| Project/Area Number |
24390464
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Kagoshima University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OHMURE Haruhito 鹿児島大学, 医歯(薬)学総合研究科, 講師 (00404484)
YAGI Takakazu 鹿児島大学, 医学部・歯学部附属病院, 講師 (10346166)
UEDA Hirotaka 鹿児島大学, 医学部・歯学部附属病院, 助教 (10583445)
NAGAYAMA Kunihiro 鹿児島大学, 医学部・歯学部附属病院, 助教 (60583458)
MAEDA Aya 鹿児島大学, 医歯(薬)学総合研究科, 助教 (10457666)
UEHARA Sawako 鹿児島大学, 医学部・歯学部附属病院, 医員 (50706257)
TSUBOUCHI Hirohito 鹿児島大学, 医歯(薬)学総合研究科, 教授 (60145480)
IDO Akio 鹿児島大学, 医歯(薬)学総合研究科, 教授 (30291545)
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| Co-Investigator(Renkei-kenkyūsha) |
SAKIYAMA Toshio 鹿児島大学, 医学部・歯学部附属病院, 准教授 (70542421)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2014: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2013: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2012: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
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| Keywords | 脳腸相関 / 顎口腔機能 / 迷走神経 / 胃 / 食道 |
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| Outline of Final Research Achievements |
In the present study, we hypothesized that there is a strong correlation between stmatognathic function and the motility function of the stomach and esophagus. (1) Initial gastric emptying is suppressed by mastication, and that the suppression is caused by mastication-induced inhibition of gastric activity. (2) Esophageal-derived autonomic nervous system modulation induces masseter muscle activity, irrespective of the presence of subjective gastrointestinal symptoms. (3) By administering proton pump inhibitor to the patients with sleep bruxism, masseter muscle activity during sleep significantly decreased. (4) Involuntary teeth clenching is related to regional brain activity in the insula and anterior cingulate cortex. These studies suggest that the function and sensation of the stomach and esophagus may be closely related with a stmatognathic function via brain activity.
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