Occurrence of fibrates and their metabolites in aquatic environments in China and their effects on aquatic organisms
| Project/Area Number |
24406008
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 海外学術 |
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| Research Field |
Environmental pharmacy
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| Research Institution | Gifu Pharmaceutical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAKANISHI Tsuyoshi 岐阜薬科大学, 薬学部, 准教授 (50303988)
IDO Akiko 岐阜薬科大学, 薬学部, 助手 (00336629)
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| Co-Investigator(Renkei-kenkyūsha) |
HIROMORI Youhei 金城学院大学, 薬学部, 助教 (60515956)
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| Research Collaborator |
YANG Min
HU Jianying
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2014: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2013: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2012: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
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| Keywords | 水環境 / フィブラート / PPCPs / PPAR |
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| Outline of Final Research Achievements |
Fibrates, which are widely used as lipidemic-modulating drugs, are poorly removed during typical drinking water treatment, and thus may remain in drinking water after treatment of source water. In this study, we established liquid chromatography-electrospray tandem mass spectrometry combined with weak anion exchange solid-phase extraction to simultaneously determine trace levels of 3 typical fibrates and 2 of their metabolites in source water and finished water samples collected from 10 drinking water treatment plants in China. In source water, all target compounds were detected at ng/L concentrations and all compounds except fenofibrate were detected in finished water. The peroxisome proliferator-activated receptor α (PPARα) agonistic activities of all target compounds were detected at mg/L concentrations by a PPARα reporter assay; therefore, the present results suggest that the fibrate concentrations in drinking water in China have no significant effect on human health.
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Report
(4 results)
Research Products
(38 results)
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[Journal Article] A mollusk retinoic acid receptor (RAR) ortholog sheds light on the evolution of ligand binding2014
Author(s)
Gutierrez-Mazariegos J, Kumar Nadendla E, Lima D, Kane M, Nishikawa J, Hiromori Y, Nakanishi T, Santos MM, Castro LFC, Bourguet W, Schubert M, Laudet V
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Journal Title
Endocrinology
Volume: 155
Pages: 4275-4286
DOI
Related Report
Peer Reviewed
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[Presentation] 卵巣機能によるTPT毒性発現修飾2014
Author(s)
大塚佑基、青木 明、中西 剛、永瀬久光
Organizer
第４回メタロミクス研究フォーラム
Place of Presentation
武蔵野大学（東京都西東京市）
Year and Date
2014-11-07 – 2014-11-08
Related Report
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