Analysis of MG56: sarcoplasmic reticulum-resident protein
Project/Area Number |
24500470
|
Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Neurophysiology and muscle physiology
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Research Institution | Kyoto University |
Principal Investigator |
NISHI Miyuki 京都大学, 健康長寿社会の総合医療開発ユニット, 准教授 (60183894)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 骨格筋 / カルシウム / 小胞体 |
Outline of Final Research Achievements |
Mitsugumin 56 (MG56), also known as the membrane-bound O-acyl-transferase family member hedgehog acyltransferase-like, was identified as a new sarcoplasmic reticulum component in striated muscle. Mg56-knockout mice grew normally for a week after birth, but shortly thereafter exhibited a suckling defect and died under starvation conditions. In the knockout skeletal muscle, regular contractile features were largely preserved, but sarcoplasmic reticulum elements swelled and further developed enormous vacuoles. In parallel, the unfolded protein response was severely activated in the knockout muscle, and presumably disrupted muscle development leading to the suckling failure. Therefore, MG56 seems essential for postnatal skeletal muscle maturation.
|
Report
(4 results)
Research Products
(12 results)
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[Journal Article] Mitsugumin 56 (hedgehog acyltransferase-like) is a sarcoplasmic reticulum-resident protein essential for postnatal muscle maturation.2015
Author(s)
Van B, Nishi M, Komazaki S, Ichimura A, Kakizawa S, Nakanaga K, Aoki J, Park KH, Ma J, Ueyama T, Ogata T, Maruyama N, Takeshima H.
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Journal Title
FEBS Lett.
Volume: in press
Issue: 10
Pages: 1095-1104
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] TRIM72 is required for effective repair of alveolar epithelial cell wounding.2014
Author(s)
Kim SC, Kellett T, Wang S, Nishi M, Nagre N, Zhou B, Flodby P, Shilo K, Ghadiali SN, Takeshima H, Hubmayr RD, Zhao X.
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Journal Title
Am J Physiol Lung Cell Mol Physiol.
Volume: 307
Issue: 6
Pages: L449-L459
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Treatment of acute lung injury by targeting MG53-mediated cell membrane repair.2014
Author(s)
Jia Y, Chen K, Lin P, Lieber G, Nishi M, Yan R, Wang Z, Yao Y, Li Y, Whitson BA, Duann P, Li H, Zhou X, Zhu H, Takeshima H, Hunter JC, McLeod RL, Weisleder N, Zeng C, Ma J.
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Journal Title
Nat Commun.
Volume: 5
Issue: 1
Pages: 1-12
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] TRIC-B channels display labile gating: evidence from the TRIC-A knockout mouse model.2013
Author(s)
Venturi, E., Matyjaszkiewicz, A., Pitt, S. J., Tsaneva-Atanasova, K., Nishi, M., Yamazaki, D., Takeshima, H. & Sitsapesan, R.
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Journal Title
Pflugers Arch.
Volume: 465
Issue: 8
Pages: 1135-1148
DOI
Related Report
Peer Reviewed
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[Journal Article] Enhanced dihydropyridine receptor calcium channel activity restores muscle strength in JP45/CASQ1 double knockout mice.2013
Author(s)
Mosca B, Delbono O, Laura Messi M, Bergamelli L, Wang ZM, Vukcevic M, Lopez R, Treves S, Nishi M, Takeshima H, Paolini C, Martini M, Rispoli G, Protasi F, Zorzato F.
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Journal Title
Nat. Commun.
Volume: 4
Pages: 1541-1549
Related Report
Peer Reviewed
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[Journal Article] Endogenously determined restriction of food intake overcomes excitation-contraction uncoupling in JP45KO mice with aging2012
Author(s)
Delbono, O., Messi M. L., Wang, Z., Treves, S., Mosca, B., Bergamelli, L., Nishi, M., Takeshima, H., Shi H., Xue B. & Zorzato, F
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Journal Title
Exp. Gerontol
Volume: 4
Issue: 4
Pages: 304-316
DOI
Related Report
Peer Reviewed
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[Journal Article] Recombinant human MG53 protein modulates therapeutic cell membrane repair.2012
Author(s)
Weisleder N, Takizawa N, Lin P, Wang X, Cao C, Zhang Y, Tan T, Ferrante C, Zhu H, Chen P-J, Yan R, Sterling M, Zhao X, Hwang M, Cai C, Cheng H, Takeshima H, Xiao R. & Ma J.
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Journal Title
Sci. Transl. Med.
Volume: 4
Issue: 139
Pages: 1-10
DOI
Related Report
Peer Reviewed
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[Journal Article] TRIM50 regulates vesicular trafficking for acid secretion in gastric parietal cells.2012
Author(s)
Nishi, M., Aoyama, F., Kisa, F., Zhu, H., Sun, M., Lin, P., Ohta, H., Yamamoto, S., Kakizawa, S., Sakai, H., Ma, J., Sawaguchi, A. & Takeshima, H.
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Journal Title
J. Biol. Chem.
Volume: 287
Issue: 40
Pages: 33523-33532
DOI
Related Report
Peer Reviewed
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[Presentation] The MBOAT family protein Mitsugumin 56 contributes to postnatal maturation in the muscle sarcoplasmic reticulum.2014
Author(s)
Van, B., Nishi, M., Komazaki, S., Park, K. H., Yamazaki, D., Ma, J. & Takeshima, H.
Organizer
Biophysical Society 58th annual meeting
Place of Presentation
Sanfrancisco, CA, USA
Related Report
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[Presentation] TRIM50 regulates ventricular trafficking for acid secretion in gastric parietal cells.2013
Author(s)
Nishi, M., Aoyama, F., Kisa, F., Zhu, H., Sun, M., Lin, P., Van, Bo., Ma, J., Sawaguchi, A., & Takeshima, H.
Organizer
Biophysical Society 57th annual Meeting
Place of Presentation
Philadelphia, USA
Related Report
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