• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Development of a minimally invasive pin-point-treatment of cancer cells utilizing active hydrogen discharged from hydrogen storage alloys

Research Project

Project/Area Number 24500512
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionNagasaki University

Principal Investigator

KAGAWA akio  長崎大学, 工学研究科, 教授 (00093401)

Research Collaborator YAMAMOTO Masataka  長崎大学, 工学研究科, 助教
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords水素貯蔵合金 / パラジウム / ニッケル / 鉄 / 癌細胞 / 正常細胞 / 水素吸蔵合金 / 三次元培地
Outline of Final Research Achievements

Three subjects have been investigated in the present work.(1) effects of composition and sample shape on the death of cancer cells, (2) the mechanism of cell death and (3) evaluation of bending motion of hydrogen storage alloy(HSA) micro-actuator. The optimum alloy composition is Pd-5at.%Ni and HeLa cancer cell death was observed in the region 2-3 mm apart from the HSA sample.In Pd-7at.%Fe alloy, the death of HeLa cancer cells and MDCK normal cells by anoikis was detected, while a selective cancer cell death was observed in Pd-5at.%Fe alloy specimen.The mechanism of the selective death of cancer cells is clarified on the basis of experiments using fluorescent reagents. The selective death of cancer cells is attributed to a lack of the enzyme, “catalaze” in the cancer cells. The bending motion of micro-actuator utilizing HSA is extensively modified by Pd-spattering and choosing an optimum sample shape.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (12 results)

All 2014 2013 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (9 results) (of which Invited: 2 results)

  • [Journal Article] Influence of Active Hydrogen Discharged from Palladium-Nickel Alloy Powder on Biological Cells2013

    • Author(s)
      A. Motoishi, A. Kagawa, M. Matsuzaki, K. Tanaka, M. Yamamoto and Y. Tagawa
    • Journal Title

      Materials Science Forum

      Volume: 699 Pages: 273-278

    • NAID

      120006986205

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Mechanism of Cancer Cell Death Induced by Hydrogen Discharged from Palladium Base Hydrogen Storage Alloy2013

    • Author(s)
      M. Matsuzaki, A. Kagawa, A. Motoishi, K. Tanaka, M. Yamamoto and Y. Tagawa
    • Journal Title

      Materials Science Forum

      Volume: 699 Pages: 284-290

    • NAID

      120006986204

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Designs for miniaturization of bending actuator utilizing hydrogen storage alloy2013

    • Author(s)
      A. Kagawa, K. Taniguchi and M.Yamamoto
    • Journal Title

      Journal of Alloys and Compounds

      Volume: 563 Pages: 203-206

    • NAID

      120006986126

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] パラジウム系水素吸蔵合金から放出される水素の癌細胞死滅効果2014

    • Author(s)
      平野慎一,山本将貴,大貝猛,香川明男
    • Organizer
      日本金属学会 第155回秋期講演大会
    • Place of Presentation
      名古屋大学東山キャンパス(名古屋市)
    • Year and Date
      2014-09-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] 水素吸蔵合金を利用したアクチュエータ2014

    • Author(s)
      香川明男
    • Organizer
      日本機械学会年次大会
    • Place of Presentation
      東京電機大学(東京都足立区)
    • Year and Date
      2014-09-10
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 水素吸蔵合金の応用-水素駆動アクチュエータと水素を利用した新規癌治療法の開発-

    • Author(s)
      香川明男
    • Organizer
      日本金属学会九州支部 秋期講演会 本多記念講演会
    • Place of Presentation
      長崎大学 文教キャンパス 総合教育研究棟 大講義室(長崎市文教町)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Pd-Fe水素吸蔵合金からの放出水素の生体細胞への影響

    • Author(s)
      久保昇之,本石藍子,山本将貴,大貝 猛,香川明男
    • Organizer
      日本金属学会 第153回秋期講演大会
    • Place of Presentation
      金沢大学 角間キャンパス 自然科学本館 (石川県金沢市)
    • Related Report
      2013 Research-status Report
  • [Presentation] Influence of Active Hydrogen Discharged from Palladium-Nickel Alloy Powder on Biological Cells

    • Author(s)
      A. Motoishi, A. Kagawa, M. Matsuzaki, K. Tanaka, M. Yamamoto and Y. Tagawa
    • Organizer
      Materials Science and Chemical Engineering 2013
    • Place of Presentation
      Singapore
    • Related Report
      2012 Research-status Report
  • [Presentation] Mechanism of Cancer Cell Death Induced by Hydrogen Discharged from Palladium Base Hydrogen Storage Alloy

    • Author(s)
      M. Matsuzaki, A. Kagawa, A. Motoishi, K. Tanaka, M. Yamamoto and Y. Tagawa
    • Organizer
      Materials Science and Chemical Engineering 2013
    • Place of Presentation
      Singapore
    • Related Report
      2012 Research-status Report
  • [Presentation] Bending Motion of a Miniature Actuator Utilizing Hydrogen Storage Alloy

    • Author(s)
      A. Kagawa, K. Taniguchi, K.Kubo, M.Mizumoto and T.Ohgai
    • Organizer
      ACTUATOR 12
    • Place of Presentation
      Bremen, Germany
    • Related Report
      2012 Research-status Report
  • [Presentation] パラジウム系水素吸蔵合金粉末からの放出水素の癌細胞死滅効果

    • Author(s)
      本石藍子、山本将貴、大貝 猛、香川明男
    • Organizer
      日本金属学会 第151回秋季講演大会
    • Place of Presentation
      愛媛大学
    • Related Report
      2012 Research-status Report
  • [Presentation] パラジウム系水素吸蔵合金アクチュエータ用回転モジュールの動作特性

    • Author(s)
      高田慎也、山本将貴、大貝 猛、香川明男
    • Organizer
      日本金属学会 第151回秋季講演大会
    • Place of Presentation
      愛媛大学
    • Related Report
      2012 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi