Identification of genes for ulcerative colitis utilizing SAM mice
| Project/Area Number |
24500487
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory animal science
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| Research Institution | Shinshu University |
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Principal Investigator |
MORI Masayuki 信州大学, 学術研究院医学系, 准教授 (60273190)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 潰瘍性大腸炎 / マウス / Abcb1a / 遺伝子 / 疾患モデル |
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| Outline of Final Research Achievements |
It was found that development of ulcerative colitis under the compromised Abcb1a function is influenced by modifier genes located on chromosomes 16 and 13 by using SAMP1 and FVB/N mouse strains that have a loss-of-function mutation in the Abcb1a gene, which functions in the exclusion of a wide range of drugs from the cell. It was also revealed that one of the modifier genes is located in the interval of approximately 7 Mb on chromosome 16. Furthermore, a missense nucleotide substitution polymorphism in the Ifnar1 gene was discovered between the two mouse strains that the SAM strains. However, it was not clear if the polymorphism is actually involved in the determination of development of ulcerative colitis under the compromised Abcb1a function.
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Report
(4 results)
Research Products
(8 results)
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[Journal Article] Exome sequencing of senescence-accelerated mice (SAM) reveals deleterious mutations in degenerative disease-causing genes.2013
Author(s)
Tanisawa K., Mikami E., Fuku N., Honda Y., Honda S., Ohsawa I., Ito M., Endo S., Ihara K., Ohno K., Kishimoto Y., Ishigami A., Maruyama N., Sawabe M., Iseki H., Okazaki Y., Hasegawa-Ishii S., Takei S., Shimada A., Hosokawa M., Mori M., Higuchi K., Takeda T., Higuchi M., Tanaka M.
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Journal Title
Exome sequencing of senescence-accelerated mice (SAM) reveals deleterious mutations in degenerative disease-causing genes
Volume: 14(1):
Pages: 1-15
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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