• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Confirmation of the elimination of filariasis and early finding of its recurrence by habitant friendly urine diagnosis and vector mosquito investigation

Research Project

Project/Area Number 24406014
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section海外学術
Research Field Parasitology (including Sanitary zoology)
Research InstitutionAichi Medical University

Principal Investigator

ITOH MAKOTO  愛知医科大学, 医学部, 教授 (90137117)

Co-Investigator(Kenkyū-buntansha) HIRAYAMA Kenji  長崎大学, 熱帯医学研究所, 教授 (60189868)
HAMANO Shinjiro  長崎大学, 熱帯医学研究所, 教授 (70294915)
SUNAHARA Toshihiko  長崎大学, 熱帯医学研究所, 助教 (50264156)
TAKAGI Hidekazu  愛知医科大学, 医学部, 講師 (90288522)
Research Collaborator KIMURA Eisaku  愛知医科大学, 医学部, 名誉教授 (70153187)
NAGAOKA Fumiaki  愛知医科大学, 医学部, 助手
WEERASOORIYA Mirani V  ルフナ大学(スリランカ), 医学部, 教授
YAHATHUGODA Thishan C.  ルフナ大学(スリランカ), 医学部, 講師
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2014: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2012: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Keywordsフィラリア症 / 尿診断 / 媒介蚊 / LAMP / 糸状虫 / 疫学調査 / 糸状虫症
Outline of Final Research Achievements

This study aimed to establish a combination system of both immunodiagnosis with urine samples and LAMP with mosquito samples to confirm eliminations and find resurgences of lymphatic filariasis with minimum burden of inhabitants.
The system, which detects anti-filaria antibodies in urine and Wuchereria bancrofti DNA in Culex quinquefaciatus with LAMP, was applied to former endemic areas, and was shown as resident friendly, labor saving and sensitive.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report

Research Products

(33 results)

All 2015 2014 2013 2012 Other

All Journal Article (15 results) (of which Peer Reviewed: 13 results,  Open Access: 4 results,  Acknowledgement Compliant: 2 results) Presentation (16 results) Book (2 results)

  • [Journal Article] Serological surveillance development for tropical infectious diseases using simultaneous microsphere-based multiplex assays and finite mixture models.2014

    • Author(s)
      Fujii Y, Kaneko S, Nzou SM, Mwau M, Njenga SM, Tanigawa C, Kimotho J, Mwangi AW, Kiche I, Matsumoto S, Niki M, Osada-Oka M, Ichinose Y, Inoue M, Itoh M, Tachibana H, Ishii K, Tsuboi T, Yoshida LM, Mondal D, Haque R, Hamano S, Changoma M, Hoshi T, Kamo K, Karama M, Miura M, Hirayama K.
    • Journal Title

      PLoS Negl

      Volume: 8 Pages: 1-15

    • DOI

      10.1371/journal.pntd.0003040

    • NAID

      120006986460

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] <i>Ascaris lumbricoids</i> Infection as a Risk Factor for Asthma and Atopy in Rural Bangladeshi Children2014

    • Author(s)
      Hawlader MD, Ma E, Noguchi E, Itoh M, Arifeen SE, Persson L, Moore SE, Raqib R, Wagatsuma Y
    • Journal Title

      Trop.Med.Health

      Volume: 42 Issue: 2 Pages: 77-85

    • DOI

      10.2149/tmh.2013-19

    • NAID

      130003392442

    • ISSN
      1348-8945, 1349-4147
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A case of mucocutaneous leishmaniasis diagnosed by serology.2014

    • Author(s)
      Okumura Y, Yamauchi A, Nagano I, Itoh M, Hagiwara K, Takahashi K, Uezato H, Maeda M, Seishima M.
    • Journal Title

      Journal of Dermatology

      Volume: 41 Pages: 739-42

    • DOI

      10.1111/1346-8138.12564

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Risk Factors and Spatial Distributions of Schistosoma mansoni infection among Primary School Children in Mbita, western Kenya2014

    • Author(s)
      Sachiyo Nagi, Evans Chadeka, Toshihiko Sunahara, Faith Mutungi, Yombo K. Dan Justin, Satoshi Kaneko, Yoshio Ichinose, Sohkichi Mastumoto, Sammy M. Njenga, Masahiro Hashizume, Masaaki Shimada and Shinjiro Hamano
    • Journal Title

      PLoS Negl Trop Dis

      Volume: 8 Pages: 1-10

    • DOI

      10.1371/journal.pntd.0002991

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Rapid assessment procedures to detect hidden endemic foci in areas not subjected to mass drug administration in Sri Lanka2014

    • Author(s)
      Yahathugoda TC, Weerasooriya MV, Sunahara T, Kimura E, Samarawickrema WA, Itoh M
    • Journal Title

      Parasitol Int

      Volume: 63 Pages: 87-93

    • DOI

      10.1016/j.parint.2013.09.008

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] リーシュマニア症の診断と治療2014

    • Author(s)
      眞鳥繁隆、上里博、伊藤誠
    • Journal Title

      Monthly Book Derma

      Volume: 125 Pages: 17-23

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Enzyme-linked immunosorbent assay for the diagnosis of Wuchereria bancrofti infection using urine samples and its application in Bangladesh2013

    • Author(s)
      Samad MS, , Itoh M, Moji K, Hossain M, Mondal D, Alam MS, Kimura E
    • Journal Title

      Parasitol Int

      Volume: 62 Pages: 564-567

    • DOI

      10.1016/j.parint.2013.08.007

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunodiagnosis of alveolar echinococcosis using urine samples.2013

    • Author(s)
      Itoh M, Sako Y, Itoh S, Ishikawa Y, Akabane M, Nakaya K, Nagaoka F, Ito A.
    • Journal Title

      Parasitol Int

      Volume: 62(6) Pages: 514-516

    • DOI

      10.1016/j.parint.2013.07.007

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Topographic models for predicting malaria vector breeding habitats: potential tools for vector control managers2013

    • Author(s)
      Nmor JC, Sunahara T, Goto K, Futami K, Sonye G, Akweywa P, Dida G, Minakawa N
    • Journal Title

      Parasit Vectors

      Volume: 16 Pages: 1-13

    • DOI

      10.1186/1756-3305-6-14

    • NAID

      120006985872

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ELISA with recombinant rKRP42 antigen using urine samples : a tool for predicting clinical visceral leishmaniasis cases and its outbreak2012

    • Author(s)
      Islam MZ
    • Journal Title

      Am J Trop Med Hyg

      Volume: 87 Pages: 658-662

    • DOI

      10.4269/ajtmh.2012.12-0168

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Application of RFLP-PCR-Based Identification for Sand Fly Surveillance in an Area Endemic for Kala-Azar in Mymensingh, Bangladesh2012

    • Author(s)
      Alam MS
    • Journal Title

      J Parasitol Res

      Volume: 2,0122012

    • DOI

      10.1155/2012/467821

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Visual detection of filaria-specific IgG4 in urine using red-colored high density latex beads.2012

    • Author(s)
      Nagaoka F
    • Journal Title

      Parasitol Int

    • DOI

      10.1016/j.parint.2012.09.002

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intestinal mast cells and eosinophils in relation to Strongyloides rattiadult expulsion from the small and large intestines of rats2012

    • Author(s)
      Shintoku Y
    • Journal Title

      Parasitology

    • DOI

      10.1017/s0031182012001837

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Visceral Leishmaniasis Eradication is a Reality: Data from a Community-based Active Surveillance in Bangladesh2012

    • Author(s)
      Ferdousi F
    • Journal Title

      Trop.Med.Health

      Volume: 40 Issue: 4 Pages: 133-139

    • DOI

      10.2149/tmh.2012-25

    • NAID

      10031156768

    • ISSN
      1348-8945, 1349-4147
    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ミャンマー中部の病院で実施した陰嚢水腫手術例におけるフィラリア症の検討2012

    • Author(s)
      児玉一男
    • Journal Title

      Clinical Parasitology

      Pages: 46-48

    • Related Report
      2012 Annual Research Report
  • [Presentation] スリランカにおけるWuchereria bancrofti媒介蚊の感染率の季節変動2015

    • Author(s)
      高木秀和、 Yahathugoda TC、Weerasooriya MV、木村英作、伊藤 誠
    • Organizer
      第84回日本寄生虫学会
    • Place of Presentation
      杏林大学
    • Year and Date
      2015-03-21 – 2015-03-22
    • Related Report
      2014 Annual Research Report
  • [Presentation] ベトナム南部における媒介蚊からみた森林マラリア伝播の分子疫学的研究2015

    • Author(s)
      前野芳正、Culleton R、Quang NT、川合 覚、伊藤 誠、Marchand RP、中澤秀介
    • Organizer
      第84回日本寄生虫学会
    • Place of Presentation
      杏林大学
    • Year and Date
      2015-03-21 – 2015-03-22
    • Related Report
      2014 Annual Research Report
  • [Presentation] Giargia intestinalisにおけるassemblage AとBは別種とすべきか2015

    • Author(s)
      水野哲志、 Syafruddin D、伊藤 誠、所 正治
    • Organizer
      第84回日本寄生虫学会
    • Place of Presentation
      杏林大学
    • Year and Date
      2015-03-21 – 2015-03-22
    • Related Report
      2014 Annual Research Report
  • [Presentation] Visceral leishmaniasis in Bangladesh: active survey with urine samples2014

    • Author(s)
      伊藤誠,Mohammad Sohel Samad ,東城文柄,小笠原絵美,長岡史晃,長田康孝,原田倫代,野入英世
    • Organizer
      第55回日本熱帯医学会
    • Place of Presentation
      国立国際医療研究センター
    • Year and Date
      2014-11-01 – 2014-11-03
    • Related Report
      2014 Annual Research Report
  • [Presentation] 内臓リーシュマニア症流行地の小学生の抗体保有状況の調査2014

    • Author(s)
      伊藤 誠
    • Organizer
      第70回日本寄生虫学会 西日本支部大会
    • Place of Presentation
      兵庫医療大学
    • Year and Date
      2014-10-18 – 2014-10-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] Survey of schoolchildren for visceral leishmaniasis with urine samples2013

    • Author(s)
      Samad MS
    • Organizer
      第82回日本寄生虫学会
    • Place of Presentation
      東京
    • Year and Date
      2013-03-31
    • Related Report
      2012 Annual Research Report
  • [Presentation] ケニア西部の小学生における寄生虫感染とリスク要因に関する研究2013

    • Author(s)
      凪幸世
    • Organizer
      第82回日本寄生虫学会
    • Place of Presentation
      東京
    • Year and Date
      2013-03-30
    • Related Report
      2012 Annual Research Report
  • [Presentation] Human immunity against parasites2012

    • Author(s)
      Itoh M
    • Organizer
      JSPS Asia Africa Science Platform Program : The eco-epidemiology of forest and zoonotic malaria ; Inuyama PRI symposium Monkey Malaria in Focus : recent perspectives on forest and zoonotic malaria
    • Place of Presentation
      犬山(愛知)
    • Year and Date
      2012-12-18
    • Related Report
      2012 Annual Research Report
  • [Presentation] Application of ELISA to detect urinary IgG4 for the mass-survey of lymphatic filariasis in Bangladesh2012

    • Author(s)
      Samad MS
    • Organizer
      12 th Asian-Pacific Congress for Parasitic Zoonosis
    • Place of Presentation
      神戸
    • Year and Date
      2012-10-07
    • Related Report
      2012 Annual Research Report
  • [Presentation] Evaluation of control programs for visceral leishmaniasis with urine2012

    • Author(s)
      Itoh M
    • Organizer
      3rd International Conference on Neglected Tropical Diseases
    • Place of Presentation
      Dhaka (Bangladesh)
    • Year and Date
      2012-09-02
    • Related Report
      2012 Annual Research Report
  • [Presentation] Confirmation of the usefulness of ELISA to detect urinary IgG4 for diagnosis of lymphatic filariasis in Bangladesh2012

    • Author(s)
      Samad MS
    • Organizer
      3rd International Conference on Neglected Tropical Diseases
    • Place of Presentation
      Dhaka (Bangladesh)
    • Year and Date
      2012-09-01
    • Related Report
      2012 Annual Research Report
  • [Presentation] Efficacy of Urinary Test to Mass-Survey in VL and Contribution of LAMP

    • Author(s)
      Itoh M, Takagi H, Noiri E
    • Organizer
      Fifth World Congress on Leishamaniasis
    • Place of Presentation
      Recife, Brazil
    • Related Report
      2013 Annual Research Report
  • [Presentation] Active survey for visceral leishmaniasis with urine samples

    • Author(s)
      Samad MS, Nagaoka F, Ogasawara E, Osada Y, Harada M, Noiri E, Itoh M
    • Organizer
      2nd National Conference on Tropical Medicine & Toxicology
    • Place of Presentation
      Chittagong, Bangladesh
    • Related Report
      2013 Annual Research Report
  • [Presentation] Evaluation of lymphatic filariasis elimination program by urine ELISA in Bangladesh

    • Author(s)
      Samad MS、伊藤誠、木村英作
    • Organizer
      第83回日本寄生虫学会大会
    • Place of Presentation
      松山(愛媛)
    • Related Report
      2013 Annual Research Report
  • [Presentation] LAMP 法による流行地で採取した媒介蚊からの Wuchereria bancrofti 検出

    • Author(s)
      高木秀和、Yahathugoda TC、Weerasooriya MV、木村英作、伊藤誠
    • Organizer
      第83回日本寄生虫学会大会
    • Place of Presentation
      松山(愛媛)
    • Related Report
      2013 Annual Research Report
  • [Presentation] A predictive medel of residual areas of filariasis in Sri Lanka using remote sensing environmental and topography data

    • Author(s)
      Rathnapala U, Yahathugoda T C, Weerasoriya M, 砂原俊彦, 木村 英作, 伊藤誠, 小林信之, 平山謙二
    • Organizer
      第54回日本熱帯医学会総会
    • Place of Presentation
      長崎
    • Related Report
      2013 Annual Research Report
  • [Book] 今日の治療指針 20152015

    • Author(s)
      伊藤 誠
    • Total Pages
      2
    • Publisher
      医学書院
    • Related Report
      2014 Annual Research Report
  • [Book] 感染症症候群(第2版)、上 病原体別感染症編、VI.原虫症、寄生虫症、フィラリア症2013

    • Author(s)
      木村英作、伊藤誠、角坂照貴
    • Total Pages
      4
    • Publisher
      日本臨床社
    • Related Report
      2013 Annual Research Report

URL: 

Published: 2012-04-23   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi