Optical analysis of significance of the depolarization wave to the brainstem neural circuit formation
| Project/Area Number |
24500466
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurophysiology and muscle physiology
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| Research Institution | Komazawa Women's University |
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Principal Investigator |
SATO Katsushige 駒沢女子大学, 公私立大学の部局等, 教授 (80291342)
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| Co-Investigator(Renkei-kenkyūsha) |
SATO Yoko (MOMOSE Yoko) 関東学院大学, 人間環境学部, 教授 (70251501)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | optical recording / voltage-sensitive dye / brainstem / functiogenesis / depolarization wave / neural circuit formation / embryo / spontaneous activity / 光学的イメージング / 膜電位感受性色素 / 脳幹 / 機能発生 / 脱分極波 / 神経回路網形成 / 自発興奮 |
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| Outline of Final Research Achievements |
Spontaneous embryonic movements, called embryonic motility, are produced by correlated spontaneous activity in the cranial and spinal nerves, which is driven by brainstem and spinal networks. Using optical imaging with a voltage-sensitive dye, we have revealed previously in the chick and rat embryos that this correlated activity is a widely propagating wave of neural depolarization, which we termed the depolarization wave. One important consideration is whether a depolarization wave with similar characteristics occurs in other species, especially in different mammals. Here, we provide evidence for the existence of the depolarization wave in the mouse embryo by summarizing spatiotemporal characteristics and pharmacological natures of the widely propagating wave activity. The findings show that a synchronized wave with common characteristics is expressed in different species, suggesting its fundamental roles in neural development.
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Report
(4 results)
Research Products
(37 results)
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[Journal Article] Evaluation of voltage-sensitive fluorescence dyes for monitoring neuronal activity in the embryonic central nervous system.2013
Author(s)
Mullah, S. H.-E.-R., Komuro, R., Yan, P., Hayashi, S., Inaji, M., Momose- Sato, Y., Loew, L. M. and Sato, K.
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Journal Title
J Membr Biol.
Volume: 246
Pages: 679-688
DOI
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Peer Reviewed
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[Presentation] Visual imprinting in chicks requires activation of highly-expressed NR2B-containing NMDA receptors in the neural circuit of the hyperpallium. Avian Model Systems.2014
Author(s)
Nakamori, T., Sato, K., Kinoshita, M., Tanaka, K. and Ohki-Hamazaki, H.
Organizer
Avian Model Systems
Place of Presentation
Cold Spring Habor Laboratory, NY, USA.
Related Report
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[Presentation] Evaluation of voltage-sensitive fluorescence dyes for monitoring neuronal activity in the embryonic CNS.2013
Author(s)
Mullah, S. H.-E.-R. , Komuro, R., Yan, P., Inaji, M., Urmy, J., Momose-Sato, Y., Loew, L. M. and Sato, K.
Organizer
Society for Neuroscience 43rd Annual Meeting
Place of Presentation
San Diego, USA
Related Report
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[Presentation] Developmental changes in the LTP in the neonatal rat corticostriatal projection: Optical imaging with a voltage-sensitive dye.2012
Author(s)
Mullah, S. H.-E.-R. , Inaji, M., Nariai, T., Urmy, J., Momose-Sato, Y., Ohno, K. and Sato, K.
Organizer
Society for Neuroscience 42nd Annual Meeting
Place of Presentation
New Orleans, USA
Related Report
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