Generation of novel inflammatory disease model caused by dysregulation of IL-1 signaling
Project/Area Number |
24500488
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Laboratory animal science
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Research Institution | The University of Tokyo |
Principal Investigator |
KAKUTA Shigeru 東京大学, 農学生命科学研究科, 准教授 (80345032)
|
Co-Investigator(Kenkyū-buntansha) |
MATSUMOTO Kiyoshi 信州大学, ヒト環境科学研究支援センター, 教授 (40173893)
MORI Masayuki 信州大学, 医学(系)研究科(研究院), 准教授 (60273190)
NAGASE Hisashi 信州大学, 医学部, 助教 (70303451)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
Keywords | 炎症 / 疾患モデル動物 / インターロイキン |
Outline of Final Research Achievements |
Mice lacking for IL-1 receptor antagonist (Ra), an endogenous inhibitor, spontaneously develop rheumatoid arthritis and psoriasis-like dermatitis. Although it is reported that IL-1Ra consists two isoforms (soluble/s and intracellular/ic) and pre-IL-1α acts as a putative transcriptional factor, their functions remain unknown. In this study, we newly generated s/icIL-1Ra isoform specific deficient mice and pre-IL1α/NLS mutated mice. Analysis of C57BL/6 background s/icIL-1Ra deficient mice indicates that s/icIL-1Ra isoforms act in a mutually complementary manner. BALB/c background sIL-1Ra deficient mice are novel and useful arthritis model with high breeding efficiency.
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Report
(4 results)
Research Products
(41 results)
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[Journal Article] IL-1 receptor 1 antagonist-deficient mice develop autoimmune arthritis due to intrinsic activation of IL-17-producing CCR2+Vγ6+γδ T cells2015
Author(s)
Akitsu A, Ishigame H, Kakuta S, Chung S, Ikeda S, Shimizu K, Kubo S, Liu Y, Umemura M, Matsuzaki G, Yoshikai Y, Saijo S, Iwakura Y.
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Journal Title
Related Report
Peer Reviewed / Open Access
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[Journal Article] CCR8 regulates contact hypersensitivity by restricting cutaneous dendritic cell migration to the draining lymph nodes.2015
Author(s)
Yabe R, Shimizu K, Shimizu S, Azechi S, Choi BI, Sudo K, Kubo S, Nakae S, Ishigame H, Kakuta S, Iwakura Y.
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Journal Title
Int Immunol.
Volume: 27(4)
Issue: 4
Pages: 169-181
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Gene Targeting Study Reveals Unexpected Expression of Brain expressed X-linked 2 in Endocrine and Tissue Stem/progenitor Cells in Mice2014
Author(s)
Keiichi Ito, Satoshi Yamazaki, Ryo Yamamoto, Yoko Tajima, Ayaka Yanagida, Toshihiro Kobayashi, Megumi Kato-Itoh, Shigeru Kakuta, Yoichiro Iwakura, Hiromitsu Nakauchi, Akihide Kamiya,
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Journal Title
J Biol Chem
Volume: 289(43)
Issue: 43
Pages: 29892-911
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Chemokine Receptor CCR8 Is Required for Lipopolysaccharide-Triggered Cytokine Production in Mouse Peritoneal Macrophages.2014
Author(s)
Oshio T, Kawashima R, Kawamura YI, Hagiwara T, Mizutani N, Okada T, Otsubo T, Inagaki-Ohara K, Matsukawa A, Haga T, Kakuta S, Iwakura Y, Hosokawa S, Dohi T.
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Journal Title
PLoS One
Volume: 9(4)
Issue: 4
Pages: 1-12
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Stage-specific roles for Cxcr4 signaling in murine hematopoietic stem/progenitor cells in the process of bone marrow repopulation.2014
Author(s)
Lai CY, Yamazaki S, Okabe M, Suzuki S, Maeyama Y, Iimura Y, Onodera M, Kakuta S, Iwakura Y, Nojima M, Otsu M, Nakauchi H.
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Journal Title
Stem Cells.
Volume: -
Issue: 7
Pages: 1929-42
DOI
Related Report
Peer Reviewed
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[Journal Article] Generation of a mouse model with down-regulated U50 snoRNA (SNORD50) expression and its organ-specific phenotypic modulation2013
Author(s)
Soeno Y, Fujita K, Kudo T, Asagiri M, Kakuta S, Taya Y, Shimazu Y, Sato K, Tanaka-Fujita R, Kubo S, Iwakura Y, Nakamura Y, Mori S, and Aoba T
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Journal Title
PLoS ONE
Volume: 8
Issue: 8
Pages: e72105-e72105
DOI
Related Report
Peer Reviewed
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[Journal Article] Vaspin is an adipokine ameliorating ER stress in obesity as a ligand for cell-surface GRP78/MTJ-1 complex2012
Author(s)
Nakatsuka A, Wada J, Iseda I, Teshigawara S, Higashio K, Murakami K, Kanzaki M, Inoue K, Terami T, Katayama A, Hida K, Eguchi J, Horiguchi CS, Ogawa D, Matsuki Y, Hiramatsu R, Yagita H, Kakuta S, Iwakura Y, Makino H
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Journal Title
Diabetes
Volume: 61(11)
Issue: 11
Pages: 2823-2832
DOI
NAID
Related Report
Peer Reviewed
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