Exploration of bacterial factors that inactivate complement regulatory factors and induce invasive infectious diseases
| Project/Area Number |
24390410
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TERAO Yutaka 新潟大学, 医歯学総合研究科, 教授 (50397717)
SUMITOMO Tomoko 大阪大学, 大学院歯学研究科, 助教 (50423421)
NAKATA Masanobu 大阪大学, 大学院歯学研究科, 准教授 (90444497)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2014: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2013: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2012: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
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| Keywords | レンサ球菌 / 補体 / 免疫回避 / 細菌 / 感染症 / 免疫 / 補体制御因子 / NETs |
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| Outline of Final Research Achievements |
Evasion of the human immune system is a hallmark of pathogenic streptococci that cause invasive infections, and leads to exacerbation of pathological condition during the course of infection. In this study, we revealed that a group A streptococcal protease, SpeB, cleaves C1 esterase inhibitor, and the cleavage is attributable to bacterial survival and aberration of complement system. Moreover, we demonstrate a mechanism by which streptococcus species frequently isolated from subacute bacterial endocarditis evades neutrophil killing.
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Report
(4 results)
Research Products
(66 results)
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[Presentation] Enzymatically active extracellular hyaluronidase (HylA) of group A Streptococcus promotes intracellular survival and virulence.2014
Author(s)
Yamaguchi M, Yamaguchi Y, Nakata M, Henningham A, Olson J, Dahesh S, Cole J, Kawabata S, Varki A, and Nizet V.
Organizer
SFG and JSCR2014 Joint Annual Meeting
Place of Presentation
Honolulu, HI, USA
Year and Date
2014-11-16 – 2014-11-19
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[Presentation] Group A streptococcal cycteine proteases, SpeB and Sib35, cleave epithelial junctions.2013
Author(s)
住友倫子,東野美晴,小南明里,中田匡宣,寺尾豊,川端重忠,
Organizer
第86回日本細菌学会総会
Place of Presentation
幕張メッセ,千葉市,千葉県
Related Report
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[Presentation] 8-Nitro-cGMP exerts anti-bacterial effect through inactivation of bacterial GAPDH2013
Author(s)
Minkyung Jung, 小野勝彦,岡本竜哉,井田知章,藤井重元,居原秀,澤智裕,川端重忠,熊谷嘉人,赤池孝章.
Organizer
第86回日本細菌学会総会
Place of Presentation
幕張メッセ,千葉市,千葉県
Related Report
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