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Occurrence of fibrates and their metabolites in aquatic environments in China and their effects on aquatic organisms

Research Project

Project/Area Number 24406008
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section海外学術
Research Field Environmental pharmacy
Research InstitutionGifu Pharmaceutical University

Principal Investigator

NAGASE Hisamitsu  岐阜薬科大学, 薬学部, 教授 (40141395)

Co-Investigator(Kenkyū-buntansha) NAKANISHI Tsuyoshi  岐阜薬科大学, 薬学部, 准教授 (50303988)
IDO Akiko  岐阜薬科大学, 薬学部, 助手 (00336629)
Co-Investigator(Renkei-kenkyūsha) HIROMORI Youhei  金城学院大学, 薬学部, 助教 (60515956)
Research Collaborator YANG Min  
HU Jianying  
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2014: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2013: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2012: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Keywords水環境 / フィブラート / PPCPs / PPAR
Outline of Final Research Achievements

Fibrates, which are widely used as lipidemic-modulating drugs, are poorly removed during typical drinking water treatment, and thus may remain in drinking water after treatment of source water. In this study, we established liquid chromatography-electrospray tandem mass spectrometry combined with weak anion exchange solid-phase extraction to simultaneously determine trace levels of 3 typical fibrates and 2 of their metabolites in source water and finished water samples collected from 10 drinking water treatment plants in China. In source water, all target compounds were detected at ng/L concentrations and all compounds except fenofibrate were detected in finished water. The peroxisome proliferator-activated receptor α (PPARα) agonistic activities of all target compounds were detected at mg/L concentrations by a PPARα reporter assay; therefore, the present results suggest that the fibrate concentrations in drinking water in China have no significant effect on human health.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (38 results)

All 2015 2014 2013 2012

All Journal Article (9 results) (of which Peer Reviewed: 9 results,  Open Access: 1 results) Presentation (29 results) (of which Invited: 5 results)

  • [Journal Article] Organotin compounds cause structure-dependent induction of progesterone in human choriocarcinoma Jar cells.2015

    • Author(s)
      Hiromori Y, Yui H, Nishikawa JI, Nagase H, Nakanishi T
    • Journal Title

      The Journal of Steroid Biochemistry and Molecular Biology

      Volume: in press Pages: 190-198

    • DOI

      10.1016/j.jsbmb.2014.10.010

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gene expression differences in the duodenum of 129/Sv and DBA/2 mice compared with that of C57BL/6J mice2014

    • Author(s)
      Imai S, Tokumoto M, Fujiwara Y, Honda A, Hasegawa T, Seko Y, Lee JY, Nagase H, Satoh M
    • Journal Title

      The Journal of Toxicological Sciences

      Volume: 39 Issue: 1 Pages: 173-177

    • DOI

      10.2131/jts.39.173

    • NAID

      130004447110

    • ISSN
      0388-1350, 1880-3989
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A mollusk retinoic acid receptor (RAR) ortholog sheds light on the evolution of ligand binding2014

    • Author(s)
      Gutierrez-Mazariegos J, Kumar Nadendla E, Lima D, Kane M, Nishikawa J, Hiromori Y, Nakanishi T, Santos MM, Castro LFC, Bourguet W, Schubert M, Laudet V
    • Journal Title

      Endocrinology

      Volume: 155 Issue: 11 Pages: 4275-4286

    • DOI

      10.1210/en.2014-1181

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] DNA microarray analysis of hepatic gene expression in mice exposed to cadmium for 30 days2013

    • Author(s)
      Maki Tokumoto 他5名
    • Journal Title

      The Journal of Toxicological Sciences

      Volume: 38 Issue: 1 Pages: 155-157

    • DOI

      10.2131/jts.38.155

    • NAID

      10031138738

    • ISSN
      0388-1350, 1880-3989
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Practical method for PCB degradation using Pd/C-H2-Mg system2013

    • Author(s)
      Akiko Ido
    • Journal Title

      Chemosphere

      Volume: 90 Issue: 1 Pages: 57-64

    • DOI

      10.1016/j.chemosphere.2012.06.074

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of megalin and the soluble form of its ligand RAP in Cd-metallothionein endocytosis and Cd-metallothionein-induced nephrotoxicity in vivo2012

    • Author(s)
      Akira Onodera
    • Journal Title

      Toxicology Letters

      Volume: 212 Issue: 2 Pages: 91-96

    • DOI

      10.1016/j.toxlet.2012.05.012

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Trichloroethylene enhances TCR-CD3-induced proliferation of CD8<sup>+</sup> rather than CD4<sup>+</sup> T cells2012

    • Author(s)
      Ryo Kobayashi
    • Journal Title

      The Journal of Toxicological Sciences

      Volume: 37 Issue: 2 Pages: 381-387

    • DOI

      10.2131/jts.37.381

    • NAID

      10030126895

    • ISSN
      0388-1350, 1880-3989
    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Detection of retinoic acid receptor agonistic activity and identification of causative compounds in municipal wastewater treatment plants in Japan2012

    • Author(s)
      Kazuko Sawada
    • Journal Title

      Environmental Toxicology and Chemistry

      Volume: 31 Issue: 2 Pages: 307-315

    • DOI

      10.1002/etc.741

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pd/C-catalyzed dechlorination of polychlorinated biphenyls under hydrogen gas-free conditions2012

    • Author(s)
      Shinji Ishihara
    • Journal Title

      Journal of Hazardous Materials

      Volume: 229-230 Pages: 15-19

    • DOI

      10.1016/j.jhazmat.2012.05.005

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] 成熟期マウスの性腺機能によるトリフェニルスズの毒性発現性修飾2015

    • Author(s)
      松田健志、大塚佑基、青木 明、中西 剛、永瀬久光
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸学院大学 他(兵庫県神戸市)
    • Year and Date
      2015-03-25 – 2015-03-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] 卵巣機能によるTPT毒性発現修飾2014

    • Author(s)
      大塚佑基、青木 明、中西 剛、永瀬久光
    • Organizer
      第4回メタロミクス研究フォーラム
    • Place of Presentation
      武蔵野大学(東京都西東京市)
    • Year and Date
      2014-11-07 – 2014-11-08
    • Related Report
      2014 Annual Research Report
  • [Presentation] In vivo profiling of potential Estrogenic Action induced by Royal Jelly in Female using Estrogen Reporter (E-Rep) mice2014

    • Author(s)
      Nakanishi T
    • Organizer
      The First Congress of the International Federation of Apitherapy and the VII-th. of the Romanian Apitherapy Society
    • Place of Presentation
      Brasov, Romania
    • Year and Date
      2014-10-17 – 2014-10-21
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 有機スズ化合物の毒性発現に対するMajor Urinary Protein1の影響2014

    • Author(s)
      青木 明、大塚佑基、中西 剛、永瀬久光
    • Organizer
      フォーラム2014:衛生薬学・環境トキシコロジー
    • Place of Presentation
      つくば国際会議場(茨城県つくば市)
    • Year and Date
      2014-09-19 – 2014-09-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] トリフェニルスズの全身免疫系に対する加齢化促進作用の検討2014

    • Author(s)
      廣森洋平、酒井紀行、小林 亮、上代大地、中西 剛、永瀬 久光
    • Organizer
      第21回日本免疫毒性学会学術年会
    • Place of Presentation
      徳島文理大学(徳島県徳島市)
    • Year and Date
      2014-09-11 – 2014-09-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] Organotin compounds cause structure-dependent induction of progesterone in human choriocarcinoma Jar cells2014

    • Author(s)
      Nakanishi T, Hiromori Y, Nishikawa J, Nagase H
    • Organizer
      EuroTox 2014: 50th Congress of the European Societies of Toxicology
    • Place of Presentation
      Edinburgh, UK
    • Year and Date
      2014-09-07 – 2014-09-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] TPTの成熟期雌性マウスにおける28日間反復経口投与毒性試験と卵巣機能による毒性発現修飾2014

    • Author(s)
      青木 明、大塚佑基、中西 剛、永瀬久光
    • Organizer
      第25回日本微量元素学会学術集会
    • Place of Presentation
      岡山大学創立五十周年記念館(岡山県岡山市)
    • Year and Date
      2014-07-03 – 2014-07-04
    • Related Report
      2014 Annual Research Report
  • [Presentation] 脳の性分化と胎生期エストロゲンシグナル2014

    • Author(s)
      中西 剛
    • Organizer
      第41回日本毒性学会学術年会
    • Place of Presentation
      神戸コンベンションセンター(兵庫県神戸市)
    • Year and Date
      2014-07-02 – 2014-07-04
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 核内受容体を介した有機スズ化合物の毒性2014

    • Author(s)
      廣森洋平、中西 剛、永瀬久光
    • Organizer
      第41回日本毒性学会学術年会
    • Place of Presentation
      神戸コンベンションセンター(兵庫県神戸市)
    • Year and Date
      2014-07-02 – 2014-07-04
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 酵母 two-hybrid 法を用いたヒトおよびマウスPXRアゴニスト活性評価系の構築2014

    • Author(s)
      桑山 隼、廣森洋平、西川淳一、中西 剛、永瀬久光
    • Organizer
      第41回 日本毒性学会学術年会
    • Place of Presentation
      神戸コンベンションセンター(兵庫県神戸市)
    • Year and Date
      2014-07-02 – 2014-07-04
    • Related Report
      2014 Annual Research Report
  • [Presentation] The Roles of Major Urinary Protein 1 As a Regulator for Adipocyte Differentiation in Mice2014

    • Author(s)
      Aoki A, Nagase H, Nakanishi T
    • Organizer
      16th International Congress of Endocrinology & the Endocrine Society’s 96th Annual Meeting & Expo
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2014-06-21 – 2014-06-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] TPTの成熟期雌性マウスにおける28日間反復経口投与毒性試験と 卵巣機能による毒性発現修飾2014

    • Author(s)
      大塚佑基 他3名
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本大学(熊本)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 有機スズ化合物の樹状細胞機能修飾を介した免疫抑制作用について2014

    • Author(s)
      佐藤友明 他2名
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本大学(熊本)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 化学物質による免疫機能の老化-トリフェニルスズの胸腺萎縮機構解明を例に-2013

    • Author(s)
      中西 剛
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2013-03-29
    • Related Report
      2012 Annual Research Report
  • [Presentation] Chromium (VI)-induced Transformation is Enhanced by Zinc Deficiency in BALB/3T3 Clone A31-1-1 Cells2013

    • Author(s)
      Tomoki Kimura 他5名
    • Organizer
      International Congress of Toxicology 2013
    • Place of Presentation
      COEX(Seoul)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Structure-activity studies on the RXR agonist activity of organotins2013

    • Author(s)
      Tsuyoshi Nakanishi 他3名
    • Organizer
      Eurotox 2013
    • Place of Presentation
      Congress Centre(Interlaken)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 酵母 two-hybrid 法を用いたヒトおよびマウスPXRアゴニスト活性評価系の構築2013

    • Author(s)
      桑山 隼 他4名
    • Organizer
      フォーラム2013 衛生薬学・環境トキシコロジー
    • Place of Presentation
      九州大学(福岡)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 付着生物の核内受容体と有機スズ化合物の防汚作用との関係に関する研究2013

    • Author(s)
      中西 剛 他3名
    • Organizer
      日本マリンエンジニアリング学会(JIME)海洋環境研究委員会第3回ワークショップ
    • Place of Presentation
      神戸大学(神戸)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 核内受容体を介した有機スズ化合物の毒性2013

    • Author(s)
      廣森洋平 他2名
    • Organizer
      メタルバイオサイエンス研究会2013
    • Place of Presentation
      静岡県立大学(静岡)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] トリフェニルスズの28日間反復経口投与毒性試験2013

    • Author(s)
      大塚佑基 他3名
    • Organizer
      メタルバイオサイエンス研究会2013
    • Place of Presentation
      静岡県立大学(静岡)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Structure activity relationships in organotin-induced toxicity via retinoid X receptor signaling pathway2013

    • Author(s)
      Tsuyoshi Nakanishi
    • Organizer
      International Society of Trace Element Research in Humans 2013
    • Place of Presentation
      京王プラザホテル(東京)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] トリフェニルスズの全身免疫系に対する加齢化促進作用の検討2012

    • Author(s)
      廣森洋平, 他5名
    • Organizer
      第3回メタロミクス研究フォーラム
    • Place of Presentation
      昭和薬科大学(東京)
    • Year and Date
      2012-08-30
    • Related Report
      2012 Annual Research Report
  • [Presentation] 核内受容体としての有機スズ化合物とその毒性2012

    • Author(s)
      中西 剛
    • Organizer
      第39回日本毒性学会学術年会
    • Place of Presentation
      仙台国際センター (仙台)(招待講演)
    • Year and Date
      2012-07-18
    • Related Report
      2012 Annual Research Report
  • [Presentation] トリフェニルスズの全身免疫系に対する加齢化促進作用の検討2012

    • Author(s)
      廣森洋平, 他5名
    • Organizer
      第39回日本毒性学会学術年会
    • Place of Presentation
      仙台国際センター (仙台)
    • Year and Date
      2012-07-18
    • Related Report
      2012 Annual Research Report
  • [Presentation] 2,3,7,8-tetrachlorodibenzo-p-dioxinによるaryl hydrocarbon receptor非依存的な経路を介した乳癌細胞増殖抑制作用2012

    • Author(s)
      青木 明, 他6名
    • Organizer
      第39回日本毒性学会学術年会
    • Place of Presentation
      仙台国際センター (仙台)
    • Year and Date
      2012-07-17
    • Related Report
      2012 Annual Research Report
  • [Presentation] トリクロロエチレンによるT細胞増殖亢進作用に関する検討2012

    • Author(s)
      小林亮, 他2名
    • Organizer
      第39回日本毒性学会学術年会
    • Place of Presentation
      仙台国際センター (仙台)
    • Year and Date
      2012-07-17
    • Related Report
      2012 Annual Research Report
  • [Presentation] 核内受容体を介した有機スズ化合物の生体影響に関する研究2012

    • Author(s)
      中西 剛
    • Organizer
      第23回日本微量元素学会学術集会
    • Place of Presentation
      シェーンバッハ・サボー(東亰)(招待講演)
    • Year and Date
      2012-07-06
    • Related Report
      2012 Annual Research Report
  • [Presentation] Triphenyltin promotes thymic aging via PPARy signaling pathway.2012

    • Author(s)
      Tsuyoshi Nakanishi, 他5名
    • Organizer
      Eurotox 2012
    • Place of Presentation
      Stockholm Waterfront Congress Centre (Stockholm)
    • Year and Date
      2012-06-19
    • Related Report
      2012 Annual Research Report
  • [Presentation] PPARβ/δリガンドのスクリーニング法2012

    • Author(s)
      中西 剛
    • Organizer
      BIO tech 2012 アカデミックフォーラム
    • Place of Presentation
      東京ビッグサイト(東京)
    • Year and Date
      2012-04-26
    • Related Report
      2012 Annual Research Report

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Published: 2012-04-24   Modified: 2019-07-29  

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