Investigation of the transmission dynamics of MDR- and XDR-tuberculosis in Asian countries
| Project/Area Number |
24406021
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 海外学術 |
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| Research Field |
Public health/Health science
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| Research Institution | Hokkaido University |
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Principal Investigator |
Suzuki Yasuhiko 北海道大学, 人獣共通感染症リサーチセンター, 教授 (90206540)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAJIMA CHIE 北海道大学, 人獣共通感染症リサーチセンター, 特任助教 (60435964)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2014: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2013: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2012: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
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| Keywords | 多剤耐性結核 / 超多剤耐性結核 / 遺伝子型別 / 結核菌群菌 / 多剤耐性 / 超多剤耐性 / 遺伝子変異 / 伝播動態調査 |
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| Outline of Final Research Achievements |
We selected Nepal, Bangladesh, Myanmar, Thailand and the philippines as the countries without sufficient investigation of multidrug-resistant (MDR)- and extensively drug resistant (XDR)-tuberculosis (TB). We isolated 2208 Mycobacterium tuberculosis strains from those who were showing tuberculosis or tuberculosis-like symptoms and stored as strain banks in each country. In addition, we extracted DNA from these strains and stored as DNA bank in both Japan and those countries.
By genotyping and the analysis of drug resistance associating gene mutations, we found that many of the MDR- and XDR-TB were caused by M. tuberculosis strains with Beijing genotype and the strains were showing rapid transmission dynamics.
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Report
(5 results)
Research Products
(23 results)
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[Journal Article] ntra-subspecies sequence variability of the MACPPE12 gene in Mycobacterium avium subsp. Hominissuis2014
Author(s)
Iwamoto T, Arikawa K, Nakajima C, Nakanishi N, Nishiuchi Y, Yoshida S, Tamaru A,Tamura Y, Hoshino Y, Yoo H, Park YK, Saito H, Suzuki Y
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Journal Title
Infection, Genetics and Evolution
Volume: 21
Pages: 476-483
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] A simple multiplex PCR for the identification of Beijing family of Mycobacterium tuberculosis with a lineage-specific mutation in Rv0679c2013
Author(s)
Nakajima C, Tamaru A, Rahim Z, Poudel A, Maharjan B, Aye KS, Ling H, Hattori T, Iwamoto T, Fukushima Y, Suzuki H, Suzuki Y, Matsuba T
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Journal Title
J. Clin. Microbiol.
Volume: 51
Pages: 2025-2032
DOI
Related Report
Peer Reviewed
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[Presentation] Genetic diversity and transmission dynamics of multidrug-resistant Tuberculosis in Nepal2016
Author(s)
Bhagwan Maharjan, Yasuhiko Suzuki, Chie Nakajima, Ajay Poudel, Harald Hoffmann, Korkut Avsar, Bhabana Shrestha, Jeewan Thapa, Yogendra Shah, Rajendra Pant
Organizer
US-Japan Cooperative Medical Science Program 50th Anniversary, TB and Leprosy Panel Meeting
Place of Presentation
Bethesda, MD, USA
Year and Date
2016-01-13
Related Report
Int'l Joint Research
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[Presentation] Molecular characteristics and genotypes of Mycobacterium tuberculosis isolated from an outbreak of Thailand-Myanmar border2016
Author(s)
Janisara Rudeeaneksin, Benjawan Phetsuksiri, Supranee Bunchoo, Sopa Srisungngam, Wiphat Klayut, Somchai Sangkitporn, Anupong Sujariyakul, Krairerk Suthum, Nattakan Tipkrual, Yukari Fukushima, Haruka Suzuki, Chie Nakajima, Yasuhiko Suzuki
Organizer
US-Japan Cooperative Medical Science Program 50th Anniversary, TB and Leprosy Panel Meeting
Place of Presentation
Bethesda, MD, USA
Year and Date
2016-01-13
Related Report
Int'l Joint Research
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