Sox17 haploinsufficiency as applied to human disease model for newborn hepatitis.
Project/Area Number |
24500485
|
Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Laboratory animal science
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Research Institution | Tokyo Medical and Dental University |
Principal Investigator |
KANAI MASAMI 東京医科歯科大学, 実験動物センター, 教授 (70321883)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | へテロ不全 / 疾患モデル動物 / 新生児肝炎 / Sox17 / ヘテロ不全 / TARGATT / マウス / 胆のう / C57BL/6 / 疾患モデルマウス / 肝炎 / 先天性疾患 |
Outline of Final Research Achievements |
In this study, we have observed the phenotype about the condition of a patient of the newborn hepatitis that showing Sox17 haploinsufficiency comparative with Sox17 conditional knockout lines for liver, pancreas and gallbladder, morphologically. In addition, as a candidate of the new human disease model, we confirmed gene introduction efficiency by use of TARGATT (the transgenic mouse system which can control a copy number in site specific). We will apply it as a disease model compared with Sox17 heterozygous mouse and point mutated SHIVA mouse (Met 72 mutated to Arg; with the liver metabolism abnormality symptom).
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Report
(4 results)
Research Products
(33 results)
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[Journal Article] Sox17-mediated maintenance of fetal intra-aortic hematopoietic cell clusters.2014
Author(s)
Nobuhisa I, Osawa M, Uemura M, Kishikawa Y, Anani M, Harada K, Takagi H, Saito K, Kanai-Azuma M, Kanai Y, Iwama A, Taga T.
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Journal Title
Mol Cell Biol.
Volume: 34(11)
Pages: 1976-1990.
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Sox17 haploinsufficiency results in perinatal biliary atresia and hepatitis in C57BL/6 background mice.2013
Author(s)
Uemura M, Ozawa A, Nagata T, Kurasawa K, Tsunekawa N, Nobuhisa I, Taga T, Hara K, Kudo A, Kawakami H, Saijoh Y, Kurohmaru M, Kanai-Azuma M, Kanai Y.
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Journal Title
Development
Volume: 140(3)
Pages: 639-648
DOI
Related Report
Peer Reviewed
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