nakatsuka M, Ozawa N, Sugi T, Takeshita T, Nishida M
  • Journal Title: J Obstet Gynaecol. Volume: 35 Issue: 2 Pages: 155-158
  • DOI: 10.3109/01443615.2014.936839
  • Peer Reviewed
• [Journal Article] Tissue-Specific Stem Cells in the Myometrium and Tumor-Initiating Cells in Leiomyoma. (2015)
  • Author(s): Ono M, Bulun SE, Maruyama T
  • Journal Title: Biol Reprod. Volume: 91 Issue: 6 Pages: 1-7
  • DOI: 10.1095/biolreprod.114.123794
  • Peer Reviewed
• [Journal Article] Genome-wide copy number analysis and systematic mutation screening in 58 patients with hypogonadotropic hypogonadism (2014)
  • Author(s): Izumi Y, Suzuki E, Kanzaki S, Yatsuga S, Kinjo S, Igarashi M, Maruyama T, Sano S, Horikawa R, Sato N, Nakabayashi K, Hata K, Umezawa A, Ogata T, Yoshimura Y, Fukami M
  • Journal Title: Fertil Steril Volume: 102(4) Issue: 4 Pages: 1130-1136
  • DOI: 10.1016/j.fertnstert.2014.06.017
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] 【平成26年度日本産科婦人科学会優秀論文賞】 Partial regeneration and reconstruction of the rat uterus through recellularization of a decellularized uterine matrix. (2014)
  • Author(s): Miyazaki K, Maruyama T
  • Journal Title: Biomaterials. Volume: 35 Issue: 31 Pages: 8791-8800
  • DOI: 10.1016/j.biomaterials.2014.06.052
  • Peer Reviewed
• [Journal Article] Endometrial stem / progenitor cells. (2014)
  • Author(s): Maruyama T
  • Journal Title: J Obstet Gynaecol Res. Volume: 40 Issue: 9 Pages: 2015-2022
  • DOI: 10.1111/jog.12501
  • Peer Reviewed
• [Journal Article] System amino acid transporter SNAT2 shows subtype-specific affinity for betaine and hyperosmotic inducibility in placental trophoblasts. (2014)
  • Author(s): Nishimura T, Yagi R, Usuda M, Oda K, Yamazaki M, Suda S, Takahashi Y, Okazaki F, Sai Y, Higuchi, K, Maruyama T, Tomi M, Nakashima E
  • Journal Title: Biochim Biophys Acta. Volume: VOL. 1838 Issue: 5 Pages: 1306-12
  • DOI: 10.1016/j.bbamem.2014.01.004
  • Peer Reviewed
• [Journal Article] Paracrine activation of WNT/β-catenin pathway in uterine leiomyoma stem cells promotes tumor growth (2013)
  • Author(s): Ono M, Yin P, Navarro A, Moravek MB, Coon JS 5th, Druschitz SA, Serna VA, Qoang W, Brooks DC, Malpani SS, Ma J, Ercan CM, Mittal N, Monsivais D, Dyson MT, Yemelyanov A, Maruyama T, Chkravarti D, Kimm JJ, Kurita T, Gottardi CJ, Bulun SE
  • Journal Title: Proc Natl Acad Sci USA Volume: 110(42) Issue: 42 Pages: 17053-8
  • DOI: 10.1073/pnas.1313650110
  • Peer Reviewed
• [Journal Article] Molecular analysis of a mutated FSH receptor detected in a patient with spontaneous ovarian hyperstimulation syndrome. (2013)
  • Author(s): Uchida S, Uchida H, Maruyama T, Kajitani T, Oda H, Miyazaki K, Maki Kagami, Yoshimura Y
  • Journal Title: PLoS One. Volume: VOL. 8 Issue: 9 Pages: e75478-e75478
  • DOI: 10.1371/journal.pone.0075478
  • Peer Reviewed
• [Journal Article] Possible involvement of nerve growth factor in dysmenorrhea and dyspareunia associated with endometriosis. (2013)
  • Author(s): Kajitani T, Maruyama T, Asada H, Uchida H, Oda H, Nishikawa-Uchida S, Miyazaki K, Arase T, Ono M, Yoshimura Y
  • Journal Title: Endocr J. Volume: VOL. 60 Pages: 1155-64
  • NAID: 130004770386
  • Peer Reviewed
• [Journal Article] The nose knows tubal function? (2013)
  • Author(s): Maruyama T
  • Journal Title: Fertil Steril Volume: 100(2) Issue: 2 Pages: 353-354
  • DOI: 10.1016/j.fertnstert.2013.04.026
  • Peer Reviewed
• [Journal Article] Achievement of pregnancies in women with primary ovarian insufficiency using close monitoring of follicle development: case reports. (2013)
  • Author(s): Maruyama T, Miyazaki K, Uchida H, Uchida S, Masuda H, Yoshimura Y
  • Journal Title: Endocr J. Volume: VOL. 60 Pages: 791-7
  • NAID: 10031184548
  • Peer Reviewed
• [Journal Article] Human uterine stem/ progenitor cells : Implications for uterine physiology and pathology (2013)
  • Author(s): Maruyama T, Miyazaki K, Masuda H, Ono M, Uchida H, Yoshimura Y
  • Journal Title: Placenta Volume: 27 Pages: 77-81
  • DOI: 10.1016/j.placenta.2012.12.010
  • Peer Reviewed
• [Journal Article] ヒト子宮内膜再構成システムを用いたin vivo幹細胞アッセイの開発と内膜幹細胞の同定． (2013)
  • Author(s): 宮崎 薫，丸山哲夫，升田博隆，小田英之，内田明花，内田 浩，吉村泰典
  • Journal Title: 日本生殖内分泌雑誌［平成24年度学術奨励賞受賞］ Volume: 18巻 Pages: 21-5
• [Journal Article] Achievement of pregnancies in women with primary ovarian insufficiency using close monitoring of follicle development : case reports (2013)
  • Author(s): Maruyama T, Miyazaki K, Uchida H, Uchida S, Masuda H, Yoshimura Y
  • Journal Title: Endocrine Journal. Volume: (In press)
  • NAID: 10031184548
  • Peer Reviewed
• [Journal Article] Human uterine stem/ progenitor cells : Implications for uterine physiology and palhology (2013)
  • Author(s): Maruyama T, Miyazaki K, Masuda H, Ono M, Uchida H, Yoshimura Y
  • Journal Title: Placenta. Volume: 27
  • Peer Reviewed
• [Journal Article] Somatic stem cells in the myometrium and in myomas (2013)
  • Author(s): Maruyama T, Ono M, Yoshimura Y
  • Journal Title: Semin Reprod Med Volume: 31(1) Issue: 01 Pages: 77-81
  • DOI: 10.1055/s-0032-1331801
  • Peer Reviewed
• [Journal Article] 目で見る生殖幹細胞 (2013)
  • Author(s): 升田博隆,丸山哲夫,吉村泰典
  • Journal Title: HORMONE EFONTIER IN GYNECOLOGY. Volume: 20 Pages: 6-9
• [Journal Article] 特集 生殖と自然免疫 子宮内膜の粘膜免疫機構 (2013)
  • Author(s): 荒瀬 透,丸山哲夫,宮崎 薫,柴田璃香,升田博隆,内田 浩,吉村泰典
  • Journal Title: HORMONE EFONTIER IN GYNECOLOGY. Volume: 20 Pages: 39-44
• [Journal Article] β-Catenin signaling regulates Foxa2 expression during endometrial hyperplasia formation (2013)
  • Author(s): Villacorte M, Suzuki K, Hirasawa A, Ohkawa Y, Suyama M, Maruyama T, Aoki D, Ogino Y, Miyagawa S, Terabayashi T, Tomooka Y, Nakagata N, Yamada G
  • Journal Title: Oncogene Volume: 32 Issue: 29 Pages: 3477-3482
  • DOI: 10.1038/onc.2012.376
  • Peer Reviewed
• [Journal Article] Stem cell theory for the pathogenesis of endometriosis (2013)
  • Author(s): Maruyama T, Yoshimura Y
  • Journal Title: Front Biosci. Volume: 4 Pages: 6-9
  • Peer Reviewed
• [Journal Article] Stem cell-like differentiation potentials of endometrial side population cells as revealed by a newly developed in vivo endometrial stem cell assay (2012)
  • Author(s): Miyazaki K, Maruyama T, Masuda H, Yamasaki A, Uchida S, Oda H, Uchida H, Yoshimura Y
  • Journal Title: PLoS One Volume: 7(12) Issue: 12 Pages: e50749-e50749
  • DOI: 10.1371/journal.pone.0050749
  • Peer Reviewed
• [Journal Article] Involvement of epithelial mesenchymal transition of human endometrial epithelial cells in human embryo implantation : evidence from studies using in vitro model (2012)
  • Author(s): H.Uchida, T.Maruyama, S.Nishikawa-Uchida, H.Oda, K.Miyazaki, A.Yamasaki, Y.Yoshimura
  • Journal Title: Journal of Biological Chemistry Volume: 287 Issue: 7 Pages: 4441-4450
  • DOI: 10.1074/jbc.m111.286138
  • Peer Reviewed
• [Journal Article] Psychological adjustment and psychosocial stress among Japanese couples with a history of recurrent pregnancy loss (2012)
  • Author(s): M.Kagami, T.Maruyama, T.Koizumi, K.Miyazaki, S.Nishikawa-Uchida, H.Oda, H.Uchida, D.Fujisawa, N.Ozawa, L.Schmidt, Y.Yoshimura
  • Journal Title: Human Reproduction Volume: 27 Issue: 3 Pages: 787-794
  • DOI: 10.1093/humrep/der441
  • Peer Reviewed
• [Journal Article] ホルモン依存性子宮関連疾患に関する研究の新たな展開 -ヒト子宮における幹細胞の意義と役割- (2012)
  • Author(s): 丸山哲夫
  • Journal Title: 公益財団法人山口内分泌疾患研究振興財団 内分泌に関する最新情報 2012 Volume: (WEB論文)
• [Presentation] Decellularization of the rat uterus yielded scaffold capable of tissue regeneration without immune rejection upon allotransplantation. (2015)
  • Author(s): Kaoru Miyazaki, Yuki Ueno, Hirotaka Masuda, Hiroshi Uchida, Tetsuo Maruyama
  • Organizer: 62nd Society for Reproductive Investigation (SRI).
  • Place of Presentation: San Francisco (USA)
  • Year and Date: 2015-03-25 – 2015-03-28
• [Presentation] 子宮における幹細胞 ― 雌性生殖器官の再生・再建と疾患メカニズムの解明を目指して ― ． (2014)
  • Author(s): 丸山哲夫
  • Organizer: 第25回阪大医療組織工学フォーラム
  • Place of Presentation: 大阪大学（大阪府吹田市）
  • Year and Date: 2014-12-15
  • Invited
• [Presentation] Stem/progenitor cells in the human uterus: implications for uterine tumors. (2014)
  • Author(s): Tetsuo Maruyama
  • Organizer: 19th World Congress on Advances in Oncology and 17th International Symposium on Molecular Medicine.
  • Place of Presentation: Athens (Greece)
  • Year and Date: 2014-10-09
  • Invited
• [Presentation] 【シンポジウム】 幹細胞を用いた子宮内膜の再生・再建． (2014)
  • Author(s): 丸山哲夫
  • Organizer: 第87回日本内分泌学会
  • Place of Presentation: 福岡国際会議場（福岡県福岡市）
  • Year and Date: 2014-04-24 – 2014-04-26
  • Invited
• [Presentation] 幹細胞から見た子宮内膜症の発生・病態メカニズムと治療戦略． (2014)
  • Author(s): 丸山哲夫
  • Organizer: 第35回日本エンドメトリオーシス学会［教育講演］
  • Place of Presentation: 城山観光ホテル（鹿児島県鹿児島市）
  • Invited
• [Presentation] 希少部位子宮内膜症発生モデルマウスの開発の試み． (2014)
  • Author(s): 小田英之，丸山哲夫，山崎彰子，宮崎 薫，荒瀬 透，内田 浩，升田博隆，吉村泰典
  • Organizer: 第35回日本エンドメトリオーシス学会［日本エンドメトリオーシス学会演題発表賞（基礎部門）］
  • Place of Presentation: 城山観光ホテル（鹿児島県鹿児島市）
• [Presentation] 習慣流産において25(OH)ビタミンDは末梢血NK細胞を抑制する． (2013)
  • Author(s): 太田邦明，丸山哲夫，森田峰人，Joanne Kwak-Kim，吉村泰典
  • Organizer: 第28回日本生殖免疫学会［学会賞］
  • Place of Presentation: 平成記念会館（兵庫県西宮市）
• [Presentation] ベンチサイドから：ヒト子宮幹細胞研究のこれまでと未来予想図． (2013)
  • Author(s): 丸山哲夫
  • Organizer: 第126回関東連合産科婦人科学会［ワークショップ］
  • Place of Presentation: アクトシティ浜松（静岡県浜松市）
  • Invited
• [Presentation] Application of decellularzed rat uterus as a three-dimensional scaffold to in vitro and in vivo uterine tissue engineering. (2013)
  • Author(s): Kaoru Miyazaki, Tetsuo Maruyama, Hirotaka Masuda, Naoko Hida, Hiroshi Uchida, Yasunori Yoshimura
  • Organizer: 69th American Society for Reproductive Medicine (ASRM) Annual Meeting.［Society of Reproductive Biologists and Technologists (SRBT) BASIC SCIENCE AWARD］
  • Place of Presentation: Boston, USA.
• [Presentation] Role of stem cells in the pathogenesis of endometriosis: implications for prevention and therapy of endometriosis targeting stem cells. (2013)
  • Author(s): Tetsuo Maruyama
  • Organizer: 23th International Conference of Russian Association of Human Reproduction (RAHR).
  • Place of Presentation: Volgograd, Russia.
  • Invited
• [Presentation] 着床におけるエピジェネティクスと上皮間葉転換(epithelial-to-mesenchymal transition, EMT) (2013)
  • Author(s): 丸山哲夫，内田 浩
  • Organizer: 第31回日本受精着床学会［ワークショップ］
  • Place of Presentation: 別府国際コンベンションセンター（大分県別府市）
  • Invited
• [Presentation] Novel decellularization and recellularization techniques for reconstruction and regeneration of the uterus in rat. (2013)
  • Author(s): Kaoru Miyazaki, Tetsuo Maruyama, Hirotaka Masuda, Hideyuki Oda, Naoko Hida, Hiroshi Uchida, Yasunori Yoshimura
  • Organizer: 29th Annual Meeting of the European Society of Human Reprodution and Embryology(ESHRE).
  • Place of Presentation: London, United Kingdom.
• [Presentation] 脱細胞化マトリックスを用いた子宮の再構築． (2013)
  • Author(s): 宮崎 薫，丸山哲夫，升田博隆，内田 浩，吉村泰典
  • Organizer: 第86回日本内分泌学会[若手研究奨励賞（YIA）]
  • Place of Presentation: 仙台国際センター（宮城県仙台市）
• [Presentation] ［25 SGI President' s Presenter Awards受賞］Development of in vino human endometrial stem cell assay (2013)
  • Author(s): Kaoru Miyazaki, Tetsuo Maruyama, Hirotaka Masuda, Akiko Yamasaki, Sayaka Uchida, Hideyuki Oda, Hiroshi Uchida, and Yasunori Yoshimura
  • Organizer: 60th Annual Meeting of Society for Gynecologic Investigation(SGI)
  • Place of Presentation: Orlando, FL, USA.
• [Presentation] 子宮内膜症動物実験モデル (2013)
  • Author(s): 升田博隆,丸山哲夫,松崎有未,岡野栄之,吉村泰典
  • Organizer: 第34回日本エンドメトリオーシス学会
  • Place of Presentation: 栃木総合文化センター(栃木県)(招請講演:ワークショップ)
• [Presentation] ヒト子宮内膜幹細胞の分化能を明らかにするin vivo解析システムの開発 (2013)
  • Author(s): 宮崎 薫,丸山哲夫,升田博隆,小田英之,内田明花,内田 浩,吉村泰典
  • Organizer: 第34回日本エンドメトリオーシス学会
  • Place of Presentation: 栃木総合文化センター(栃木県)
• [Presentation] [平成24年度学術奨励賞受賞]ヒト子宮内膜再構成システムを用いたin VIVO幹細胞アッセイの開発と内膜幹細胞の同定 (2012)
  • Author(s): 宮崎 薫,丸山哲夫,廾田博隆,小田英之,内田明花,内田 浩,吉村泰典
  • Organizer: 第17回日本生殖内分泌学会
  • Place of Presentation: サピアタワー(東京都)
  • Year and Date: 2012-12-08
• [Presentation] Isolation and characterization of human myometrial stem/progenitor cells : implicat ions for pregnancy-induced myomctrial remodeling (2012)
  • Author(s): Tetsuo Maruyama, Masanori Ono, Takashi Kajitani, Hiroshi Uchida, Hideyuki Oda, Sayaka Uchida, Kaoru Miyazaki, Torn Arase, Takashi Nagashima, Hirotaka Masuda, Hideyuki Okano, Yumi Matsuzaki, Yasunori Yoshimura
  • Organizer: 63rd The Korean Society for Reproductive for Reproductive Medicine Meeting(KSRM)
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2012-12-01
• [Presentation] [第14回神澤医学賞受賞講演]子成体幹細胞を用いた雌性生殖器官の再生・再建と疾患モデルの構築 (2012)
  • Author(s): 丸山哲夫
  • Organizer: 第14回神澤医学研究振興財団講演会
  • Place of Presentation: ホテルオークラ(東京都)(招請講演)
  • Year and Date: 2012-06-01
• [Presentation] 単一の新規マーカーにより分離されたヒト子宮内膜間葉系幹細胞の機能解析 (2012)
  • Author(s): 升田博隆,丸山哲夫,吉村泰典, Caroline Gargett
  • Organizer: 第57回日本生殖医学会
  • Place of Presentation: ブリックホール(長崎県)
• [Presentation] ヒト子宮内膜幹細胞のin vivo解析・同定システムの開発 (2012)
  • Author(s): 宮崎 薫,丸山哲夫,升田博隆,小田英之,内田明花,内田 浩,吉村泰典
  • Organizer: 第57回日本生殖医学会
  • Place of Presentation: ブリックホール(長崎県)
• [Presentation] [第20回日本胎盤学会相馬賞受賞] Characterization of sodium dependent betaine uptake in human placental brush-border membrane (2012)
  • Author(s): Hiromi Eguchi, Masatoshi Tomi, Tomohiro Nishimura, Kenji Oda, Mai Yamazaki, Risa Yagi, Mariko Usuda, Kei Higuchi, Tetsuo Maruyama, Emi Nakashima
  • Organizer: 18th International Federation of Placenta Association Meeting(IFPA)
  • Place of Presentation: Hiroshima, Japan
• [Presentation] Examining the role of SLC10A3 in the placenta (2012)
  • Author(s): Tomohiro Tawara, Tomohiro Nishimura, Masatoshi Tomi, Mai Yamazaki, Rina Matsushita, Kei Higuchi, Tetsuo Maruyama, Emi Nakashima
  • Organizer: 18th International Federation of Placenta Association Meeting(IFPA)
  • Place of Presentation: Hiroshima, Japan
• [Presentation] Human uterine stem/progenitor cells: implications for uterine physiology and pathology (2012)
  • Author(s): Tetsuo Maruyama
  • Organizer: 18th International Federation of Placenta Association Meeting(IFPA)
  • Place of Presentation: Hiroshima, Japan(招請講演)
• [Presentation] ヒト子宮由来幹細胞 -何が分かって何ができるか- (2012)
  • Author(s): 丸山哲夫
  • Organizer: 第30回日本受精着床学会
  • Place of Presentation: 大阪国際会議場(大阪府)(招請講演:ワークショップ)
• [Presentation] Thioredoxin, a small redox protein, in ovarian follicles of women undergoing IVF-ET (2012)
  • Author(s): Ikuko Kishi, Tetsuo Maruyama, Miho Ohishi, Yasuo Akiba, Hironori Asada, Yasuhiro Konishi, Masao Nakano, Kiyoshi Kamei, Yasunori Yoshimra
  • Organizer: 28th Annual Meeting of European Society of Human Reproduction and Embryology(ESHRE)
  • Place of Presentation: Istanbul, Turkey.
• [Presentation] Combined treatment with estrogen and progesterone promotes ectopic survival of intravenously injected human endometrial cells in immunodeficient mice (2012)
  • Author(s): Tetsuo Maruyama, Akiko Yamasaki, Kaoru Miyazaki, Toru Arase, Hiroshi Uchida, Yasunori Yoshimura
  • Organizer: 28th Annual Meeting of European Society of Human Reproduction and Embryology(ESHRE)
  • Place of Presentation: Istanbul, Turkey.
• [Presentation] Human uterine stem/ progenitor cells (2012)
  • Author(s): Tetsuo Maruyama
  • Organizer: 2nd The State Key Laboratory of Reproductive Biology Symposia in Reproductive Biology(SKLRB)
  • Place of Presentation: Beijing, Chaina(招請講演)
• [Presentation] BMP type II receptor(BMPR2)は着床後の妊娠維持に必須である．
  • Author(s): 長島 隆，Martin M. Matzuk，丸山哲夫，吉村泰典
  • Organizer: 第18回日本生殖内分泌学会［学術奨励賞］
  • Place of Presentation: シェーンバッハ・サボー（東京都千代田区）
• [Presentation] 成人期：早発卵巣不全・早発閉経に関する諸問題．
  • Author(s): 丸山哲夫
  • Organizer: 第18回日本生殖内分泌学会［シンポジウム］
  • Place of Presentation: シェーンバッハ・サボー（東京都千代田区）
  • Invited
• [Presentation] 自然発症OHSS患者に見いだされた変異FSH受容体の解析．
  • Author(s): 内田明花，内田 浩，丸山哲夫，梶谷 宇，小田英之，宮崎 薫、各務真紀，吉村泰典
  • Organizer: 第18回日本生殖内分泌学会
  • Place of Presentation: シェーンバッハ・サボー（東京都千代田区）
• [Presentation] 子宮・胎盤の炎症とdanger signal．
  • Author(s): 丸山哲夫
  • Organizer: 第21回日本胎盤学会［ランチョンセミナー］
  • Place of Presentation: ウィンク愛知（愛知県名古屋市）
  • Invited
• [Presentation] Regeneration and reconstruction of the uterus as a future infertility treatment.
  • Author(s): Tetsuo Maruyama
  • Organizer: International Federation of Fertility Societies (IFFS) Regional Meeting 2014.
  • Place of Presentation: Boston, USA.
  • Invited
• [Presentation] Differential management of patients with explained and unexplained recurrent pregnancy loss.
  • Author(s): Tetsuo Maruyama
  • Organizer: The 13th Korea-Japan Joint Conference of Obstetrics and Gynecology.
  • Place of Presentation: Seoul, Korea.
  • Invited
• [Presentation] Human endometrial stem cells; implications for endometrial physiology and pathology.
  • Author(s): Tetsuo Maruyama
  • Organizer: The 99th Annual Congress of Korean Society of Obstetrics and Gynecology (KSOG).
  • Place of Presentation: Seoul, Korea.
  • Invited
• [Book] 三次元ティッシュエンジニアリング ～ 細胞の培養・操作・組織化から品質管理、脱細胞化まで ～ (2015)
  • Author(s): 宮崎 薫，丸山哲夫
  • Total Pages: 400
  • Publisher: エヌ・ティー・エス
• [Book] Endometriosis: Pathogenesis and Treatment (2014)
  • Author(s): Maruyama T
  • Total Pages: 468
  • Publisher: Springer, Japan.
• [Remarks] テレビ東京「話題の医学:ヒト子宮内膜の再生と幹細胞」2012年12月30日午前5時～5時15分放映