The analysis of brain damage by dysfunction of the endoplasmic reticulum signaling
Project/Area Number |
24500440
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Neurochemistry/Neuropharmacology
|
Research Institution | Yasuda Women's University |
Principal Investigator |
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Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 細胞生物学 / 神経科学 / 細胞内ストレス応答 / 国際情報交換 |
Outline of Final Research Achievements |
To elucidate the role of endoplasmic reticulum stress signaling in brain development, we examined the brain of PERK-deficient mice. We showed that the size of whole brain and olfactory bulb were smaller in PERK-deficient mice. In addition, the endoplasmic reticulum stress occurs in mouse subplate neurons at developmental stage. These results suggest that ER stress response have the important role in brain development.
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Report
(4 results)
Research Products
(1 results)