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Brain atlas of the miniature pig to establish new animal model for image-assisted stereotaxic surgery.

Research Project

Project/Area Number 24500480
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Fusional brain recording science
Research InstitutionKyoto Sangyo University

Principal Investigator

SAITO Toshiyuki  京都産業大学, 総合生命科学部, 教授 (10162215)

Co-Investigator(Kenkyū-buntansha) WATANABE Eiju  自治医科大学, 医学部, 客員教授 (50150272)
Co-Investigator(Renkei-kenkyūsha) SASAKI Sei-ichi  茨城県立医療大学, 保健医療学部, 教授 (50153987)
Research Collaborator DAN Ippeita  
OGURO Keiji  
YOKOTA Hidenori  
UGA Minako  
Project Period (FY) 2012-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords統合脳地図 / ミニブタ / ナビゲーション / 脳の前臨床研究 / 脳の神経生理学的研究 / 連続脳凍結切片 / 核磁気共鳴断層撮影 / 脳地図作成 / 矢状断連続脳切片 / ニューロナビゲーション
Outline of Final Research Achievements

There are quite limited experimental large animals for use in preclinical brain research. In this study, we aimed to make the brain atlas of the miniature pigs for promoting the preclinical research. Mexican hairless pig has been used. In the brain of this animal, we examined to get images with the common standard planes by Magnetic Resonance (MR) measurement and those of the serial brain sections. There have been observed the intracerebral markers to set the common horizontal standard plane, anterior and posterior commissure. These markers were identified by the MR imaging and by Nissl staining of the brain sections. Besides, we put glass-markers visualized by MRI to adjust the common vertical standard planes in both the MR images and the brain sections. Technically, the common standards planes are able to be set in both the MR images and the brain sections, thereby partially making a draft of the integrated brain atlas using Mexican hairless pig.

Report

(5 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (9 results)

All 2016 2014 2013 2012 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (6 results) Remarks (1 results)

  • [Journal Article] Direct cortical hemodynamic mapping of somatotopy of pig nostril sensation by functional near-infrared cortical imaging (fNCI)2014

    • Author(s)
      Uga M, Saito T, Sano T, Yokota H, Oguro K, Rizki EE, Mizutani T, Katura T, Dan I, Watanabe E
    • Journal Title

      NeuroImage

      Volume: 91 Pages: 138-145

    • DOI

      10.1016/j.neuroimage.2013.12.062

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Evoked potential mapping of the rostral region by frameless navigation system in Mexican hairless pig.2013

    • Author(s)
      Toshiyuki Saito, Minako Uga, Daisuke Tsuzuki, Hidenori Yokota, Keiji Oguro, Tsuyoshi Yamamoto, Ippeita Dan, Eiju Watanabe
    • Journal Title

      Journal of Neuroscience Methods

      Volume: 212 Pages: 100-105

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] ミニブタの脳地図作製の技術的検証2016

    • Author(s)
      齋藤敏之・宇賀美奈子・佐々木誠一・渡辺英寿
    • Organizer
      第159回日本獣医学会学術集会
    • Place of Presentation
      日本大学生物資源科学部(神奈川県・藤沢市)
    • Year and Date
      2016-09-06
    • Related Report
      2015 Annual Research Report
  • [Presentation] The development of functional Near-infrared Cortical Imaging (fNCI): the direct cortical hemodynamic mapping of the miniature pig's somatosensory area.2014

    • Author(s)
      Uga M, Saito T, Yokota H, Oguro K, Rizki EE, Mizutani M, Dan I, Watanabe E.
    • Organizer
      fNIRS 2014
    • Place of Presentation
      University of Montreal, Montreal, Canada
    • Year and Date
      2014-10-10 – 2014-10-12
    • Related Report
      2014 Research-status Report
  • [Presentation] Functional Near-infrared Cortical Imaging (fNCI) of the miniature pig brain : the comparison of hemoglobin species.2014

    • Author(s)
      Uga M, Saito T, Tsuzuki D, Yokota H, Oguro K, Rizki EE, Mizutani T, Dan I, Watanabe E.
    • Organizer
      Neuroscience 2014
    • Place of Presentation
      Nagoya Congress Center, Nagoya
    • Year and Date
      2014-09-11 – 2014-09-13
    • Related Report
      2014 Research-status Report
  • [Presentation] Application of frameless navigation method for evoked potential mapping in the brain of Mexican hairless pig.2012

    • Author(s)
      Minako Uga, Toshiyuki Saito, Daisuke Tsuzuki, Hidenori Yokota, Keiji Oguro, Tsuyoshi Yamamoto, Ippeita Dan, Eiju Watanabe
    • Organizer
      8th FENS Forum of Neuroscience
    • Place of Presentation
      Barcelona, Spain
    • Related Report
      2012 Research-status Report
  • [Presentation] ミニブタにおけるframless stereotaxy の検証2012

    • Author(s)
      齋藤敏之、宇賀美奈子、續木大介、横田英典、小黒恵司、山本剛、檀一平太、渡辺英寿
    • Organizer
      第154回日本獣医学会学術集会
    • Place of Presentation
      岩手大学、岩手県盛岡市
    • Related Report
      2012 Research-status Report
  • [Presentation] 頭蓋骨上の基準点に基づくフレームレスナビゲーションシステムを用いたミニブタの脳座標の決定2012

    • Author(s)
      宇賀美奈子、齋藤敏之、續木大介、横田英典、小黒恵司、山本剛、檀一平太、渡辺英寿
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋国際会議場、名古屋市
    • Related Report
      2012 Research-status Report
  • [Remarks] 総合生命科学部 齋藤 敏之教授らのグループが脳表面から光で直接脳血流変化を計測する新技術の開発に成功

    • URL

      http://www.kyoto-su.ac.jp/department/nls/news/20140114_news01.html

    • Related Report
      2014 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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