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The development of new regenerative therapy for periodontal-bone tissue defects by using de-differentiated fat cells

Research Project

Project/Area Number 24390444
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Dental engineering/Regenerative dentistry
Research InstitutionKagoshima University

Principal Investigator

KAZUYUKI Noguchi  鹿児島大学, 医歯学総合研究科, 教授 (90218298)

Co-Investigator(Kenkyū-buntansha) NAKAMURA Toshiaki  鹿児島大学, 大学院・医歯学総合研究科, 助教 (60381183)
SAKODA Kenji  鹿児島大学, 大学院・医歯学総合研究科, 助教 (70419654)
YOSHIMOTO Takehiko  鹿児島大学, 大学院・医歯学総合研究科, 客員研究員 (60419653)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2014: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2012: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Keywords脱分化脂肪細胞 / 歯周組織 / 骨 / 再生 / DFAT / 歯周病 / 骨組織再生 / 歯周組織再生 / 細胞移植 / 再生療法
Outline of Final Research Achievements

The purpose of this study was established that the molecular biologic base of new cell-transplant therapy for lost of periodontal and bone tissues by using de-differentated fat cells (DFAT). Within the limits of the present study, we demonstrated that the poly lactic-co-glycolic acid/hydroxylapatite (PLGA/ HA) composite is a promising scaffold with an appropriate stiffness and resorption rate, and that its combination with osteo-differentiated rat DFAT may be effective for bone formation in rat calvarial defects model. Furthermore, in vitro study demonstrated that the combination of bone morphogenetic protein (BMP)-9 and FK506 effectively induces osteoblastic differentiation of rDFAT cells.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (9 results)

All 2014 2013 2012

All Journal Article (3 results) (of which Peer Reviewed: 2 results) Presentation (6 results)

  • [Journal Article] An exploratory study on the efficacy of rat dedifferentiated fat cells (rDFATs) with a poly lactic-co-glycolic acid/hydroxylapatite (PLGA/HA) composite for bone formation in a rat calvarial defect model2014

    • Author(s)
      Yoshinori Shirakata, Toshiaki Nakamura, Yukiya Shinohara, Katsuyoshi Taniyama, Kenji Sakoda, Takehiko Yoshimoto, Kazuyuki Noguchi
    • Journal Title

      Journal of Materials Science: Materials in Medicine

      Volume: 25 Issue: 3 Pages: 899-908

    • DOI

      10.1007/s10856-013-5124-x

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Co-stimulation with bone morphogenetic protein-9 and FK506 induces remarkable osteoblastic differentiation in rat dedifferentiated fat cells2013

    • Author(s)
      Toshiaki Nakamura, Yukiya Shinohara, Sawako Momozaki, Takehiko Yoshimoto, Kazuyuki Noguchi
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 440 Issue: 2 Pages: 289-294

    • DOI

      10.1016/j.bbrc.2013.09.073

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 細胞移植による歯周組織再生2013

    • Author(s)
      迫田賢二、白方良典、中村利明、野口和行
    • Journal Title

      鹿児島県歯科医師会会報

      Volume: 110 Pages: 7-9

    • Related Report
      2013 Annual Research Report
  • [Presentation] BMP-9とFK506の共刺激はラット脱分化脂肪細胞(rDFATs)の骨芽細胞様分化を促進する2014

    • Author(s)
      中村利明, 篠原敬哉, 桃嵜佐和子, 野口和行
    • Organizer
      日本歯科保存学会2014年度春季学術大会(第140回)
    • Place of Presentation
      滋賀 (滋賀県立芸術劇場)
    • Year and Date
      2014-06-19 – 2014-06-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] BMP-9とFK506の共刺激はラット脱分化脂肪細胞(rDFATs)の骨芽細胞様分化を促進する2014

    • Author(s)
      中村利明, 篠原敬哉, 桃嵜佐和子, 野口和行
    • Organizer
      日本歯科保存学会2014年度春季学術大会
    • Place of Presentation
      滋賀
    • Related Report
      2013 Annual Research Report
  • [Presentation] An exploratory study on the efficacy of rat dedifferentiated fat cells (rDFATs) with poly lactic-co-glycolic acid/hydroxylapatite (PLGA/HA) composite for bone formation in a rat calvarial defect model2013

    • Author(s)
      Yoshinori Shirakata, Yukiya Shinohara, Katsuyoshi Taniyama, Toshiaki Nakamura, Kenji Sakoda, Takehiko Yoshimoto,Kazuyuki Noguchi
    • Organizer
      the 10th Asian Pacific Society of Periodontology (APSP) Meeting
    • Place of Presentation
      奈良
    • Related Report
      2013 Annual Research Report
  • [Presentation] BMP-9とFK506の共刺激によるラット脱分化脂肪細胞(rDFATs)の骨芽細胞様分化2013

    • Author(s)
      中村利明, 篠原敬哉, 桃嵜佐和子, 吉元剛彦, 野口和行
    • Organizer
      平成25年度日本歯周病学会九州五大学・日本臨床歯周病学会九州支部合同研修会
    • Place of Presentation
      福岡
    • Related Report
      2013 Annual Research Report
  • [Presentation] 脱分化脂肪細胞(DFAT)のBone morphogenetic proteins刺激による骨芽細胞様分化2012

    • Author(s)
      中村利明、吉元剛彦、迫田賢二、野口和行
    • Organizer
      第55回春季日本歯周病学会学術大会
    • Place of Presentation
      北海道・札幌コンベンションセンター
    • Related Report
      2012 Annual Research Report
  • [Presentation] 脱分化脂肪細胞(DFAT)を用いたラット頭蓋骨欠損モデルにおける骨組織再生2012

    • Author(s)
      中村利明,迫田賢二,谷山勝義,篠原敬哉,野口和行
    • Organizer
      第137回日本歯科保存学会2012年度秋季学術大会
    • Place of Presentation
      広島県・広島国際会議場
    • Related Report
      2012 Annual Research Report

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Published: 2012-04-24   Modified: 2019-07-29  

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