| Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2014: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2013: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2012: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
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| Outline of Final Research Achievements |
We selected Nepal, Bangladesh, Myanmar, Thailand and the philippines as the countries without sufficient investigation of multidrug-resistant (MDR)- and extensively drug resistant (XDR)-tuberculosis (TB). We isolated 2208 Mycobacterium tuberculosis strains from those who were showing tuberculosis or tuberculosis-like symptoms and stored as strain banks in each country. In addition, we extracted DNA from these strains and stored as DNA bank in both Japan and those countries.
By genotyping and the analysis of drug resistance associating gene mutations, we found that many of the MDR- and XDR-TB were caused by M. tuberculosis strains with Beijing genotype and the strains were showing rapid transmission dynamics.
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