HMGB1-induced vaspressin deficiency contributes to septic shock
| Project/Area Number |
24390402
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Emergency medicine
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| Research Institution | Kagoshima University |
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Principal Investigator |
ITO Takashi 鹿児島大学, 医歯(薬)学総合研究科, 講師 (20381171)
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| Co-Investigator(Kenkyū-buntansha) |
MARUYAMA Ikuro 鹿児島大学, 大学院医歯学総合研究科, 特任教授 (20082282)
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| Co-Investigator(Renkei-kenkyūsha) |
NAKAHARA Mayumi 鹿児島大学, 大学院医歯学総合研究科, 特任助教 (90707514)
KAWAHARA Ko-ichi 大阪工業大学, 工学部生命工学科, 特任教授 (10381170)
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| Research Collaborator |
NAGASATO Tomoka 藤森工業株式会社
YAMADA Shingo 株式会社シノテスト
TAKENAKA Yukari 鹿児島大学, 大学院医歯学総合研究科
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2014: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2013: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2012: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
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| Keywords | 敗血症性ショック / バソプレシン / HMGB1 / DAMPs / 敗血症 / ショック / 集中治療医学 / DAMPｓ |
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| Outline of Final Research Achievements |
Vasopressin deficiency contributes to the vasodilatation in the later stages of septic shock, and supplementary arginine vasopressin (AVP) infusion is increasingly being used to stabilize cardiocirculatory function in patients with advanced vasodilatory shock. However, the exact mechanism responsible for the vasopressin deficiency remains to be determined. Here we show that high mobility group box 1 protein (HMGB1), a late mediator of endotoxin lethality, is responsible for the vasopressin deficiency in endotoxemic rats. Administration of a neutralizing antibody against HMGB1 increased plasma vasopressin levels in endotoxemic rats, while administration of exogenous HMGB1 decreased plasma vasopressin levels.
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Report
(4 results)
Research Products
(16 results)
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[Journal Article] Cleavage of host cytokeratin-6 by lysine-specific gingipain induces gingival inflammation in periodontitis patients.2015
Author(s)
Tancharoen S, Matsuyama T, Kawahara K, Tanaka K, Lee LJ, Machigashira M, Noguchi K, Ito T, Imamura T, Potempa J, Kikuchi K,Maruyama I.
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Journal Title
PLoS One.
Volume: 10
Issue: 2
Pages: e0117775-e0117775
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Potential of the angiotensin receptor blockers (ARBs) telmisartan, Irbesartan, and candesartan for inhibiting the HMGB1/RAGE axis in prevention and acute treatment of stroke.2013
Author(s)
Kikuchi K, Tancharoen S, Ito T, Morimoto-Yamashita Y, Miura N, Kawahara K, MaruyamaI, Murai Y, Tanaka E
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Journal Title
Int. Mol. Sci.
Volume: 14
Issue: 9
Pages: 18899-18924
DOI
Related Report
Peer Reviewed
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