Singular perturbation/bifurcation analysis of the cardiac sinoatrial node model in consideration of its heterogeneous structure and the study on the generation mechanism of synchronized oscillations
Project/Area Number |
24500274
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Sensitivity informatics/Soft computing
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Research Institution | Kyoto University |
Principal Investigator |
DOI Shinji 京都大学, 工学(系)研究科(研究院), 教授 (50217600)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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Keywords | 心臓 / ペースメーカ / 洞房結節 / 同期振動 / 数理モデル / 分岐解析 / 特異摂動 / 心臓洞房結節 / 振動子結合系 / 同期リズム / 特異摂動系 / 分岐現象 / ヒト心室筋細胞モデル / 分岐 |
Outline of Final Research Achievements |
Using a mathematical model of cardiac sinoatrial node cells, we study the generation mechanism of cardiac rhythm. It is shown that the characteristics as singularly perturbed system of the single cell model induce a strange (spurious) chaotic rhythm when numerical precisions are not enough. In consideration of the heterogeneous or inhomogeneous structure of sinoatrial node, we also analyzed the bifurcation structure of different types of sinoatrial cells electrically coupled through gap junctions. As a result, it is shown that the coupled system of heterogeneous cells shows different synchronized rhythms from those of homogeneous coupled system.
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Report
(4 results)
Research Products
(30 results)