| Project/Area Number |
24390405
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Emergency medicine
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| Research Institution | Keio University |
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Principal Investigator |
HORI Shingo 慶應義塾大学, 医学部, 教授 (80129650)
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| Co-Investigator(Kenkyū-buntansha) |
SANO Motoaki 慶應義塾大学, 医学部, 准教授 (30265798)
SUZUKI Masaru 慶應義塾大学, 医学部, 講師 (70265916)
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| Co-Investigator(Renkei-kenkyūsha) |
OHTA Shigeo 日本医科大学, 大学院医学研究科, 教授 (00125832)
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| Research Collaborator |
HAYASHIDA Kei 慶應義塾大学, 医学部, 助教 (20445258)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2014: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2013: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2012: ¥11,960,000 (Direct Cost: ¥9,200,000、Indirect Cost: ¥2,760,000)
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| Keywords | 水素吸入療法 / 心停止蘇生後 / 分子状水素 / 心停止後症候群 / 虚血再灌流障害 / 抗酸化薬 / 酸化ストレス / 蘇生後脳症 / 脳機能不全 / 蘇生後症候群 |
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| Outline of Final Research Achievements |
This study is a translational research aimed at clinical application of hydrogen inhalation therapy (HIT) in out-of-hospital cardiac arrest (CA) patient. First, we verified the usefulness of hydrogen inhalation using a rat CA model. Brain function scores and survival rates in the HIT group were improved compared to the control group. It showed the most improvement effect by the combined use of HIT and therapeutic hypothermia. In addition, we evaluated the safety and efficacy of HIT for patients successfully resuscitated after CA. There were no side effects and clinical disadvantages. Four patients of all 5 eligible patients discharged from hospital with alert consciousness. We are planning to verify the efficacy of HIT for post-CA patients by multicenter randomized trial.
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